Variations in the quality of tuberculosis care in urban India: A cross-sectional, standardized patient study in two cities. by Ada Kwan, Benjamin Daniels, Vaibhav Saria, Srinath Satyanarayana, Ramnath Subbaraman, Andrew McDowell, Sofi Bergkvist, Ranendra K Das, Veena Das, Jishnu Das, Madhukar Pai

“…<h4>Background</h4>India has the highest burden of tuberculosis (TB). Although most patients with TB in India seek care from the private sector, there is limited evidence on quality of TB care or its correlates. …”
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Exploring the Chemical Composition and Antimicrobial Activity of Extracts from the Roots and Aboveground Parts of <i>Limonium gmelini</i> by Dariya Kassymova, Francesco Cairone, Donatella Ambroselli, Rosa Lanzetta, Bruno Casciaro, Aizhan Zhussupova, Deborah Quaglio, Angela Casillo, Galiya E. Zhusupova, Maria Michela Corsaro, Bruno Botta, Silvia Cammarone, Maria Luisa Mangoni, Cinzia Ingallina, Francesca Ghirga

“…Further investigation is needed to isolate and validate the most active constituents for potential therapeutic applications.…”
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A 15-year study of neuraminidase mutations and the increasing of S247N mutation in Spain by Iván Sanz-Muñoz, Alejandro Martín-Toribio, Adrián García-Concejo, Irene Arroyo-Hernantes, Marina Toquero-Asensio, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Silvia Rojo-Rello, Marta Domínguez-Gil, Eduardo Tamayo-Gómez, Marta Hernández-Pérez, José M Eiros

“…Our results showed that the occurrence of NA resistance mutations remained constant in the four viruses during the 15 seasons evaluated, being around 0.5–5 %. Most of the resistance was found in the A(H1N1)pdm09 subtype (around 70 %), especially from the 2023–2024 season onwards, when a significant increase in the occurrence of S247N mutation was observed. …”
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UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice by Dalei Sun, Shu Ouyang, Xiaoxuan Xu, Jingjing Yan, Heqian Wang, Chenkai Lan, Wubin Ouyang, Liangjun Zhong, Jun Lin

“…Local high-dose UMI-77 (Group Ba) demonstrated the most potent efficacy, reducing BOP by 76 % (0.67 ± 0.5 vs. …”
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Worldwide hotspots and trends in stem cell therapy for kidney disease in the last decade: a bibliometric and visualization analysis from 2015 to 2024 by Shengchun Liao, Shengchun Liao, Shengchun Liao, Xinyue Zhang, Yiting Zhou, Yiting Zhou, Yiting Zhou, Lingchen Wang, Lingchen Wang, Chi Chen, Chi Chen, Chaoyang Ye, Chaoyang Ye, Yuan Zhou, Yuan Zhou, Yuan Zhou, Chen Wang, Chen Wang, Chen Wang

“…Additionally, Lerman LO was the most prolific author in this field. Currently, there is a growing focus on mesenchymal stem cells and acute kidney injury models in this field. …”
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Effect of bagging on nutritional quality and mineral element content of peach fruit in different varieties by CHEN Meng, ZHANG Xue, LI Yue, LI Yong, CHEN Xiaolong, CHEN Jian, YU Xiangyang

“…[Conclusion] The bagging did not affect fruit mass or firmness but significantly reduced the contents of soluble solids, vitamin C, amino acids, total phenols, and most mineral elements, leading to reduce the nutritional quality of the peach fruits. …”
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Repellent Activity of DEET Combined with Botanical Compounds Against <i>Amblyomma sculptum</i> Nymphs: Laboratory and Field Evaluations by Mayara Macêdo Barrozo, Haile Dean Figueiredo Chagas, Gabrielly Bernardes Rodrigues Damaceno, Emilly Faria Santos, Rafael Assunção Carvalho, Isabela Santos Silva, Francisca Letícia Vale, Lainny Jordana Martins Pereira e Sousa, Hermes Ribeiro Luz, Lorena Lopes Ferreira, Caio Monteiro

