DDX41 resolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death by Honghao Bi, Kehan Ren, Pan Wang, Ermin Li, Xu Han, Wen Wang, Jing Yang, Inci Aydemir, Kara Tao, Renee Ma, Lucy A. Godley, Yan Liu, Vipul Shukla, Elizabeth T. Bartom, Yuefeng Tang, Lionel Blanc, Madina Sukhanova, Peng Ji

“…Abstract Deleterious germline DDX41 variants constitute the most common inherited predisposition disorder linked to myeloid neoplasms (MNs), yet their role in MNs remains unclear. …”
Get full text

Phantom tumour: inflammatory pseudotumour of the liver: a rare case report and review of literature by Jesheen Mann, Akash Shukla, Biswa Ranjan Patra

“…Introduction: The term ‘inflammatory pseudotumour’ (IPT) denotes a heterogeneous group of mass-forming lesions.1 IPT most commonly occurs in the lung, but it can be found in other locations, including the central nervous system, kidneys, ovaries, urinary bladder, breasts and liver.2IPT of the liver (IPTL) is a rare benign lesion characterised by chronic infiltration of inflammatory cells and an area of fibrosis that closely mimics a malignant tumour.3,4The aetiology and pathogenesis of IPTL remain unknown. …”
Get full text

Zr-MOF/MXene composite for enhanced photothermal catalytic CO2 reduction in atmospheric and industrial flue gas streams by Yang Meng, Feng Yue, Shuo Zhang, Lingji Zhang, Cong Li, Mengke Shi, Yongpeng Ma, Mario Berrettoni, Xiaojing Zhang, Hongzhong Zhang

“…For high-concentration CO2 in industrial flue gas, the composite utilized residual heat at 80 °C without additional energy input, exhibiting excellent CO2 reduction efficiency with CO and CH4 production rates of 127 μmol·g-1·h-1 and 330 μmol·g-1·h-1, respectively, resulting in a total production rate 4.76 times higher than that in the air. Compared to most reports on thermocatalytic CO2 reduction (>300 °C), this material shows significant advantages below 100 °C. …”
Get full text

Diabetes mellitus screening and its associated factors among women in Lesotho: evidence from the 2023–2024 demographic and health survey by Enyew Getaneh Mekonen, Deresse Abebe Gebrehana, Tadesse Tarik Tamir, Alebachew Ferede Zegeye, Berhan Tekeba

“…Methods A cross-sectional study was employed using data from the most recent national representative dataset. A total sample of 3,297 women aged between 15 and 49 years was included in the study. …”
Get full text

Pantothenate kinase-associated neurodegeneration (Hallerworden–Spatze disease): clinical aspects, diagnosis, treatment (literature review and own data) by Yu. H. Antypkin, L. H. Kyrylova, O. O. Miroshnykov, O. O. Yuzva, L. Yu. Silaieva, O. V. Berehela, L. A. Myroniak

“…MRI signs in the form of specific changes in the T2-weighted mode, which detects typical areas of hyperintensive signal in globus pallidus, surrounded by a border of hypointensive signal (“tiger’s eye”) are particular important. Neuroimaging data most likely make possible to suspect a correct diagnosis, reducing the time and cost of additional examinations. …”
Get full text

Potential Use of Tropical and Subtropical Fruits By-Products in Pig Diet: In Vitro Two-Step Evaluation by Dieu donné Kiatti, Francesco Serrapica, Nadia Musco, Rossella Di Palo, Serena Calabrò

“….), cashew (<i>Anacardium occidentale</i> L.) and mango (<i>Mangifera indica</i> L.) are among the most cultivated plants in tropical and subtropical regions due to the high demand around the world. …”
Get full text

Environmental testing of winter bread wheat varieties and lines in the conditions of the southern part of the Rostov region by S. N. Gromova, O. V. Skripka, S. V. Podgorny, A. P. Samofalov, V. L. Chernova

“…The current study was carried out in 2019–2021 using the material and technical base of the FSBSI Agricultural Research Center “Donskoy”, in order to research winter bread wheat samples of various ecological and geographical origin according to productivity and some economically valuable traits, to identify the most adapted of them for the conditions of the southern part of the Rostov region. …”
Get full text

Cervical Cancer Cells Express Markers Associated with Immunosurveillance by Adriana Gutiérrez-Hoya, Octavio Zerecero-Carreón, Arturo Valle-Mendiola, Martha Moreno-Lafont, Rubén López-Santiago, Benny Weiss-Steider, Isabel Soto-Cruz

“…Cervical cancer is the second most frequent cancer in women in Mexico, and its development depends on the presence of human papillomaviruses in the uterine cervix. …”
Get full text

The feasibility of pathogenetic therapy for chronic viral hepatitis C in adult HIV-infected patients by E. B. Bun'kova, N. A. Bileva, M. I. Sinel'nikov, A. E. Bilev

“…Antiretroviral therapy was not associated with the results of pathogenetic therapy of chronic viral hepatitis C according to the indicators of cytolysis syndrome and "right subcostal syndrome", despite the fact that most of the prescribed drugs had a hepatotoxic effect.…”
Get full text

