Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…The primary reason for first‐line osimertinib discontinuation was toxicity in 32 (60.4%, 17 patients with pneumonitis) and disease progression in 20 (37.7%) patients. The most common rechallenge EGFR‐TKI was afatinib (n = 24, 45.3%), followed by gefitinib (n = 16, 30.2%) and erlotinib (n = 8, 15.1%). …”
Get full text

HIV–HPV Co-Infection and Identification of Novel High-Risk HPV Among Women at Two Hospital Centers in Cotonou, Republic of Benin by Clémence D. Gouton, Ifeoluwa O. Bejide, Oludayo O. Ope-ewe, Marius Adjagba, Simon Azonbakin, Gaonyadiwe Muzanywa, Florence T. Akinyi, Arnaud Agbanlinsou, Yanique Goussanou, Onikepe Folarin, Anatole Laleye, Christian T. Happi, Chinedu A. Ugwu

“…Fifteen HR-HPV genotypes were identified, with HPV 45 most prevalent in WLWHIV and HPV 16 in WWHIV. Notably, HR-HPV 67, 70, and 82 were detected for the first time in Benin. …”
Get full text

Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy by Fang Lu, Si Chen, Honglei Guo, Qing Li, Lin Wu, Ying Pan, Yangfan Wu, Hua Shu, Simeng Liu, Bo Zhang, Huijuan Mao, Changying Xing, Hongwei Liang, Suyan Duan, Yanggang Yuan

“…However, the immunopathogenic mechanisms underlying B cell involvement in PMN remain elusive.MethodsWe employed single-cell RNA sequencing on peripheral blood mononuclear cell samples (PBMC) obtained from 6 patients with PMN and 3 healthy controls (NC) to explore the transformation of B cells and their interaction with immune cells.ResultsCompared with NC, the most significant alterations were in plasma cells and regulatory B (Breg) cells in PMN patients. …”
Get full text

Early Adoption and Utilization of Perfluorohexyloctane for Dry Eye Disease in the United States by Shen Lee B, Pizzicato L, Langford E, Shi L, Divino V, Alexander A, Nair AA

“…Over the 90-day follow-up, most (72.0%) PFHO patients refilled the prescription for their index therapy compared to 37.4% of CsA patients. …”
Get full text

Epidemiological characteristics and management of Gram-negative bacteraemia in different immunocompromised hosts: Observational single-center study. by Alice Toschi, Renato Pascale, Dino Gibertoni, Riccardo Pasquali, Andrea Grechi, Irene Grassi, Marta Malosso, Ludovica Mangione, Cecilia Bonazzetti, Beatrice Tazza, Matteo Rinaldi, Armando Amicucci, Caterina Campoli, Zeno Pasquini, Simone Ambretti, Pier Giorgio Cojutti, Francesca Bonifazi, Pierluigi Viale, Maddalena Giannella

“…Urinary tract infection was the most common source of BSI in nm-IC (nm-IC: 50.1%, HM:15%; SOT: 33.3%; mSC: 25.9%, p < 0.001), intra-abdominal infection was the more frequent source among SOT and mSC (SOT:42.3%; mSC: 49.3%, nm-IC: 27.8%, HM:29%; p < 0.001). …”
Get full text

ODE TO JOY: BEETHOVEN’S NINTH SYMPHONY IN CINEMATOGRAPHIC INTERPRETATIONS / «К РАДОСТИ»: ДЕВЯТАЯ СИМФОНИЯ Л. БЕТХОВЕНА В КИНЕМАТОГРАФИЧЕСКИХ ИНТЕРПРЕТАЦИЯХ... by KONONENKO NATALIA G. / КОНОНЕНКО Н.Г.

