Shaping national rare diseases definition in Saudi Arabia: outcome from health ecosystem multisectoral workshop by Ghada Mohammed Abozaid, Ghada Mohammed Abozaid, Hussain Abdulrahman Al-Omar, Abdulaziz Alrabiah, Hiba Alomary, Amy Jayne McKnight

“…Among quantitative criteria, “Prevalence” (82%) emerged as the most accepted, aligned with international practices, although opinions were mixed on the inclusion of population size thresholds, underscoring the definitional complexity of defining RDs with both precision and flexibility.DiscussionThis study provides a foundational basis and scientific root for defining rare diseases in the Saudi context, addressing key gaps in healthcare policies. …”
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Exploring Long Covid Prevalence and Patient Uncertainty by Sociodemographic Characteristics Using GP Patient Survey Data by Mirembe Woodrow, Nida Ziauddeen, Dianna Smith, Nisreen A. Alwan

“…Improved awareness is needed amongst the general population and health care professionals to ensure those most vulnerable in society are identified and provided with care and support. …”
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A multimodal deep learning architecture for predicting interstitial glucose for effective type 2 diabetes management by Muhammad Salman Haleem, Daphne Katsarou, Eleni I. Georga, George E. Dafoulas, Alexandra Bargiota, Laura Lopez-Perez, Miguel Rujas, Giuseppe Fico, Leandro Pecchia, Dimitrios Fotiadis, Gatekeeper Consortium

“…While recent advances in deep learning enable modeling of temporal patterns in glucose fluctuations, most of the existing methods rely on unimodal inputs and fail to account for individual physiological differences that influence interstitial glucose dynamics. …”
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Forecasting the development of poultry farming based on time series by Anatolii Kulyk, Katerina Fokina-Mezentseva, Alla Saiun, Daryna Saiun

“…The findings confirm an increasing trend in the time series and demonstrate that the SARIMAX model outperforms the alternatives, providing the most precise forecasts for the next two years. …”
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Implications of machine learning techniques for prediction of motor health disorders in Saudi Arabia by Ehab M. Almetwally, I. Elbatal, Mohammed Elgarhy, Amr R. Kamel

“…The RF technique achieves the largest area under the curve, and the RF technique is the most effective of all ML algorithms, according to the results of the applied ML algorithms. …”
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Optimizing Breeding Strategies for Pekin Ducks Using Genomic Selection: Genetic Parameter Evaluation and Selection Progress Analysis in Reproductive Traits by Jun Zhou, Jiang-Zhou Yu, Mei-Yi Zhu, Fang-Xi Yang, Jin-Ping Hao, Yong He, Xiao-Liang Zhu, Zhuo-Cheng Hou, Feng Zhu

“…Although genomic selection is thought to remedy this shortcoming, most studies now use simulated data or one or two generations of data to assess its effects. …”
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17β-Estradiol Promotes Tumorigenicity Through an Autocrine AREG/EGFR Loop in ER-α-Positive Breast Cancer Cells by Sun Young Yoon, Yisun Jeong, Jai Min Ryu, Se Kyung Lee, Byung Joo Chae, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Sangmin Kim, Jeong Eon Lee

“…Here, we investigated how ER activation by 17β-estradiol (E2), the most potent form of estrogen, affects the expression or activity of EGFR or EGFR-related genes in ER+ breast cancer cells. …”
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Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights by Sayed M. S. Abo El-Souad, Mohamed A. Dawoud, Mahmoud Ibrahim, Mona M. Soliman

“…The crude extract of A. niger was developed to identify the chemical constituents by gas chromatography. The most active component in the extract, as analyzed by 1H NMR, revealed that 2,2,4,4-tetramethylpentane was the primary compound responsible for these effects, which demonstrated significant inhibitory activity against Staphylococcus aureus and Bacillus cereus, with inhibition zones of 23 mm and 20 mm, respectively. …”
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Elucidating the role of fatty acid reprogramming in ovarian cancer: insights cross-talk between blood, subcutaneous fat, and ovarian cancer tissues by Xiaocui Zhong, Mamona Bilal, Yanqiu Zhou, Xiaojia Yang, Zuchao Qin, Qibing Li, Yang Yang, Ting-Li Han, Ting-Li Han, Min Li

“…Furthermore, receiver operating characteristic (ROC) analysis highlight that three plasma FA showed the best specificity and sensitivity in differentiating the OC group from the NC group (Area Under The Curve, AUC > 0.89), including caprylic acid, myristoleic acid, and tetracosaenoic acid. Most of the significant FA in subcutaneous fat and ovarian tissue showed a high risk of OC. …”
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Quand le débat public échoue à prévenir le conflit : retour sur la contestation d’un projet industriel de transition énergétique dans les Landes (France) by Sylvie Clarimont

