Co-existence of plasmid-mediated blaNDM-1 and blaNDM-5 in Escherichia coli sequence type 167 and ST101 and their discrimination through restriction digestion by Amrita Bhattacharjee, Priyanka Basak, Shravani Mitra, Jagannath Sarkar, Shanta Dutta, Sulagna Basu

“…One such gene, blaNDM, has spread globally via plasmids. blaNDM confers resistance against all β-lactam antibiotics, except monobactams. Most of the earlier literature reported the presence of single blaNDM variant. …”
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Laserterapia de baixa intensidade com terapia fotodinâmica no tratamento de onicomicose [Low intensity laser therapy with photodynamic therapy in the treatment of onychomycosis] [... by Fernanda Dorigon Frigo, Eugenio Fuentes Pérez Júnior, Ariane da Silva Pires, Vânia Lima Coutinho, Francisco Gleidson de Azevedo Gonçalves, Juliana Agra Lima

“…Conclusion: laser therapy with photodynamic therapy in the treatment of onychomycosis in patients with type 2 Diabetes Mellitus shows promising results with clinical improvement in most cases. RESUMEN Objetivo: evaluar los resultados de la aplicación de la terapia láser de baja intensidad con terapia fotodinámica en el tratamiento de la onicomicosis en pacientes con Diabetes Mellitus tipo 2. …”
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Chronic disease medications accessibility among Sudanese patients during war by Thoraya Salah Murtada Sidahmed, Al-Romaysa M. Osman Khalafalla El-Haj, Hiba Salah Abdelgadir, Afra K. Ahmed, Asjad Elias Sidieg Mohammed, Abdelfatah Abdelelah El Zain Hassan, Ebaa Ismat Mahmoud Ahmed, Hiba Algaali Altayeb Babikir, Khalid Mukhtar Awad Hamza, Alaa Hamid Yousif Ahmed, Mojtaba Majdy Elfakey Omer, Shahad Yahya Awadelkarim Elbadawi, Logaine Tarig Abdelwahab Mohammed, Rawan Ali Ahmed Mohamed Ahmed, Hind Elmukashfi ShamsEldin Elobied, Hind Salah Abdelgadir, Ruba Ahmed Osman Mohamed, Hala Hashim Salim Hamza, Omnia Yousif Abdalmalik Alfaki, Arwa Yagoub Elmadani Ibrahim, Rawan Izzeldin Babiker Farah, Abeer Hussien Musa Mohamed, Amaal Izzeldin Ahmed Altamar, Lana Awad Jahallah Hassab Alrasoul, Ali Mohamedahmed Ali Mohamed, Mohamedelamin Abdelgayoum Khalifa, Tarig Siddig Abdelgader Mohieldin, Soujod Emad Elden Mohamed Elamen

“…As a result, many sought alternatives through private healthcare facilities (35.0%) or local pharmacies (51.5%). The most common chronic conditions among respondents were diabetes (48.5%) and hypertension (33.3%). …”
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PSYCHOLOGICAL FACTORS OF THE FORMATION OF LEGAL AWARENESS OF STUDENTS OF HISTORICAL AND MEDICAL EDUCATION PROFILES by Dribas Svetlana, Semenov Konstantin

“…The problem of legal awareness of young people in modern conditions of the development of Ukrainian society is the most relevant task. At the same time, the study of legal awareness among students of the historical education profile is in a certain way predictable and has a fairly good track record in science, which cannot be said about the students of the medical profile. …”
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Effect of community-led delivery of HIV self-testing on HIV testing and antiretroviral therapy initiation in Malawi: A cluster-randomised trial. by Pitchaya P Indravudh, Katherine Fielding, Moses K Kumwenda, Rebecca Nzawa, Richard Chilongosi, Nicola Desmond, Rose Nyirenda, Melissa Neuman, Cheryl C Johnson, Rachel Baggaley, Karin Hatzold, Fern Terris-Prestholt, Elizabeth L Corbett

“…Overall, the proportion of men was 39.0% (3,072/7,880). Most participants obtained primary-level education or below, were married, and reported a sexual partner. …”
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Virtual reality navigation for the early detection of Alzheimer’s disease by Sayuri Shima, Reiko Ohdake, Yasuaki Mizutani, Harutsugu Tatebe, Riki Koike, Atsushi Kasai, Epifanio Bagarinao, Epifanio Bagarinao, Kazuya Kawabata, Kazuya Kawabata, Akihiro Ueda, Mizuki Ito, Junichi Hata, Shinsuke Ishigaki, Junichiro Yoshimoto, Hiroshi Toyama, Takahiko Tokuda, Akihiko Takashima, Hirohisa Watanabe, Hirohisa Watanabe

