Egg desensitization is achieved effectively and safely through a low maintenance dose protocol by Diana Toscano-Rivero, MD, Nofar Kimchi, MD, Wei Zhao, BSc, Jana Abi-Rafeh, BSc, Danbing Ke, PhD, Duncan Lejtenyi, MSc, Liane Beaudette, RN, Christine McCusker, MD, Bruce D. Mazer, MD, Moshe Ben-Shoshan, MD

“…Adverse reactions occurred in 15.6% of 5971 doses, mostly mild. Skin prick test wheal diameters decreased significantly (P < .001); s-IgE levels declined whereas s-IgG4 levels increased (P < .001), and sIgG4/sIgE ratios improved. …”
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Structural Brain Morphometry in Children with Attention Deficit Hyperactivity Disorder and Comorbid Mild Cognitive Impairments by George A. Karkashadze, Alexey I. Firumyants, Nikita S. Shilko, Nataliya S. Sergienko, Yulia V. Nesterova, Leonid M. Yatsyk, Elena N. Rudenko, Mikhail I. Polle, Tatiana A. Salimgareeva, Tinatin Yu. Gogberashvili, Nataliya E. Sergeeva, Tatiana A. Konstantinidi, Safarbegim Kh. Sadilloeva, Marina A. Kurakina, Viktor V. Dyachenko, Inessa A. Povalyaeva, Evgeniy V. Bogdanov, Anastasia I. Rykunova, Elena A. Vishneva, Elena V. Kaytukova, Kamilla E. Efendieva, Leyla S. Namazova-Baranova

“…MCI without ADHD group has shown bilateral enlargement of lateral ventricles, decrease in the volume of right pallidum and seven gyri cortex, mostly on the right side, as well as decrease in the volume of four cerebellar lobules. …”
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Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial by Mitzi M. Gonzales, Valentina R. Garbarino, Tiffany F. Kautz, Xuemei Song, Marisa Lopez-Cruzan, Leslie Linehan, Candice E. Van Skike, Gabriel A. De Erausquin, Veronica Galvan, Miranda E. Orr, Nicolas Musi, Yingxin He, Randall J. Bateman, Chen-Pin Wang, Sudha Seshadri, Ellen Kraig, Dean Kellogg

“…After treatment, we find that twenty, mostly mild adverse events occur, systolic blood pressure and hemoglobin A1c increase, multiple erythrocyte parameters decrease, and there are no significant cognitive changes. …”
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Evaluation of molecular and serological testing for imported urogenital schistosomiasis screening in a referral tropical medicine centre in Barcelona, Spain by Patricia Martínez-Vallejo, Alejandro Mediavilla, Aroa Silgado, Francesc Zarzuela, Lidia Goterris, Carles Rubio Maturana, Nuria Serre-Delcor, Inés Oliveira-Souto, Fernando Salvador, Joan Joseph-Munne, María Luisa Aznar, Diana Pou, Begoña Treviño, Israel Molina, Javier Sotillo, Elena Sulleiro

“…It is estimated that more than 200 million people are affected worldwide, mostly in Africa. The gold standard diagnosis of urogenital schistosomiasis (UGS) is the microscopic visualisation of Schistosoma haematobium eggs in concentrated urine; however, its sensitivity is low. …”
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Clinical characteristics and risk factors for recurrence of Kikuchi-Fujimoto disease in children: a case-control study by Bing Liu, Yi Sun, Wen-yuan Shi, Bing Hu, Ling-yun Guo, Tian-ming Chen, Xiao-ming Ge, Yun-yan Wu, Gang Liu

“…Conclusions KFD in children is more common in males and mostly occurs at school age. KFD in children is characterized by tenderness in the lymph node and leukopenia with less multiple lymph node involvement. …”
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Cellular and Molecular Atlas of Peripheral Blood Mononuclear Cells from a Pregnant Woman After Recovery from COVID-19 by Lili Du, Yingyu Liang, Xiaoyi Wang, Lijun Huang, Xingfei Pan, Jingsi Chen, Dunjin Chen, Dandan Shi

