The role of neotectonics and climate variability in the Pleistocene-to-Holocene hydrological evolution of the Fuente de Piedra playa lake (southern Iberian Peninsula) by A. Jiménez-Bonilla, L. Martegani, L. Martegani, M. Rodríguez-Rodríguez, F. Gázquez, F. Gázquez, M. Díaz-Azpíroz, S. Martos, K. Reicherter, I. Expósito

“…Consequently, the FdP flooded surface mostly remained constant and in equilibrium with climate variables and its watershed along its lifespan. …”
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Perceived stress and family adaptability in head and neck cancer patients receiving radiotherapy: the chain-mediated effect of social support and family resilience by Xiaoru Li, Xiaoru Li, Xiaoru Li, Yu Zhu, Yu Zhu, Yu Zhu, Hongwei Wan, Hongwei Wan, Hongwei Wan

“…Bootstrap methods to analyze independent and chained mediation effects between variables.ResultsThe research participants had a mean age of 43.63 ± 12.78 years, were mostly male (61.7%), married (85.8%), had a university education (51.6%), were uninsured (50.9%), had ear, nose, and throat tumors (56.3%), and had an illness duration of 1-6 months (43.4%). …”
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Descriptive Epidemiology and Mortality Risk Factors of COVID-19 Outbreak in Delta State, Nigeria, March – August 2020 by Adaora Rosemary Ejikeme, Bola Biliaminu Lawal, Shalom Ogbonna, Ehimario Igumbor, Mildred Okowa, Ivie Airefetalor, Daniel Otoh, Angela Okocha-Ejeko, Onyinyechi Emefiene, Ann Ojimba, Henry Uguru-Ekechi, Rhoda Atteh, Nkiruka Obiazor, Chukwuma David Umeokonkwo, Muhammad Shakir Balogun, Oladipupo Ipadeola, Abdulhakeem Abayomi Olorukooba, Aboyowa Edukugho, Bolaji Ahmed, Oladipo Ogunbode

“…Conclusion: Males in the youthful age-group were mostly affected. Independent predictors of mortality were being elderly or symptomatic at time of testing. …”
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Stereotactic radiosurgery alone for patients with 16 or more brain metastases: Retrospective single-institution analysis by Michael T. Milano, Sara Hardy, Dandan Zheng, Terris Igwe, Daniel Huang, Amit K. Chowdhry, Jihyung Yoon, Tyler M. Schmidt, Kevin A. Walter, Hyunuk Jung, Yuwei Zhou, Kenneth Y. Usuki

“…Twenty-eight underwent 3-fraction SRS (mostly 8–9 Gy per fraction), and 1 underwent single-fraction SRS (20 Gy). …”
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Voices from the frontline: findings from a thematic analysis of a rapid online global survey of maternal and newborn health professionals facing the COVID-19 pandemic by Lenka Benova, Aduragbemi Banke-Thomas, Emma Radovich, Francesca L Cavallaro, Andrea Pembe, Oona Maeve Renee Campbell, Thomas van den Akker, Bouchra Assarag, Thérèse Delvaux, Mitsuaki Matsui, Alexandre Delamou, Wendy Jane Graham, Bosede Afolabi, Annettee Nakimuli, Louise Tina Day, Aline Semaan, Constance Audet, Elise Huysmans, Hannah Blencowe, Séverine Caluwaerts, Leonardo Chavane, Giorgia Gon, Peter Kascak, Sarah Moxon

“…Overall, 47% of participants in LMICs and 69% in HICs felt mostly or completely knowledgeable in how to care for COVID-19 maternity patients. …”
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Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts by Yangpeng Li, Zhu Liu, Christopher O'Shea, Jianhong Li, Xian Luo, Tangting Chen, Xianhong Ou, Weichao Liu, Guoliang Hao, Christopher L.-H. Huang, Davor Pavlovic, Xiaoqiu Tan, Ming Lei

“…Such CaT and APD alternans occurred mostly semiannually in specific regions of the ventricular pre-occurrence of VT. …”
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EGFR pathway subgroups in Chilean colorectal cancer patients, detected by mutational and expression profiles, associated to different clinicopathological features by Karin Alvarez, Paulina Orellana, Cynthia Villarroel, Luis Contreras, Hiroshi Kawachi, Maki Kobayashi, Ana Maria Wielandt, Marjorie De la Fuente, Juan Carlos Triviño, Udo Kronberg, Pilar Carvallo, Francisco López-Köstner