“…The motif known as the “Freudenmelodie” (“the melody of joy”) holds a prominent place among the most popular classical musical topoi in cinema. Its multilayered semantics has contributed to an extensive history of extramusical associations with Beethoven’s opus. …”
Get full text

Xylazine prevalence and concentration in the Los Angeles fentanyl market, 2023–2025 by Joseph Friedman, Caitlin A. Molina, Adam J. Koncsol, Ruby Romero, Morgan E. Godvin, Elham Jalayer, Spider Davila, Oscar Arellano, Amanda Cowan, Brian Hurley, Chelsea L. Shover

“…Background: The veterinary sedative xylazine has been mostly described on the East Coast—yet early reports indicate that it is now arriving to West Coast fentanyl markets. …”
Get full text

Isolation and characterization of diphenyl ether degrading bacterium Sphingomonas sp. DZ-3 by Feng Zhuo, Wang Sheng, Bai Naling, Zhao Yuhua

“…The results indicated that Mg²⁺ appeared to be the most important metal ion for the biodegradation of DZ-3 with a relative importance of 31.01%, followed by Co²⁺(25.45%), Ni²⁺(15.12%), in which Mg²⁺ had a positive effect on the degradation, while Co²⁺ and Ni²⁺ had negative ones. …”
Get full text

Immune-checkpoint HLA-G gene polymorphisms, 3’-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population by Neeti Nadda, Renu Yadav, Neelanjana Roy, Nita Singh, Sonu Kumar, Shashi Bala Paul, Shivanand Gamanagatti, Anoop Saraya, Shalimar, Baibaswata Nayak

“…We did not observe significant association of the most studied SNP, rs371194629 (INDEL, +2960), with HCC or treatment response. …”
Get full text

Gold and Silver Nanoparticles Efficiently Modulate the Crosstalk Between Macrophages and Cancer Cells by Adamecz DI, Veres É, Papp C, Árva H, Rónavári A, Marton A, Vizler C, Gácser A, Kónya Z, Igaz N, Kiricsi M

“…We assessed the expression of macrophage polarization and functional markers using RT-qPCR and Proteome Profiler Array and evaluated macrophage migration and matrix metalloproteinase activity by specific assays.Results: Protein and mRNA levels of most examined factors – except tumor necrosis factor-alpha – such as C-C-motif chemokine ligands 2 and 22, interleukin-23, inducible nitric oxide synthase, cyclooxygenase-2, the macrophage mannose receptor CD206, transforming growth factor-beta, and chitinase-like-3 protein decreased, and the expression of polarization markers revealed a shift towards M1-like phenotype in macrophages co-cultured with AgNP- or AuNP-treated 4T1 cells. …”
Get full text

A comprehensive review of diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) techniques in protonic ceramic cells (PCCs): Current status and future perspective by Zixian Wang, Fan Liu, Yuqing Meng, Wenjuan Bian, Haiyan Zhao, Chuancheng Duan, Michael T. Benson, Meng Li, Bin Liu, Dong Ding

“…This review critically examines the most up-to-date applications of DRIFTS for characterizing key components of PCCs, including oxygen electrodes, protonic electrolytes, and hydrogen electrodes for different applications, with a focus on revealing hydration properties and catalytic reactions, and guiding rational material design. …”
Get full text

Association of maternal lipid levels with birth weight and cord blood insulin: a Bayesian network analysis by Naveed Sattar, Krishnarajah Nirantharakumar, Jinhua Lu, Xiu Qiu, Huimin Xia, Jingya Wang, Malcolm James Price, Kar Keung Cheng, Yashu Kuang, Songying Shen, Jianrong He, Marta Pittavino, G.Neil Thomas

“…Maternal prepregnancy overweight/obesity appears the most influential upstream metabolic risk factor for both maternal and neonatal metabolic health; these data imply weight management may need to be addressed from the preconception period and during early pregnancy.…”
Get full text

Revistas médicas cubanas: ¿es posible una igualdad académica? by Rubén Cañedo Andalia, Alberto R. Piritz Assa, Rafael M. Trinchet Soler

“…ABSTRACT The classification of Cuban medical journals according to the geographical origin of most of the authors hinders their development under the present conditions of scientific and technological advancement of the country. …”
Get full text

Patterns of immune recovery in people living with HIV who initiated antiretroviral therapy as late presenters by Sandra Pinto-Cardoso, Monserrat Chávez-Torres, Mariana López-Filloy, Santiago Ávila-Ríos, Karla Romero-Mora, Amy Peralta-Prado

