3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis by G. Gerini, E. Mari, P. Pontecorvi, S. Camero, E. Romano, D. Ranieri, F. Megiorni, P. Fioramonti, A. Angeloni, C. Marchese, S. Ceccarelli

“…Abstract Background Adipose-derived mesenchymal stem cells (ASCs) represent a valid therapeutic option for clinical application in several diseases, mostly due to the paracrine activity of their secretome, exerting pro-angiogenic, antinflammatory and immunosuppressive effects. …”
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Factors associated with health-related quality of life in women with paid work at breast cancer diagnosis: a German repeated cross-sectional study over the first five years after p... by Batoul Safieddine, Siegfried Geyer, Stefanie Sperlich, Johannes Beller, Dorothee Noeres

“…At that stage, income was mostly associated with physical (ß=0.002; CI:0.0002, 0.003) and mental wellbeing (ß=0.002; CI:0.0005, 0.003) with higher summary scores for higher income especially in women aged ≤ 61 years. …”
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Engagement with healthcare providers and healthcare system navigation among Australians with chronic conditions: a descriptive survey study by Jeffrey Braithwaite, Yvonne Zurynski, Joanna Holt, Louise A Ellis, Chiara Pomare, James Ansell, James Gillespie, Jo Root, Isabelle Meulenbroeks, Leanne Wells

“…Logistic regression analyses (estimating ORs) determined the associations between having a chronic condition and the navigation and engagement scores, while controlling for age, gender, level of education and income.Participants 1024 Australians aged 18–88 years (mean=46.6 years; 51% female) recruited from the general population.Results Over half (n=605, 59.0%) of the respondents had a chronic condition, mostly back pain, mental disorders, arthritis and asthma. …”
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Isolation and identification of a matrine-producing fungal strain from petroleum-contaminated soil by Mao Dongxia, Guo Dandan, Wu Lingling, Tian Xiaoxue, Zhang Shengxiang, Liu Tao, Ma Xiaokui

“…The sporangiophores were conical, mostly solitary, showing to grow directly from the hyphae. …”
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Policy Spotlight Effects on Critical Time-Sensitive Diseases: Nationwide Retrospective Cohort Study on Taiwan’s Hospital Emergency Capability Categorization Policy by Chih-Yuan Lin, Chih-Ching Liu, Yu-Tung Huang, Yue-Chune Lee

“…ResultsIn our cohort of 9923 patients, refined through 1:1 propensity score matching, 5566 (56.09%) were male and were mostly older adults. Our analysis revealed that the CHEC policy effectively improved system efficiency and patient outcomes, resulting in significant reductions in medical orders (–7.29 items, 95% CI –10.09 to –4.48; P<.001), short-term mortality rates (–0.09%, 95% CI –0.17% to –0.02%; P=.01) and long-term mortality rates (–0.09%, 95% CI –0.15% to –0.04%; P=.001), and total medical expenses (–5328.35 points per case, 95% CI –10,387.10 to –269.60; P=.04), despite a modest increase in diagnostic fees (376.37 points, 95% CI 92.42-660.33; P=.01). …”
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Influence of structural surface roughness on the strength of layered fill bodies based on PFC2D by Jinxing WANG, Zongsheng HU, Huazhe JIAO, Xiaolin YANG, Qi ZHANG, Xiaohui LIU, Ping XU, Junqiang XU, Xun CHEN

“…The backfill at the lower part of the stratified plane remains mostly intact. As the cemented surface roughness increases, the failure gradually becomes more uniform across the backfill specimens, mainly in the form of overall penetrating tension failure. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Although it was postulated that sEVs can traverse the highly restrictive BBB via transcytosis—data mostly based on the indirect detection of transported cargo—direct evidence for sEV transport across the BBB remains elusive due to challenges in sEV labelling, detection limits, and inherent limitations of existing in vitro BBB models. …”
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Aortic isthmus flow reversal in fetal coarctation of the aorta and the associated factors by Guihong Chen, Yongfeng Han, Congxin Sun, Wei Xiang, Wei Zhao, Pei Zhou, Tianxiao Yu, Zhuo Chen, Bulang Gao, Shuping Ge, Jie Mi

“…Aortic isthmus flow reversal was mostly in the full systole (n = 17 or 60.7%) or late systole and early‐middle diastole (n = 10 or 35.7%) in the CoA‐positive fetuses (n = 27 or 96.4%), significantly (p < 0.001) different from that in the false‐positive or control group. …”
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Effectiveness of myocarditis therapy depending on the diagnosis approach (with or without myocardial biopsy) by O. V. Blagova, A. V. Nedostup, V. P. Sedov, A. Yu. Zaitsev, V. M. Novosadov, E. A. Kogan

“…If it is impossible to perform a biopsy, complex non-invasive strategy makes it possible to diagnose myocarditis with different probability rate and conduct an effective IST, the refusal of which mostly is not justified.…”
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KEANEKARAGAMAN SPESIES AMFIBI DAN REPTIL DI KAWASAN SUAKA MARGASATWA SERMODAERAH ISTIMEWA YOGYAKARTA by D S Yudha, R Eprilurahman, I A Muhtianda, D F Ekarini, O C Ningsih

“…It consists of several unique habitats for wildlife such as herpetofauna (amphibians and reptiles). Forest habitat mostly composed by secondary forest with the vegetation coverage less than 90% in 90-250 meters above sea level. …”
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How does dispersal shape the genetic patterns of animal populations in European cities? A simulation approach by Savary, Paul, Tannier, Cécile, Foltête, Jean-Christophe, Bourgeois, Marc, Vuidel, Gilles, Khimoun, Aurélie, Moal, Hervé, Garnier, Stéphane

