INVESTIGATION OF THE ACTIVITY OF 1.3-DIAZINONE-4 NEW DERIVATIVES AND THEIR NON-CYCLIC PRECURSORS IN RESPECT OF ESCHERICHIA COLI by S. A. Luzhnova, A. V. Voronkov, I. P. Kodonidi, N. M. Gabitova, Suda Billel

“…The substances under the laboratory ciphers of PYaTd8 and PYaTs4 are the most active in respect to the studied strains. At the same time, the MIC50 (minimum inhibitory concentration) of all the compounds does not exceed 10–20 μg / ml, which makes them promising for the further study.…”
Get full text

Species status and genetic isolation in the Subalpine Warbler complex: Insights from mitochondrial DNA analysis by Utku Perktaş, Andrew G. Gosler

“…Using AMOVA, we found that most genetic variation is between populations rather than within them, indicating significant genetic differentiation. …”
Get full text

Detection of Water Surface Using Canny and Otsu Threshold Methods with Machine Learning Algorithms on Google Earth Engine: A Case Study of Lake Van by Pinar Karakus

“…The Otsu thresholding method was employed to determine water surfaces, as it is the most favored technique for calculating NDWI, AWEI, and MNDWI indices from Landsat 8 images. …”
Get full text

Prenatal Diagnosis of Autosomal Dominant Polycystic Kidney Disease: Case Report by Elitsa Gyokova, Eleonora Hristova-Atanasova, Elizabeth Odumosu, Antonia Andreeva

“…<b>Background and Clinical Significance:</b> Polycystic kidney disease (PKD) is the most common inherited kidney condition, affecting approximately 500,000 individuals in the US. …”
Get full text

Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562 by Nehad M. El-Dydamony, Rana M. Abdelnaby, Rasha Abdelhady, Omaima Ali, Mohamed I. Fahmy, Rasha R. Fakhr Eldeen, Amira A. Helwa

“…Seven compounds exhibited the highest activity against both cell lines where compounds 4d and 7f were the most active against K562 cell line. Exploring their molecular mechanisms by enzyme inhibition assay on PI3Kδ/γ and AKT-1 showed that compound 7f was promising more than 4d with IC50 = 6.99 ± 0.36, 4.01 ± 0.55, and 3.36 ± 0.17 uM, respectively. …”
Get full text

The impact of physical activity on working memory in children with ADHD: a meta-analysis by Gong Cheng, Gong Cheng, Ce Song, XiaoQin Hong

“…Subgroup analyses indicated that interventions with moderate duration and frequency (45–60 minutes per session, 8–12 weeks, ≤2 times per week, and ≤25 total hours) were associated with the most stable and effective outcomes.ConclusionPhysical activity interventions are effective in improving working memory in children with ADHD, especially when implemented with optimal session duration, frequency, and total intervention time. …”
Get full text

Shifts in dissolved organic matter and nutrients in tundra ponds along a gradient of permafrost erosion by Thomas Pacoureau, Flora Mazoyer, Roxane Maranger, Milla Rautio, Isabelle Laurion

“…Over three consecutive summers, water was collected from a series of ponds on degrading syngenetic permafrost, representing the most common geomorphological categories: erosive or stable ice-wedge trough ponds and coalescent polygon ponds. …”
Get full text

Impact of planting dates and seeding densities on soil water depletion pattern, root distribution, and water productivity of industrial hemp by Preetaman Bajwa, Sukhbir Singh, Arjun Kafle, Manpreet Singh, Rupinder Saini, Calvin Trostle

“…Over both years, SD1 had the lowest production and water productivity for most of the yield parameters. In conclusion, May planting at higher seeding densities can enhance water productivity in West Texas conditions.…”
Get full text

Improving Material Tracking for Sustainable Construction: A Standard Operating Procedure (SOP) Framework for Resource Efficiency by Dema Munef Ahmad, László Gáspár, Hummam Mohammed Shaheen, Talal Ahmad Al-Shihabi, Rana Ahmad Maya, Francisco Silva Pinto

“…The findings highlight procurement and implementation as the phases most prone to inefficiencies, particularly around material receiving, quality checks, and on-site placement. …”
Get full text

Aesthetic Breast Reconstruction With De-epidermized Deep Inferior Epigastric Artery Perforator Flap and Thoracoabdominal Advancement Flap by Haïzam Oubari, MD, MSc, Fabien Boucher, MD, Abdulrahman Hashim, MD, Franck Dupuy, MD, Hristo Shipkov, MD, PhD, Ali Mojallal, MD, PhD

“…Background:. Most regard the deep inferior epigastric artery perforator (DIEP) flap as the gold standard in autologous breast reconstruction, with good breast aesthetics achieved and low donor site morbidity. …”
Get full text

