Watercress-derived glucosinolates as potential allosteric PTP1B inhibitors: a dual in silico and in vitro study on insulin signaling modulation by Noha A. Ahmed, Ahmed A. Allam, Hassan A. Rudayni, Fahad M. Alshabrmi, Faris F. Aba Alkhayl, Doaa A. Abdelrheem, Al Mokhtar Lamsabhi, Sarah I. Othman, Emadeldin M. Kamel

“…Potential Energy Landscape (PEL) analysis further confirmed that these two compounds occupied the most stable low-energy conformational states, reinforcing their favorable binding to PTP1B. …”
Get full text

Disulfidptosis-related gene SLC3A2: a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma by Xinyi Zhang, Yiqi Lin, Liang Shi, Aixia Zhai, Chao Wu, Qian-Ying Zhu

“…IntroductionNasopharyngeal carcinoma (NPC), one of the most common malignancies of the head and neck, is characterised by a complex pathogenesis and an unfavourable prognosis. …”
Get full text

MICROPOLARIZATION IN THE TREATMENT OF ACUTELY DEVELOPED VERTIGO by E. V. Shevchenko, D. V. Baymuratova, G. R. Ramazanov, S. S. Petrikov

“…Background Vertigo is the most common complaints addressed to a neurologist. …”
Get full text

Synthesis and Insecticidal Activity of Novel Camptothecin Derivatives Containing Analogs of Chrysanthemic Acid Moieties by Li DENG, Lan ZHANG, Li-dong CAO, Ru-liang XIE, Yan-ning ZHANG, Wei-zhi HE, Hong-yun JIANG

“…Compound 2a was also found to be the most effective cytotoxic compound to the tested insect cell lines, IOZCAS-Spex-II, which were established from the fat bodies of S. exigua. …”
Get full text

Novel selenoprotein neighborhoods suggest specialized biochemical processes by Daniel H. Haft, Igor Tolstoy

“…Here, we report the discovery of 18 novel selenoprotein families or second selenocysteine sites in previously unrecognized extensions of protein translations. Most of these families had some confounding factors—too small a family, too few selenoproteins in the family, selenocysteine (U) too close to one end, a skew toward understudied or uncultured lineages, and consequently were missed previously. …”
Get full text

Integrating climate change and fine-scale habitat suitability to assess amphibian range shift in Mount Emei, China by Zijian Sun, Tian Zhao, Suwen Hu, Guangfeng Chen, Wei Zhu, Xiwen Peng, Shengqi Su

“…Abstract Background Habitat range shifts driven by climate change threaten global biodiversity, with impacts likely to be most pronounced at mountainous regions. As key consumers, amphibians play critical roles in mountainous ecosystems by contributing to nutrient cycling, soil aeration through burrowing activities, and aquatic bioturbation. …”
Get full text

Spatiotemporal Variations in Socioeconomic and Hydrological Factors Impacting Water Quality in Thailand’s Major Rivers by Khanittha Uthaipan, Zhongwei Yuan, Yangyang Zhao, Wissarut Intararuang, Varintha Vasinamekhin, Chalermrat Sangmanee, Somkiat Khokiattiwong, Minhan Dai

“…During this period, socioeconomic development, characterized by a 2.8% population increase, 6.1% gross domestic product growth, and 9.4% expansion of built-up areas, was most pronounced in the lower Chao Phraya River basin. …”
Get full text

Prediction of barite scale formation and inhibition in hydrocarbon reservoirs using AI modeling: Focus on different optimization algorithms by Ouafa Belkacem, Ahmed Rezrazi, Kamel Aizi, Lokmane Abdelouahed, Maamar Laidi, Abdelhafid Touil, Leila Cherifi, Salah Hanini

“…The ELM model emerged as the most precise (RMSE = 0.0005, R² = 0.999), closely followed by the SVR-PSO model (RMSE = 0.0008, R² = 0.999). …”
Get full text

Exploring public preferences and demand for ovarian cancer screening: a discrete choice experiment by Rebekah Hall, Anne E. Spencer, Abigail Lloyd, Willie Hamilton, Antonieta Medina-Lara

“…Ovarian cancer deaths (0.42, [95% CI: 0.40 – 0.44]) was the most important attribute overall, followed by the rate of false positive results (0.30, [95% CI: 0.30-0.30]). …”
Get full text

Resilience of Neural Networks Underlying the Stroop Effect in the Aftermath of Severe COVID-19: fMRI Pilot Study by Valérie Beaud, Nicolas Farron, Eleonora Fornari, Vincent Dunet, Sonia Crottaz-Herbette, Stephanie Clarke

“…In controls, the Stroop effect yielded an increase in activity in prefrontal, cingulate and parieto-temporal clusters as well as in the nucleus accumbens during the first part, and the activity receded during the second part in most regions. Two distinct response profiles were found among patients: (i) a Stroop effect-linked increase during the first part followed by a partial decrease during the second part, as in healthy subjects; and (ii) a weak or absent Stroop effect increase during the first part followed by a partial increase during the second part. …”
Get full text

scE2EGAE: enhancing single-cell RNA-Seq data analysis through an end-to-end cell-graph-learnable graph autoencoder with differentiable edge sampling by Shuo Wang, Yuanning Liu, Hao Zhang, Zhen Liu

“…The results show that, on the scRNA-Seq data denoising task, scE2EGAE outperforms most of the methods, proving that it can learn cell-to-cell graphs containing real information of cell-to-cell relationships. …”
Get full text