“…After reclustering and Augur analysis, we found that CD16 monocytes and mucosal-associated invariant T (MAIT) cells were mostly affected within different myeloid, T, and NK cell subtypes in our COVID_RS patient. …”
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Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling by Aseervatham Anusha Amali, Douglas Jie Wen Tay, Douglas Jie Wen Tay, Yiqi Seow, Marie Loh, Marie Loh, Marie Loh, Sharada Ravikumar, Jocelyn Jin Yu, Shaun Seh Ern Loong, Siew Wai Fong, Chang Jie Mick Lee, Jonathan Jordon Cailu Lim, Louis Hanqiang Gan, Winston Lian Chye Koh, Ying Ding, Qi Hui Sam, Zhaohong Tan, Rachel Ying Min Tan, Chong Boon Lua, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Amit Singhal, Shyam Prabhakar, Wee Joo Chng, Wee Joo Chng, Laurent Renia, Laurent Renia, David Chien Boon Lye, David Chien Boon Lye, Lisa F. P. Ng, Lisa F. P. Ng, Kai Sen Tan, Kai Sen Tan, Roger Foo, Roger Foo, Chang Chuan Melvin Lee, Chang Chuan Melvin Lee, Barnaby Young, Barnaby Young, Louis Yi Ann Chai, Louis Yi Ann Chai

“…To date, these studies have yielded loci mostly in non-functional domains of unknown biological significance and invariably require large sample sizes, potentially missing lower frequency variants, especially in under-represented or minority populations.MethodsTo identify unique genetic traits predisposing to severe COVID-19 in Asians, we employed an alternative strategy using whole exome sequencing of representative cohort of severe versus mild COVID-19 patients. …”
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Longer-term virologic outcomes on tenofovir-lamivudine-dolutegravir in second-line ART by Jennifer K. van Heerden, Ying Zhao, Claire M. Keene, Rulan Griesel, Zaayid Omar, René Goliath, Kayla Delaney, Gert van Zyl, Gary Maartens, Graeme Meintjes

“…Eligible participants had two consecutive HIV-1 RNA ≥ 1000 copies/mL on first-line ART, mostly tenofovir-emtricitabine-efavirenz. Participants were switched to tenofovir-lamivudine-dolutegravir (TLD) with lead-in 50 mg dolutegravir twice daily in stage one (n = 62), and randomised to TLD with additional lead-in 50 mg dolutegravir or placebo for the first 14 days in stage two (n = 130). …”
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ImageNomer: Description of a functional connectivity and omics analysis tool and case study identifying a race confound by Anton Orlichenko, Grant Daly, Ziyu Zhou, Anqi Liu, Hui Shen, Hong-Wen Deng, Yu-Ping Wang

“…Most packages for the analysis of fMRI-based functional connectivity (FC) and genomic data are used with a programming language interface, lacking an easy-to-navigate GUI frontend. …”
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Clinical activity of durvalumab for patients with advanced mismatch repair-deficient and repair-proficient endometrial cancer. A nonrandomized phase 2 clinical trial by Linda Mileshkin, Elizabeth Barnes, Tarek Meniawy, Kristy Robledo, Michael Friedlander, Geraldine Goss, Jermaine Coward, Yoland Antill, Michelle Cummins, Sally Baron-Hay, Martin R Stockler, Catherine Shannon, Philip Beale, Peey-Sei Kok, Deborah Smith, Sonia Yip, Amanda Spurdle, Yeh Chen Lee, Janine Lombard, John Andrews

“…Immune-related adverse events occurred in 14 women, mostly grades 1–2.Conclusion Durvalumab monotherapy showed promising activity and acceptable safety in AEC with dMMR regardless of prior lines of chemotherapy, but activity was limited in AEC with pMMR.Trial registration numbers ANZGOG1601, ACTRN12617000106336, and NCT03015129.…”
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Open-Label Phase 1/2 Study of Daratumumab-Based Desensitization Before Kidney Transplantation by Caroline Pilon, Nizar Joher, Cédric Usureau, Emmanuelle Boutin, Anna Boueilh, Jean-Luc Taupin, Allan Thiolat, José L. Cohen, Vissal David Kheav, Florence Canoui-Poitrine, Maryvonnick Carmagnat, Philippe Grimbert, Marie Matignon

“…Safety analysis showed 4 serious non-treatment-emergent adverse events (non-TEAEs), 36 mild TEAEs, mostly infusion-related reactions, grade 1 and 2 (causing 2 temporary drug discontinuations), but no serious TEAEs. …”
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Toxicity, Half-Life and Antitumor Activity of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as Novel Antimitotic CYP1A1-Targeted Prodrugs in Female Mouse Models by Atziri Corin Chavez Alvarez, Chahrazed Bouzriba, Vincent Ouellette, Mathieu Gagné-Boulet, Alexandre Patenaude, Sylvie Pilote, René C.-Gaudreault, Chantale Simard, Sébastien Fortin

