0.01% atropine combined with carteolol hydrochloride can inhibit the scleral remodeling in guinea pigs with form-deprivation myopia by Qin Xiang, Jing Yang, Qing Liu, Jing Fang, Xin Li, Xinyu Fu, Xu Gao, Zhou Fu

“…Abstract Myopia is the most widespread refractive error caused by an increase in the axial length (AL) of the eyeball, and is also a major risk factor for other blinding eye diseases, seriously endangering human health and quality of life. …”
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G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo by Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

“…Abstract Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. …”
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The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation by Christoph Fickentscher, Iryna Magorivska, Christina Janko, Mona Biermann, Rostyslav Bilyy, Cecilia Nalli, Angela Tincani, Veronica Medeghini, Antonella Meini, Falk Nimmerjahn, Georg Schett, Luis E. Muñoz, Laura Andreoli, Martin Herrmann

“…It is likely that the most important pathogenic factor of the anti-β2GP1-IgG is related to the different glycosylation observed in healthy and diseased individuals. …”
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Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota by Xingduo Liu, Chaoqun Sun, Yuqiong Dai, Feifei Duan, Tianzhen He, Menglu Zhen, Enxi Liang, Shuting Zhang, Yun Xia, Nianchun Hu, Ruoting Zhan, Ruoting Zhan, Dong Deng, Sijun Liu

“…Gut microbiota composition, diversity, and function were then analyzed by 16S rRNA sequencing.ResultsThe results of Behavioral experiment indicate that Danggui Shaoyao San and its disassembled prescriptions can ameliorate spatial memory deficits (Morris water maze), enhance recognition memory (novel object recognition), and reduce anxiety-like behaviors (open field test), with the DSS group demonstrating the most pronounced effects. In addition, through 16S sequencing analysis we predicted DSS and its disassembled prescriptions reduced harmful bacteria (Firmicutes, Akkermansia) while increasing beneficial bacteria (Bacteroidetes, Bifidobacterium, Lactobacillus). …”
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Soft Power of Higher Education as a Global Leadership Factor by N. L. Antonova, A. D. Sushchenko, N. G. Popova

“…In the era of information and knowledge, one of the most effective tools for this task is soft power of education. …”
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Examination of Factors Affecting the Development of Osteoporosis in Children with Duchenne Muscular Dystrophy by Yiğithan Güzin, Safa Mete Dağdaş, Özlem Ateş, Özkan Alataş, Ayşe Özbay Yıldız, Bakiye Tunçay, Pınar Gençpınar, Figen Baydan, Hakan Birinci, Bumin Nuri Dündar, Nihal Olgaç Dündar

“…Objective: Duchenne muscular dystrophy (DMD), which is primarily treated with glucocorticoids, is the most common genetic progressive neuromuscular disease in children, which can lead to osteoporosis and fractures. …”
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Cognitive Assessments in Randomized Controlled Trials of Acute or Secondary Prevention Stroke Treatments 2011 to 2024: A Scoping Review by Sajeevan Sujanthan, Jesse Buchman, Aaron Herlick, Damyen Henderson‐Lee Wah, William Betzner, Alisia Southwell, Theresa Aves, Pugaliya Puveendrakumaran, Idris Fatakdawala, Vanessa Norouzi, Teruko Kishibe, Michael D. Hill, Raed A. Joundi, Ryan T. Muir, Bijoy K. Menon, Jennifer S. Rabin, Katie N. Dainty, Morgan Barense, Krista L. Lanctôt, Aravind Ganesh, Richard H. Swartz

“…The Mini‐Mental State Examination (22/43 studies, 52%) and Montreal Cognitive Assessment (18/43 studies, 42%) were used in the most RCTs. There were 66 distinct cognitive tasks used, with greatest diversity in memory tasks (19), executive tasks (11) and global screens (11). …”
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Large Language Model–Assisted Risk-of-Bias Assessment in Randomized Controlled Trials Using the Revised Risk-of-Bias Tool: Usability Study by Jiajie Huang, Honghao Lai, Weilong Zhao, Danni Xia, Chunyang Bai, Mingyao Sun, Jianing Liu, Jiayi Liu, Bei Pan, Jinhui Tian, Long Ge

