Photophysical Properties and Protein Binding Studies of Piperazine-Substituted Anthracene-BODIPY Dyads for Antimicrobial Photodynamic Therapy by Stephen O’Sullivan, Leila Tabrizi, Kaja Turzańska, Ian P. Clark, Deirdre Fitzgerald-Hughes, Mary T. Pryce

“…Antimicrobial activity of <b>BDP-1</b> and <b>BDP-2</b> was most potent when irradiated at 370 nm compared to the other wavelengths employed. …”
Get full text

The infection characteristics and autophagy defect of dermal macrophages in STZ‐induced diabetic rats skin wound Staphylococcus aureus infection model by Xiaoying Xie, Rihui Zhong, Ling Luo, Xianghua Lin, Lisi Huang, Songyin Huang, Lijia Ni, Baiji Chen, Rui Shen, Li Yan, Chaohui Duan

“…Staphylococcus aureus (S. aureus), most frequently detected in DFI, recently was suggested as an intracellular pathogen that can invade and survive within mammalian host cells. …”
Get full text

Comprehensive genomic epidemiology and antimicrobial resistance profiles of clinical Klebsiella pneumoniae species complex isolates from a tertiary hospital in Wenzhou, China (2019... by Weiyan Jiang, Yanhui Chen, Meimei Lai, Yongan Ji, Suzhen Lin, Jiao Shao, Xiaojian Chen

“…Results All CRKP isolates exhibited high levels of resistance to carbapenems, cephalosporins, and aminoglycosides. The most prevalent carbapenemase genes were bla KPC−2 (100%), with significant associations between bla KPC−2 and ST11. …”
Get full text

CLINICAL INDICES OF DENTAL STATUS OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASES by N. Yu. Yemelyanova

“…The main stomatologic complaints of all patients are dryness in the oral cavity, taste distortion, halitosis and hyperesthesia. The most common complaint of the vast majority of all patients was dryness in the oral cavity, which, in the respondents' opinion, was associated with the basic therapy of somatic disease. …”
Get full text

MRI-based deep learning and radiomics for predicting the efficacy of PD-1 inhibitor combined with induction chemotherapy in advanced nasopharyngeal carcinoma: A prospective cohort... by Yiru Wang, Fuli Chen, Zhechen Ouyang, Siyi He, Xinling Qin, Xian Liang, Weimei Huang, Rensheng Wang, Kai Hu

“…The random forest algorithm was employed to identify the most valuable features. A prediction model was then created using these radiomic characteristics and DLFs to determine the effectiveness of PD-1 inhibitor combined with GP chemotherapy. …”
Get full text

Precision Oral Medicine: A DPR Segmentation and Transfer Learning Approach for Detecting Third Molar Compress Inferior Alveolar Nerve by Yuan-Jin Lin, Shih-Lun Chen, Yi-Cheng Mao, Tsung-Yi Chen, Cheng-Hao Peng, Tzu-Hsiang Tsai, Kuo-Chen Li, Chiung-An Chen, Wei-Chen Tu, Patricia Angela R. Abu

“…Extraction of the third molar of the mandible is one of the most common oral surgical procedures. Preoperative monitoring and assessment are crucial to mitigate neurological risks. …”
Get full text

Longitudinal efficacy of risdiplam treatment in Chinese children with spinal muscular atrophy by Yue Yan, Danhui Zhu, Kai Ma, Xufeng Luo, Xiaoli Zhang, Xiaolong Deng, Mei Lu, Yang Li, Jianwei Li, Feng Gao, Shanshan Mao

“…The CHOPINTEND score increased by 1.8 points/month (95%CI 0.8 to 2.9, p = 0.001) in children with short disease duration before treatment, 2.7 points/month (95%CI 2.4 to 3.0, p < 0.001) in children with type 1 and 2.7 points/month (95%CI 2.1 to 3.3, p < 0.001) in patients with 2 copies of survival motor neuron 2 gene. Pneumonia was the most frequently reported adverse event, whereas laboratory tests yielded no unusual findings. …”
Get full text

“Us” or “Them”: Internal Migrants in the Perceptions of the Siberian Cities’ Citizens (on the Example of Irkutsk, Krasnoyarsk and Tomsk) by Dmitry O. Timoshkin, Fedor A. Smetanin, Diana E. Gorshkova, Andrei A. Voloshin, Kirill A. Ivanov, Iuliia O. Koreshkova, Arina E. Sorokina, Sofiya A. Ignatenko, Galina A. Shaposhnikova-Murashova

“…The study examines the process of civic identity formation in contemporary Russia in relation to the production and crossing of boundaries between “imagined communities”. Most existing research focuses on how cross-border migration influences the host community’s rethinking of its identity. …”
Get full text

Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China by Liu Yang, Huiyu Gao, Ying Wang, Dan Norbäck, Zhuohui Zhao, Xi Fu, Yu Sun, Xin Zhang

“…Rhinitis is one of the most common respiratory diseases, influenced by various environmental factors such as green space, air pollution and indoor microbiomes. …”
Get full text

MicroRNA-143-3p and miR-452-5p: A Fingerprint for the Diagnosis of Aortic Stenosis in the Geriatric Population by Mónica Ramos, Francisco Javier Enguita, Fernando Bonet, Rocío Ayala, Francisco Javier Gómez-Pavón, Oscar Campuzano, Rocío Toro, Maribel Quezada-Feijoó

“…<b>Background/Objectives:</b> Aortic stenosis (AS) is the most common valvular pathology in the geriatric population and is the primary cause of valve replacement. …”
Get full text

Is National Early Warning Score (NEWS) effective in older populations with acute illnesses? by Luke Oakes, Ella Riley, Amna Riaz, Radhiya Bakth, David Goldsmith, Vibhor Barve, Zahra Nejad, Sarah Md Fuad, Kausik Chatterjee

