A foundational triage system for improving accuracy in moderate acuity level emergency classifications by Tuo Liu, Yang Gu, Hongyi Chen, Yan Zhang, Leqi Zheng, Xuanqi Huang, Yanjun Xu, Cai Wen, Mansheng Chen, Jiaqi Lin, Dongguo Huang, Feixia Chen, Yulan Zhong, Hui Chen, Yanfeng Guo, Mei Lu, Guangwei Zhang, Hao Wu, Changdong Wang, Xiaotu Xi, Li Li, Tao Yu

“…Results Here we show that on the most difficult level for human to distinguish (moderate acuity level), our KUTS substantially outperforms the previous shallow single-modal methods, deep single-modal methods and deep multi-modal methods on AUC score, by an average of 0.19, 0.35, and 0.13 (from 0.76, 0.60, 0.82 to 0.95), respectively. …”
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Prenatal diagnosis, ultrasound findings and pregnancy outcome of 7q11.23 deletion and duplication syndromes: what are the fetal features? by Xiaojin Luo, Hongyan Niu, Fei Zhou, Xiaohang Chen, Yuanyuan Pei, Weiqiang Liu, Fengxiang Wei

“…Cardiovascular abnormalities and intrauterine growth restriction are the most common clinical manifestations observed in prenatal 7q11.23 deletion syndrome. …”
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Subsets of follicular lymphoma 3B have divergent outcomes: results from the prospective multicenter MER and LEO cohorts by Patrizia Mondello, Brianna Negaard, Andrew L. Feldman, Brian K. Link, Carla Casulo, Dai Chihara, David Russler-Germain, Jason Romancik, Caitlin Gribbin, Sara Haddadi, Eric Mou, Ivana N. Micallef, Patrick B. Johnston, Joseph Novak, Yucai Wang, Rebecca L. King, Anne J. Novak, Thomas M. Habermann, Peter Martin, Brad Kahl, Grzegorz S. Nowakowski, Loretta J. Nastoupil, James R. Cerhan, Christopher R. Flowers, Izidore S. Lossos, Richard W. Burack, Matthew J. Maurer, Stephen M. Ansell

“…Our data suggest that most FL3B have a good outcome, while a subset has an aggressive behavior.…”
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Polysomnography validation of SANSA to detect obstructive sleep apnea by Cathy Goldstein, Hamid Ghanbari, Surina Sharma, Nancy Collop, Andrew Namen, Douglas B. Kirsch, Michael Drucker, Rami Khayat, Mark Pollock, Brennan Torstrick, Colleen Walsh, Emily Herreshoff, David S. Frankel, Ilene M. Rosen

“…Performance of participating site PSG scores were also evaluated against consensus PSG scores for comparison.ResultsSANSA demonstrated excellent agreement with PSG for most performance parameters. AHI correlation was 0.91 (95% CI: 0.89, 0.93) using Rule 1B and 0.90 (95% CI: 0.87, 0.92) using Rule 1A. …”
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Original drugs approved by the Food and Drug Administration (Center for Drug Evaluation and Research) in 2024 by D. V. Kurkin, N. A. Osadchenko, A. R. Makarova, D. A. Galkina, D. A. Bakulin, O. V. Shatalova, A. V. Strygin, V. I. Petrov, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, A. V. Zaborovsky, D. V. Yunina, K. N. Koryanova, E. I. Morkovin, M. A. Dzhavakhyan, V. I. Zvereva, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…The search for new rational combinations of antibiotics remains relevant. Most of the original drug market is still made up of small molecules, among which there are medicines — ligands of new targets and oligonucleotide sequences.…”
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IgG glycosylation profiling of systemic lupus erythematosus using lectin microarray by Shangzhu Zhang, Xiaofeng Zeng, Qian Wang, Jiuliang Zhao, Xinping Tian, Mengtao Li, Yan Zhao, Dong Xu, Chaojun Hu, Yang Wu, Minhui Wang

