Statin-induced risk of diabetes does not reduce cardiovascular benefits in primary prevention: a 6-year propensity-score matched study in a large population by Maria Lembo, Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Stanislovas S. Jankauskas, Paola Gallo, Roberto Piccinocchi, Carmine Morisco, Gaetano Piccinocchi, Luca Bardi, Stefano Cristiano, Giovanni Esposito, Giuseppe Giugliano, Fahimeh Varzideh, Maria Virginia Manzi, Bruno Trimarco, Gaetano Santulli

“…Abstract Background The long-term risk of cardiovascular (CV) events in individuals who develop new-onset type 2 diabetes (T2D) after having received statin therapy in primary prevention is mostly unknown. Methods We designed a population-based cohort study in individuals without T2D and atherosclerotic CV disease (ASCVD), divided in two groups according to the presence of statin therapy. …”
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Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous mycobacteria by Céline Boidin-Wichlacz, Marc Maresca, Isabelle Correia, Olivier Lequin, Vanessa Point, Magali Casanova, Alexis Reinbold, Olga Iranzo, Sharon A. Huws, Priscille Brodin, Linda B. Oyama, Aurélie Tasiemski, Stéphane Canaan, Jean-François Cavalier

“…Membrane permeabilization and monolayer lipid insertion assays suggested that these peptides mostly act by insertion into the mycobacterial membrane resulting in a rapid membranolytic effect. …”
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Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its Fren... by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…In contrast, SRP strains were detected in 98 of the samples, mostly from the southern part of the river, at population densities that did not exceed 3 ´ 104 bacteria L-1. …”
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Analysis of detection of repeat blood donors with unqualified alanine aminotransferase by ZENG Zijian, LIAO Fenfang, XIE Junmou, WAN Zhiting, DU Rongsong, LI Zhongping, LIANG Haojian, LI Shijie, JI Yanli, LIANG Huaqin, WANG Hao

“…[Conclusion] The ALT unqualified rates of repeat blood donors were mostly non-specific elevation without TTD. Repeat blood donors with multiple ALT disqualifications tend to have continuous high ALT. …”
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Adjunctive IgM-enriched immunoglobulin therapy with a personalised dose based on serum IgM-titres versus standard dose in the treatment of septic shock: a randomised controlled tri... by Giacomo Grasselli, Patrizia Murino, Emanuela Biagioni, Martina Tosi, Giorgio Berlot, Giacomo Castiglione, Alberto Corona, Maria Giovanna De Cristofaro, Abele Donati, Paolo Feltracco, Francesco Forfori, Fiorentino Fragranza, Ornella Piazza, Livio Tullo

“…Immunoglobulin preparations enriched with the IgM component have largely been used in sepsis, mostly at standard dosages (250 mg/kg per day), regardless of clinical severity and without any dose adjustment based on immunoglobulin serum titres or other biomarkers. …”
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A worldwide event-based debris flow barrier dam dataset from 1800 to 2023 by H. Cheng, H. Cheng, K. Hu, K. Hu, S. Liu, S. Liu, X. Zhang, X. Zhang, H. Li, H. Li, Q. Zhang, Q. Zhang, L. Ning, L. Ning, M. R. Gouli, M. R. Gouli, P. Li, P. Li, A. Yang, A. Yang, P. Zhao, P. Zhao, J. Liu, J. Liu, L. Wei, L. Wei

“…The understanding of debris flow barrier dams (DFBDs) is poor, mostly due to existing studies focusing on individual events and a lack of summarization of multiple DFBD events. …”
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CRISPR/Cas9-mediated knockout of SLC15A4 gene involved in the immune response in bovine rumen epithelial cells by Mao-cheng JIANG, Zi-xuan HU, Ke-xin WANG, Tian-yu YANG, Miao LIN, Kang ZHAN, Guo-qi ZHAO

“…Meanwhile, the down-regulated genes were mostly enriched in the nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. …”
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Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series by Olav Dajani, Iain Philips, Ester Kristine Størkson, Trude R. Balstad, Leo R. Brown, Asta Bye, Ross Dolan, Christine Greil, Marianne Hjermstad, Gunnhild Jakobsen, Stein Kaasa, James McDonald, Inger Ottestad, Judith Sayers, Melanie Simpson, Mariana S. Sousa, Ola Magne Vagnildhaug, Michael S. Yule, Barry J. A. Laird, Richard J. E. Skipworth, Tora S. Solheim, Mark Stares, Jann Arends, the Cancer Cachexia Endpoints Working Group

