Multicenter Study Examining Temporal Trends in Traumatic Intracranial Hemorrhage Over Six Years Using Joinpoint Regression by Timbre Backen, Kristin Salottolo, David Acuna, Carlos H. Palacio, Gina Berg, Andrea Tsoris, Robert Madayag, Kaysie Banton, David Bar-Or

“…Similarly, the proportion of geriatric patients (≥65 years old) increased 2.4% biannually from July 2016 to July 2019 (BPC = 2.4, p = 0.001) as did injuries due to falls (BPC = 2.2, p = 0.01). Three of the four most prevalent comorbidities significantly increased: hypertension linearly increased 2.1% biannually, functional dependence increased 25.5% biannually through June 2019, and chronic anticoagulant use increased 19.0% biannually through June 2019 and then 3.1% thereafter. …”
Get full text

Evolution and Prognostic Variables of Cystic Fibrosis in Children and Young Adults: A Narrative Review by Mădălina Andreea Donos, Elena Țarcă, Elena Cojocaru, Viorel Țarcă, Lăcrămioara Ionela Butnariu, Valentin Bernic, Paula Popovici, Solange Tamara Roșu, Mihaela Camelia Tîrnovanu, Nicolae Sebastian Ionescu, Laura Mihaela Trandafir

“…<b>The objective</b> of our narrative review is to summarize the most recent information concerning the value and significance of clinical parameters in predicting outcomes, such as gender, diabetes, liver and pancreatic status, lung function, radiography, bacteriology, and blood and sputum biomarkers of inflammation and disease, and how variations in these parameters affect prognosis from the prenatal stage to maturity. …”
Get full text

Precise Modulation of Reorganization Energy through Methyl Substitution for High Performance Organic Solar Cells by Li Chen, Chaoyue Zhao, Joshua Yuk Lin Lai, Rongkun Zhou, Aleksandr Sergeev, Kam Sing Wong, Huawei Hu, Zilong Zheng, Han Yu, Sai Ho Pun, Guangye Zhang, He Yan

“…Among the synthesized materials, BQx‐MeCl exhibited the lowest energy loss and the most balanced electron and hole mobilities, resulting in a superior power conversion efficiency (PCE) of 19.2% in a binary device. …”
Get full text

Multi-institutional beta testing of a novel cervical esophagogastric anastomosis simulatorCentral MessagePerspective by Jules Lin, MD, Deborah M. Rooney, PhD, Stephen C. Yang, MD, MAMSE, Mara Antonoff, MD, Michael T. Jaklitsch, MD, Allan Pickens, MD, Jinny S. Ha, MD, MHS, Monisha Sudarshan, MD, Alejandro Bribriesco, MD, David Zapata, MD, Kathleen Weiss, MD, Christopher Johnson, MD, Doug Hennigar, BSME, Mark B. Orringer, MD

“…The interrupted outer layer of the anastomosis rated lowest, suggesting this task was the most difficult. The simulator was rated as a highly valuable training tool. …”
Get full text

The key design features and effectiveness of social network interventions for HIV testing and linkage services in low‐ and middle‐income countries: a systematic review and meta‐ana... by Madalo Mukoka, Takondwa C. Msosa, Hussein H. Twabi, Robina Semphere, Marriott Nliwasa, Guy Harling, Alison Price, Katherine Fielding, Augustine T. Choko

“…Nine studies engaged key populations. The most common strategy involved recruiting and training seeds, who then delivered HIV services to network members. …”
Get full text

Production, Diversity, and Distribution of Aquaculture Commodities in Tuban, Indonesia by Syifania Hanifah Samara, Muhamad Amin, Wahyu Isroni, Veryl Hasan, Muhammad Browijoyo Santanumurti, Muhammad Ar Rozzaaq Nugraha, Muyassar H. Abualreesh

“…Indonesia is one of the leading countries in high volumes of fishery production in most of its areas, including the Regency of Tuban in East Java Province. …”
Get full text

Research on the effectiveness of health information dissemination via the “Shanghai CDC” WeChat public account by GUO Ying, WANG Xiaoxuan, XIA Wen, HUANG Xiaoyan, HU Xuanmeng, SHEN Qi, DONG Chen

“…Enhancing article titles by increasing informational content and degree adverbs (e.g., "highly," "most," and "extremely") and negative adverbs (e.g., "no") can improve dissemination reach. …”
Get full text