“…Receiver operating characteristic (ROC) analysis evaluated the diagnostic value of these glycosylation changes in SLE and its subgroups, including neuropsychiatric SLE (NPSLE), lupus nephritis (LN), pulmonary arterial hypertension, immune thrombocytopaenia and SLE without major organ involvement (WMOI).Results Compared to DC and HC groups, the IgG glycan level of Galβ3GalNAc (binding Jacalin (11.3%) and Maclura pomifera lectin (14.4%)) was significantly increased, whereas most IgG glycan levels were significantly decreased, including core fucose, high mannose, GlcNAc, GalNAc and Galβ4GlcNAc in the SLE group (all p<0.05).The IgG glycan levels were elevated in GalNAc and galactose patterns in the NPSLE group compared to the WMOI group, as well as higher Galβ3GalNAc and galactose patterns in NPSLE and LN compared to HCs.Moreover, ROC curve analysis showed PNA levels might have moderate potential for discriminating SLE from pSS.Conclusions Patients with SLE show disease-specific alterations in serum IgG glycosylation, and aberrant Galβ3GalNAc, galactose and GalNAc glycosylation may have diagnostic value for SLE and NPSLE. …”
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ROLE OF STREPTOCOCCUS PNEUMONIAE IN THE STRUCTURE OF BACTERIAL INFECTIONS IN THE CHILDREN HOSPITALIZED TO INPATIENT HOSPITALS IN MOSCOW IN 2011–2012 by A. A. Baranov, L. S. Namazova-Baranova, N. A. Mayanskiy, T. V. Kulichenko, T. A. Polunina, A. V. Lazareva, N. M. Alyabyeva, L. K. Katosova, O. A. Ponomarenko, I. E. Koltunov, A. M. Ivanenko, E. A. Degtyaryova, N. V. Kondratenko, A. A. Korsunsky, K. V. Konstantinov, D. A. Tulupov, M. A. Lazareva

“…Nasopharyngeal pneumococcal carriage analysis revealed the prevalent serotypes — 19F, 14, 23F, 3, 6A and B; they were present in 3/4 of all cases; 19F was the most frequent (> 20%). Diversity of the S. pneumoniae serotypes detected in middle ear liquid was less significant — 17 serotypes (in comparison with 24 serotypes in nasopharynx). …”
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BLH3 Regulates the ABA Pathway and Lignin Synthesis Under Salt Stress in <i>Lilium pumilum</i> by Wenhao Wan, Lingshu Zhang, Xingyu Liu, Huitao Cui, Miaoxin Shi, Hao Sun, Wei Yang, Xinran Wang, Fengshan Yang, Shumei Jin

“…RT-qPCR analysis revealed that <i>LpBLH3</i> is most highly expressed in the leaves of <i>L. pumilum</i>. …”
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Effect of Resistance Training on Hepatic Bile Acid, beta-Klotho Protein and Expression of Farnesoid X Receptor, Fibroblast Growth Factor 15 and Fibroblast Growth Factor Receptor 4... by Mehri Gholipour, Najme Rezaeian, Mohammad Karimi, Sadegh Cheragh-Birjandi

“…Despite the recommendations for patients with NAFLD to participate in regular exercise, the type, intensity and duration of exercise that is most beneficial for these patients is not clearly determined yet. …”
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Blood type susceptibility to SARS-CoV-2 at a tertiary hospital in Accra, Ghana by Prince N. Odoom, Olayinka S. Okoh, Yaa Y. Asare, Clara O. Mac-Arthur, Judith D. Azumah, Albert Mensah, Akua K. Yalley, Kwamena W. Sagoe, Nicholas I. Nii-Trebi

“…The total SARS-CoV-2 seropositivity was 61.4% (157/277). Most of the participants (245/277, 88.4%) were unvaccinated. …”
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Differences in the management of heart failure with preserved ejection fraction among physicians from Europe, the Middle East and North Africa: an international survey by Omar Ahmad, Nathan Mewton, Dania Mohty, Najmeddine Echahidi, Clara Saldarriaga, Anastasia Shchendrygina, Sydney Goldfeder de Gracia, Mohamed H Omer, Mosaad Alhussain, Suleiman M Kharabsheh, Fakhr Ayoubi, Kamal Alghalayni, Jehad Alburaiki, Bahaa Fadel, Feras Bader, Hadi Skouri, Mohamad Hamade, Marta Załęska-Kocięcka, Federica Guidetti

“…Pharmacotherapy preferences showed both regional similarities and differences, with SGLT2 inhibitors being the most preferred drug of choice universally. In contrast, there was a higher ranking of mineralocorticoid receptor antagonists in Europe (p=0.007) and greater reported use of angiotensin receptor-neprilysin inhibitors in MENA (p=0.03).Conclusion This large international survey offers a descriptive mapping of HFpEF care practices across Europe and MENA, revealing overall guideline alignment but also regional differences in diagnostic test use and pharmacotherapy preferences. …”
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Tracking Clinical Competency Growth: A Longitudinal Study of Medical Students in a Multidisciplinary Emergency Department Internship Program by Sung TC, Shih HI, Kawaguchi T, Chi CH, Hsu HC