“…Conclusion In CC trials, oncological endpoints were mostly secondary and only few significant findings have been reported. …”
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Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients by Estefania Simoes, Ricardo Uchida, Mariana P. Nucci, Fabio L. S. Duran, Joanna D. C. C. Lima, Leonardo R. Gama, Naomi A. Costa, Maria C. G. Otaduy, Fang C. Bin, Jose P. Otoch, Paulo Alcantara, Alexandre Ramos, Alessandro Laviano, Mauricio Berriel Diaz, Margaret M. Esiri, Gabriele C. DeLuca, Stephan Herzig, Geraldo Busatto Filho, Marilia Seelaender

“…Conclusions Our results indicate that cachexia compromises CNS morphology mostly causing changes in the GM of cachectic patients, leading to alterations in regional volume patterns, functional connectivity, neuronal morphology, neuroglia profile and inducing neuroinflammation, all of which may contribute to the loss of homeostasis control and to deficient information processing, as well as to the metabolic and behavioural derangements commonly observed in human cachexia. …”
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Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer by Jeffrey Schlom, Carl H. June, George A. Fisher, John J. Nemunaitis, Kristen M. Hege, Emily K. Bergsland, Robert S. Warren, James G. McArthur, Andy A. Lin, Stephen A. Sherwin

“…Symptoms consistent with low-grade, cytokine release syndrome were observed in both trials without clear evidence of on target/off tumor toxicity. Detectable, but mostly short-term (≤14 weeks), persistence of CART72 cells was observed in blood; one patient had CART72 cells detectable at 48 weeks. …”
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Lycorine Pre-Treatment Alleviates Microglia Inflammation After Cerebral Ischemia by Inhibiting NF-κB Phosphorylation by Wuyan Zheng, Wanyu Wu, Yuhan Li, Bo Qin, Yuping Wang, Yunhan Zeng, Betty Yuen Kwan Law, Vincent Kam Wai Wong

“…Nevertheless, the specific role of microglia in the inflammatory response triggered by IS remains mostly unclear. The primary target of this investigation is to study the neuroinflammatory impact of lycorine (LYC) during the IS process. …”
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Integrating anamnestic and lifestyle data with sphingolipid levels for risk-based prostate cancer screening by Caterina Peraldo-Neia, Paola Ostano, Melissa Savioli, Maurizia Mello-Grand, Ilaria Gregnanin, Francesca Guana, Francesca Crivelli, Francesco Montagnani, Michele Dei-Cas, Rita Paroni, Antonella Sinopoli, Francesco Ferranti, Nicolò Testino, Marco Oderda, Andrea Zitella, Chiara Fiameni, Amedeo Gagliardi, Alessio Naccarati, Luca Clivio, Paolo Gontero, Stefano Zaramella, Giovanna Chiorino

“…Univariable logistic regression was applied to identify ananmestic and lifestyle variables mostly associated with PCa. Penalized logistic regression models predictive of PCa or ISUP > 1 PCa were built both using the 814 subjects with complete information for such variables, applying a 10-fold cross validation approach, and dividing the dataset into a training (n = 445: 132 PCa, 313 non-PCa) and a test (n = 369: 147 PCa, 222 non-PCa) set. …”
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Real-World Analysis of Short-Term Effectiveness of Oral Semaglutide: Impact on Glycometabolic Control and Cardiovascular Risk by Sara Palazzi, Federica Sentinelli, Antonella Zugaro, Sara Morgante, Livia Santarelli, Sandra Melanzi, Annamaria De Mutiis, Deamaria Piersanti, Barbara Macerola, Marco Iezzi, Pietro Mercuri, Alessandro Ferranti, Daniele Tienforti, Maria Gisella Cavallo, Arcangelo Barbonetti, Marco Giorgio Baroni

“…<b>Results</b>: Among 167 participants (mean age 66.5 years, mostly obese, baseline HbA1c 8.4% ± 1.5), 83.2% received a 7 mg dose. …”
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Utilization of cervical cancer screening and its associated factors among women living with HIV in East Africa: a systematic review and meta-analysis by Gebrie Getu Alemu, Getaneh Awoke Yismaw, Habtamu Abebe Getahun, Habtamu Wagnew Abuhay, Mekuriaw Nibret Aweke, Meron Asmamaw Alemayehu, Nebiyu Mekonnen Derseh, Tigist Kifle Tsegaw, Tilahun Yemanu Birhan, Banchlay Addis, Berhanie Addis Ayele, Emebet Birhanu Lealem, Eyob Akalewold Alemu, Fetlework Gubena Arage

