Advancing Monoclonal Antibody Manufacturing: Process Optimization, Cost Reduction Strategies, and Emerging Technologies by Ranbhor R

“…Future developments in continuous processing, advanced analytics, and cell line engineering will be essential in meeting growing global demand while ensuring economic viability and accessibility of mAb therapeutics.Plain Language Summary: Though monoclonal antibodies (mAbs) have changed therapy for cancer and autoimmune illnesses, they struggle with accessibility because of manufacturing complexity and high cost.Our analysis shows: continuous processing provides up to 35% cost reductions for 100– 500kg annual production in comparison to batch techniques; hybrid facilities reach break-even 2– 5 years sooner than conventional setups; and innovative tripeptide delivery systems increase mAb titers by 35%.The combination of machine learning and sophisticated analytics is most encouraging since it allows real-time monitoring and parameter modification to enhance product uniformity and resource use.These developments could increase patient access by opening doors to more reasonably priced mAb therapies, and they could also enhance manufacturing economic conditions for manufacturers. …”
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Winter wheat productivity and grain quality while minimizing agricultural techniques in the conditions of the Central Blackearth Region by I. I. Gureev, A. V. Gostev, L. B. Nitchenko, V. A. Lukiyanov, S. V. Khlyupina, I. A. Prushchik

“…The minimization of primary tillage methods in most cases has contributed to a decrease of winter wheat productivity, content of gluten, protein, and grain nature weight, compared with plowing. …”
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Accuracy of Large Language Models for Infective Endocarditis Prophylaxis in Dental Procedures by Paak Rewthamrongsris, Jirayu Burapacheep, Vorapat Trachoo, Thantrira Porntaveetus

“…All LLMs had a narrower confidence interval with a pre-prompt, and most, except Claude 3 Opus, showed improved performance. …”
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Ecological testing results of the winter bread wheat varieties and lines developed in the FSBSI «ARC «Donskoy» in the Kursk region by A. Ya. Aidiev, D. M. Marchenko, М. М. Ivanisov, А. А. Emeliyanova, E. V. Logvinova

“…As a result of ecological testing, there has been identified a number of varieties and lines that are most adapted to the soil and climatic conditions of the Kursk region. …”
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Prognosis and postoperative surveillance of benign ovarian tumors in children: a single-center retrospective study by XiaoLi Chen, DuoTe Cai, Yi Chen, Weiwei Chen, YueBin Zhang, ZhiGang Gao, QingJiang Chen

“…Annual imaging follow-up for at least 3 years postoperative can detect most recurrence cases.…”
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Epidemiological and demographic drivers of ischemic stroke attributed to high fasting plasma glucose from 1990 to 2021: findings from the 2021 global burden of disease study by Yanwen Dong, Yangyang Wang, Yangyang Wang, Xiaomei Lan, Xiaomei Lan, Huiyan Zeng

“…In contrast, in low, low-middle, and middle SDI regions, the population remains the most significant influence, with the impact of aging increasing. …”
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Pelvic nerve endometriosis: MRI features and key findings for surgical decision by Justine Bourg, Edouard Ruaux, Pierre Adrien Bolze, Marie Gavrel, Mathilde Charlot, François Golfier, Isabelle Thomassin-Naggara, Pascal Rousset

“…Nerve involvement typically results from the direct extension of deep infiltrating endometriosis, though it may also occur in isolation. The nerves most commonly affected include the inferior hypogastric and lumbosacral plexuses, as well as the sciatic, pudendal, obturator, and femoral nerves. …”
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Mineral supplementation by artificial salt licks is comparatively effective as natural salt licks for Malaysian mammals by Nor Bazilah Razali, Mohammad Saiful Mansor, Farah Ayuni Farinordin, Mohd Izzat-Husna Ahmad Zaini, Siti Hajar Atiqah Razali, Pazil Abdul Patah, Shahril Mod Husin, Mohamed Shah Redza Hussein, Shukor Md Nor

“…Results Twenty-nine mammal species were identified across salt licks, with 16 species being salt lick users, including eight herbivorous, five frugivorous and three carnivorous mammals, most of which moved in groups and solitarily. The mammal species assemblages across both salt lick and habitat types demonstrated a predominantly nested pattern, with herbivorous and frugivorous mammals being the primary users. …”
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Isolated Feet Edema in Turner Syndrome by Prenatal Ultrasonography – Case Report and Literature Review by Ma J, Liang L, Liu S, Yan K, Zhang L

“…Jing Ma,* Li Liang,* Shanshan Liu, Kailin Yan, Li Zhang Department of Ultrasound Medicine, Tangdu Hospital, Air Force Medical University, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zhang, Department of Ultrasound Medicine, Tangdu Hospital, 569# Xinsi Road, Baqiao District, Xi’an, People’s Republic of China, Email lilyzhang319_20@hotmail.comPurpose: Turner syndrome (TS), also known as congenital ovarian hypoplasia syndrome, is a sex chromosome abnormality caused by a complete/partial absence of the second sex chromosome with complete X chromosome. The most common findings by prenatal ultrasonography of TS include thickened nuchal translucency, cystic hygroma, cardiovascular system abnormalities, urinary system diseases, and growth retardation.Case Presentation: We present a unique case of TS with the ultrasonographic features of dorsal skin edema on both feet and a progressive slow growth of humerus length (HL) and femur length (FL) at the second trimester of spontaneous pregnancy. …”
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Real-world study of first-line immunotherapy combined with chemoradiotherapy in esophageal squamous cell carcinoma by Xiaohan Zhao, Chengang Weng, Wuhan Yang, Hongmei Gao, Hesong Wang, Wenzhao Deng, Shuchai Zhu, Wenbin Shen