“…Indeed, in our cohort, most INR were non-MSM, while PWoH were all MSM. Conclusions In the Instituto Nacional de Enfermedades Respiratorias, a tertiary reference centre, a disproportionate number of individuals are diagnosed with HIV-1 with severe immunodeficiency and/or opportunistic infections; they represent a high-risk population for the INR phenotype. …”
Get full text

Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus by Martina Brandolini, Ludovica Ingletto, Giorgio Dirani, Silvia Zannoli, Andreea Maria Lapusneanu, Massimiliano Guerra, Alessandra Mistral De Pascali, Davide Lelli, Francesco Defilippo, Antonio Lavazza, Mattia Calzolari, Michele Dottori, Laura Dionisi, Claudia Colosimo, Giulia Gatti, Anna Marzucco, Maria Sofia Montanari, Laura Grumiro, Monica Cricca, Alessandra Scagliarini, Vittorio Sambri

“…Cerebrospinal fluid samples yielded the most consistent results compared to urine and sandfly pools. …”
Get full text

MANAGEMENT OF INDIVIDUAL WORK FOR THE SECOND YEAR STUDENTS BY INTRODUCTION THE MULTIMEDIA PRESENTATION IN „PROPAEDEUTIC OF PEDIATRIC THERAPEUTIC STOMATOLOGY” by O.V. Bazalytska, I.R. Kostiuk, G.M. Melnychuk, N.I. Shovkova, M.V. Bilyshchuk, O.M. Cherepiuk, O.E. Koshkin, R.P. Oliinyk, V.V. Starchenko

“…Introduction of new technologies and multimedia, particularly into educational process is the most promising way to gain the information. In this view we suggest multimedia presentation for individual study of the topics for the second year students (including foreign students) to control the quality of independent study performed during practical classes. …”
Get full text

Outbreak of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Napoli on a Dairy Cow Farm by Matteo Ricchi, Anita Filippi, Erika Scaltriti, Martina Tambassi, Stefano Pongolini, Luca Bolzoni, Alice Prosperi, Camilla Torreggiani, Medardo Cammi, Alessandro Chiatante, Norma Arrigoni, Elisa Massella, Andrea Luppi, Chiara Garbarino

“…<i>enterica</i> is spread worldwide with many serovars associated with the infection of domestic bovines. The most spread are <i>S</i>. Dublin, <i>S</i>. Typhimurium and <i>S</i>. …”
Get full text

Unveiling the Interior Structure and Thermal Evolution of Super-Earth GJ 486b by Chandan K. Sahu, Liton Majumdar, Sudipta Mridha, Harshit Krishna

“…Recent ground- and space-based surveys have shown that planets between Earth and Neptune in size, known as “super-Earths,” are among the most frequently found planets in the Galaxy. Although the JWST era has provided high-quality atmospheric data on many such super-Earths, modeling tools are crucial for understanding their unobservable interiors. …”
Get full text

Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…We also report that LV adjustmenst detect most atrophic patterns associated with HIV and HAND across multiple subcortical regions with more strong statistical strengths, especially the areas of the basal ganglia (putamen, pallidum, caudate nucleus), hippocampus, thalamus, ventral DC, basal forebrain, third ventricle, fourth ventricle, and inferior lateral ventricle. …”
Get full text

The Existing Interventions to Promote Self-Care and Self-Monitoring Preventing Hypertension Among Thai Risk People: A Scoping Review by Banharak S, Potempa K, Limpawattana P, Pamungkas RA, Mahikul W, Jeamjitvibool T, Karaket A, Siriprathum S, Ransinyo K

“…Finally, knowledge, behaviors, and biomarkers were the most frequently assessed outcomes. This scoping review provided recommendations that future research should expand intervention strategies, emphasize biomarkers, adopt modern delivery methods like AI chatbots and mobile apps, and include follow-ups beyond 12 weeks to ensure lasting impact.Keywords: hypertension, intervention, review, self-care, self-management, self-monitoring…”
Get full text