“…Predictor importance ranking using machine learning and receiver operating characteristic curves identified plasma p-tau181 as the most significant predictor of PI. ApoE genotype and plasma p-tau181 showed positive and negative PI associations (ApoE: coefficient = 0.650, p = 0.037; p-tau181: coefficient = −0.899, p = 0.041). …”
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Enhancing Nutritional and Functional Properties of Broccoli Leaves Through Selenium Biofortification: Potential for Sustainable Agriculture and Bioactive Compound Valorization by Melina Soledad Buttarelli, Gabriel Céccoli, Betiana Soledad Trod, María Micaela Stoffel, Marianela Simonutti, Carlos Alberto Bouzo, Valeria Rosana Turowski, Adrián Alejandro Perez, Mercè Llugany, María-Jesús Sánchez-Martín, Lucas Damián Daurelio, María Gabriela Guevara, Fernando Felipe Muñoz

“…Multivariate analysis revealed that 2 mM selenite application was the most effective treatment, significantly improving several parameters. …”
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Results of dose-dense neoadjuvant chemotherapy in the treatment of stages IB2—IIB cervical cancer by A. S. Mamontova, O. A. Smirnova, A. O. Nyuganen, A. V. Abramova, S. S. Bagnenko, A. F. Urmancheeva, E. A. Ulrich, A. V. Mishchenko, I. V. Berlev

“…The use of dose-dense NACT is an effective treatment mode for patients with IB2-IIB CC (FIGO), which in most cases allows achieving a tumor response with subsequent improvement in immediate and long-term results and can be considered as an alternative to standard treatment for locally advanced CC.…”
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Investigation of Population Changes and Determination of the Bean Pod Borer Helicoverpa armigera (Lepidoptera:Noctuidae) Peak in Bean Phaseolus vulgaris Linnaeus Fields by Pheromon... by Sedighe Ashtari

“…Introduction beans Phaseolus vulgaris Linnaeus, is one of the most important legumes cultivated in many countries around the world. …”
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Novel pathogenic splicing mutation in COL11A1 in a patient with Stickler syndrome verified by minigene splicing assay by Jie Zhang, Jie Zhang, Jie Zhang, Yaxin Huang, Yaxin Huang, Yaxin Huang, Yafei Deng, Yafei Deng, Yafei Deng, Xiaochun Yang, Hong Shi, Yuecheng Yang, Tao Lv, Tao Lv, Tao Lv, Yuanlong Yan, Yuanlong Yan, Yuanlong Yan, Ming He, Fang Liu, Fang Liu, Fang Liu

“…The literature review revealed that the most common phenotypes associated with STL type 2 include myopia and hearing impairment.ConclusionWe identified a novel acceptor splice site variant causing aberrant splicing of COL11A1. …”
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Dynamic Muscle Stimulation of the Periorbital Area for Improvement of Blinking in Dry Eye Patients by Chelnis JG, Chelnis A

“…These, in turn, may be useful for managing signs and symptoms of DED due to MGD.Plain Language Summary: Evaporative dry eye disease (DED) is one of the most common pathologies of the ocular surface. This multi-factorial disease is mostly due to poor function of meibomian glands within the eyelids (MGD). …”
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Global Trajectories of Colorectal Cancer Burden From 1990 to 2021 and Projection to 2040 by Xiaolu Chen, Xuesi Dong, Yadi Zheng, Chenran Wang, Zilin Luo, Jiaxin Xie, Zeming Guo, Xiaoyue Shi, Xinyue Zhu, Yongjie Xu, Wei Cao, Fei Wang, Ni Li

“…Results Three trajectories of colorectal cancer burden were observed: slowly increasing, rapidly increasing, and slowly decreasing age‐standardized incidence rate, corresponding to stable, increasing, and decreasing mortality rate. Most countries showed slowly increasing incidence rates (49.0%, n = 100) and stable age‐standardized mortality rates (51.0%, n = 104). …”
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Influence of the biophosphomag preparation and biologically active substances from milk thistle seeds (Silybum marianum) on the metabolism of lymphocytes and their functional featu... by Petro Fedyshyn, Olga Pavliuk, Ivan Stupak, Taisa Dovbynchuk, Yulia Pysmenna, Volodymyr Liashenko, Natalia Senchylo, Serhii Holopura, Liliia Kalachniuk, Liudmyla Garmanchuk

“…V3, OVA and OVA+ preparations do not exhibit cytotoxic or cytostatic effects on T lymphocytes. The most pronounced effect is exerted by the OVA+ preparation, which causes an increase in the level of glucose in the culture medium and the activity of dehydrogenases, as well as an increase in the content of SH-groups in cells, which indicates its potential in supporting cellular metabolism and protection. …”
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Acoustic-based machine learning approaches for depression detection in Chinese university students by Yange Wei, Yange Wei, Shisen Qin, Fengyi Liu, Rongxun Liu, Yunze Zhou, Yuanle Chen, Xingliang Xiong, Wei Zheng, Guangjun Ji, Yong Meng, Fei Wang, Fei Wang, Ruiling Zhang

