Precision targeting of rhabdomyosarcoma by combining primary CAR NK cells and radiotherapy by Franz Rödel, Elise Gradhand, Winfried S Wels, Martin Michaelis, Lisa Marie Reindl, Lida Jalili, Tobias Bexte, Sabine Harenkamp, Sophia Thul, Stephanie Hehlgans, Alina Wallenwein, Florian Rothweiler, Jindrich Cinatl, Halvard Bonig, Meike Vogler, Evelyn Ullrich

“…Background: Rhabdomyosarcoma (RMS) is the most common type of soft-tissue sarcoma in children, and it remains a challenging cancer with poor outcomes in high-risk and metastatic patients. …”
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Precision public health alliances as a model and method for community engagement by Margaret L. McGladrey, Mary Elizabeth Lacy, Kristen McQuerry, Rachel Hogg-Graham, Svetla Slavova, Emily R. Clear, Kory Heier, Caitline Phan, Megan Hall, Ryan Parker, Mindy Keeton, Jennifer Sword, Thomas Ard, Charbel Salem

“…This replicable PPHA pilot in rural Kentucky and Ohio is an innovative method and model for how to engage communities most effectively in identifying and taking action to improve their chief health concerns.…”
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Statine-based peptidomimetics as SARS-CoV-2 Papain-like protease inhibitors: in Silico and in vitro studies by Raiane Dandara Pereira Pimentel, Priscila Goes Camargo, Pedro Henrique R. de A. Azevedo, Larissa Esteves Carvalho Constant, Stephany da Silva Costa, Diego Allonso, Carlos Rangel Rodrigues, Magaly Girão Albuquerque, Luiza R. S. Dias, Estela Maris F. Muri, Camilo Henrique da Silva Lima

“…Compounds 426 and 432 were the most promising, with IC50 of 0.85 µM and 1.46 µM, respectively, values comparable to the GRL-0617 reference inhibitor. …”
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Application of a Hybrid Model Based on CEEMDAN and IMSA in Water Quality Prediction by GUO Li-jin, WU Hao-tian

“…[Objectives] To enhance water quality prediction accuracy, this study aims to address the following challenges: (1) traditional prediction methods often rely on simple, elementary decomposition techniques, limiting their ability to extract meaningful data features. (2) Single models and basic optimization algorithms result in low prediction accuracy. (3) Most approaches fail to leverage the advantages of different networks to analyze components of varying complexity, leading to inefficient model utilization. (4) Few studies incorporate error correction after prediction. …”
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Features of the covid-19 epidemic and characteristics of patients during the spread of the delta SARS-COV-2 in Russia by A. A. Fomicheva, N. N. Pimenov, S. V. Komarova, A. V. Urtikov, N. N. Tsapkova, A. A. Proshkina, S. H.R. de Silva, A. E. Vlasenko, D. A. Strelkova, G. V. Nekludova, S. A. Rachina, S. N. Avdeev, V. P. Chulanov

“…The median age of patients was 49 [36–63] years, 61,1% were women. Most of patients were 30–39 years old (21,0%), the lowest proportion was among 18–29 years old (12.1%) (p<0,05). …”
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Procedural and Antithrombotic Therapy Optimization in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Narrative Review by Domenico Simone Castiello, Federica Buongiorno, Lina Manzi, Viviana Narciso, Imma Forzano, Domenico Florimonte, Luca Sperandeo, Mario Enrico Canonico, Marisa Avvedimento, Roberta Paolillo, Alessandra Spinelli, Stefano Cristiano, Fiorenzo Simonetti, Federica Semplice, Dario D’Alconzo, Donato Maria Vallone, Giuseppe Giugliano, Alessandro Sciahbasi, Plinio Cirillo, Felice Gragnano, Paolo Calabrò, Giovanni Esposito, Giuseppe Gargiulo

“…In the past decades, percutaneous coronary intervention (PCI) has become the most common modality for myocardial revascularization in patients with coronary artery disease (CAD). …”
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NEW POSSIBILITIES OF STAPHYLOCOCC INFECTION THERAPY by M. V. Matyushkina, V. V. Godovan, T. L. Grydina, I. I. Seyfullina, K. F. Shemonaeva

