Dissolved oxygen and nitrates gradient influence marine microbial complexity and stability in Beibu Gulf by Qing He, Qingxiang Chen, Xinyi Qin, Shengyao Zhou, Rajapakshalage Thashikala Nethmini, Gonglingxia Jiang, Qinghua Hou, Xiaolei Li, Laizhen Huang, Ke Dong, Lingling Xie, Nan Li

“…Deterministic processes significantly structured bacterial communities. The BL had the most complex network, while the ML showed the highest stability. …”
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Species diversity estimation in a typical tropical forest: which phenological stage and spatial resolution are suitable? by Ping Zhao, Ping Zhao, Ping Zhao, Yuan Zeng, Yuan Zeng, Yuan Zeng, Zhaoju Zheng, Zhaoju Zheng, Cong Xu, Cong Xu, Jinchen Wu, Jinchen Wu, Jinchen Wu, Xuan Mu, Xuan Mu, Xuan Mu, Zhaofu Zhou, Zhaofu Zhou, Zhaofu Zhou, Junhua Chen, Junhua Chen, Junhua Chen, Tao Zhang, Dan Zhao, Dan Zhao, Dan Zhao

“…Among four types of heterogeneity metrics, spectral information consistently explained most variance in species diversity indices across all periods. …”
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Development and external validation of a risk prediction score (DASHI) for cardiovascular events following acute respiratory infections: derivation and validation retrospective coh... by Joseph J. Lee, Constantinos Koshiaris, Cynthia Wright-Drakesmith, Jennifer A. Davidson, Charlotte Warren-Gash, F.D. Richard Hobbs, James P. Sheppard

“…We derived a clinical prediction score from the most parsimonious logistic regression model. We validated each model and the score in the external dataset using C statistics, calibration plots, and expected to observed ratios. …”
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Development and validation of a machine learning-based risk prediction model for stroke-associated pneumonia in older adult hemorrhagic stroke by Yi Cao, Yi Cao, Haipeng Deng, Shaoyun Liu, Xi Zeng, Yangyang Gou, Weiting Zhang, Yixinyuan Li, Hua Yang, Min Peng

“…The results indicated that among the four machine learning algorithms (XGBoost, LR, SVM, and Naive Bayes), the LR model demonstrated the best and most stable predictive performance. Age, smoking, low GCS score, low Braden score, and nasogastric tube were identified as predictive factors for SAP in these patients. …”
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Discordance between physical and cognitive health problems over one year after critical care: Insights from severe COVID-19 patients by Leandro U. Taniguchi, Natalia G. Gonçalves, Naomi V. Ferreira, Laiss Bertola, Thiago J. Avelino-Silva, Murilo B. Dias, Ludhmila A. Hajjar, Wilson Jacob-Filho, Claudia K. Suemoto, Márlon J.R. Aliberti

“…Physical and/or cognitive problems were experienced in 83% of responders at least once during follow-up, and half reported any problem even after one year. Most participants experienced health problems in a single health domain, with co-occurrence less than 9% in every assessment (Cramer’s V bias-corrected less than 0.1 in any assessment). …”
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Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arth... by Raquel López-Mejías, Fernanda Genre, Mercedes García-Bermúdez, Begoña Ubilla, Santos Castañeda, Javier Llorca, Carlos González-Juanatey, Alfonso Corrales, José A. Miranda-Filloy, Trinitario Pina, Carmen Gómez-Vaquero, Luis Rodríguez-Rodríguez, Benjamín Fernández-Gutiérrez, Alejandro Balsa, Dora Pascual-Salcedo, Francisco J. López-Longo, Patricia Carreira, Ricardo Blanco, Javier Martín, Miguel A. González-Gay

“…Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. …”
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Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk by Yan Ma, Yongjun Wang, Renzheng Chen, Yabin Wang, Yan Fang, Cheng Qin, Tianhu Wang, Xiaoying Shen, Tingwen Zhou, Lei Tian, Ting Sun, Li Fan, Xiaoning Wang, Dong Han, Feng Cao

“…Abstract Doxorubicin (DOX) is the most effective chemotherapeutic for breast cancer, but it is usually associated with severe cardiotoxicity. …”
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Clinical Outcomes in Non Valvular Atrial Fibrillation Patients Receiving Oral Anticoagulation Therapy using CHA2DS2-VASc and HAS-BLED Scores: A Cohort Study from Western Gujarat, I... by Sohilkhan Riyazkhan Pathan, Bharat M Gajjar, Sunilkumar Karna, Kushal Pujara