Molecular mechanisms and targeted therapy of progranulin in metabolic diseases by Xiaxia Wang, Yonglin Liang, Fan Yang, Yangyang Shi, Ruiwen Shao, Ruge Jing, Tong Yang, Qiao Chu, Dong An, Qi Zhou, Jiayi Song, Haolan Chen, Chun Liu

“…Osteoarthritis, rheumatoid arthritis, intervertebral disc degeneration, osteoporosis, periodontitis, and diabetes-related complications—representing the most prevalent metabolic diseases—currently lack effective treatments due to incomplete understanding of their precise pathogenic mechanisms. …”
Get full text

Surgical outcome of pediatric intestinal obstruction in Amhara comprehensive specialized hospitals, September 2024 by Alazar Tamirat, Jemberu Nigussie, Gebeyaw Biset

“…Abstract Background Intestinal obstruction is the most common acute abdominal disorders in children requiring emergency surgical management. …”
Get full text

Resection of lesions in the ileum of patients with IgG4-related disease may ameliorate disease progression without steroid administration by Akihiro Watanabe, Takashi Goto, Hitomi Kamo, Ryuji Komine, Naomi Kuroki, Takanobu Sugase, Tsuyoshi Takaya, Rintaro Koga, Hiroshi Hojo, Shoji Taniguchi, Kazuhiko Ibusuki, Kazumi Koga

“…The ideal diagnostic method is pathological examination, but because the clinical manifestations of IgG4-RD are very diverse and nonspecific, the disease may often go undiagnosed until an unrelated biopsy or resection specimen is obtained. The most common treatment for IgG4-RD is steroid use. …”
Get full text

Disposition of emergency department patients presenting with angiotensin-converting enzyme inhibitor-induced angioedema by Blake Briggs, David Cline, Iltifat Husain

“…Abstract Background Angiotensin-converting enzyme inhibitors (ACEI) are the most common cause of drug-induced angioedema in the United States. …”
Get full text

AN INTIMATE DIALOGUE WITH GOD IN JOHN DONNE’S “HOLY SONNETS”: PETRARCHAN CONTEXT by Mariana M. Markova

“…However, his further relations with God, once again, seem to be built according to the Petrarchan model, most fully described in the last text of the sequence. …”
Get full text

Outliers and anomalies in training and testing datasets for AI-powered morphometry—evidence from CT scans of the spleen by Yuriy Vasilev, Yuriy Vasilev, Anastasia Pamova, Tatiana Bobrovskaya, Anton Vladzimirskyy, Anton Vladzimirskyy, Olga Omelyanskaya, Elena Astapenko, Artem Kruchinkin, Novik Vladimir, Kirill Arzamasov, Kirill Arzamasov

“…Using visual methods (1.5 interquartile range; heat map; boxplot; histogram; scatter plot), machine learning algorithms (Isolation forest; Density-Based Spatial Clustering of Applications with Noise; K-nearest neighbors algorithm; Local outlier factor; One-class support vector machines; EllipticEnvelope; Autoencoders), and mathematical statistics (z-score, Grubb’s test; Rosner’s test).ResultsWe identified measurement errors, input errors, abnormal size values and non-standard shapes of the organ (sickle-shaped, round, triangular, additional lobules). The most effective methods included visual techniques (including boxplots and histograms) and machine learning algorithms such is OSVM, KNN and autoencoders. …”
Get full text

Attributing the spatial-temporal contributions of inflow nitrogen and phosphorus loads to lake water quality and insights for effective mitigation strategies by Zhilong Zhao, Bo Yao, Yu Li, Zhaokui Ni, Shengrui Wang

“…The Xiaguan Area and June were the most critical for IPL reduction.…”
Get full text

Assessing the Level of Consumption by Children in Households by K. V. Kuznetsov

“…It should be noted that most of the research on this topic was carried out at the end of the 20th century. …”
Get full text

Clinical Implications of High Melioidosis Serology Indirect Haemagglutination Assay Titre: A 20-Year Retrospective Study from the Top End of the Northern Territory, Australia by Cassandra Ho, Kevin Freeman, Celeste Woerle, Mila Mahoney, Mark Mayo, Robert W. Baird, Ella M. Meumann, Bart J. Currie

“…The indirect haemagglutination assay (IHA) is the most widely used serology test globally, but it is not standardised among the limited number of laboratories that perform it. …”
Get full text

Chemical and Biological Study of the Essential Oil Isolated from Fruits of <i>Citrus</i> x <i>limonia</i> by Eduardo Valarezo, Jailene Paucar-Costa, Belén Morales-Guamán, Alfredo Caraguay-Martínez, Ximena Jaramillo-Fierro, Nixon Cumbicus, Miguel Angel Meneses

“…Monoterpene hydrocarbons were the most representative group in terms of number of compounds (thirteen) and in terms of relative abundance (91.39%). …”
Get full text

Daratumumab induces cell-mediated cytotoxicity of primary effusion lymphoma and is active against refractory disease by Prabha Shrestha, Yana Astter, David A. Davis, Ting Zhou, Constance M. Yuan, Ramya Ramaswami, Hao-Wei Wang, Kathryn Lurain, Robert Yarchoan

“…PEL cell lines were also evaluated and most had high CD38 expression. We then assessed Dara’s effects on complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) of PEL cell lines as well as its clinical benefits on two patients with PEL. …”
Get full text