“…Generalized Estimating Equations (GEE) modeling assessed performance trends and inter-cohort differences between 2018 and 2019.Results: Significant improvements were observed across all competencies, with the most notable gains in history taking, clinical judgment, communication, prescription, and documentation. …”
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In vitro Study of Fungus-Like Organisms Peronospora ficariae and Wilsoniana bliti as Potential Inhalant Allergens by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…Additionally, these fungi can pose a health hazard to humans, as they are significant sources of allergens. The most prominent allergenic fungi include Alternaria, Aspergillus, Cladosporium, Penicillium, and Fusarium. …”
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Antibacterial and Anti-Adherence Efficacy of Silver Nanoparticles Against Endodontic Biofilms: An In Vitro and Ex Vivo Study by Mariana Goretti Pérez-Sáenz, Rita Elizabeth Martínez-Martínez, Erasto Armando Zaragoza-Contreras, Rubén Abraham Domínguez-Pérez, Simón Yobanny Reyes-López, Alejandro Donohue-Cornejo, Juan Carlos Cuevas-González, Karla Lizette Tovar-Carrillo, Erika de Lourdes Silva-Benítez, José Luis Ayala-Herrera, León Francisco Espinosa-Cristóbal

“…<b>Background/Objectives:</b> Root canal infections represent a serious challenge to the success of endodontic treatment. The most commonly used antimicrobial irrigants, such as sodium hypochlorite (NaOCl), have certain limitations, while endodontic biofilms pose a significant microbiological complexity in the endodontic field. …”
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Effects of dietary Vitamin A on growth performance, antioxidant and immune capacity of mandarin fish (Siniperca chuatsi) by Xiaolu Yan, Lingcheng Pan, Min Zhao, Junkang Ma, Fubao Wang, Xuliang Zhai, Yang Xue, Haiping Liu, Yongjun Chen, Yuanfa He, Hongqin Li, Li Luo

“…A quadratic regression analysis established the most effective vitamin A dosage to be between 9255.6 and 9280.0 IU/kg, as determined by WGR and FCR.…”
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Assessment of CD20 Marker as a Prognostic Predictor for Patients with Classical Hodgkin Lymphoma by Atarji E, Daous YM, Barefah A, Alahwal H, Albaity B, Hakami NY, Alkhatabi H, Qadah T

“…Statistical significance was set at p &lt; 0.05.Results: Of 52 CHL patients, 11 (21.2%) showed CD20-positive Hodgkin Reed-Sternberg (HRS) cells. Most parameters showed no significant differences between the CD20-positive and CD20-negative groups, except for serum albumin level (p = 0.042). …”
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The current status and prospects of gut microbiota combined with PD-1/PD-L1 inhibitors in the treatment of colorectal cancer: a review by Min Deng, Xiaoyu Li, Huiming Wu, Dingwen Xue, Yize Wang, Renkai Guo, Yipeng Cui, Chenfei Jin, Fei luo, Huiyu Li

“…Conclusion The treatment regimen combining gut microbiota with PD-1/PD-L1 inhibitors has shown promising therapeutic prospects in both animal studies and clinical research, although most clinical trials are data remain limited. Future studies should focus on: (1) gene-edited probiotic strains with targeted modifications; (2) the synergistic effects of multiple probiotics; and (3) conducting high-quality, multicenter clinical trials.…”
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Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway by Zhibin Liu, Ke Huang, Hai Huang, Eungyung Kim, Hyeonjin Kim, Chae Yeon Kim, Dong Joon Kim, Sang In Lee, Sangsik Kim, Do Yoon Kim, Kangdong Liu, Zae Young Ryoo, Mee-Hyun Lee, Lei Ma, Myoung Ok Kim

“…Esophageal squamous cell carcinoma (ESCC), one of the most frequent malignant tumors of the digestive system, is marked by a poor prognosis and high mortality rate. …”
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A bottom-up approach to find lead compounds in expansive chemical spaces by Álvaro Serrano-Morrás, Andrea Bertran-Mostazo, Marina Miñarro-Lleonar, Arnau Comajuncosa-Creus, Adrià Cabello, Carme Labranya, Carmen Escudero, Tian V. Tian, Inna Khutorianska, Dmytro S. Radchenko, Yurii S. Moroz, Lucas Defelipe, David Ruiz-Carrillo, Maria Garcia-Alai, Robert Schmidt, Matthias Rarey, Patrick Aloy, Carles Galdeano, Jordi Juárez-Jiménez, Xavier Barril

“…To address this challenge, we have conceived an innovative strategy that explores the chemical universe from the bottom up, performing a systematic search on the fragment space (exploration phase), to then mine the most promising areas of on-demand collections (exploitation phase). …”
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Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status by Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Francesca Tinti, Enea Bonci, Antonello Giovannetti, Claudio Casella, Adolfo Marco Perrotta, Domenico Bagordo, Manuel Murciano, Alessandro Galani, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange

“…Cystic fibrosis (CF) is one of the most frequent genetic diseases. The discovery and implementation of new therapies prolonged the survival of CF patients in the last years. …”
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