“…Forest areas contributed more to habitat connectivity than UGS, due to their larger area and mostly peri-urban location. Hence, population-level genetic diversity was higher in forests than in UGS and genetic differentiation was higher between UGS populations than between forest populations. …”
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Examine frameworks policies and strategies for effective information governance in healthcare organizations. by Richard Okyere Boadu, Victor Wireko Adu, Kwame Adu Okyere Boadu, Baishatu Ibrahim, Prince Akey, Amponsah Amishadas Mensah, Godwin Adzakpah, Nathan Kumasenu Mensah

“…Efforts were also identified in ensuring privacy and confidentiality during the storage, processing and transmission of patient data mostly by deploying methods such as authentication (58.9%), use of secured computers and software (71.2%) and using secure electronic platforms (66.0%) respectively indicating a keen attention for data stewardship and governance. …”
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Adherence to Visits to Medical Institutions and Quality of Therapy after Acute Coronary Syndrome (according to the LIS Registry 3) by N. P. Zolotareva, A. V. Zagrebelny, M. L. Ginzburg, S. Yu. Martsevich, O. M. Drapkina

“…In both groups, committed and not committed to attending a medical facility, there is a negative dynamics in the quality of taking medications after discharge from the hospital, however, in the group of patients committed to attending a medical facility, it was noted that the odds of taking antiplatelet agents after discharge was 3.4 times higher (OR 3.449, p=0.002), beta-blockers – 4 times (OR 4.103, p&lt;0.001), statins – 4.5 times (OR 4.450, p&lt;0.001), in relation to the group of patients who are not observed in the medical facility after discharge from the hospital.Conclusion. 1-6 years after discharge from the hospital after the reference event, the quality of therapy deteriorated significantly in both groups, mostly in non-adherent patients. Significant differences in the quality of medication intake (antiplatelet agents, statins, β-blockers) were noted in the group of adherents to visiting health care facilities in comparison with those who were not committed to visiting health facilities. …”
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Retinal progenitor cells (jCell) for retinitis pigmentosa by Jing Yang, Jing Yang, Baruch D. Kuppermann, David Liao, Mitul C. Mehta, Chinhui Hsiang, Chinhui Hsiang, Steven Menges, Steven Menges, David S. Boyer, Henry Klassen, Henry Klassen

“…Each dose group contained equal numbers of subjects from Cohorts 1 and 2.ResultsIntravitreal RPC injection was well tolerated and associated with mostly transient mild to moderate adverse events. …”
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Modeling CMAQ dry deposition treatment over the western Pacific: a distinct characteristic of mineral dust and anthropogenic aerosols by S. S.-K. Kong, J. S. Fu, N.-H. Lin, N.-H. Lin, G.-R. Sheu, G.-R. Sheu, W.-S. Huang

“…The modeled PM<span class="inline-formula">₁₀</span> pattern by E20 at the upper level (700 hPa) was mostly consistent with the observed PM<span class="inline-formula">₁₀</span> at the Lulin Atmospheric Background Station (LABS; 23.47° N, 120.87° E; 2862 m a.s.l.), which is a typical background site in the western Pacific, particularly in capturing the peak value. …”
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NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…Abstract Background Parkinson’s disease (PD) is a neurodegenerative disorder characterized by protein aggregates mostly consisting of misfolded alpha-synuclein (αSyn). …”
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Competencies of lower-level community health centre leaders in annual health work planning and their influence on district performance in Busoga sub-region: A retrospective study. by Kharim Mwebaza Muluya, Gangu David Muwanguzi, Abdulmujeeb Babatunde Aremu, Naziru Rashid, Irene Wananda, Jonah Fred Kayemba, Collin Ogara, Musa Waibi, John Francis Mugisha, Peter Waiswa

“…Annual health work planning in local governments faces implementation obstacles every year. This mostly affects lower-level community health centres in Busoga region. …”
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Preconception thyroid function in relation to pregnancy lipids among women attending a fertility center by Xilin Shen, Tim I. M. Korevaar, Tamarra James-Todd, Paige L. Williams, Jennifer B. Ford, Dan Zhang, Maarten A Broeren, Kathryn M. Rexrode, Russ Hauser, Jorge E. Chavarro, Lidia Mínguez-Alarcón, for the Earth Study Team

“…The association of thyroid function and dyslipidemia in women has been mostly studied in the general population, and epidemiological evidence during pregnancy is scarce. …”
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Desain Layanan E-Surat untuk Desa Waru Barat, Pamekasan, Madura menggunakan QR-Code by Wahyudi Agustiono, Intan Rofika Putri, Devie Rosa Anamisa

“…Therefore, e-certificate seems to be useful especially for Waru Barat Village authority, Pamekasan District, Madura, whose people mostly work outside or even overseas. Eventually, they often need to obtain certificates from the authority for various purposes. …”
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Application of fluorescence spectroscopy and laser confocal technology in shale geological evaluation by LI Ping, ZHAI Zheng, WANG Xin, LI Zheng, LIN Jing, HAN Dongmei, AN Tianxia

“…In the fourth member of Shahejie Formation （Es4） of Dongying Sag， The crude oil in calcite veins of mud shale is mainly light oil， and the crude oil in mudstone pores is mostly medium to heavy oil. The crude oil in asphalt and organic matter in mud shale is heavy oil and thickened oil. …”
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