Exploring the Potential of a P2X3 Receptor Antagonist: Gefapixant in the Management of Persistent Cough Associated with Interstitial Lung Disease by Tomoyuki Takahashi, Atsushi Saito, Takafumi Yorozuya, Hirotaka Nishikiori, Koji Kuronuma, Hirofumi Chiba

“…However, statistical significance was not reached due to high interindividual variability, with gefapixant being effective in some and ineffective in others. The most common adverse event was taste disorder, leading to discontinuation in one patient, but symptoms tended to lessen over the course of treatment. …”
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18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography-Positive Lymph Node Endometriosis Masquerading as Lymph Node Metastasis of a Malignant Tumor by Makoto Akiyama, Izumi Suganuma, Taisuke Mori, Izumi Kusuki, Haruo Kuroboshi, Fumitake Ito, Hiroshi Matsushima, Morio Sawada, Jo Kitawaki

“…Endometriosis is defined as the presence of endometrium-like tissues at extrauterine sites, most commonly in the abdominal cavity. Lymph node endometriosis is a rare but clinically important type of endometriosis that can mimic lymph node metastasis of a malignant tumor. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is a useful tool for diagnosing malignant tumors, although it occasionally shows false positive results in tissues with high metabolic activity caused by severe inflammation. …”
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Comprehensive genomic characterization and differential expression analysis of m6A RNA methylation regulatory proteins (writers, readers, and erasers) in Suaeda Salsa under abiotic... by Yuke Ma, Huijuan Yin, Wenhui Guo, Bao Li, Yu Chen, Jingjing Zhang, Kongshu Ji, Qiong Yu

“…Abstract Background N 6 -methyladenosine (m6A), the most abundant mRNA modification, serves as a reversible epigenetic marker plays an increasingly pivotal role in gene regulation across diverse biological processes including embryo development, cell differentiation, flowering and stress responses in plants. …”
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The effect of physical activity on resilience of Chinese children: the chain mediating effect of executive function and emotional regulation by Yifan Xu, Kai Qi, Shuqiao Meng, Xiaoxiao Dong, Shimeng Wang, Dandan Chen, Aiguo Chen

“…Among them, emotion regulation played the most prominent independent mediating role, contributing 68.38% of the indirect effect. …”
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The Role of Tau in Neuronal Function and Neurodegeneration by Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, María Elena Hernández-Aguilar, Deissy Herrera-Covarrubias, Luis Isauro García-Hernández, María Rebeca Toledo-Cárdenas, Donají Chi-Castañeda

“…Alzheimer’s disease (AD) is the most prevalent tauopathy, where abnormal Tau accumulation in the temporal and frontal lobes correlates with cognitive decline and behavioral symptoms. …”
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Laser Ablated Citrate-Stabilized Silver Nanoparticles Display Size and Concentration Dependant Biological Effects by Jelena Filipović Tričković, Miloš Momčilović, Gordana Joksić, Sanja Živković, Bojana Ilić, Miloš Ognjanović, Mirjana Novaković, Ana Valenta Šobot

“…Many features determine their beneficial or toxic potential, such as their synthesis type, size, morphology, coating, and concentration. Most synthesis types rely on the use of synthetic chemicals, which contributes to their toxicity. …”
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The effect of patient education on maternal fasting blood glucose in gestational diabetes mellitus in randomized controlled trials: a systematic review and meta-analysis by Alissa Paudel, Regis C. Pearson, Elizabeth Mirsky, Alexandria Quesenberry Wilson, Alixandra Hunzicker, Kelsey L. Grabeel, Justin Thorne, Jill M. Maples

“…Due to the number of studies a moderator analysis could not be conducted to determine the most effective educational intervention strategies. …”
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Anomalous systemic arterial supply to the basal segment of the lung with giant aberrant artery: a case report by Takahiro Utsumi, Haruaki Hino, Shintaro Kuwauchi, Nobuya Zempo, Kaori Ishida, Natsumi Maru, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Koji Tsuta, Tomohiro Murakawa

“…Conclusions We present a case of ABLL that was successfully managed by surgical resection of the left lower lobe with most of the giant aberrant artery and subsequent embolization of the remnant portion. …”
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Chemistry of Mezcal: Volatile Profile of Artisanal Mezcal Made from Wild Agaves of Oaxaca by Rosa Elvira Sánchez-Fernández, Artemio Pérez-López, Anabel Morales-Solis, Yesenia Manilla-Tellez, Erika Daniela Reyes-Carmona, Graciela Avila-Uribe

“…A total of 82 volatile compounds were identified, with esters, terpenes, and higher alcohols being the most abundant. Eight key compounds, including ethyl acetate, acetic acid, 1-butanol, furfural, methanol, and 2-methyl-1-propanol, were quantified due to their significant impact on mezcal’s quality and authenticity. …”
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Development of eugenol derivatives with 5-LOX inhibitory activity by José L. Pereira Filho, Renato B. Pereira, Tatiana F. Vieira, Sérgio F. Sousa, José R. A. Coelho, Nuno F. S. Pinto, Catarina M. M. Coelho, Maria José G. Fernandes, Elisabete M. S. Castanheira, Maria S. T. Gonçalves, David M. Pereira

