Outcomes in patients with cardiac amyloidosis undergoing catheter ablation for atrial arrhythmias by Adrian M. Petzl, MD, Justice Oranefo, MD, Alireza Oraii, MD, Michael Riley, MD, PhD, David Lin, MD, FHRS, Ramanan Kumareswaran, MD, Robert D. Schaller, DO, FHRS, Gregory E. Supple, MD, FHRS, Timothy M. Markman, MD, FHRS, Gustavo Guandalini, MD, Matthew C. Hyman, MD, PhD, David S. Frankel, MD, FHRS, Andrew E. Epstein, MD, FHRS, Saman Nazarian, MD, PhD, FHRS, Fermin C. Garcia, MD, Rajat Deo, MTR, MD, David J. Callans, MD, FHRS, Francis E. Marchlinski, MD, FHRS, Sanjay Dixit, MD, FHRS

“…LVA was seen in 73% of patients undergoing LA arrhythmia, and it occupied 50.4% of the LA surface, most commonly the posterior wall (53%). However, its presence did not correlate with long-term arrhythmia-free survival (P = 0.957). …”
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Dynamics of Morbidity and Etiological Structure of Acute Respiratory Infections on the Eve and in the First Year of COVID-19 in the Irkutsk Region by N. A. Kravchenko, V. B. Kazanova, M. I. Khakimova, T. A. Gavrilova, Z. A. Zaikova, A. D. Botvinkin

“…The proportion of children in the structure of CAP incidence decreased from 39.4% to 12.6% (p < 0.001), and the proportion of adults increased from 60.6% to 87.3% (p < 0.001). These changes were most pronounced during the «second wave» of COVID-19 at the end of 2020. …”
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Exploring physical, sexual and mental health consequences of gender-based violence among women and girls during conflict in Tigray, Ethiopia by Girmatsion Fisseha Abreha, Hadgay Hagos Adhanu, Abera Berhe Aregawi, Alem Desta Wuneh, Freweni Tesfay, Gebretsadik Kiros Lema, Balem Demstu, Hale Teka, Awol Yemane, Hagos Gidey, Kibrom Berhanu Gebreselassie, Tigist Hagos, Helen Bitew Tareke, Tensay Kahsay W/gebriel, Yemane Berhane Tesfau, Brhane Ayele, Ataklti Hailu Atsbaha, Teame Zegeye, Yaynshet Gebreyohannes Redda, Abrahim Hassen, Hagos Godefay, Afework Mulugeta

“…Results Of the survivors, 435 (82.4%) had been raped and 404 (76.5%) had experienced a triple trauma burden of sexual, physical, and psychological violence. Most survivors had experienced consequences ranging from mild (34.5%) to severe injuries (42.1%), mental health and behavioral problems (75.6%) like posttraumatic stress disorder (12.1%), stress (63.5%), anxiety (38.6%), depression (27.5%), sleeping disturbance (35.2%), nightmare (29.0), flashbacks and social isolation. …”
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Efficacy and safety of 3D-therapy at HCV-related subcompensated liver cirrhosis (genotype 1b) by P. O. Bogomolov, M. V. Matsiyevich, A. O. Buyeverov, V. D. Beznosenko, Ye. V. Fedosova, M. Yu. Petrachenkova, S. V. Koblov, K. Yu. Kokina, O. S. Kuzmina, N. V. Voronkova

“…The early treatment termination was caused by progression of hepatic encephalopathy symptoms and/or jaundice development (4 cases). Most cases of the progression­related treatment termination due to liver failure were reversible after CAT interruption. …”
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Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set... by Huan Gao, Xue Zhang, Ziqi Liu, Xiaoge Yang, Yajie Li, Mengxing Cui, Han Wang, Xiaoyu Chen, Weiying Zhang, Zhihan Liu, Yongjiang Yu, Liping Chen, Daochuan Li, Yongmei Xiao, Wen Chen, Qing Wang

“…Further experimental results demonstrated that phloridzin provided the most effective protection against MEHP-induced apoptosis in TM3 cells probably through the p53 and MAPK signaling pathways. …”
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Evaluation of ctDNA-guided adjuvant therapy de-escalation in head and neck squamous cell carcinoma: a comparative cohort study by Xu Zhang, Qigen Fang, Junhui Yuan, Liyuan Dai, Ruihua Luo, Tao Huang, Tao Huang, Yinfei Wu