“…PAIB-SOs are prodrugs bioactivated into potent antimitotics by the cytochrome P450 1A1 (CYP1A1), which is a frequent enzyme in resistant BC cells, but mostly missing in normal cells. Our screening program studies of PAIB-SO chemolibraries selected three prototypical PAIB-SOs as antimitotic prodrugs amenable for studies using BC animal models. …”
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Evaluation of eco-driving performance of electric vehicles using driving behavior-enabled graph spectrums: A naturalistic driving study in China by Hui Zhang, Yiyue Luo, Naikan Ding, Toshiyuki Yamamoto, Chenming Fan, Chunhui Yang, Wei Xu, Chaozhong Wu

“…However, current researches on ecological driving behavior mostly use structured data to reflect the characteristics of ecological driving behavior, and it is difficult to accurately reveal the recessive relationship between driving behavior and energy consumption. …”
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3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis by G. Gerini, E. Mari, P. Pontecorvi, S. Camero, E. Romano, D. Ranieri, F. Megiorni, P. Fioramonti, A. Angeloni, C. Marchese, S. Ceccarelli

“…Abstract Background Adipose-derived mesenchymal stem cells (ASCs) represent a valid therapeutic option for clinical application in several diseases, mostly due to the paracrine activity of their secretome, exerting pro-angiogenic, antinflammatory and immunosuppressive effects. …”
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Relación entre el nivel de actividad física y el rendimiento académico en estudiantes de una institución universitaria. Estudio multicéntrico. (Relationship between the level of p... by Julian David Ceron Bedoya, Wilson Gonzalez Marmolejo , Diana Liceth Mora Rojas, Esther Julia Fernandez Barona

“…Results: Women perform more physical activity of mild intensity while men perform more physical activity of moderate intensity; students belonging to low socioeconomic strata have a mild level of physical activity, while students belonging to the middle or high strata tend to have mostly a moderate level of physical activity. It was found that having a moderate or vigorous level of physical activity increases twice the possibility of a student obtaining a GPA higher than 3.7 (on a scale of 0 - 5). …”
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Factors associated with health-related quality of life in women with paid work at breast cancer diagnosis: a German repeated cross-sectional study over the first five years after p... by Batoul Safieddine, Siegfried Geyer, Stefanie Sperlich, Johannes Beller, Dorothee Noeres

“…At that stage, income was mostly associated with physical (ß=0.002; CI:0.0002, 0.003) and mental wellbeing (ß=0.002; CI:0.0005, 0.003) with higher summary scores for higher income especially in women aged ≤ 61 years. …”
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O perspectivă inedită asupra romanului latin by Carmen-Nicola Jumara

“…The writer has to face different difficulties in his endeavours of creating a convincing work of art, and the means he uses are mostly instinctive and don’t always coincide with the methods the critics adopt. …”
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Estimation of the energy cost of activities in grazing dairy cows using the oxygen pulse–heart rate method by Daniel Talmón, Alejandra Jasinsky, Federica Marin, Gabriel Menegazzi, Pablo Chilibroste, Mariana Carriquiry

“…Hourly energy expenditure (kJ/h) was similar between grazing and consuming TMR at the feed bunk, indicating that the extra energy required by dairy cows when fed in a grazing system is mostly explained by the longer time spent to harvest the pasture and the energy cost of walking between the pasture and the milking parlor compared with confined cows fed TMR. …”
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Female maturation and rematuration acceleration of Mutiara strain catfish (Clarias gariepinus) using combination of oocyte developer hormone and astaxanthin addition diet by Fatahillah Maulana Jufri, Agus Oman Sudrajat, Mia Setiawati

“…ABSTRACT   Reproductive design for gonadal maturation process mostly related with some factors such as environmental signals, reproductive organs, hormonal and nutrition. …”
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Engagement with healthcare providers and healthcare system navigation among Australians with chronic conditions: a descriptive survey study by Jeffrey Braithwaite, Yvonne Zurynski, Joanna Holt, Louise A Ellis, Chiara Pomare, James Ansell, James Gillespie, Jo Root, Isabelle Meulenbroeks, Leanne Wells

“…Logistic regression analyses (estimating ORs) determined the associations between having a chronic condition and the navigation and engagement scores, while controlling for age, gender, level of education and income.Participants 1024 Australians aged 18–88 years (mean=46.6 years; 51% female) recruited from the general population.Results Over half (n=605, 59.0%) of the respondents had a chronic condition, mostly back pain, mental disorders, arthritis and asthma. …”
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