“…At the signaling question level, LLMs achieved 83.2% average accuracy (95% CI 77.5-88.9), with accuracy exceeding 70% for most questions except 2.4 (assignment), 2.5 (assignment), 3.3, and 3.4. …”
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An Integrative Machine Learning Model for Predicting Early Safety Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation by Abilkhair Kurmanaliyev, Kristina Sutiene, Rima Braukylienė, Ali Aldujeli, Martynas Jurenas, Rugile Kregzdyte, Laurynas Braukyla, Rassul Zhumagaliyev, Serik Aitaliyev, Nurlan Zhanabayev, Rauan Botabayeva, Yerlan Orazymbetov, Ramunas Unikas

“…<i>Results</i>: The random forest model identified left femoral artery diameter and aortic valve calcification volume as the most influential predictors of early safety outcomes. …”
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Molecular diagnostics for perioperative microbial identification in periprosthetic joint infection: A scoping review and proposal of a diagnostic flow chart by Pier Francesco Indelli, Trifon Totlis, Bruno Lovreković, Michael Engl, Bruno Violante, Pawel Skowronek, Guillaume Demey, Stefano Ghirardelli, Chiara Maci, Antonella Castagna, Laura Schianchi, Chiara Tassan Din, James Harty, Goksel Dikmen, Christian Schaller, Marko Ostojić

“…Abstract Purpose Periprosthetic joint infections (PJI) are among the most feared complications of joint reconstruction. …”
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The Study of the Effectiveness of Meloxicam “Movalis” Application in Postoperative Patients with Planovalgus Foot Deformity by Yatskevych A., Trutyak I., Abrahamovych U., Yatskevych O.

“…The scheme of treatment has a positive effect on the components of the syndrome of inflammation, but the anti swelling effect is expressed the most. There were no vesicles in patients of the research group, while they were detected in 2.3 % of patients in the control group. …”
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Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer by Hui Wang, Ying Chen, Min Wu, Jian Liu, Jingyu Wang, Yifan Yang, Chaoyang Sun, Shan He, Shen Qu, Xun Tian, Jinglan Chen, Han Jiang, Liting Liu, Yafei Huang

“…Background Tumor-associated macrophages (TAMs) are among the most prevalent cells within the tumor microenvironment (TME) of cervical cancer (CC). …”
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Specific features of current intraperitoneal therapy in patients with ovarian cancer by A. G. Kedrova, S. A. Levakov, S. E. Krasil’nikov, T. A. Maksimenko, V. I. Voznesenskiy, A. V. Gerasimov, D. A. Astakhov, V. V. Kosyy, O. E. Nechaeva

“…However, the long-expected data of the most recent randomized trial GOG 0252 have proven deplorable and led to the activation of discussions on the role of IP therapy.Objective: to generalize the experience of 4 oncology departments with IP therapy in patients with disseminated OC and to compare the findings with those obtained by the world’s leading medical centers.Materials and methods. …”
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Isolation and relationship analysis of Listeria phages with various serotype hosts and morphological characterization by Jinni chen, Yan Wang, Lingyun Liu, Hao Zhou, Pan Mao, Lingling Li, Ji Pu, Xuefang Xu, Jing Yang, Jingdong Song, Hui Sun, Xia Luo, Kui Dong, Changyun Ye

“…Listeria phages specifically target and lyse Lm, offer a promising alternative for biocontrol and phage therapy. However, most existing studies focus on the lytic characteristics of Listeria phages using limited sample sizes. …”
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Abiotic drivers of activity in a large, free-ranging, freshwater teleost, Murray cod (Maccullochella peelii). by Jason D Thiem, Ian J Wooden, Lee J Baumgartner, Gavin L Butler, Jamin Forbes, Matthew D Taylor, Robyn J Watts

