Load transmission via the supraspinatus cord prevents muscle fatty degeneration, a biomechanical study by Omar E. Rodriguez-Alejandro, MD, Bethany G. Ricci, BS, Christopher C. Schmidt, MD, Sean P. Cooke, BS, Austin J. Cook, MS, Justin G. Buce, MS, Joshua D. Dworkin, MD, Mark C. Miller, PhD, Patrick J. Smolinski, PhD

“…In this study, we aimed to map the anatomic insertions of the CHL and superior rotator cuff onto the humeral head and then sequentially release the footprint to determine which structures are the most critical for force transmission. Methods: Twenty fresh-frozen cadaveric specimens (average age 69 ± 10 years, 9 males) were tested in a shoulder simulator under physiological conditions at 0° and 30° of shoulder abduction. …”
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Extracellular Vesicle Protein Panel Enables Early Lung Cancer Detection in a Large Clinical Cohort by Linxiao Han, Yuanlin Song, Lin Tong, Jiayuan Sun, Xiaoju Zhang, Shujing Chen, Ying Li, Ziqi Wang, Lei Gao, Qiaoliang Zhu, Yencheng Chao, Xiaocen Wang, Ge Zhang, Wensi Zhu, Ludan He, Jie Liu, Qin Wang, Zuoren Wu, Yuanyuan Ji, Chunxue Bai, Xiuzhen Lv, Jian Zhou

“…EV‐SFTPA1 proved to be the most effective marker, exhibiting a sensitivity of 89.4% in patients with early lung cancer. …”
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The Insurance-Like Effect of CSR on Corporate Performance Against JCPOA. A Difference-in-Difference Approach by Yusur Faiq Abbas Sifawy, Pari Chalaki, Parviz piri

“…Additionally, the results derived from the difference-in-differences approach reveal that the negative impact of the JCPOA withdrawal on firm performance was most pronounced in the first four years following the exit and was not significant in the subsequent years. …”
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Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer by Jeffrey Xiao, Joshua Kim, Brandon Park, David J. Baylink, Cedric Kwon, Victoria Tran, Scott Lee, Kevin Codorniz, Laren Tan, Pamela Lobo Moreno, Amy Schill-Depew, Saied Mirshahidi, David De Semir, Diana Hanna, Kiran Naqvi, Huynh Cao, Chien-Shing Chen, Joanne Xiu, Heinz-Josef Lenz, Hamid Mirshahidi, Mark E Reeves, Yi Xu

“…MRTX1133 (MRTX), a novel inhibitor of KRAS G12D (the most common KRAS mutation found in pancreatic and colon cancers) has shown promise as a therapeutic agent. …”
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THE VALUE OF COMPETENCE-BASED APPROACH IN THE PREPARATION OF DENTAL HYGIENISTS by V.M. Kosenko

“…The study revealed that teachers consider the following general competencies the most important: the ability to learn and be trained according to the modern standards (64.3%); ability to communicate in their native language both orally and in writing (71.4%); the ability to search, process and analyze information from different sources (28.5%); ability to be critical and self-critical (39.3%); ability to communicate in a foreign language (39.3%). …”
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TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction by Gal Markel, Michal J Besser, Eytan Ruppin, Oscar Krijgsman, Daniel S Peeper, Judit Díaz-Gómez, Ettai Markovits, David W Vredevoogd, Georgi Apriamashvili, Pierre L Levy, Sanju Sinha, Zowi R Huinen, Nils L Visser, Beaunelle de Bruijn, Julia Boshuizen, Susan E van Hal-van Veen, Maarten A Ligtenberg, Onno B Bleijerveld, Chun-Pu Lin, Santiago Duro Sánchez, Juan Simon Nieto, Alex van Vliet, Maarten Altelaar

“…A dual-readout design using the activation marker CD137 allowed us to uncouple genes involved in PD-1 regulation from those governing general T cell activation.Results We found that the inactivation of one of several members of the TMED/EMP24/GP25L/p24 family of transport proteins, most prominently TMED10, reduced PD-1 cell surface abundance, thereby augmenting T cell activity. …”
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Recuperação da motricidade voluntária do membro superior de pacientes com hemiplegia após acidente vascular cerebral: avaliação prognostica Recovery of voluntary motion in upper ex... by Abrão Anghinah