“…Introduction: Non Valvular Atrial Fibrillation (NVAF) is one of the most common sustained arrhythmias. The Congestive heart failure, Hypertension, Age, Diabetes, Stroke/TIA (or Thrombembolism), Vascular disease, Age, Sex category (for CHA2DS2-VASc) score, which includes Congestive heart failure, Hypertension, Age ≥75 (doubled), Diabetes, Stroke (doubled), Vascular disease, Age 65-74 and Sex category (female), as well as the Hypertension, Abnormal Renal/Liver function, Stroke, Bleeding history or predisposition, Labile International Normalised Ratio (INR), Elderly, Drugs/alcohol concomitantly (for HAS-BLED)-comprising Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly and Drugs/alcohol concomitantly-assists in assessing bleeding risk. …”
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Research on Habitat and Species Diversity of Spontaneous Plants in the Dujiangyan Canal Corridors by Rui HAN, Qingjuan YANG

“…These species encompass 10 life forms, with perennial herbaceous plants being the most abundant, followed by annual and biennial herbaceous plants. …”
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Generative AI/LLMs for Plain Language Medical Information for Patients, Caregivers and General Public: Opportunities, Risks and Ethics by Pal A, Wangmo T, Bharadia T, Ahmed-Richards M, Bhanderi MB, Kachhadiya R, Allemann SS, Elger BS

“…Responses were reported to be reasonably accurate and sufficiently readable and detailed. The most commonly reported risks were oversimplification, over-generalization, lower accuracy in response to complex questions, and lack of transparency regarding information sources. …”
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Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia by Meaghan M. Broman, Nadia A. Lanman, Nadia A. Lanman, Renee E. Vickman, Renee E. Vickman, Gregory M. Cresswell, Harish Kothandaraman, Andree Kolliegbo, Juan Sebastian Paez Paez, Juan Sebastian Paez Paez, Alexander P. Glaser, Alexander P. Glaser, Brian T. Helfand, Brian T. Helfand, Gervaise Henry, Douglas W. Strand, Omar E. Franco, Simon W. Hayward, Simon W. Hayward, Timothy L. Ratliff, Timothy L. Ratliff

“…IntroductionBenign prostatic hyperplasia (BPH) is among the most common age-associated diseases in men. Prostatic immune cell infiltration is frequently observed with aging coincident with BPH; however, the contribution of age-related changes in immune cells to BPH is not clear. …”
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Exploring the concept of surgical transition: surgical activity in the light of economic development in Sierra Leone, Liberia, Ghana and India by Juul M. Bakker, Juul M. Bakker, Alex J. van Duinen, Alex J. van Duinen, Alex J. van Duinen, Alex J. van Duinen, Priti Patil, Priyansh Nathani, Priyansh Nathani, Adam Gyedu, Adam Gyedu, Håvard A. Adde, Pranav Bhushan, Nobhojit Roy, Nobhojit Roy, Nobhojit Roy, Anita Gadgil, Håkon A. Bolkan, Håkon A. Bolkan, Håkon A. Bolkan

“…Increases in surgical volume were most notable among older age groups, gender disparities in access diminished as systems developed. …”
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Chitosan nanoparticles-encapsulated cannabis extracts and their antimicrobial potential against skin pathogens by Tomáš Skala, Jordi Ventura, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Adéla Fraňková, Antoni Llopis-Lorente, Antoni Llopis-Lorente, Andrea Bernardos, Andrea Bernardos, Andrea Bernardos, Jan Tauchen, Zdeňka Kahánková, Vít Hubka, Pavel Klouček

“…Considering the extract:chitosan ratio (1:10 w/w, 1:20 w/w respectively) and the encapsulation efficiency (EE) range from 44.65 ± 4.39% to 94.44 ± 0.93%, total amount of extracts encapsulated in chitosan nanoparticles ranged from 2.96 ± 0.05 to 5.61 ± 0.19% in 1 g of chitosan nanopowder. Most significant antimicrobial effect was observed against the fungi Nannizzia fulva CCF 6025, where the MIC80 of the pure extract from Jonas 1 variety was 256 μg/mL while the encapsulated extract in chitosan nanoparticles (1:10 w/w extract:chitosan ratio) inhibited growth at a concentration of 256 μg/mL of nanoparticles (corresponding to 13.05 ± 0.13 μg/mL of extract). …”
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Inflammatory and Nutritional Biomarker in Different Subtypes of Early Stage Diffuse Large B-Cell Lymphoma: Towards a Diagnostic Model by Oehadian A, Gunadi SV, Mersiana L, Susandi E, Wijaya I, Martha JW, Supriyadi R, Prihatni D

“…ALI demonstrated the best balance between sensitivity (76.7%) and specificity (63.3%), making it the most reliable marker for distinguishing DLBCL subtypes.Conclusion: SII, PNI, and ALI differ significantly between DLBCL subtypes. …”
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mHealth Social Support Versus Standard Support for Diabetes Management in Safety-Net Emergency Department Patients: Randomized Phase-III Trial by Elizabeth Burner, Danielle Hazime, Michael Menchine, Wendy Mack, Janisse Mercado, Adriana Aleman, Antonio Hernandez Saenz, Sanjay Arora, Shinyi Wu