“…In France, citizen participation has been encouraged by a significant legislative trend since the 1980s and 1990s, which has led to the implementation of various types of public consultation processes (Raymond, 2009), some permanent, others temporary and most of which now have to include the participation of residents (Blondiaux, 2008; Muller, 2005). …”
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Cervix cytology samples revealed increased methylation of the human markers FAM19A4/miR124‐2 up to 8 years before adenocarcinoma by Ylva Lindroth, Louise Pedersen, Jacob Alssamaray, Tim Berglund, Avalon Sundqvist, Christer Borgfeldt, Ola Forslund

“…HPV‐testing has a high sensitivity to identify women at risk to develop cancer, and has been implemented in cervical screening programs in several countries. But in most HPV‐positive women the infection will clear and they will not develop cancer. …”
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Clinical management and analysis of immune-related adverse events in neoadjuvant immunotherapy for locally advanced rectal cancer by AN Yang, WANG Chentong, QIU Xiaoyuan, ZHOU Jiaolin, LIN Guole

“…Endocrine toxicities were most frequent (36.6%, 15/41), primarily characterized by progression from hyperthyroidism to hypothyroidism; 75.0% required thyroid hormone replacement therapy. …”
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The epidemiology of infectious meningitis in Ghana: a systematic review and meta-analysis by Samuel A. Akwetey, Abdul-Halim Osman, Fleischer C. N. Kotey, Aaron Awere-Duodu, Alex Odoom, Bismark Opoku-Asare, Eric S. Donkor

“…All bacterial isolates from meningitis cases were susceptible to ceftriaxone. The most common Neisseria meningitidis serogroups were W135, A, Y, and X, while Serotype 1 dominated among the Streptococcus pneumoniae serotypes. …”
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Sedimentary environment and organic matter accumulation of Wufeng-Longmaxi shales, southwest Yangtze Plate, China: Insights from geochemical and petrological evidence by An-kun Zhao, Dong Wang, Qian Zhang, Zi-hui Lei, Qian Yu, Di Zhang, Ye-xin Zhou

“…ABSTRACT: Upper Ordovician–Lower Silurian Wufeng-Longmaxi Formation is the most developed strata of shale gas in southern China. …”
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Epidemiological trends of urolithiasis in working-age populations: Findings from the global burden of disease study 1990-2021. by Weitao Yao, Xin Wei, Qiang Jing, Xiaobin Yuan, Fan Liu, Xuhui Zhang

“…<h4>Background</h4>One of the most prevalent urinary disorders worldwide, urolithiasis has symptoms and a high rate of recurrence. …”
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Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study by Yuhui Chen, Li Chen, Liang Xian, Haibing Liu, Jiaxing Wang, Shaohuai Xia, Liangfeng Wei, Xuewei Xia, Shousen Wang

“…Conclusions The implementation of our proposed OTBI classification system and its use alongside the other prognostic factors identified here may improve the prediction of patient prognosis and aid in the selection of the most suitable treatment strategies.…”
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Predictability of Air Pollutants Based on Detrended Fluctuation Analysis: Ekibastuz Сoal-Mining Center in Northeastern Kazakhstan by Oleksandr Kuchanskyi, Andrii Biloshchytskyi, Yurii Andrashko, Alexandr Neftissov, Svitlana Biloshchytska, Sergiy Bronin

“…Environmental comfort and air pollution are among the most important indicators for assessing the population’s quality of life in urban agglomerations. …”
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Global, regional and national burdens of bipolar disorders in adolescents and young adults: a trend analysis from 1990 to 2019 by Yifan Chen, Long Sun, Meiqi Wang, Yunxi Zhong, Xiaoying Su, Qixiu Li, Ziming Shao

“…At the national level, the most pronounced increase in the incidence was in Greenland.Conclusions The global increase in incidence among adolescents and young adults between 1990 and 2019 indicates that strategies to improve their mental health still need to be emphasised.…”
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Fostering open science and responsible research practices: A pre-post study [version 1; peer review: 1 approved, 2 approved with reservations] by Marcos Britto Correa, Jaisson Cenci, Lex Bouter, Fausto Medeiros Mendes, David Moher, Maximiliano Sérgio Cenci, Marie Charlotte Huysmans, Tatiana Pereira-Cenci, Marina Christ Franco, Ewald Bronkhorst

“…Conclusions The number of participants’ OSF outputs showed little or no improvement after the intervention. The most important impact difference could be identified in terms of the participants’ perceptions and intentions to adhere to such practices in the future.…”
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A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma by Christophe-Sébastien Arnold, Anna-Maria Alazzi, Serena Shunmugam, Jan Janouškovec, Laurence Berry, Sarah Charital, Thierry Gautier, Samuel Duley, Delphine Jublot, Catherine Lemaire-Vieille, Marie-France Cesbron-Delauw, Pierre Cavailles, Jérôme Govin, Nicholas J. Katris, Yoshiki Yamaryo-Botté, Cyrille Y. Botté

“…Lipidomic analyses and stable isotope labelling reveal a unique accumulation of C14:0 in the apicoplast, which is then lacking in most major lipid classes subsequently synthesized in the ER. …”
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