“…The analysis of the data supplied by the two groups led to the following conclusions: a) the critical level of remission of symptoms and the spontaneous recovery of voluntary movements ocurred around the 70th day after the installation of hemiplegia; b) the 256 average score acquired 70 days after the onset of the hemiplegia represents the critical level stabilization (plateau); c) although the presence of early initial movements, immediately after the installation of hemiplegia, is a valuable data for the prognosis, the characterization of early movement patterns is of most important meaning; d) patients with hemiplegia after cerebrovascular acident who present the thumb flexion-extension and opposition movements showed a better prognosis than those whose initial movements were represented by the elbow flexion and/or arm flexion-adduction.…”
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A cross-sectional analysis of schistosomiasis case detection by rectal mucosal biopsy among patients attending the digestive endoscopy unit of the internal medicine department by Kaly Keïta, Stéphane Loique Djeugoué, Boua Daoud Camara, Alassane Alfousséni Doumbia, Cheick Oumar Kamissoko, Oumar Sandji, Adama Sinayoko, Abdoulaye Keïta, Maïmouna Togo, Charles Dara, Garan Dabo, Abdoulaye Mamadou Traoré, Ibrahima Amadou Dembélé, Djibril Sy, Djénèbou Traoré, Assétou Soukho Kaya, Mamadou Dembélé, Abdoulaye Kassoum Koné, Daouda Kassoum Minta, Hamar Alassane Traoré

“…Introduction: The detection of schistosome eggs in stool or urine specimens is the most used technique in population-based studies, while the rectal mucosal biopsy is the commonly used technique in hospital setting. …”
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Phase 1b/2 study evaluating safety, efficacy and immune effects of TLR9 agonist cavrotolimod with anti-PD-1 antibodies among patients with advanced solid tumors by Douglas E Feltner, Adil Daud, Brent A Hanks, Shailender Bhatia, Michael K Wong, Sunandana Chandra, Trisha M Wise-Draper, Philip A Friedlander, Melissa A Burgess, Glenn J Hanna, C Lance Cowey, George Ansstas, Ciara M Kelly, Mohammed M Milhem, Cesar A Perez, Ryan M Weight, Alice S Bexon, Douglas E Laux, Theresa M Medina, Steven J O’Day, Timothy S Kristedja, Weston L Daniel, Scott Mix, Laurel Sindelar, Martin F Bexon, Robert E Michel

“…Cavrotolimod, alone and in combination with anti-PD-1 therapy, had a manageable safety profile with mostly transient adverse events (AEs). The most frequent Grade 3/4 cavrotolimod-related AEs were fatigue and injection site reactions. …”
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Genetic diversity of Dioctophyme renale in Southern South America by Lucas F. Arce, Florencia Facelli Fernández, Nahili Giorello, Marcos Butti, Lucas L. Maldonado, Juan P. Arrabal, María B. Natalini, Martín Kowalewski, Daniela Pedrassani, Carolina Silveira Mascarenhas, Josaine C. da Silva Rappeti, Florencia Zilli, Pablo M. Beldomenico, Verónica Lia, Gisela R. Franchini, Laura Kamenetzky

“…Here, we provide the descriptions of the genetic diversity of the parasite in the region by analysing 73 adult D. renale samples collected from domestic and wild carnivores. The most common hosts were (Canis lupus familiaris) and maned wolf (Chrysocyon brachyurus Fam. …”
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Psychosocial risks and mental health of health and social care workers in the context of the COVID-19 pandemic by Nadia Vilahur Chiaraviglio

“…Many of our certainties in the European continent were shaked by the unequivocal evidence of our vulnerability as individuals and our lack of preparedness as a society to manage a health emergency of unknown boundaries, despite having one of the most well-developed health systems across the globe. …”
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Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients by Qi Sun, Qingsong Lin, Yanxia Lv, Zhiying Tian, Qiushuang Yan, Yaqing Yu, Xue Fu, Hongjing Yao, Fujun Sun, Yonghui Xia, Guoqing Zhu, Sizhou Feng

“…Results For patients with hematological diseases, the serum PCT was slightly elevated in the BSI group. We found that most hematological patients with bloodstream infection were in the stage of severe neutropenia. …”
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The impact of high-salt diet and diuretics on the development of the aestival phenomenon in patients with chronic heart failure by Dmitrii O. Dragunov, Dmitrii O. Dragunov, Anna V. Sokolova, Anna V. Sokolova, Vadim M. Mitrokhin, Grigory P. Arutyunov

“…Multivariate logistic regression confirmed that diuretic therapy was independently associated with these changes: PropUrea/eOSM (OR = 3.52, 95% CI: 1.94–7.26, p < 0.001), and PropNa/eOSM (OR = 0.16, 95% CI: 0.06–0.39, p < 0.001). These effects were most pronounced in patients consuming >10 g/day of salt.ConclusionThis study demonstrated that in patients with chronic heart failure (CHF), intensive loop diuretic therapy—especially when combined with high sodium intake—is associated with a shift in plasma osmolytes, marked by increased urea and reduced sodium contributions to osmolality. …”
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Research Progress on Selective Depolymerization of Waste Plastics to High-Quality Liquid Fuels by Xinze LI, Zhicheng LUO, Rui XIAO