The Requirements and Development Potential of Interdisciplinary Digital Health Data Exchange in Mobile Nursing and Care Settings in German-Speaking Countries: Delphi Study by Verena Kollmann, Nathalie Traugott, Susanne Hensely-Schinkinger, Doris Zeidler, Elisabeth Haslinger-Baumann

“…Cross-border data exchange, telemonitoring, and artificial intelligence integration were seen as valuable, while the topic of access rights, particularly for assistant roles, provoked the most disagreement, indicating a need for further clarification in policy and practice. …”
Get full text

Accuracy of clinical symptoms and nuclear imaging in the diagnosis of infection in revision shoulder arthroplasty by Cristina Bassi, MD, FRCSC, Diane Nam, MSc, MD, FRCSC, Elham Sabri, MSc, Darren Drosdowech, MD, FRCSC, J.W. Pollock, MSc, MD, FRCSC, Dominique Rouleau, MD, FRCSC, Taryn Hodgdon, MD, FRCPC, Katie McIlquham, HBScHK, Jonathan Doyon, MD, FRCSC, Peter Lapner, MD, FRCSC

“…Background: Prosthetic shoulder infection is the most common reason for revision arthroplasty within 2 years of the index procedure. …”
Get full text

Utilitarian diversity and options for the sustainable use of the bush banana Uvaria chamae P. Beauv. in Benin (West Africa) by Emilienne Houévo Daï, Rodrigue Idohou, Sèwanoudé Scholastique Mireille Toyi, Juliano Sènanmi Hermann Houndonougbo, Fortuné Akomian Azihou, Amadé Ouédraogo, Stefan Hotes, Achille Ephrem Assogbadjo

“…The main use categories, summarized from all the respondents, were medicinal (97%), food (84.10%), magico-religious (52.92%), firewood (25.52%), and material for handicrafts (7.30%). The most valued plant parts were roots, fruits, leaves, and branches. …”
Get full text

A rare deleterious missense mutation in the AXIN2 gene in Chinese women with polycystic ovary syndrome by Ying Zhang, Yu Chen, Fa-Ying Liu, Jing-Wen Fu, Xian-Xian Liu, Jun Tan, Ou-Ping Huang, Yang Zou

“…Previous genome-wide association study (GWAS) showed that Wing-less-related integration site (Wnt) signaling is the most affected pathway among PCOS-related risk genes, and genetic mutations in the Wnt/β-catenin signaling may lead to abnormal development of PCOS.Objective To explore the possibility of axis inhibitor-2 (AXIN2) variants in Chinese women with PCOS and assess their pathogenicities.Methods A total of 365 Chinese women with PCOS and 905 women without PCOS as control were recruited from Jiangxi Provincial Maternal and Child Health Hospital, All of the 11 exons and flanking regions of the AXIN2 gene were amplified by polymerase chain reaction (PCR), the potential variants were analyzed by Sanger sequencing. …”
Get full text

Traditional Chinese medicine diagnostic prediction model for holistic syndrome differentiation based on deep learning by Zhe Chen, Dong Zhang, Chunxiang Liu, Hui Wang, Xinyao Jin, Fengwen Yang, Junhua Zhang

“…Results: The TCM-BERT-CNN model had a higher precision (0.926), recall (0.9238), and F1 score (0.9247) than the BERT, TextCNN, Long Short-Term Memory (LSTM) of Recurrent Neural Network (RNN), and attention mechanism-based LSTM (LSTM-attention) models and achieved superior results in model performance and predictive classification of most TCM syndromes. Symptom feature visualization demonstrated that the TCM-BERT-CNN model can effectively identify the correlation and characteristics of symptoms in different syndromes with a strong correlation, which conforms to the diagnostic characteristics of TCM syndromes. …”
Get full text

Pien-Tze-Huang alleviates lithocholic acid-induced cholestasis in mice by shaping bile acid-submetabolome by Yan Cao, Yanhong Zhai, Qihong Deng, Shufen Song, Wei Li, Youran Li, Yifan Lu, Jun Li, Zheng Cao, Yuelin Song

“…Abstract Background Cholestasis is one of the most common and devastating manifestations of liver diseases. …”
Get full text

Evaluating chain-of-thought prompting in a GPT chatbot for BCID2 interpretation and stewardship: how does AI compare to human experts? by Daniel M. Tassone, Matthew M. Hitchcock, Connor J. Rossier, Douglas Fletcher, Julia Ye, Ian Langford, Julie Boatman, J. Daniel Markley