“…Four derivatives exhibited significant 5-LOX inhibitory activity, which prompted further studies. The most promising compounds, 4-allylbenzene-1,2-diol 2, ethyl-4-(4-allyl-2-methoxyphenoxy)butanoate 4e, 3-(2-methoxy-4-(oxiran-2-ylmethyl)phenoxy)propyl acetate 5d and 4-(3-(tert-butoxy)-2-hydroxypropyl)-2-methoxyphenol 7c, were submitted to in silico assays to validate their affinity and stability towards 5-LOX, which helped clarify the mechanism by which these molecules interact and inhibit this enzyme.…”
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Hydraulic Performance Modeling of Inclined Double Cutoff Walls Beneath Hydraulic Structures Using Optimized Ensemble Machine Learning by Mohamed Kamel Elshaarawy, Martina Zeleňáková, Asaad M. Armanuos

“…The analysis revealed that L/B was the most influential predictor for U/U o and i R /i Ro , while d 2/D played a crucial role in determining q/q o . …”
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Consumers’ acceptance of eggs as a function of hen genotype and rearing system by M. Castrica, G. Scappaticci, C. Balzaretti, R. Piscitelli, F. Sirri, C. Alamprese

“…Considering the overall liking attribute, the significantly most preferred samples (p < 0.05) resulted RM_C (6.60), BPxS_C (5.90), and RMxS_F (6.80). …”
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A biosketch of William Richard Gowers with a new review of his inpatient case history notes Resumo biográfico de William Richard Gowers com uma nova revisão das notas de pacientes... by Thiago Cardoso Vale, Andrew Lees, Francisco Cardoso

“…Epilepsy (16.5%), followed by spinal cord diseases (10.3%), cerebrovascular diseases (9.5%), and functional disorders (7.9%) were the most common diagnoses.</p><br><p>William Richard Gowers (1845&#8211;1915) passou sua vida profissional trabalhando no <italic>National Hospital for the Relief and Cure for the Paralyzed and Epileptic</italic> e no <italic>University College Hospital</italic> na Queen Square, em Londres, Reino Unido. …”
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Biochanin A enhances type H vessel formation and improves epiphysis deformities following ischemic osteonecrosis in juvenile mouse by Qian Huang, Yuchen Zhang, Shengping Tang, Xinda Zheng, Boxiang Li, Yun Liu, Xiaofei Ding, Jinmin Zhao, Qian Liu, Shijie Liao

“…Legg–Calvé–Perthes disease (LCPD) ranks as one of the most severe hip conditions that can lead to permanent deformity of the femoral head in children. …”
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Clinical prediction model for MODY type diabetes mellitus in children by D. N. Laptev, E. A. Sechko, E. M. Romanenkova, I. A. Eremina, O. B. Bezlepkina, V. A. Peterkova, N. G. Mokrysheva

“…Based on clinical data, a feedforward neural network (NN) was implemented - a multilayer perceptron.MATERIALS AND METHODS: Development of the most effective algorithm for predicting MODY in children based on available clinical indicators of 1710 patients with diabetes under the age of 18 years using a multilayer feedforward neural network.RESULTS: The sample consisted of 1710 children under the age of 18 years with T1DM (78%) and MODY (22%) diabetes. …”
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Design and Analysis of Carbon‐Supported NiMo HER Catalysts and Electrodes for High Performance All PGM‐Free AEM Electrolysers by Lukas Heinius, Malte Klingenhof, Gregor Weiser, Pierre Schröer, Lukas Metzler, Susanne Koch, Sören Selve, Severin Vierrath, Peter Strasser

“…The performance of the catalysts was tested using rotating disc electrode (RDE) and anion exchange membrane (AEM) single‐cell electrolyser to downselect the most active material. The influence of pH, catalyst loading and type of carbon support was investigated to optimize the operating conditions. …”
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Modern principles of diagnosis and treatment of Kinsbourne encephalopathy (a clinical case) by A. H. Kyrychenko, V. V. Ohorenko, V. M. Ahafonov, K. O. Dereza, T. O. Zalizniak, T. O. Nikolaienko

“…Due to the fact that Kinsbourne encephalopathy has a paraneoplastic etiology in most cases, the child underwent brain MRI and CT as well as laboratory and instrumental examinations of the internal organs. …”
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Long-term results of therapy with sequential use of rituximab and belimumab in patients with systemic lupus erythematosus by S. K. Solovyev, A. A. Mesnyankina, E. A. Aseeva, N. Yu. Nikishina

“…Clinical remission was achieved and maintained in 7 patients, exacerbation at different time points after discontinuation of bDMARDs occurred in 3 patients, efficacy waned in one patient, and no result was achieved with combination therapy in another patient.   Conclusion. The most pronounced positive result can be expected when a bDMARDs are prescribed as early as possible after diagnosis of SLE (in the first 2 years of the disease). …”
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A Comparative Study on Effects of Three Butyric Acid-Producing Additives on the Growth Performance, Non-specific Immunity, and Intestinal Microbiota of the Sea Cucumber Apostichopu... by Longzhen Liu, Cong Wei, Yongmei Li, Mingyang Wang, Yuze Mao, Xiangli Tian

“…Collectively, in terms of enhancing growth and non-specific immunity, as well as improving intestinal microbiota, dietary live cells of C. butyricum exhibited the most effective effects in A. japonicus.…”
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The mRNA expression levels of calpains and their activity in malignant and dysplastic epithelium of the upper respiratory tract by E. A. Sidenko, G. V. Kakurina, O. V. Cheremisina, L. V. Spirina, E. E. Shashova, D. A. Korshunov, I. V. Kondakova

“…Detection of early cancer in the upper respiratory tract is often challenging, as symptoms are largely non-specific, and most cases are diagnosed at an advanced stage.Aim. …”
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