THE EFFICACY OF HIGH-DOSE CONSOLIDATION AND AUTOLOGOUS BONE MARROW TRANSPLANTATION IN FIRST REMISSION OF ACUTE MYELOID LEUKEMIA by I. A. Samorodova, S. N. Bondarenko, V. N. Ovechkina, A. V. Klimovich, E. I. Podolceva, N. V. Medvedeva, A. S. Nizamutdinova, E. V. Karyagina, B. I. Smirnov, I. S. Moiseev, L. S. Zubarovskaya, B. V. Afanasyev

“…Introduction. The question of the most adequate treatment strategy of AML in cases when it is impossible to perform allogeneic HSCT because of any reason still remains open.The aim of this study was to assess the long-term survival of patients with AML who received chemotherapy (CT) or autologous HSCT as consolidation in the first remission of the disease. …”
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Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids by Thomas A. Kluiver, Yuyan Lu, Stephanie A. Schubert, Lianne J. Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L. Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W. de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C. van den Heuvel, Vincent E. de Meijer, Ruben H. de Kleine, Jan J. Molenaar, Thanasis Margaritis, Hendrik G. Stunnenberg, Ronald R. de Krijger, József Zsiros, Hans Clevers, Weng Chuan Peng

“…Abstract Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. …”
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INFLUENCE OF CERTAIN D-METALS ON FORMATION OF ADVANCED GLYCATION END PRODUCTS, AGGREGATION AND AMYLOID TRANSFORMATION OF ALBUMIN IN GLYCATION REACTION by R. A. Litvinov, A. V. Gontareva, L. E. Usmiyanova, D. R. Klimenko

“…Among such ions as nickel (II), cobalt (II), iron (II), iron (III), copper (II) and zinc (II), copper (II) ions turned out to be the most active in their ability to accelerate the AGEs formation, suppress the fluorescence of tryptophan and tyrosine, enhance the aggregation and amyloid transformation of BSA in the glycation reaction. …”
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Characteristics and driving factors of power generation performance in microbial fuel cells: an analysis based on the CNKI database by Ruikai Zhang, Wentao Dai, Hongyong Xiang, Hongyong Xiang, Hongyong Xiang, Jie Chen, Jie Chen, Jie Chen, Ting Yi, Jiayi Li, Jiebin Zhang, Qiuxi Yang, Rui Xiao, Xiang Li

“…Microbial fuel cells (MFCs) have become one of the most promising technologies in the field of ecology and environmental science due to their dual functions of power generation and pollutant removal. …”
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A novel framework for esophageal cancer grading: combining CT imaging, radiomics, reproducibility, and deep learning insights by Muna Alsallal, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Anupam Yadav, Subbulakshmi Ganesan, Aman Shankhyan, Sofia Gupta, Kamal Kant Joshi, Hayder Naji Sameer, Ahmed Yaseen, Zainab H. Athab, Mohaned Adil, Bagher Farhood

“…Radiomic features were classified into four reliability levels based on their ICC (Intraclass Correlation) values. Most of the features had excellent (ICC > 0.90) or good (0.75 < ICC ≤ 0.90) reliability. …”
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Predictive nomogram model for severe coronary artery calcification in end-stage kidney disease patients by Xinfang Tang, Hanyang Qian, Shijiu Lu, Hui Huang, Jing Wang, Fan Li, Anning Bian, Xiaoxue Ye, Guang Yang, Kefan Ma, Changying Xing, Yi Xu, Ming Zeng, Ningning Wang

“…In the four branches of the coronary arteries, LAD calcification is the most common. Our validated nomogram model, based on clinical risk factors, can help predict the risk of severe coronary calcification in ESKD patients who cannot undergo coronary CT analysis.…”
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Assessing water requirements and suitability for apple growth at county scale in China: a phenological modeling approach during key growth stages by Xiaoya Ru, Xiaoya Ru, Xiaoya Ru, Tianzhi He, Tianzhi He, Guochao Yan, Guochao Yan, Yong He, Yong He, Zhujun Zhu, Zhujun Zhu, Qiang Yu, Jianqiang He