“…Three groups gather mainly early-stage tumors, whereas a fourth group is mostly conformed by advanced tumors. We described here that 71.4% of tumors from one group have a mutated PI3K/PTEN pathway, in comparison to other groups having 32%, 27%, and 25%. …”
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Mortality risk associated with clinical signs of possible serious bacterial infection (PSBI) in young infants in Africa and Asia: protocol for a secondary pooled analysis by Adejumoke Idowu Ayede, Samir K Saha, Saifuddin Ahmed, Mohammad Shahidul Islam, Gary L Darmstadt, Fabian Esamai, Antoinette Tshefu Kitoto, Ebunoluwa A Adejuyigbe, Yasir Bin Nisar, Shamim Ahmad Qazi, Vaishnavi Bhamidi, Khusbu Adhikari, Ivana Marić, Robinson D Wammanda

“…Moreover, studies to validate the importance of clinical signs of PSBI have mostly used the need for hospitalisation as the outcome. …”
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Effects of indoor biophilic environments on cognitive function in elderly patients with diabetes: study protocol for a randomized controlled trial by Jiajia Dai, Jiajia Dai, Mohan Wang, Han Zhang, Zhengfang Wang, Xue Meng, Xue Meng, Yanan Sun, Yanan Sun, Yuan Sun, Yuan Sun, Wenhui Dong, Zhiying Sun, Kuo Liu, Kuo Liu

“…Previous studies have focused mostly on improving cognition in elderly diabetic patients through three methods: medication, cognitive training, and lifestyle intervention. …”
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Blueprint for clinical N-of-1 strategies with off-label precision treatments in monogenic epilepsies by Victoria M. Defelippe, Eva H. Brilstra, Willem M. Otte, Ghislaine J. M. W. van Thiel, Helen J. Cross, Finbar O’Callaghan, Valentina De Giorgis, Emilio Perucca, Kees P. J. Braun, Floor E. Jansen

“…To date, however, information on the efficacy of these treatments is mostly based on case-reports and retrospective studies. …”
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The Application and Validity of a New Composite Radiographic Index for Patients with Osteonecrosis of the Jaws by Zafeiroula Yfanti, Sotirios Tetradis, Nikolaos G. Nikitakis, Konstantina Eleni Alexiou, Emmanouil Vardas, Christos Angelopoulos, Kostas Tsiklakis

“…Extensive lytic changes, sclerosis, sequestration, periosteal bone formation, and inferior alveolar canal involvement were mostly observed in clinical Stage 3. Furthermore, a statistically significant correlation between clinical stage and CRIm classification was found (rho = 0.446; <i>p</i>-value < 0.001). …”
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MTAP deficiency is highly homogeneous in advanced, muscle-invasive urothelial carcinoma of the urinary bladder by Natalia Gorbokon, Katharina Teljuk, Viktor Reiswich, Florian Lutz, Sebastian Dwertmann Rico, Clara Lühr, Christian Bernreuther, Yaryna Klos Al Bunni, Cosima Völkel, Henning Plage, Maximilian Lennartz, Margit Fisch, Sarah Minner, Ronald Simon, Guido Sauter, Henrik Zecha, Stefan Steurer, Thorsten Schlomm, Tatjana Vlajnic, Lukas Bubendorf, Michael Rink, Martina Kluth, Florian Viehweger, Morton Freytag

“…Among 41 consecutive pT2-4 carcinomas from which 1–15 (average 6.4) whole sections were analyzed, MTAP was homogeneously deficient in 34.1%, heterogeneously deficient in 4.9% and homogeneously retained in 61.0%. MTAP deficiency is mostly homogeneous in advanced urothelial carcinoma. …”
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Pre-infection liver function is associated with all-cause mortality among hemodialysis patients with SARS-CoV-2 Omicron variant infection by Quanchao Zhang, Caibao Lu, Han Wang, Shaofa Wu, Lili Jiang, Jie Li, Zhifen Wu, Bingshuang Tang, Bingfeng Yang, Shengli Liao, Liao Wang, Hongwei Chen, Moqi Li, Wenchang He, Yiqin Wang, Jin He, Jinghong Zhao, Ling Nie

“…The deceased patients were observed to be mostly older males with an increased prevalence of diabetes and tumors, signifying higher AST and C-reactive protein levels. …”
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Interplay between bacterial clones and plasmids in the spread of blaSHV-12- and blaCTX-M-14-carrying Escherichia coli from the livestock environment by Sandra Martínez-Álvarez, Susana Sanz, Pierre Châtre, María de Toro, Carmen Olarte, Pauline François, Isabel Benito, Minerva Viguera, Myriam Zarazaga, Jean-Yves Madec, Marisa Haenni, Carmen Torres