Bizarre behavior during intracarotid sodium amytal testing (Wada test): are they predictable? Reações bizarras durante o teste do amital sódico intracarotídeo (TASI ou Teste de Wad... by Luciano de Paola, Maria Joana Mäder, Francisco M.B. Germiniani, Patrícia Coral, Jorge A.A. Zavala, Djon J. Watzo, Jorge Kanegusuku, Carlos E.S. Silvado, Lineu C. Werneck

“…Even though it may last several minutes, in most cases it is subtle and easily manageable. We report a series of patients in whom those reactions were unusually bizarre, including agitation and aggression. …”
Get full text

Clinical profile and liver function assessment in children with typhoid fever by Ahmed Abdul Hadi Mohsen, Ghada Ali Yaqoob, Faris M. Al-Haris, Alaa Jumaah Manji Nasrawi

“…All patients presented with fever, 25 (58.1 %) with anorexia, 22 (51.2 %) with abdominal pain, 17 (39.5 %) with headache, 14 (32.6 %) with vomiting, and other symptoms were less frequent. Regarding signs, most patients had hepatomegaly — 19 (44.2 %), 12 (27.9 %) were toxic looking, abdominal tenderness was detected in 10 (23.3 %) children, splenomegaly in 7 (16.3 %), edema in 2 (4.7 %), jaundice in 2 (4.7 %), and only 1 (2.3 %) patient had skin rash. …”
Get full text

Investigating the efficacy of bioactive compounds from selected plant extracts against Gibberella fujikuroi species complex associated with damping off disease in sweet corn by Alyaa Abd Ali, Ayoob Obaid Alfalahi, Aalaa Khudhair Hassan, Ahlam Khalofah, Eilyn Mena, Abdelfattah A. Dababat, Fouad Mokrini

“…., Oxalis pes-caprae L. and Ducrosia ismaelis was conducted using GC-MS analysis. The most abundant bioactive compounds in the three selected extracts (E. vesicaria, O. pes-caprae L. and D. ismaelis) were 1-eicosanol, (Z)6,(Z)9-Pentadecadien-1-ol and n-Hexadecanoic acid, and Nonadecane, respectively. …”
Get full text

The Possibilities of Thromboelastography in Assessing Safety of Neuraxial Blocks in Gestational Thrombocytopenia (Clinical Study) by E. N. Plakhotina, T. N. Belousova, N. B. Kuzina, A. N. Kuzovlev, E. V. Bryantsev

“…Gestational thrombocytopenia (GT) is the most common type of thrombocytopenia during pregnancy. …”
Get full text

Trastuzumab deruxtecan versus trastuzumab emtansine for human epidermal growth factor receptor 2 positive metastatic breast cancer: cost-effectiveness analysis from Iranian experie... by Neda Yaghoubi, Behzad Fatemi, Razieh Ahmadi, Yalda Metghalchi, Bita Shahrami, Mohammad Vaezi, Soheila Rezaei

“…One-way sensitivity analysis identified the unit price of T-DXd as the most influential parameter. PSA results indicated that T-DXd has a 52% probability of being cost-effective. …”
Get full text

Genetic landscape of hypertrophic cardiomyopathy in Hong Kong Chinese population by Derek P. H. Lee, Derek P. H. Lee, Ye Cao, Lilei Zhang

“…We aim to characterize the genetic landscape of HCM in patients from Hong Kong Chinese population.MethodsFrom March 2023 to March 2024, fifty-three unrelated patients with an unequivocal clinical diagnosis of HCM were enrolled at a single tertiary center in Hong Kong and underwent genetic testing using a standardized 19-gene panel.ResultsIn this cohort study, we identified 13 patients (24.5%) with a predominant pathogenic or likely pathogenic (P/LP) variant and 12 patients (22.6%) with a predominant variant of unknown significance (VUS). Most of the P/LP variants identified were in MYBPC3 (46.2%, n = 6) or MYH7 (38.5%, n = 5). …”
Get full text

CacyBP/SIP - RPL6 interaction: potential influence on ribosome function by Ewelina Jurewicz, Małgorzata Maksymowicz-Trivedi, Omid Saberi-Khomami, Olga Iwańska, Agata Starosta, Ewa Kilańczyk, Paweł Bieganowski, Adam Jarmuła, Wiesława Leśniak, Sławomir Filipek, Anna Filipek

“…The results, showing markedly higher Hsp70 production in control cells, indicate that CacyBP/SIP, most probably through interaction with RPL6 and/or other RPs, may have some influence on ribosome function and, possibly, on protein synthesis in the cell.…”
Get full text

Klinefelter syndrome and ADHD: a short systematic review by Lorenzo Zamboni, Francesca Fusina, Francesca Fusina, Rebecca Casari, Fabio Lugoboni, Thomas Zandonai, Thomas Zandonai, Sara Cappelletti, Angela Federico

“…Klinefelter Syndrome (KS) is the most common sex chromosome anomaly in the world, and it is characterized by the presence of an extra X chromosome (47, XXY). …”
Get full text

Direct Consideration of Process History During Intensified Design of Experiments Planning Eases Interpretation of Mammalian Cell Culture Dynamics by Samuel Kienzle, Lisa Junghans, Stefan Wieschalka, Katharina Diem, Ralf Takors, Nicole Erika Radde, Marco Kunzelmann, Beate Presser, Verena Nold

“…With the proposed OFMC-format, optimization of bioprocesses can leverage which factor settings are most beneficial in which state of the mammalian culture and thus elevate performance and quality to the next level.…”
Get full text