“…Among ctDNA-positive patients, POCRT benefit was significantly greater in the ctDNA-guided cohort (HR 0.73, 95%CI 0.57-0.83; p=0.026) compared to ctDNA-positive patients receiving traditional management (HR 0.87, 95%CI 0.73-0.93; p=0.047; interaction p=0.039).ConclusionPostoperative ctDNA analysis identifies HNSCC patients who benefit most from POCRT, enabling a 41% relative reduction in treatment utilization while maintaining superior locoregional control. …”
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Effect of the application on fungicides and of different cultural practices on bean (Phaseolus vulgaris L.) seed production and quality Efecto de la aplicación de fungicidas y de m... by Estrada Salazar Edgar Iván

“…The critical point was close to 3 applications. The most outstanding selection systems were those that included seed selection. …”
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In Situ Vaccination with Poly-ICLC Combined with Systemic Nivolumab for the Treatment of Unresectable Hepatocellular Carcinoma by Liang JD, Liang PC, Shun CT, Chen CH, Wu YM, Hsu YC, Lee YT, Yang PM, Huang GT, Salazar AM, Lee HS, Sheu JC, Weng MT

“…Gene analysis indicated that interferon-gamma signaling was the most enriched pathway in tumors of the responders.Conclusion: This combination therapy was safe and effective, with two out of four patients demonstrating objective responses. …”
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QTL mapping of seedling biomass and root traits under different nitrogen conditions in bread wheat (Triticum aestivum L.) by Meng-jiao YANG, Cai-rong WANG, Muhammad Adeel HASSAN, Yu-ying WU, Xian-chun XIA, Shu-bing SHI, Yong-gui XIAO, Zhong-hu HE

“…Twelve new QTLs detected on chromosomes 1AL (1) in the control, 1DS (2) in high N treatment, 4BL (5) in low and high N treatments, and 7DS (3) and 7DL (1) in low N treatments, are first reported in influencing the root and biomass related traits for N uptake. The most stable QTLs (RRS.caas-4DS) on chromosome 4DS, which were related to ratio of root to shoot dry weight trait, was in close proximity of the Rht-D1 gene, and it showed high phenotypic effects, explaining 13.1% of the phenotypic variance. …”
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Celiac Disease in Children, Particularly with Accompanying Type 1 Diabetes, Is Characterized by Substantial Changes in the Blood Cytokine Balance, Which May Reflect Inflammatory Pr... by Tamara Vorobjova, Aili Tagoma, Astrid Oras, Kristi Alnek, Kalle Kisand, Ija Talja, Oivi Uibo, Raivo Uibo

“…Circulating anti-EV IgA and IgG were evaluated using ELISA. The most important finding of the study is the significant increase of the serum levels of IL-5, IL-8, IL-13, IL-15, IL-17F, IL-22, IL-27, IP-10, MIP-1β, sIL-2Rα, sTNFRII, and TNFα in CD patients compared to controls and its correlation with the degree of small bowel mucosa damage graded according to the Marsh classification. …”
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Comparison of conventional culture and automated blood culture system for microbiologic diagnosis of pleural infection by Young Ho Lee, Min Seo Kang, Jinyoung Yang, Si-Ho Kim, Jae-Hoon Ko, Sun Young Cho, Tae Yeul Kim, Hee Jae Huh, Nam Yong Lee, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck, Kyungmin Huh

“…Among organisms isolated from ABCS alone, viridans group streptococci, Staphylococcus aureus, and Klebsiella spp. were the most common organisms identified. Higher pleural fluid glucose and blood white blood cells and lower CRP were significant factors associated with exclusive ABCS positivity. …”
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Occult tethered cord syndrome: insights into clinical and MRI features, prognostic factors, and treatment outcomes in 30 dogs with confirmed or presumptive diagnosis by Javier Espinosa Romero, Steven De Decker, Koen Santifort, Koen Santifort, Rodrigo Gutierrez-Quintana, Maria Ortega, Ane Uriarte, Abtin Mojarradi, Quinten van Koulil, Despoina Douralidou, Irene Espadas, Miguel Benito Benito, Carlo Anselmi, Charlotte Dye, Patricia Alvarez, Juan José Minguez, Abbe Crawford, Christoforos Posporis

“…Pain/dysesthesia in the lumbosacral region/tail/pelvic limbs was the most common presenting complaint (97%), followed by pelvic limb gait abnormalities (70%), behavioral changes (67%), impaired physical activity (63%), and urinary/fecal incontinence (17%). …”
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Evaluation of the effectiveness of allogeneic tendon graft sterilization with supercritical carbon dioxide by A. A. Budaev, N. V. Borovkova, A. M. Fayn, A. Yu. Nikolaev, M. S. Makarov, M. V. Storozheva, K. I. Skuratovskaya, A. Yu. Vaza, I. V. Fomicheva, T. V. Chernen'kaya, A. А. Kanibolotskiy