“…Notably, 36.7% experienced grade ≥ 2 trAEs, bone marrow suppression most commonly happened, and 5.1% developed esophageal fistulas. …”
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The current status of nano-hydrogel preparations for osteochondral repair: Systematic Review by Abebe Feyissa Amhare, Abebe Feyissa Amhare, Lichun Qiao, Huan Deng, Jinyan Lin, Jun Wang, Wei Wang, Jing Han

“…Studies varied in scaffold design, bioactive integration, and fabrication techniques. Most nano-hydrogels demonstrated high biocompatibility, tunable degradation, and enhanced tissue integration. …”
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Gendered lives, gendered Vulnerabilities: An intersectional gender analysis of exposure to and treatment of schistosomiasis in Pakwach district, Uganda. by Sarah N Ssali, Rosemary Morgan, Salama Nakiranda, Christopher K Opio, Mariam Otmani Del Barrio

“…Using the World Health Organisation (WHO)'s intersectional gender analysis toolkit, this study was undertaken to identify which social stratifiers most intersected with gender to influence vulnerability to and access to treatment for schistosomiasis disease, to understand how best to implement interventions against it.…”
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Efficacy of alpelisib with rational use of metformin in HR+/HER2- advanced breast cancer patients with <i>PIK3CA</i> mutations (m): retrospective analysis in routine practice of se... by D. A. Filonenko, R. V. Orlova, M. I. Gluzman, A. A. Vakhitova, A. Yu. Goryainova, K. S. Grechukhina, I. I. Bykonya, L. G. Zhukova

“…We suggest that prophylactic of HG allowed maintenance of full dose of ALP in most patients and thus increased the efficacy of ALP. …”
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Whole genome analysis reveals the distribution and diversity of plasmid reservoirs of NDM and MCR in commercial chicken farms in China by Xuan Wu, ZhiRong Zhang, Rong Xiang

“…IncX3 (n = 57) and IncFII (n = 5) were the most common blaNDM-5-carrying plasmid types. Several plasmid replicons were associated with mcr genes, including IncI2, IncX4, and novel plasmids. …”
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Phytochemical profiling, in silico molecular docking for antioxidant activity, and corrosion inhibition properties of Pistacia lentiscus L. extract by Mouhcine Hayani, Tariq Benabbouha, Nidal Naceiri Mrabti, Said Eljebri, Mohammed Bouskout, Abeer Hashem, Nouf H. Alotaibi, Ajay Kumar, Elsayed Fathi Abd_Allah, Touriya Zair

“…Six phenolic compounds were identified by high-performance liquid chromatography, with gallic acid being the most abundant (91.70 ± 0.43 mg/g), followed by rutin (5.25 ± 0.01 mg/g) and parahydroxybenzoic acid (2.83 ± 0.01 mg/g). …”
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Prediction of Alzheimer’s Disease Based on Multi-Modal Domain Adaptation by Binbin Fu, Changsong Shen, Shuzu Liao, Fangxiang Wu, Bo Liao

“…However, the structure and semantics of different modal data are different, and the distribution between different datasets is prone to the problem of domain shift. Most of the existing methods start from the single-modal data and assume that different datasets meet the same distribution, but they fail to fully consider the complementary information between the multi-modal data and fail to effectively solve the problem of domain distribution difference. …”
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The Effectiveness of the Method Chiva in Patients with Chronic Venous Insufficiency and Comorbid Lesions: own Experience by Yarka A.

“…Chronic venous insufficiency (CVI) of the lower extremities is one of the most popular topics both in vascular surgery and the entire practice of medicine. …”
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Diagnostic Accuracy of Pre-Biopsy MRI and CT Features for Predicting Vertebral Biopsy Yield in Suspected Vertebral Discitis Osteomyelitis: A Retrospective Single-Center Study by Amirmasoud Negarestani, Andrew Pasion, Caleb Bhatnagar, Zuhaib Khokhar, Ashima Kundu, Samantha Diulus, Jorge P. Parada, Emad Allam

“…These scoring systems may help clinicians identify patients most likely to benefit from biopsy, potentially improving outcomes and minimizing unnecessary procedures.…”
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Differential effects of work and socioeconomic status on breastfeeding duration in times of crisis by Chadia Haddad, Paula Hage Boutros, Hala Sacre, Rana Rizk, Cosette Fakih EL Khoury, Bahia Abdallah, Joanne Karam, Pascale Salameh

“…Higher education, favorable breastfeeding attitude, and fasting during breastfeeding were the most important correlates with breastfeeding duration, particularly among women of lower socioeconomic status. …”
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Linking Volcanism, Hydrothermal Venting, and Ordovician/Silurian Marine Organic-Rich Sediments in the Eastern Sichuan Basin, Southwest China by Shaojie Li, Zhou Zhu, Qilin Xiao, Suyang Cai, Huan Li

“…Such a feature may further suggest that most pyrites are precipitated during hydrothermal venting. …”
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