“…Results and Discussion: Among 94 patients (mean age 84±7 years), 11,871 NEWS alerts were analysed. Most alerts occurred between days 10 and 20 post-admission, indicating possible delays in identifying clinical decline. 73% of patients were discharged home, 23% to care facilities and 3% died. …”
Get full text

A Novel Percutaneous Volume Reduction Technique for Giant Emphysematous Bullae: Combined Percutaneous Erythromycin Sclerotherapy With Bronchoscopic Occlusion by Wang Z, Liu Z, Zhang W, Liu W, Tan J, Li X, Wu H, Li Y, Deng H, Chen J, Chen L

“…In addition, the major postoperative complications included pneumothorax (36 cases, 51%) and pleural effusion (44 cases, 63%). Most of the symptoms were mild and improved after symptomatic treatment for the involved patients. …”
Get full text

Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS by Shilpa S. Dhar, Calena Brown, Ali Rizvi, Lauren Reed, Sivareddy Kotla, Constantin Zod, Janak Abraham, Jun-Ichi Abe, Veena Rajaram, Kaifu Chen, Min Gyu Lee

“…Summary: The histone H3 lysine 4 (H3K4) methyltransferase KMT2D (also called MLL4) is one of the most frequently mutated epigenetic modifiers in many cancers, including medulloblastoma (MB). …”
Get full text

Framework for developing self-actualization skills in young adults with autism by Megumi J. Okumura, Sarah Kate Selling, Allison Uba, Susanne P. Martin-Herz, Heidi H. Seretan, Lisa Rosene, Jacy Cohen, Kathleen P. Tebb, Roberta S. Rehm

“…Conclusions: Self-actualization for adults requires skills for self-care, decision making, and effective communication. Unfortunately, most programs for YAASD emphasize vocational and simple task performance. …”
Get full text

A cone beam CT study on the changes in oropharyngeal airway parameters and hyoid position in skeletal Class Ⅱ adult female patients with different vertical skeletal types treated w... by SHEN Jiaoxiang, CHEN Zhaozheng, LIN Yihui, SU Jingjing, HUANG Wenxia

“…In the hyperdivergent group, the oropharyngeal area at the level of the epiglottis tip (OPA-E), anterior-posterior diameters of the oropharynx at the level of the epiglottis tip (E-AP), most constricted axial area of the oropharynx (OPA-MCA), and anterior-posterior diameters of MCA area of the oropharynx (MCA-AP) decreased after treatment (<i>P</i>&lt;0.001). …”
Get full text

Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis by Shridhar Bale, Elena Gustchina, Javier Guenaga, Victor Ayala, Wen-Hsin Lee, Gabriel Ozorowski, Stephen Whitney, Richard Wilson, Sabyasachi Baboo, Jolene K. Diedrich, Esmeralda D. Doyle, Lauren Hudacik, Elana Ben-Akiva, Kristen A. Rodrigues, Darrell J. Irvine, John R. Yates, James C. Paulson, Andrew B. Ward, Timothy Fouts, Richard T. Wyatt

“…The transient process circumvents the need to develop stable cell lines expressing the Env trimers that is often the most time-consuming step impacting vaccine development timelines. …”
Get full text

Estimated direct costs of non‐small cell lung cancer by stage at diagnosis and disease management phase: A whole‐disease model by Alessandra Buja, Michele Rivera, Anna De Polo, Eugenio di Brino, Marco Marchetti, Manuela Scioni, Giulia Pasello, Alberto Bortolami, Vincenzo Rebba, Marco Schiavon, Fiorella Calabrese, Giovanni Mandoliti, Vincenzo Baldo, PierFranco Conte

“…This study estimated the direct costs of care for patients with NSCLC by stage at diagnosis, and management phase of pathway recommended in local and international guidelines. Methods Based on the most up‐to‐date guidelines, we developed a very detailed “whole‐disease” model listing the probabilities of all potentially necessary diagnostic and therapeutic actions involved in the management of each stage of NSCLC. …”
Get full text

Micro-climate of nature-based solutions in stockholm royal seaport by Artur Branny, Erik Andersson, Timon McPhearson

“…We aimed to quantify to what extent NbS are contributing to ecosystem services such as cooling.To answer this, we installed eighteen microsensor weather stations across the biggest and most recent sustainable urban development in Sweden - Stockholm Royal Seaport. …”
Get full text

Progressive resistance and flexibility exercises versus usual care advice for improving pain and function after distal radius fracture in adults aged 50 years or over: protocol for... by David J. Keene, Juul Achten, Ioana Marian, Marloes Franssen, Elizabeth Tutton, Warren Sheehan, Colin Forde, Hannah Crook, Jenny Gould, Richard Grant, Duncan Appelbe, Sarah E. Lamb, Matthew L. Costa

“…Aims: Distal radius fractures are very common injuries; the majority affect females aged 50 years or over. Most patients experience pain and stiffness in their wrist and upper limb weakness, making activities of daily living difficult. …”
Get full text

Risk prediction of QTc prolongation occurrence in cancer patients treated with commonly used oral tyrosine kinase inhibitors: machine learning modeling or conventional statistical... by Hsiang-Wen Lin, Tien-Chao Lin, Chien-Ning Hsu, Tzu-Pei Yeh, Yu-Chieh Chen, Liang-Chih Liu, Chen-Yuan Lin

“…Baseline QTc prolongation and a history of cardiovascular disease (excluding arrhythmia, cardiomyopathy, etc.) contributed the most to incremental risk probability (0.471 and 0.282, respectively), after controlling for other factors. …”
Get full text