“…SHAP analysis suggested that Mel-frequency cepstral coefficients (MFCC) features contributed most to the model's classification efficacy.ConclusionsThe integration of acoustic features and LDA model demonstrates a high accuracy in distinguishing depression among Chinese university students, suggesting its potential utility in rapid and large-scale depression screening. …”
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Racial and socioeconomic disparities in long term survival after surgery and radiation for spinal cord hemangioblastoma by Abdul Karim Ghaith, Xinlan Yang, Joshua Weinberg, Shaan Bhandarkar, Taha Khalilullah, Abdel-Hameed Al-Mistarehi, Khaled Zaitoun, Meghana Bhimreddy, Arjun K. Menta, Antony Fuleihan, Kamel Chebaro, Jawad Khalifeh, Andrew Grossbach, Nicholas Theodore, Daniel Lubelski

“…Significant differences were observed across racial groups in age, insurance status, income quartiles, and comorbidity scores, though sex distribution and facility type utilization were comparable. Most patients were treated at academic centers, and surgery alone was the predominant treatment modality, with no racial disparities in extent of resection or use of radiation. …”
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Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

“…Parace­tamol (83.67%) was the most consumed, followed by azithromycin (36.73%), prednisolone (31.10%),amoxicillin_clavulanic acid (30.53%), zinc (27.38%), vitamin C (27.08 %), vitamin D(16.31%), magnesium(12.92%),and even hydroxychloroquine(25.56%). …”
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Genetic dissection of leaf rust resistance in a diversity panel of tetraploid wheat (Triticum turgidum) by Jitendra Kumar Yadav, Shruti Sinha, Hariom Shukla, Ankur Singh, Tanmaya Kumar Sahu, Shailendra Kumar Jha, Jyoti Kumari, Manjusha Verma, Sundeep Kumar, Rakesh Singh, Gyanendra Pratap Singh, Amit Kumar Singh

“…Among these pathotypes, 77–5 (121R63-1) and 77–9 (121R60-1) are the most prevalent since 2016. As virulent pathotypes continue to evolve and adapt, there is an urgent need to continually explore the vast germplasm repositories of wheat and its related species to identify novel genetic resources and genes that confer resistance to these evolving leaf rust pathotypes. …”
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In vitro and in silico evaluation of synthetic compounds derived from bi-triazoles against asexual and sexual forms of Plasmodium falciparum by Leandro do Nascimento Martinez, Minelly Azevedo da Silva, Saara Neri Fialho, Marcinete Latorre Almeida, Amália dos Santos Ferreira, Aurileya de Jesus Gouveia, Welington da Silva Paula do Nascimento, Ana Paula de Azevedo dos Santos, Norton Rubens Diunior Lucas Pejara Rossi, Jansen Fernandes de Medeiros, Natalie Ferreira Araújo, Quelli Larissa Oliveira de Santana, Carlos Roland Kaiser, Sabrina Baptista Ferreira, Maisa da Silva Araujo, Carolina Bioni Garcia Teles

“…None of the compounds demonstrated cytotoxic or haemolytic activity, with SI values above 51 for the three most active compounds, highlighting their selectivity. …”
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Global burden and risk factors of type 2 diabetes mellitus from 1990 to 2021, with forecasts to 2050 by Qian Huang, Qian Huang, Yang Li, Yang Li, Minggang Yu, Minggang Yu, Minggang Yu, Zhizi Lv, Zhizi Lv, Zhizi Lv, Fengyi Lu, Fengyi Lu, Ning Xu, Ning Xu, Qingqing Zhang, Qingqing Zhang, Jiayun Shen, Jiayun Shen, Jinfeng Zhu, Hua Jiang, Hua Jiang

“…Oceania stood out as an exception, with the highest relative burdens across all four indicators, most notably in the Marshall Islands and Fiji. The increases in incidence, DALYs, and prevalence were predominantly driven by population growth and epidemiological shifts, with aging contributing significantly to the rise in mortality. …”
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Feasibility of a co-designed and personalised intervention to improve vegetable intake in rural-dwelling young adults by Katherine Mary Livingstone, Jonathan C. Rawstorn, Stephanie R. Partridge, Yuxin Zhang, Eric O, Stephanie L. Godrich, Sarah A. McNaughton, Gilly A. Hendrie, Kathleen M. Dullaghan, Gavin Abbott, Lauren C. Blekkenhorst, Ralph Maddison, Scott Barnett, John C. Mathers, Laura Alston

“…Almost all intervention participants liked having access to the recipe library (93%) and reported that the e-newsletters prompted them to access the intervention (90%). Most accessed the goal-setting function (78%), food environment map (76%), and healthy eating resources (63%). …”
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