“…So far, it is one of the four most common causes of nosocomial infections. Emergence and widespread resistance to various forms of medicines for staphylococci is more characteristic than for any other bacteria species. …”
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Comparative assessment of Al2O3, CuO, and Al2O3-CuO Co-doping on the structural, optical, thermal, mechanical, and gamma-ray shielding properties of Bi2O3-B2O3-K2O glass system by Abely E. Mwakuna, C. Laxmikanth, K. Samatha, R.K.N.R. Manepalli

“…Although BBK2 provides the most effective attenuation, BBK4 stands out as the preferred option, offering comparable shielding capabilities to BBK2, excellent mechanical properties, and thermal stability similar to BBK3, making it highly suitable for γ-ray shielding applications at 0.662 MeV, where both mechanical and thermal efficiency are critical.…”
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In vivo assessment of GABAergic inhibition and glutamate facilitation in treatment-resistant schizophrenia: a TMS study integrating clinical, cognitive, and neurophysiological eval... by Annarita Barone, Gianmaria Senerchia, Giuseppe De Simone, Marco Manzo, Mariateresa Ciccarelli, Stefano Tozza, Valentina Virginia Iuzzolino, Myriam Spisto, Raffaele Dubbioso, Felice Iasevoli, Rosa Iodice, Andrea de Bartolomeis

“…Our findings point to a neurophysiological continuum in schizophrenia, with TRS patients demonstrating the most pronounced cortical hyperexcitability and impaired plasticity, and non-TRS patients showing intermediate deficits.…”
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Determination of Favipiravir in Human Blood Plasma by HPLC-MS/MS by T. N. Komarov, P. A. Karpova, O. A. Archakova, D. S. Shchelgacheva, P. K. Karnakova, N. S. Bagaeva, K. Ya. Zaslavskaya, P. A. Bely, I. E. Shohin

“…Favipiravir is one of the most well-known broad-spectrum drugs against many RNA viruses, including the severe acute respiratory syndrome virus 2 [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)]. …”
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Shifting dynamics of self-immolation in the capital of Iran? The rising trend among young, unmarried, less-educated men by MohammadAli Shokri, SaeedehSadat Khalili, Abdol-Hossein Vahabie, Atefeh Ghanbari Jolfaei, Amir-Abbas Keshavarz-Akhlaghi, Mostafa Dehmardei, Fatemeh Sadat Mirfazeli

“…It is observed that in our population men had a higher rate of being unmarried (70.96 % vs 15.15 %), lower levels of education (70.96 % vs 63.63 % did not have a university degree), higher level of unemployment (54.83 % vs 30.30 %), younger age average with most men aging 15–24 (29.06 (SD = 9.33)) vs women 35–44 (35.27(SD = 10.27)) and higher prevalence of addiction (67.74 % vs 36.36 %) compared to women. …”
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Long-term durability of bioprosthetic aortic valve replacement in young patients with bicuspid aortic stenosisCentral MessagePerspective by Christopher K. Mehta, MD, Tom X. Liu, MD, MS, Abigail S. Baldridge, DrPh, Jane Kruse, BSN, Jyothy Puthumana, MD, Robert O. Bonow, MD, Duc T. Pham, MD, Douglas R. Johnston, MD, S. Christopher Malaisrie, MD, Patrick M. McCarthy, MD

“…Moderate or greater aortic regurgitation and paravalvular leak were observed in 6.5% and 0.3%, respectively, at most recent follow-up. Conclusions: Bicuspid AS is common in patients younger than 65 years and management includes consideration of future valve intervention. …”
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T-cell receptor dynamics in digestive system cancers: a multi-layer machine learning approach for tumor diagnosis and staging by Changjin Yuan, Bin Wang, Hong Wang, Fang Wang, Xiangze Li, Ya’nan Zhen

“…Multi-layer machine learning-based diagnostic models were developed by leveraging motif-based feature and deep learning-based feature extraction using ProteinBERT from the 100 most abundant CDR3 sequences per sample. These models were used to differentiate CRC from GC, distinguish between primary and metastatic CRC lesions, and predict disease stages in CRC.ResultsTissue-specific differences in TCR repertoires were observed across CRC, GC, and between primary and metastatic lesions, as well as across disease stages in CRC. …”
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‘Planning over programs’: Challenges and opportunities affecting the participation of underserved producers in the conservation reserve program across the southeastern United State... by Parag Kadam, Alejandro Bolques, Alex Harvey, Alton Perry, Sherwynn Best, Danielle Atkins, Felicia Burke, Lincoln Larson, Erica Rieder, Kayla Stukes, Sam Cook, Ben Graham, Troy Bowman, Wayde Morse, Ben Garber, Sarah Hitchner, Puneet Dwivedi