“…Abstract Background Women living with HIV (WLHIV), mostly in East Africa, are six times more likely to develop cervical cancer and are a priority population for secondary prevention. …”
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Spinal metastases at the thoracolumbar junction – Influencing factors for surgical decision-making according to a multicentric registry by Vanessa Hubertus, Arthur Wagner, Arian Karbe, Leon-Gordian Leonhardt, Beate Kunze, Susanne Borchert, Fatma Kilinc, Michelle Mariño, Nitzan Nissimov, Charlotte Buhre, Marcus Czabanka, Marc Dreimann, Sven O. Eicker, Lennart Viezens, Hanno S. Meyer, Peter Vajkoczy, Bernhard Meyer, Julia S. Onken

“…Reoperations were necessary in 65 cases (16%), mostly due to SSI (n = 19, 29%), local recurrence (n = 15, 23%), and hardware failure (HWF) during follow-up (n = 9, 18%, i-iii, p = 0.7853). …”
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Sex-Dimorphic Differential Expression Profiles in the Brain of the Adult Chinese Soft-Shelled Turtle, <i>Pelodiscus sinensis</i> by Pan Liu, Yanchao Liu, Junxian Zhu, Chen Chen, Liqin Ji, Xiaoli Liu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Qiaoqing Xu, Jiang Zhou, Wei Li

“…However, the underlying molecular mechanisms of this phenomenon have mostly been investigated in the gonadal tissues of <i>P. sinensis</i>, and there are no articles on sex differentiation from the brain of <i>P. sinensis</i>. …”
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514 A systematic review on sleep duration and Alzheimer’s disease fluid biomarkers: Preliminary findings by Vanessa Young, Vanessa M. Young, Joy Zeynoun, Christine Gaspard, Christopher R Frei, Jayandra Jung Himali, Antonio L. Teixeira, Tiffany Kautz, Sudha Seshadri, Andree-Ann Baril

“…For the 14 studies using CSF biomarkers, lower Aβ42 (3/14), Aβ40 (1/14), or the ratio (1/14) were associated with either short or long sleep duration; t-tau (3/14) and p-tau181 (4/14) levels were mostly associated with short sleep. For the 7 blood-based biomarker studies, Aβ42 (2/7), Aβ40 (2/7), and the ratio (3/7) had mixed results with either short or long sleep. …”
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Piloting a team-based telemedicine care for hypertension focused on Black patients by Srista Manandhar, Sunit Chhetri, Danielle Sutton, Animita C. Saha, Suneet Kaur, Josh Brown, Jeff Williamson, Kathryn E. Callahan, Justin B. Moore, Yhenneko J. Taylor, Hayden B. Bosworth, Yashashwi Pokharel

“…We provided social support to 11 patients 19 times including support at home visits by CHWs, mostly for food and medications. There were challenges in supporting other social needs like housing. …”
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Efficient delivery of anlotinib and radioiodine by long circulating nano-capsules for active enhanced suppression of anaplastic thyroid carcinoma by Linlin Zhang, Chuanying Zhu, Shuo Huang, Miaomiao Xu, Chao Li, Hongliang Fu, Yafu Yin, Sheng Liang, Hui Wang, Zhilei Cui, Lei Huang

“…The Anlotinib-BSA nano-capsule (nBSA) showed a mostly uniform size distribution centering at 21–23 nm, and the nano-drug had a characteristic absorption peak at the wavelength of 325 nm. …”
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Diagnostic properties of differing BP thresholds for adverse pregnancy outcomes in standard-risk nulliparous women: A secondary analysis of SCOPE cohort data. by Laura Slade, Maya Blackman, Hiten D Mistry, Jeffrey N Bone, Milly Wilson, Nuhaat Syeda, Lucilla Poston, Peter von Dadelszen, Laura A Magee, SCOPE Consortium

“…<h4>Methods and findings</h4>Included were pregnancies in the international SCOPE cohort with birth at ≥20 weeks' gestation, 2004 to 2008. Women were mostly of white ethnicity, in their 20s, and of normal-to-overweight body mass index (BMI). …”
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