“…For supercritical carbon dioxide sterilization of tendon grafts the most optimal processing time is 1 hour.…”
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Metabolic syndrome and its associations with socio-demographic and behavioral risk factors in the Russian population aged 25-64 years by Yu. A. Balanova, A. E. Imaeva, V. A. Kutsenko, A. V. Kapustina, G. A. Muromtseva, S. E. Evstifeeva, S. A. Maksimov, N. S. Karamnova, E. B. Yarovaya, S. A. Shalnova, O. M. Drapkina

“…The risk of lipid metabolism disorders was higher among women with secondary education. Most of these associations were confirmed by multivariate analysis.Conclusion. …”
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Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial by Paul Little, Alastair D Hay, Lucy Yardley, G Ardine de Wit, Nicolaas P A Zuithoff, Sibyl Anthierens, Roderick P Venekamp, Anne G M Schilder, Roger A M J Damoiseaux, Elisabeth A M Sanders, Saskia Hullegie, Joline L H de Sévaux

“…Introduction Ear pain is the most prominent symptom of childhood acute otitis media (AOM). …”
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Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers by Maria Teresa De Angelis, Antonia Rizzuto, Angela Amaddeo, Carlo Sagnelli, Niccolò Vono, Michela Reda, Valentina Lise, Luca Parrillo, Carmela De Marco, Donatella Malanga, Gianluca Santamaria, Giuseppe Viglietto

“…Importantly, analysis of predicted non-canonical driver genes identified ACVR1B, LTBP4, SETD1A as CC-specific drivers and C4BPA, EHD1 as RC-specific drivers, underscoring divergent oncogenic mechanisms. However, the most substantial divergence was observed in transcriptomic profiling, with 56% and 33% of DEGs (in CC and RC, respectively) that were tumor-type specific. …”
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Non-invasive breath testing to detect colorectal cancer: protocol for a multicentre, case–control development and validation study (COBRA2 study) by Michael G. Fadel, James Murray, Georgia Woodfield, Ilaria Belluomo, Ivan Laponogov, Aaron Parker, Valerio Converso, James K. Ellis, Pete Wheatstone, Julie Hepburn, Chris Groves, Kevin Monahan, Brian P. Saunders, Patrik Španěl, Kirill Veselkov, Amanda J. Cross, Christos Kontovounisios, Linda D. Sharples, George B. Hanna, COBRA2 Collaborators

“…Abstract Background Colorectal cancer (CRC) is the fourth most common cancer in the United Kingdom. The five-year survival rate from CRC is only 10% when discovered at a late stage, but can exceed 90% if diagnosed early. …”
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Comparative Efficacy of 20-Degree versus 30-Degree Angled Wedges on Inferior Vena Cava Diameter and Haemodynamic Stability during Spinal Anaesthesia for Caesarean Section: A Random... by Janani Rajamannar, Mahesh Vakamudi, Gayathri Sakthivel, V Rajesh Kumar Kodali, Aruna Parameswari

“…Spinal anaesthesia also provides adequate pain relief for parturient. The most common condition that occurs during the pregnancy is supine hypotension syndrome, which gets aggravated after spinal anaesthesia. …”
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Evaluating the impact of DREAMS on HIV incidence among adolescent girls and young women: A population-based cohort study in Kenya and South Africa. by Isolde Birdthistle, Daniel Kwaro, Maryam Shahmanesh, Kathy Baisley, Sammy Khagayi, Natsayi Chimbindi, Vivienne Kamire, Nondumiso Mthiyane, Annabelle Gourlay, Jaco Dreyer, Penelope Phillips-Howard, Judith Glynn, Sian Floyd

“…<h4>Conclusions</h4>Substantial declines in HIV incidence among AGYW were observed, but most began before DREAMS introduction and did not accelerate in the first 3 years of DREAMS implementation. …”
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Development and validation of an integrative 54 biomarker-based risk identification model for multi-cancer in 42,666 individuals: a population-based prospective study to guide adva... by Renjia Zhao, Huangbo Yuan, Yanfeng Jiang, Zhenqiu Liu, Ruilin Chen, Shuo Wang, Linyao Lu, Ziyu Yuan, Zhixi Su, Qiye He, Kelin Xu, Tiejun Zhang, Li Jin, Ming Lu, Weimin Ye, Rui Liu, Chen Suo, Xingdong Chen

“…Employing five supervised machine learning approaches, we used a LASSO-based feature selection strategy to identify the most informative predictors. The model was trained and internally validated in the discovery cohort, externally applied in the validation cohort, and further evaluated through a prospective clinical follow-up to assess cancer events via clinical examinations. …”
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