“…Lack of knowledge about CRP emerged as the most significant challenge, followed by limited resources, lack of trust in the government, onerous program requirements, and other factors such as family or personal issues, or other priorities and motivations not centered on conservation. …”
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Biological role and use of L-glutamic acid and its influence on the body by O. O. Korytko

“…L-glutamic acid (GA) is an non-essential ubiquitous amino acid present in most foods in either the free form (as free glutamate, Glu) or bound to peptides and proteins. …”
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A DNA vaccine candidate provides protection against Rift Valley Fever virus in sheep under natural field conditions by Moufid Mhamadi, Moufid Mhamadi, George (Giorgi) Babuadze, Aminata Badji, Marie-Edith Nepveu-Traversy, El Hadji Ndiaye, Alioune Gaye, Mignane Ndiaye, Moundhir Mhamadi, Frank William Mendy, Cheikh Talibouya Touré, Idrissa Dieng, Moussa Dia, Ndeye Sakha Bob, Marc-Antoine de La Vega, Ousmane Faye, Amadou Alpha Sall, Mawlouth Diallo, Gary Kobinger, Gary Kobinger, Oumar Faye, Hugues Fausther-Bovendo, Hugues Fausther-Bovendo

“…Rift Valley Fever virus (RVFV) is a mosquito-borne zoonotic pathogen, that causes significant morbidity and mortality in livestock, including high abortion rates in pregnant animals and elevated case fatality in neonates, representing a major threat to both animal and human health. Vaccination is the most effective countermeasure to reduce RVFV’s impact. …”
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Intervention delivery complexity and adaptations for implementation of non-pharmacologic pain interventions by Lindsay A. Ballengee, Maggie E. Horn, Trevor A. Lentz, Devon Check, Leah L. Zullig, Steven Z. George

“…Workflow emerged as the most challenging domain for adaptation among all trials. …”
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Artificial intelligence in endoscopy and colonoscopy: a comprehensive bibliometric analysis of global research trends by Negin Letafatkar, Amr Ali Mohamed Abdelgawwad El-Sehrawy, KDV Prasad, KDV Prasad, Ahmad Alkhayyat, Ahmad Alkhayyat, Ahmad Alkhayyat, Ehsan Amini-Salehi, Maryam Hasanpour, Masoomeh Namdar Taleshani, Mohammad Hashemi, Hadi Alotaibi, Pegah Rashidian, Mohammad-Hossein Keivanlou, Soheil Hassanipour

“…The leading journal was Gastrointestinal Endoscopy, contributing 72 publications and accumulating 6,496 citations. The most frequently occurring keywords were “diagnosis,” “classification,” and “cancer.” …”
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Interventions to reengage people living with HIV who are lost to follow-up from HIV treatment programs: A systematic review and meta-analysis. by Ali Mirzazadeh, Ingrid Eshun-Wilson, Ryan R Thompson, Atousa Bonyani, James G Kahn, Stefan D Baral, Sheree Schwartz, George Rutherford, Elvin H Geng

“…In low- and middle-income countries (LMICs) (N = 16), tracing most frequently involved identification of LTFU from the electronic medical record (EMR) and paper records followed by a combination of telephone calls and field tracing (including home visits), by a team of outreach workers within 3 months of becoming LTFU (N = 7), with few incorporating additional strategies to support reengagement beyond contact (N = 2). …”
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Lentil lectin derived from Lens culinaris exhibit broad antiviral activities against SARS-CoV-2 variants by Wenbo Wang, Qianqian Li, Jiajing Wu, Yu Hu, Gang Wu, Chuanfei Yu, Kangwei Xu, Xumei Liu, Qihui Wang, Weijin Huang, Lan Wang, Youchun Wang

“…The Lens culinaris-derived lentil lectin which specifically bind to oligomannose-type glycans and GlcNAc at the non-reducing end terminus showed most potent and broad antiviral activity against a panel of mutant strains and variants, including the artificial mutants at N-/O-linked glycosylation site, natural existed amino acid mutants, as well as the epidemic variants B.1.1.7, B.1.351, and P.1. …”
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