“…IncF-blaCTX-M-14 and IncHI2-blaSHV-12 plasmids carried additional genes mostly inserted in class 1 integrons (intI1-dfrA17-aadA5-qacE-sul1 or intI1-estX-psp-aadA2-cmlA1-aadA-qacL-IS440-sul3 respectively). …”
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Strong He i Emission Lines in High N/O Galaxies at z ∼ 6 Identified in JWST Spectra: High He/H Abundance Ratios or High Electron Densities? by Hiroto Yanagisawa, Masami Ouchi, Kuria Watanabe, Akinori Matsumoto, Kimihiko Nakajima, Hidenobu Yajima, Kentaro Nagamine, Koh Takahashi, Minami Nakane, Nozomu Tominaga, Hiroya Umeda, Hajime Fukushima, Yuichi Harikane, Yuki Isobe, Yoshiaki Ono, Yi Xu, Yechi Zhang

“…We present He i /H β flux and He/H abundance ratios in three James Webb Space Telescope galaxies with significant constraints on N/O abundance ratios, GS-NDG-9422, RXCJ2248-ID, and GLASS150008 at z ∼ 6 mostly with the spectroscopic coverage from He i λ 4471 and He ii λ 4686 to He i λ 7065, and comparing with 68 local dwarf galaxies. …”
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Maternal plasma microRNAs as potential biomarkers for triaging pregnancies of unknown location and ectopic pregnancy diagnosis by Christopher Kyriacou, Sung Hye Kim, Maria Arianoglou, Shabnam Bobdiwala, Margaret Pikovsky, Nina Parker, Jennifer Barcroft, Maya Al-Memar, Phillip R. Bennett, David A. MacIntyre, Tom Bourne, Vasso Terzidou

“…Methods: Plasma was collected from women with PUL/EP (n = 120), mostly between four to eight weeks’ gestation, where outcomes of EP (n = 39), VIUP (n = 58) and NVIUP (miscarriage, n = 23) were determined using TVUS. …”
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Using an objective computer task (QbTest) to aid the identification of attention deficit hyperactivity disorder (ADHD) in the Children and Young People Secure Estate (CYPSE): a fea... by Charlotte Lucy Hall, Bryony Beresford, Prathiba Chitsabesan, Charlotte Lennox, Lesley-Anne Carter, Susan Young, Abdullah Kraam, Lloyd Wilkinson-Cunningham, Mindy Reeves, Vaseem Mohammed, Sally Trowse

“…Participants including clinical staff were mostly supportive of the study and QbTest; however, some young people found QbTest hard and there were issues with implementation of the ADHD care pathway. …”
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Performance of plasma p‐tau217 and NfL in an unselected memory clinic setting by Rebecca Z. Rousset, Thomas Claessen, Argonde C. vanHarten, Afina W. Lemstra, Yolande A. L. Pijnenburg, Wiesje M. van derFlier, Anouk den Braber, Andreas Jeromin, Inge M. W. Verberk, Charlotte E. Teunissen

“…Low p‐tau217/low NfL was associated mostly with non‐neurological diagnoses (79%), and high p‐tau217/low NfL indicated AD pathology at any stage (84%). …”
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Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice by Felix Sommer, Joana P. Bernardes, Lena Best, Nina Sommer, Jacob Hamm, Berith Messner, Víctor A. López-Agudelo, Antonella Fazio, Georgios Marinos, A. Samer Kadibalban, Go Ito, Maren Falk-Paulsen, Christoph Kaleta, Philip Rosenstiel

“…Recent findings, which have been derived mostly in simple animal models, have even established a causal relationship between age-related microbial shifts and lifespan, suggesting microbiota-directed interventions as a potential tool to decelerate aging processes. …”
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A seven-year electroretinography follow-up of a patient with melanoma-associated retinopathy stabilized on pembrolizumab treatment by Raz Tshuva-Bitton, Michael Ostrovsky, Vicktoria Vishnevskia-Dai, Nancy Agmon-Levin, Ifat Sher, Ygal Rotenstreich

“…While OCT and ERG showed mostly concordant results over the patient's follow-up, ERG proved to be a more sensitive tool for the early diagnosis of MAR. …”
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