Prognostic Modeling of Deleterious IDUA Mutations L238Q and P385R in Hurler Syndrome Through Molecular Dynamics Simulations by Madhana Priya Nanda Kumar, Esakki Dharsini Selvamani, Archana Pai Panemangalore, Sidharth Kumar Nanda Kumar, Vasundra Vasudevan, Magesh Ramasamy

“…<b>Background:</b> Out of the eleven MPS disorders, MPS I includes three syndromes, of which the first, named Hurler syndrome, affects the most. <b>Methods:</b> Several in silico tools were used, such as ConSurf (73 variants), Mutation Assessor (69 variants), PredictSNP, MAPP, PhDSNP, Polyphen-1, Polyphen-2, SIFT, SNAP, PANTHER, MetaSNP (24 variants); Missense 3D-DB (11 variants) and AlignGVGD (eight variants) for physicochemical properties; and I-Mutant, Mupro, CUPSAT, and INPS for stability predictions (four variants). …”
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Ultrasound combined with serological markers for predicting neonatal necrotizing enterocolitis: a machine learning approach by Yi Yang, Shoulan Zhou, Xiaomin Liu, Yanhong Zhang, Liping Lin, Chenhan Zheng, Xiaohong Zhong

“…SHAP analysis identified bowel peristalsis, C-reactive protein, albumin, bowel thickness, and procalcitonin as the most influential predictors. Decision curve analysis demonstrated a positive relative net benefit of the USPN model compared to the US and serological models in the validation set.ConclusionA machine learning model integrating ultrasound and serological markers significantly improves the prediction of NEC in neonates compared to single-modality approaches. …”
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Selection of Lower instrumented vertebra in early-onset scoliosis at index growth rod insertion- can we predict distal add-on at graduation surgery? by Rajneesh Misra, Sai Gautham Balasubramanian, Colin Bruce, Neil Davidson, Jayesh Trivedi, Sudarshan Munigangaiah

“…The mean chronological age was 9.16 years (at index surgery), 12.9 years (at graduation), and 14.9 years (at final follow-up). The most frequent LIV at index surgery was L4 in four cases, closely followed by L2 and L3 with three cases each at the index surgery. …”
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Dual-fiber optical tweezers integrating high-sensitivity structured-light displacement measurement system on fiber end-face by Guofeng Li, Wei Xiong, Haining Feng, Zijian Feng, Tengfang Kuang, Zhechun Lu, Xiang Han, Xin He, Xinlin Chen, Junbo Yang, Guangzong Xiao

“…Our results demonstrate a displacement sensitivity reaching the 0.1 pm/Hz1/2 level, which surpasses the performance of most results using the quadrant photodiode method. …”
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Analysis of Sera of Recipients with Allograft Rejection Indicates That Keratin 1 Is the Target of Anti-Endothelial Antibodies by Xuli Guo, Juan Hu, Weiguang Luo, Qizhi Luo, Jing Guo, Fang Tian, Yingzi Ming, Yizhou Zou

“…To validate our finding, we produced recombinant proteins representing the three most common alleles of KRT1. The serum used for immunoprecipitation showed a strong reaction to KRT1 recombinants in western blot and ELISA. …”
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Long Limb Bones Asymmetry in the Ancient Population of the Volga-Ural Steppe (Neolithic – Middle Ages) by Artem P. Grigorev

“…The longitudinal dimensions of the humerus and femur in most of the studied groups are directionally asymmetric. …”
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Study of the structure and development of oil deposits in carbonate reservoirs using field data and X-ray microtomography by D. A. Martyushev, I. N. Ponomareva, B. M. Osovetsky, K. P. Kazymov, E. M. Tomilina, A. S. Lebedeva, A. S. Chukhlov

“…In turn, the reservoir deformation is singled out as the most probable cause explaining the different rates of decline in well flow rates of the fields under consideration.…”
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History of Agroengineering Science in Saint Petersburg by V. D. Popov, A. Yu. Bryukhanov

“…In 2018, the Institute once again became a branch of VIM, with a renewed focus on comprehensive scientific research aimed at ensuring the environmental sustainability of agricultural production. (Conclusions) The most significant outcome stemming from the team’s extensive history is the continuity of knowledge transmission. …”
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Exploring a Rare Association: Systematic Review of Hypercalcemia in Nontuberculous Mycobacterial Infections by Ramon Cohen, Viviana Ostrovsky, Lior Zornitzki, Daniel Elbirt, Taiba Zornitzki

“…Notably, bisphosphonates emerged as a safe and effective option in most cases. Antibiotic therapy was deemed unnecessary when hypercalcemia was the sole symptom of NTM infection. …”
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Intelligent design of high-performance fluids for thermal management: integrating response surface methodology, weighted Tchebycheff method, and strength Pareto evolutionary algori... by Mohamed Bechir Ben Hamida, Ali Basem, Neeraj Varshney, Loghman Mostafa