Missed opportunities: The unknown impact of the COVID-19 pandemic on early childhood development in the WHO European region by J.M. White, C.L. Goodfellow, A.O. Adeleke, F.P. Awde, Y.W. Chua, A. Jovic, E. Scott

“…Results: Seven reviews met the inclusion criteria. Most studies examined young children's mental health, while others assessed language development, mother-child bonding, and broader developmental outcomes. …”
Get full text

Creativitat musical a secundària. Un estudi del pensament del professorat sobre activitats de composició i improvisació a l'educació secundària anglesa by Oscar Odena

“…The author describes the reasons behind the project, the different stages of the study, the methodology used and the most important findings. Finally, the educational implications of the study are considered with respect to curriculum development and teacher training.…”
Get full text

Whole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver by Zheng-Jun Zhou, Yu-Hang Ye, Zhi-Qiang Hu, Yue-Ru Hou, Kai-Xuan Liu, Rong-Qi Sun, Peng-Cheng Wang, Chu-Bin Luo, Jia Li, Ji-Xue Zou, Jian Zhou, Jia Fan, Cheng-Li Song, Shao-Lai Zhou

“…Abstract Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma, with poor prognosis and limited treatment options. …”
Get full text

Comportamiento epidemiológico de las enteroparasitosis en niños de 0 a 14 años del área de salud de Cristino Naranjo by Yunaidis Vázquez Orama, Ana María Julián Oliva

“…Giardia intestinalis and Enterobius vermicularis were the most frequent parasites found, representing 23% and 15% respectively. …”
Get full text

Impact of Dark Triad personality traits on COVID-19 vaccination uptake and prevention efforts: insights from the European Covid Survey (ECOS) by Sophia Bock, Sebastian Neumann-Böhme, Petra Steinorth

“…Abstract Background Even though the COVID-19 vaccination roll-out in general can be considered as one of the most successful public health campaigns in the history of medicine, general vaccination hesitancy has remained an issue of concern throughout the world. …”
Get full text

Replacement of Petroleum Based Products With Plant‐Based Materials, Green and Sustainable Energy—A Review by Sundarakannan Rajendran, Ali Al‐Samydai, Geetha Palani, Herri Trilaksana, Thanikodi Sathish, Jayant Giri, R. Saravanan, J. Isaac JoshuaRamesh Lalvani, Faouzi Nasri

“…ABSTRACT The most critical challenges confronting humanity's future is climatic change, water scarcity, and the impending end of the petroleum era are primarily driven by the depletion of fossil fuel reserves, rising global temperatures, and the rapid growth of the global population. …”
Get full text

Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses by Llorenç Solé‐Boldo, Günter Raddatz, Julian Gutekunst, Oliver Gilliam, Felix Bormann, Michelle S Liberio, Daniel Hasche, Wiebke Antonopoulos, Jan‐Philipp Mallm, Anke S Lonsdorf, Manuel Rodríguez‐Paredes, Frank Lyko

“…Abstract Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations, posing a significant medical and economic burden to health systems. …”
Get full text

SkinIncept: an ensemble transfer learning-based approach for multiclass skin disease classification using InceptionV3 and InceptionResNetV2 by Md. Hasan Imam Bijoy, Md. Mahbubur Rahman, Abdus Sattar, Aminul Haque, Mohammad Shamsul Arefin, Pranab Kumar Dhar, Tetsuya Shimamura

“…This study addresses this critical issue by developing a robust and accurate system for classifying Bangladesh’s ten most common skin diseases using convolutional neural networks (CNNs)-based transfer learning models. …”
Get full text

Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction. by W James Gauderman, Yubo Fu, Bryan Queme, Eric Kawaguchi, Yinqiao Wang, John Morrison, Hermann Brenner, Andrew Chan, Stephen B Gruber, Temitope Keku, Li Li, Victor Moreno, Andrew J Pellatt, Ulrike Peters, N Jewel Samadder, Stephanie L Schmit, Cornelia M Ulrich, Caroline Um, Anna Wu, Juan Pablo Lewinger, David A Drew, Huaiyu Mi

“…From a population health perspective, our result suggests that focusing on genes within these pathways may be effective at identifying those for whom NSAIDs-based CRC-prevention efforts may be most effective.…”
Get full text

Dynamics of Magnetization in Multilayer TbCo / FeCo Structures under the Influence of Femtosecond Optical Excitation by N. A. Ilyin, A. A. Klimov, N. Tiercelin, P. Pernod, E. D. Mishina, M. S. Gaponov, K. A. Brekhov, A. S. Sigov, V. L. Preobrazhensky

“…In metals, the material is heated first due to significant optical absorption, and significant Joule losses occur. The most important task is to search for materials in which spin processes are excited without heating. …”
Get full text