“…., H2, CH4) with liquid fuel selectivity below 15% for most polymers. To address these challenges, three actionable pathways are proposed: (1) Pilot-scale optimization: Current studies predominantly use lab-scale feeds (<100 g), necessitating trials with industrial-grade plastics containing pigments and plasticizers. …”
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ZEB1 stratifies the response to Sorafenib and Mdivi-1 combination therapy in hepatocellular carcinoma by H. Freudenstein, M. Strecker, S. Gylstorff, W. Shi, M. Boettcher, S. Medunjanin, C. Catapano, C. Siba, C. Wex, T. Wartmann, A. Y. Sanin, M. Franz, J. Arend, D. Mougiakakos, M. Pech, R. S. Croner, U. D. Kahlert, F. Stelter

“…Abstract Primary liver cancer is one of the most frequently diagnosed and deadliest cancers. …”
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Disproportionate impact of the COVID-19 pandemic on socially vulnerable communities: the case of Jane and Finch in Toronto, Ontario by Zahra Movahedi Nia, Zahra Movahedi Nia, Zahra Movahedi Nia, Cheryl Prescod, Michelle Westin, Patricia Perkins, Patricia Perkins, Mary Goitom, Mary Goitom, Kesha Fevrier, Kesha Fevrier, Sylvia Bawa, Sylvia Bawa, Jude Dzevela Kong, Jude Dzevela Kong, Jude Dzevela Kong, Jude Dzevela Kong, Jude Dzevela Kong, Jude Dzevela Kong

“…The number of patients during the COVID-19 pandemic versus before that decreased significantly more for pop-smear tests (p = 0.041) and surgery waitlists (p = 0.037) for the Jane and Finch community.ConclusionAs one of the most socially vulnerable communities of GTA, the Jane and Finch community has endured a heavier burden of the disease during the COVID-19 pandemic. …”
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The Debut of Inflammatory Musculoskeletal Pathology in Patients Receiving Anticancer Therapy with PD-1/PD-L1 Pathway Inhibitors by A. D. Koltakova, A. M. Lila, O. G. Alekseeva, A. A. Fedenko, Y. V. Gridneva, A. S. Olshanskaya

“…The knee (77%), shoulder (69%) and hand (54%) joints were most frequently affected, with bilateral involvement in 9 (69%) patients. …”
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Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling by Laura Mussalo, Alexey M. Afonin, Tana Zavodna, Zdenek Krejcik, Katerina Honkova, Claire Fayad, Muhammad Ali Shahbaz, Juho Kalapudas, Elina Penttilä, Heikki Löppönen, Anne M Koivisto, Tarja Malm, Jan Topinka, Pasi Jalava, Riikka Lampinen, Katja M. Kanninen

“…Integrative network analysis revealed multiple connections of miRNAs to differentially expressed genes in the PI3K/AKT pathway, and effects were most prominent in AD cells. Similarly, in AD cells DML were identified in transcription factor and apoptosis genes, downstream of PI3K/AKT signaling. …”
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Biomarker, efficacy and safety analysis of transcatheter arterial chemoembolization combined with atezolizumab and bevacizumab for unresectable hepatocellular carcinoma by Shaobo Zhang, Zebin Zhu, Lianxin Liu, Björn Nashan, Shugeng Zhang

“…Univariate and multivariate Cox regression analyses identified baseline PLR ≥ 148.0 as an independent risk factor for poorer survival outcomes. Additionally, most adverse events (AEs) observed during Atezo-Bev-TACE treatment were grade 1–2, with fewer grade 3–4 AEs, and no grade 5 AEs were reported. …”
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Profiling Land Use Planning: Legislative Structures in Five European Nations by Dimitrios Koumoulidis, Ioannis Varvaris, Diofantos Hadjimitsis, Marzia Gabriele, Raffaella Brumana, Ioannis Gitas, Nikos Georgopoulos, Azadeh Abdollahnejad, Eleni Gkounti, Dimitris Stavrakoudis, Donatella Caniani, Andriy Dorosh, Roman Derkulskyi, Oksana Sakal, Shamil Ibatullin, Yevhenii Khan, Oleksandr Melnyk, Anne Fromage Mariette, Marc Tondriaux, Andrzej Perkowski, Adam Sieczka, Mariusz Maciejczak, Chryssa Kopra, Georgia Kostaki, Paraskevi Chantzi

“…The need for this action is further underscored by the fact that, in most cases, land use frameworks are characterized by complementary legislation and ongoing amendments. …”
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