“…Results: The chatbot had a significantly higher rate of harmful or inadequate recommendations (13%) compared to ASP (4%, p = 0.047). The most significant discrepancy was observed in the domain of antibiotic therapy, where harmful recommendations occurred in up to 10% (p <0.05) of chatbot evaluations. …”
Get full text

Antimicrobial Susceptibility Testing to Erythromycin and Azithromycin of Clinical Isolates of Bordetella pertussis Circulating in Russia by A. S. Pimenova, N. T. Gadua, I. Yu. Andrievskaya, O. Yu. Borisova, M. S. Petrova, A. B. Borisova, S. S. Afanas'ev, I. V. Podoprigora, M. S. Afanas'ev, T. I. Moskvina, G. V. Vorob'eva, I. M. Degtyareva, O. V. Timirkina, S. A. Luk'yanceva, T. N. Trigorlova

“…The large-scale and unjustified use of antimicrobials to treat these infections has led to the emergence of resistance in most pathogens. The aim. To study antimicrobial susceptibility testing to erythromycin and azithromycin of strains of B. pertussis isolated in Russia. …”
Get full text

Adubação nitrogenada para o milho cultivado em sistema plantio direto, no Estado de Alagoas Nitrogen fertilization for corn cultivated under a no-tillage system in the State of Ala... by Simério C. S. Cruz, Francisco R. da S. Pereira, José R. Santos, Abel. W. de Albuquerque, Rodrigo G. Pereira

“…For yield, it was observed that the hybrids DOW-8550 and AG-9010 were the most promising. It may be concluded that the economic return of the N fertilization can be reached with a 120 kg ha-1 dose. …”
Get full text

Phytochemical Characterization, Bioactivities, and Nanoparticle-Based Topical Gel Formulation Development from Four <i>Mitragyna speciosa</i> Varieties by Pimporn Anantaworasakul, Weeraya Preedalikit, Phunsuk Anantaworasakul, Sudarshan Singh, Aekkhaluck Intharuksa, Warunya Arunotayanun, Mingkwan Na Takuathung, Songwut Yotsawimonwat, Chuda Chittasupho

“…In summary, KG and KY cultivars emerged as the most promising cosmeceutical candidates due to their superior phytochemical content, antioxidant capacity, enzyme-inhibitory activities, and formulation performance. …”
Get full text

Combining inhibition of galectin-3 with and before a therapeutic vaccination is critical for the prostate-tumor-free outcome by Carolina Tiraboschi, Lucas Gentilini, Carla Velazquez, Enrique Corapi, Felipe Martín Jaworski, José Daniel Garcia Garcia, Yorfer Rondón, Anne Chauchereau, Diego José Laderach, Daniel Compagno

“…In the case of immunotherapy, tumors develop robust immune escape mechanisms that abolish any protective response, and to date why prostate cancer is one of the most resistant diseases remains unresolved.Methods By using a combination of clinical data to study the transcriptome of metastasis samples from patients with castration-refractory prostate cancer, and state of the art cellular and molecular biology assays in samples from tumor-bearing mice that have been submitted to surgical resection of the tumor before receiving a vaccination, we answered several essential questions in the field of immunotherapy for prostate cancer. …”
Get full text

Cytokine profile of surgical patients with infective endocarditis by E. O. Kotova, A. S. Pisaryuk, A. V. Lokhonina, A. Y. Moiseeva, E. A. Domonova, T. A. Gusarova, J. I. Babukhina, P. V. Kakhktsyan, T. K. Fatkhudinov, Z. D. Kobalava

“…The level of cytokine gene expression by tissue macrophages, depending on the presence of embolic events, etiological affiliation to S. aureus, as well as hospital mortality and the combined endpoint (death from all causes or recurrence of IE in 6 months after surgery) did not differ between IE patients with or without events. IL-1β had the most favorable characteristics for assessing the activity of IE (IL-1β AUC 0.816 (p = 0.02)).   …”
Get full text

Geographic patterns in wildland fire exposures and county-level lung cancer mortality in the United States by Richard V. Remigio, Ian D. Buller, Michael S. Bogle, Maria E. Kamenetsky, Samantha Ammons, Jesse E. Bell, Jared A. Fisher, Neal D. Freedman, Rena R. Jones

“…There were positive (high WF exposures and high LCM rate) clusters for males and females in counties within the mid-Appalachian region and Florida, and modest differences across WF metrics in the cluster patterns were observed across the Western US and Central regions. The most positive clusters were seen between WF density by area and LCM rates among women (n = 82 counties) and a similar geographic pattern among men (n = 75 counties). …”
Get full text