“…Abstract Optimizing nanofluid thermophysical properties (TPPs) is essential for advancing heat transfer applications; however, most studies focus on two-objective optimization, limiting their real-world applicability. …”
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Seleção de variáveis para classificação de bateladas produtivas com base em múltiplos critérios A multiple criteria-based method for variable selection in industrial applications... by Michel José Anzanello

“…This paper proposes a method for selecting the most relevant process variables aimed at classifying production batches into classes based on multiple criteria (e.g., sensibility and specificity). …”
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Results of longstanding, single-center trial for pediatric Hodgkin lymphoma treatment by T. T. Valiev, E. S. Belyaeva

“…Actually, treatment results of Hodgkin lymphoma (HL) are the most dramatic oncohematology achievements, therefore modern treatment protocols designed to toxicity reduction with the same high level of patients’ survival. …”
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Invited perspectives: Thunderstorm intensification from mountains to plains by J. Fischer, P. Groenemeijer, P. Groenemeijer, A. Holzer, A. Holzer, M. Feldmann, K. Schröer, F. Battaglioli, L. Schielicke, L. Schielicke, T. Púčik, B. Antonescu, B. Antonescu, C. Gatzen, C. Gatzen

“…<p>Severe thunderstorms are among the most damaging and impactful weather phenomena. In Europe, notable clusters occur in the vicinity of complex terrain. …”
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Exploring personal, community, and societal conditions associated with South Korean new graduate nurses’ organizational socialization: a cross-sectional survey study by Jihye Song, Jeongsuk Lee, Youmin Cho, Ahyoung Jeon, Moonhee Gang

“…Results The final analysis included 262 responses, with a mean (SD) age of 24.32 (2.42) years. Most participants were female (91.60%), held a bachelor of science in nursing degree (91.98%), and were in their first nursing position (88.55%). …”
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The Effects of Individual Components of E-Cigarettes on Ion Transport and Airway Surface Liquid Height in Human Bronchial Epithelial Cells by Ozge Beyazcicek, Robert Tarran, Recep Ozmerdivenli, Ersin Beyazcicek

“…However, after 2 h, FBNic-treated HBECs exhibited a significant reduction in ASL height compared to NicSalt and other tested substances, with the most pronounced decrease observed at the 6th hour. …”
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Development of the Leisure Activity Scale for young adults: Reliability and validity by Rumiko Kinkawa, Miki Ono, Satoshi Horiuchi, Masayuki Kikkawa, Shunichiro Ito, Akifumi Shimasaki, Yu Tamada, Jiro Masuya, Mina Honyashiki, Takeshi Inoue

“…Results Factor analysis indicated that the 7‐item LAS was the most appropriate measure for use in mental health (Cronbach's α coefficient = 0.756). …”
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Current distribution of Phelsuma inexpectata, a threatened Réunion Island endemic gecko by Mickaël Sanchez, Alicia Bonanno, Margot Caubit, Alice Bousseyroux, Johanna Clémencet

“…In natural habitats, the distribution of P. inexpectata has been strongly affected, declining by c. 45%, but we identified new areas of occurrence (10.72 ha) through field surveys. Most of these new areas (79%) were found in anthropogenic habitats where the species had not been documented before. …”
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Mapping of Monodominant <i>Gilbertiodendron dewevrei</i> Forest Across the Western Congo Basin Using Sentinel-2 Imagery by Ellen Heimpel, David J. Harris, Josérald Mamboueni, David Morgan, Crickette Sanz, Antje Ahrends

“…The gray level co-occurrence matrix (GLCM) textural metrics proved the most important factors for distinguishing <i>G. dewevrei</i> forest, due to the homogenous canopy texture created by this monodominant species. …”
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The Effect of the COVID-19 Pandemic on Prescribing Medications for Opioid Use Disorder in the Mid-Michigan Region by Nooshin C. Beygui, Erin Duross, Chin-I Cheng, Katherine Mesaros, Karissa Gawronski, Juliette Perzhinsky

“…Although Medications for Opioid Use Disorder (MOUD) are the most well supported treatment for OUD, they remain underutilized by clinicians, particularly in the primary care setting, emphasizing the importance of examining factors that impact prescribing. …”
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TFDense-GAN: a generative adversarial network for single-channel speech enhancement by Haoxiang Chen, Jinxiu Zhang, Yaogang Fu, Xintong Zhou, Ruilong Wang, Yanyan Xu, Dengfeng Ke

“…Experimental results show that TFDense-GAN outperforms most existing models in terms of STOI, PESQ, and Si-SDR, achieving state-of-the-art results. …”
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