“…Newly diagnosed patients with diabetes benefited most from mHealth-augmented social support. …”
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Cancer Burden in Chinese Older Adults: Insights Into Incidence, Mortality, and Global Comparisons Using GLOBOCAN 2022 by Yuanjie Zheng, He Li, Qianru Li, Siyi He, Yi Teng, Mengdi Cao, Nuopei Tan, Jiachen Wang, Tingting Zuo, Tianyi Li, Wanqing Chen

“…Lung, colorectal, stomach, liver, esophageal, prostate, and female breast cancers were the most prevalent cancer types. Compared with the global average and four HDI‐classified regions, Chinese older adults had higher ASIRs and ASMRs for lung, stomach, liver, and esophageal cancers but lower rates for prostate and female breast cancers. …”
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Modeling of ischemicreperfusion injury of the liver and kidneys in the experiment: working out the methodology by B. I. Yaremin, E. Yu. Anosova, B. I. Kazymov, K. F. Alekberov, M. S. Novruzbekov, V. A. Zuykova, F. R. Gyul'magomedova

“…A significant shortage of high-quality donor organs remains one of the most pressing challenges, especially when it comes to extended criteria donors or asystolic donors. …”
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Immunotherapy combining tumor and endothelium cell lysis with immune enforcement by recombinant MIP-3α Newcastle disease virus in a vessel-targeting liposome enhances antitumor imm... by Lei Li, Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Guang-Hong Tan, Hengyu Chen, Cai-Chun Wang, Wu-Ping Zheng

“…Background Several agents for oncolytic immunotherapy have been approved for clinical use, but monotherapy is modest for most oncolytic agents. The combination of several therapeutic strategies through recombinant and nanotechnology to engineer multifunctional oncolytic viruses for oncolytic immunotherapy is a promising strategy.Methods An endothelium-targeting iRGD-liposome encapsulating a recombinant Newcastle disease virus (NDV), which expresses the dendritic cell (DC) chemokine MIP-3α (iNDV3α-LP), and three control liposomes were constructed. …”
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Bioactive Cyclopeptide Alkaloids and Ceanothane Triterpenoids from <i>Ziziphus mauritiana</i> Roots: Antiplasmodial Activity, UHPLC-MS/MS Molecular Networking, ADMET Profiling, and... by Sylvestre Saidou Tsila, Mc Jesus Kinyok, Joseph Eric Mbasso Tameko, Bel Youssouf G. Mountessou, Kevine Johanne Jumeta Dongmo, Jean Koffi Garba, Noella Molisa Efange, Lawrence Ayong, Yannick Stéphane Fotsing Fongang, Jean Jules Kezetas Bankeu, Norbert Sewald, Bruno Ndjakou Lenta

“…Bioactivity-guided isolation yielded thirteen purified compounds (<b>5</b>, <b>6</b>, <b>14</b>, <b>26</b>–<b>30</b>, <b>32</b>–<b>36</b>), with betulinic acid (<b>30</b>; IC₅₀ = 19.0 µM) and zizyberenalic acid (<b>32</b>; IC₅₀ = 20.45 µM) exhibiting the most potent antiplasmodial effects. Computational ADMET analysis identified mauritine F (<b>4</b>), hemisine A (<b>10</b>), and nummularine R (<b>21</b>) as particularly promising lead compounds, demonstrating favourable pharmacokinetic properties, low toxicity profiles, and predicted activity against both family A G protein-coupled receptors and evolutionarily distinct Plasmodium protein kinases. …”
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Two-dimensional analysis of plasma-derived extracellular vesicles to determine the HER2 status in breast cancer patients by Alexis Wilhelm, Charlotte Flynn, Evelyn Hammer, Johannes Roessler, Bernhard Haller, Rudolf Napieralski, Moritz Leuthner, Sanja Tosheska, Kèvin Knoops, Anjusha Mathew, Giuliano Ciarimboli, Jan Kranich, Lavinia Flaskamp, Siobhan King, Heidrun Gevensleben, Quirin Emslander, Anna Pastucha, Mathias Reisbeck, Lukas Rief, Holger Bronger, Tobias Dreyer, Andreas R. Bausch, Andreas Pichlmair, Thomas Brocker, Reinhard Zeidler, Wolfgang Hammerschmidt, Melanie Piedavent-Salomom, Carmen López-Iglesias, Gabrielle Schricker, Oliver Haydn, Marion Kiechle, Sabine Grill, Ron Heeren, Percy A. Knolle, Olaf Wilhelm, Bastian Höchst

“…Abstract Breast cancer, one of the most common cancers in women, is classified by the expression of hormone receptors and the growth factor receptor HER2, which is important for personalised tumour treatment with HER2-targeted therapies. …”
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