“…Eugenol and methyl eugenol exhibited the highest average repellent percentages (60 to 90%), with significant effects (<i>p</i> < 0.05) across most evaluation periods, in contrast to 1,8-cineole. …”
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Bjerkandera adusta TM11 for the bioremediation of fluoroquinolone antibiotics spiked in wastewater: A sustainable approach to pharmaceutical contaminant biotransformation by Hasna Befenzi, Amine Ezzariai, Jihane Baghor, Hamza Arrach, Jean Armengaud, Mélodie Kielbasa, Annick Doan, Julien Lambert, Anne Lomascolo, Quentin Albert, Craig B. Faulds, Giuliano Sciara, Tahar Mechichi, Lamfeddal Kouisni, Mohamed Hafidi, Loubna El Fels, Eric Record

“…Versatile peroxidase was the most strongly-produced enzyme potentially involved in antibiotic biotransformation. …”
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Methods of induction of labor in women with obesity: A secondary analysis of two multicenter randomized controlled trials by Dorothée M. R. Croll, Marieke D. T. De Vaan, Shinta L. Moes, Kitty W. M. Bloemenkamp, Mieke L. G. Ten Eikelder, Roel De Heus, Marta Jozwiak, Judith Kooiman, Ben Willem Mol, Corine J. M. Verhoeven, Marjon A. De Boer

“…The aim of this study is to assess which method of induction of labor is safest and most effective in women with obesity. Material and methods This is a secondary analysis of two randomized controlled trials about induction of labor. …”
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Treatment with Upadacitinib in Difficult-to-Treat (D2T) Psoriatic Arthritis (PsA): A National Multicenter Study of the First 134 Patients in Clinical Practice by Eva Galíndez-Agirregoikoa, Diana Prieto-Peña, Maria Luz García-Vivar, Joaquin Maria Belzunegui Otano, Beatriz Joven-Ibáñez, Cristina Vergara-Dangond, Marina Pavía-Pascual, Irati Urionaguena-Onaindia, Lucia Vega Alvarez, M. Ángeles Puche Larrubia, Consuelo Ramos Giráldez, Rosario Garcia-Vicuña, Vega Jovani, Angels Martínez-Ferrer, Mireia Moreno Martínez-Losa, Teresa González Hernández, Raquel Almodóvar González, Ana Urruticoechea-Arana, Cristina Macía-Villa, Inigo Gorostiza, Ricardo Blanco Alonso, Upadacitinib PsA Clinical Practice COLLABORATIVE STUDY GROUP

“…This observational, multicenter, open-label study evaluated the efficacy and safety of upadacitinib in 134 patients with psoriatic arthritis (97 women, mean age 51.8 ± 11.2 years, mean disease duration 9.94 ± 7.72 years) who showed inadequate response to advanced therapies. Most patients (74.6%) had received at least two biological/targeted synthetic disease-modifying antirheumatic drugs with different mechanisms of action. …”
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LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis by Fudong Li, Yangyang Shi, Jun Chen, Jingchuan Sun, Jiangang Shi, Kaiqiang Sun, Bing Zheng

“…Of those genes, LGR6 appeared to be the gene most closely related to IVDD severity. In addition, the mRNA level and protein level of LGR6 in macrophages co-cultured with IL-1β-treated NPCs were raised significantly, compared to the control group. …”
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The Effect of Intravenous Autologous Activated Platelet-Rich Plasma Therapy on “Profibrotic Cytokine” IL-1β Levels in Severe and Critical COVID-19 Patients: A Preliminary Study... by Karina Karina, Louis Martin Christoffel, Rita Novariani, Imam Rosadi, Iis Rosliana, Siti Rosidah, Siti Sobariah, Novy Fatkhurohman, Nurlaela Puspitaningrum, Yuli Hertati, Irsyah Afini, Difky Ernanda, Tias Widyastuti, A. D. Sulaeha, Alfida Zakiyah, Noor Aini, Grady Krisandi, Hubert Andrew