“…Activity, derived through locomotion and basic metabolism, represents the principal energy cost for most animals, although it is rarely quantified in the field. …”
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Alcohol Abstinence Rescues Hepatic Steatosis and Liver Injury via Improving Metabolic Reprogramming in Chronic Alcohol-Fed Mice by Aiwen Pi, Aiwen Pi, Aiwen Pi, Kai Jiang, Kai Jiang, Qinchao Ding, Qinchao Ding, Shanglei Lai, Shanglei Lai, Wenwen Yang, Wenwen Yang, Jinyan Zhu, Jinyan Zhu, Rui Guo, Rui Guo, Yibin Fan, Linfeng Chi, Songtao Li, Songtao Li, Songtao Li

“…Prolonged alcohol abstinence is the most effective therapy to attenuate the clinical course of ALD and even reverse liver damage. …”
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‘I Don't Think There Is a One‐Size‐Fits‐All’: A Qualitative Study Exploring Healthcare Professional and Service Provider Perspectives of Using Innovative Models of Cervical Screeni... by Claire Bavor, Tessa Saunders, Mikayla Wolfe, Megan A. Smith, Nicola Creagh, Deborah Bateson, Angela Kelly‐Hanku, Paula Jops, Marion Saville, Natalie Taylor, Kate Broun, Julia M. L. Brotherton, Claire Nightingale

“…Four overarching themes were identified: acceptability, appropriateness, screening quality and safety, and implementation considerations. Most found innovative models acceptable when appropriately tailored to the needs of different population groups, particularly through community outreach, home in‐reach and peer‐supported services. …”
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Experiences of symptom burden among young children born with esophageal atresia–tracheoesophageal fistula: a US focus group study by Michaela Dellenmark-Blom, John Bennett, Rosella Micalizzi, Lianne Cole, Kaylee Woods, Lauren Cardoni, Leah Frain, Abdimajid Mohamed, Jessica Yasuda, Peter Ngo, Anke Widenmann, Graham Slater, Benjamin Zendejas

“…Furthermore, feeding difficulties (99 statements, n = 22 parents) included the children’s Food refusal (n = 8), Need for mealtime adjustment (n = 7), Selective/restrictive eating (n = 14) and Upset/stress with feeds (n = 10). Most parents (n = 20, 91%) described that their children had symptom experiences that spanned all three categories (respiratory and digestive symptoms, feeding difficulties). …”
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No-Test Screening Protocols May Disproportionately Exclude Structurally Oppressed Communities Who Could Benefit from Accessing Medication Abortion by M. Antonia Biggs, Lauren Ralph, Katherine Ehrenreich, Shelly Kaller, Kelly Blanchard, Deb Hauser, Nathalie Kapp, Tammi Kromenaker, Ghazaleh Moayedi, Jamila Perritt, Elizabeth Raymond, Kari White, Daniel Grossman

“…Moderate/severe pelvic pain was the most common (614/1,386) patient-reported reason for ineligibility and reported significantly more by people ages 15–19, who were nulliparous, and experienced food or housing insecurity. …”
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Machine learning predicting acute pain and opioid dose in radiation treated oropharyngeal cancer patients by Vivian Salama, Vivian Salama, Laia Humbert-Vidan, Brandon Godinich, Brandon Godinich, Kareem A. Wahid, Kareem A. Wahid, Dina M. ElHabashy, Mohamed A. Naser, Renjie He, Abdallah S. R. Mohamed, Ariana J. Sahli, Katherine A. Hutcheson, Gary Brandon Gunn, David I. Rosenthal, Clifton D. Fuller, Amy C. Moreno

“…Baseline pain scores and vital signs demonstrated the most contributing features.ConclusionML models showed promise in predicting end-of-treatment pain intensity, opioid requirements and analgesics efficacy in OCC/OPC patients. …”
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