“…Despite the fruit expansion stage having the highest average water requirement (319 mm), multi-year data indicated ‘relatively suitable’ (S=0.8) conditions for most counties. In contrast, although the average water requirement during flowering-fruit setting was 120 mm, the suitability level was classified as ‘unsuitable’ (S=0.3), indicating a water shortage, particularly in Xinjiang, the northwest Loess Plateau, and northern Bohai Bay areas. …”
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Accurate prediction of damage depth of multi-story structural footings with Matlab implementation by Ang LI, Weidong WANG, Qian MOU, Feng WANG, Zhenghe MA, Lei ZHAO, Gang HUANG, Yonggen ZHOU, Shengqi TIAN

“…The results show that ① most of the working conditions in the calculation of the damage depth of multilayer structure base plate need to be solved by Taylor expansion and quadratic equation several times, and the manual calculation process is long and complicated, which is very likely to lead to deviations in the calculation results; ② by comparing the maximum damage depth of the base plate under the same working condition with the same parameters by manual calculation and machine calculation (Matlab built-in function), it can be seen that with the increase of the number of layers of the base plate, the manual solution process leads to the maximum damage depth of the base plate due to the repeated application of Taylor expansion. ③ The main interface of the software contains the number of layers, layer thickness, mechanical parameters, input boxes, calculation buttons, etc., which can quickly and intelligently identify the working conditions and calculate the maximum depth of damage of the bottom slab and the maximum depth of damage from the mining face to the bottom slab. ④ will be a mine of flat coal related lithological mechanical parameters into the software solution, by comparing and analyzing the five-layer structure of the maximum depth of destruction of the base plate theoretical value, fitting value, measured value and software value can be seen, the theoretical value and measured results deviation of 0.57 m, software value and measured value of the difference of 0.14 m, the results of multi-layer calculations under the software calculations are more in line with the actual needs, can be for the bottom of the board of the prevention and control of water hazards and safety of mining to provide a reliable technology parameter.…”
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Risk factors of immune-related endocrine toxicities in non-small cell lung cancer patients treated with pembrolizumab and its impact on patient outcomes: a multicenter retrospectiv... by Haoting Zhang, Jing Zheng, Chenyi Ren, Chenlin Ye, Xiaoyu Wu, Xiaodong Lv, Yuping Li, Jianya Zhou, Jianying Zhou

“…Among these events, immune-related endocrine toxicities (E-irAE) represents the most common form, though their etiology, risk factors, and impact on patient outcomes remain poorly understood. …”
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The image of a “Special” Tree and its Transformation in the Space of a South Korean TV Series / Образ «особенного» дерева и его трансформации в пространстве южнокорейского телесери... by TARASOVA ALEKSANDRA V. / ТАРАСОВА А.В.

“…Further, I address contemporary television series of various genres, mostly fantasy. Most of the examples are united by one particular tree, which, since 2005, has “starred” in more than twenty TV series. …”
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Prevalence of Germline Variants in Advanced Renal Cell Carcinoma in North India by Chitrakshi Nagpal, Mohit Kumar Divakar, Hemavathi Baskarane, Ghazal Tansir, Rishabh Jain, Aparna Sharma, Ranjit Kumar Sahoo, Sameer Bakhshi, Ishaan Gupta, Shilpi Minocha, Saran Kumar, Pranay Tanwar, Brusabhanu Nayak, Rishi Nayyar, Sridhar P, Seema Kaushal, Sanjay Ojha, Parnika Nangla, Kunhi Parambath Haresh, Amlesh Seth, Atul Batra

“…Fumarate hydratase was the most common RCC-associated variant (2.8%), while WT1, BRCA1, BRIP1, and ATM (1.4% each) were the commonest non–RCC-associated variants. …”
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Methicillin‐resistant Staphylococcus aureus and Pseudomonas aeruginosa community acquired pneumonia: Prevalence and locally derived risk factors in a single hospital system by Bradley W. Frazee, Amarinder Singh, Matt Labreche, Partow Imani, Kevin Ha, Jonathan Furszyfer Del Rio, Eugene Kreys, Robert Mccabe

“…Thus, the prevalence P. aeruginosa and MRSA was 2.9% in the overall CAP cohort, but 30.3% in the microbiologically confirmed cohort. The most important predictors of either P. aeruginosa or MRSA isolation were tracheostomy (odds ratio [OR] 22.08; 95% confidence interval [CI] 10.39–46.96) and gastrostomy tube (OR 14.7; 95% CI 7.14–30.26). …”
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Diagnostic Accuracy of Non-Invasive Diagnostic Tests for Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis by Sun Y, Hu D, Yu M, Liang SB, Zheng Y, Wang X, Tong G