“…Among the cytokines, interleukin-1β (IL-1β) is one of the most overexpressed in COVID-19. We speculate that administration of intravenous activated autologous platelet-rich plasma (aaPRP), which contains interleukin-1 receptor antagonist (IL-1RA), would lower IL-1β levels and benefit the severe and critical COVID-19 patients. …”
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4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells by Frederick L Locke, Yannick Bulliard, Bin Yu, Marco L Davila, Emiliano Roselli, Justin C Boucher, Gongbo Li, Hiroshi Kotani, Kristen Spitler, Kayla Reid, Estelle V Cervantes, Nhan Tu, Sae Bom Lee

“…Background Co-stimulatory signals regulate the expansion, persistence, and function of chimeric antigen receptor (CAR) T cells. Most studies have focused on the co-stimulatory domains CD28 or 4-1BB. …”
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Risk prediction for recurrent pregnancy loss based on routine inspections in the first trimester of pregnancy, a retrospective study in China by Jinming Wang, Dan Li, Yang Yeung, Zhenglong Guo, Hongke Huang, Li Wang, Weili Shi, Jianmei Huang, Wenke Yang, Yanxin Ren, Shixiu Liao, Yibin Hao

“…BackgroundRecurrent pregnancy loss (RPL) is one of the most common pregnancy complications in obstetrics and gynecology, and the incidence rate of RPL is about 2%. …”
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Multicenter research of the dependence of skin graft engraftment and the concentration of blood hemoglobin, total serum protein and albumin by D. O. Vagner, E. V. Zinoviev, V. V. Soloshenko, A. E. Chukharev, V. S. Borisov, M. Yu. Kaplunova, S. B. Bogdanov, A. A. Petrov, N. V. Ostrovsky, E. P. Malyshina, R. D. Ermolova, D. V. Cherdancev, I. V. Vladimirov

“…This relationship was most pronounced during skin grafting on granulating wounds and after radical necretomy. …”
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A Novel ceRNA Axis LOC121818100/Novel‐miR‐400/SSRP1 Regulated Muscle Growth and Injury Repair in Sheep by Fan Yang, Runqing Chi, Runan Zhang, Kai Liu, Pingqing Wang, Ran Di, Xiaoyun He, Xiangyu Wang, Yufang Liu, Mingxing Chu

“…Bioinformatics analysis showed that LOC121818100/Novel‐miR‐400/SSRP1 was most correlated with skeletal muscle development (p < 0.05). …”
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Pharmacological potential of 6,11-dihydro[1,2,4]triazolo[4’,3’:1,6]-pyrido[3,4-b]-5-carboxylic acid and its esters by S. O. Fedotov, A. S. Hotsulia

“…Molecular docking was performed using Vina software, which provides modelling and evaluation of interactions between ligand and three-dimensional protein structure, considering their energy and spatial compatibility. Results. The most favourable safety profile of in silico studies has been shown by 6,11-dihydro[1,2,4]triazolo[4’,3’:1,6]pyrido[3,4-b]-5-carboxylic acid. …”
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Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mice by Vaskar Das, Isabella Milejczyk, Michael B. Basovich, Mario Moric, Jay Kaila, Craig J. Thomas, Asokumar Buvanendran, Robert J. McCarthy

“…IntroductionLow back pain affects around 619 million people globally and is the most prevalent musculoskeletal condition worldwide. …”
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Longitudinal characterization of plasma and fecal bile acids in dairy heifers from birth to first calving in response to transition milk feeding by M.H. Ghaffari, C.S. Ostendorf, K.J. Hemmert, S. Schuchardt, C. Koch, H. Sauerwein

“…Fecal bile acid profiles in TM-fed calves clustered distinctly at birth, evolving through pre- to postweaning and calving, with increasing profile overlap over time. Most fecal bile acids, except DCA and CA, were abundant at birth but declined over time. …”
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Rhodium-based metallodrugs for biological applications: current status and future perspectives by Wang Xiang, Suisui He, Tao Kuang, Jun Yin, Bin Hu, Chao Sun, Juan He, Jun Wang, Cui-Yun Yu, Hua Wei

“…Metal complexes represent a promising avenue in drug research and development, exemplified by metallodrugs including cisplatin, carboplatin, and oxaliplatin that have been clinically approved for the treatment of various solid tumors. However, most of the reported metallodrugs suffer from compromised therapeutic efficacy due to multidrug resistance (MDR) and severe systemic toxicity. …”
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