“…For diagnosing steatosis stage 1, Hydrogen Magnetic Resonance Spectroscopy (H-MRS, DOR 15,745,657.6, 95% CI 17.2– 1,014,063.59) proved to be the most accurate. For significant fibrosis, HRI leading (DOR 80.94, 95% CI 6.46– 391.41), For advanced fibrosis, CK-18 showed the highest performance (DOR 102654.16, 95% CI 1.6– 134,059.8). …”
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Riboflavin Status in Pregnancy and Its Relationship with Blood Pressure, Heart Rate and Risk of Hypertension: Findings from the OptiPREG Observational Study by Bethany Duffy, Helene McNulty, Mary Ward, Elina Psara, Emma O’Sullivan, Geraldine Horigan, Kristina Pentieva

“…Riboflavin biomarkers are rarely assessed in humans, with most studies reliant on dietary intakes only, therefore the health consequences of riboflavin deficiency remain largely uninvestigated. …”
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Comparing smoking-related disease rates from e-cigarette use with those from tobacco cigarette use: a reanalysis of a recently-published study by Peter N. Lee, Konstantinos Farsalinos

“…These showed a significantly reduced risk for vaping, similar to or lower than expected for quitting smoking for 5 to 10 years, highly relevant given the short period of vaping following earlier smoking for most study participants. For dual use vs. smoking, pooled OR estimates were 1.41 (1.18–1.68) for MI, 1.39 (1.06–1.82) for stroke and 1.32 (1.17–1.50) for COPD. …”
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Geological conditions and reservoir characteristics of various shales in major shale-hosted regions of China by Shu-jing Bao, Tian-xu Guo, Jin-tao Yin, Wei-bin Liu, Sheng-jian Wang, Hao-han Li, Zhi Zhou, Shi-zhen Li, Xiang-lin Chen

“…The shales of the Wufeng and Silurian formations constitute the most favorable shale gas reservoirs since they exhibit the highest porosity among the three types of shales. …”
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A first large study of whole-exome sequencing (WES) in 489 patients with suspected rare genetic disorders at a tertiary centre in Malaysia by Lip Hen Moey, Go Hun Seo, Boon Eu Cheah, Wee Teik Keng, Hane Lee, Gaik Siew Ch’ng

“…In Malaysia, it is estimated that 1.5–2 million (4–6 %) people from a population of 34 million suffer from rare disorders, most of which are genetic in origin. Tests offered to patients referred to genetic clinics in Malaysia include conventional karyotyping, Fragile X testing, metabolic screening and/or single gene testing. …”
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Implementation of digestion and characterization procedures for control standardization on samples of Gilthead Seabream (Sparus aurata) and plastic polymers from the coastal enviro... by Rita Melillo, Roberto Lonis, Giuseppa Lorenzoni, Gabriella Piras, Nicola Cogoni, Simona Cau, Sara Salza, Riccardo Bazzardi, Monica Molotzu, Giuseppe Esposito, Bruna Vodret, Domenico Meloni, Sebastiano Virgilio

“…The characterization of plastic polymers by μ-FTIR revealed that the samples isolated from the coastal environment of the Asinara Gulf (Sardinia, Italy) were mostly represented by polyethylene, nylon, polyethylene terephthalate, polystyrene, polypropylene and polyurethane. …”
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Effects of community-based antiretroviral therapy initiation models on HIV treatment outcomes: A systematic review and meta-analysis. by Ingrid Eshun-Wilson, Ajibola A Awotiwon, Ashley Germann, Sophia A Amankwaa, Nathan Ford, Sheree Schwartz, Stefan Baral, Elvin H Geng

“…All studies were pragmatic, but in most cases provided additional resources. Few studies reported on implementation outcomes. …”
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Epistaxis Versus Nonepistaxis Bleeding in Anticoagulated Patients With Atrial Fibrillation: Results From the ENGAGE AF‐TIMI 48 Trial by Robert S. Semco, Regan W. Bergmark, Sabina A. Murphy, Abby L. Cange, Martin Unverdorben, Cathy Z. L. Chen, Christian T. Ruff, Elliott M. Antman, Robert P. Giugliano, Brian A. Bergmark

“…Patients with intracranial hemorrhage during follow‐up were excluded; those with >1 bleeding event were categorized according to their most severe event. The safety cohort with interval censoring during drug interruption was analyzed. …”
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