THE ORGANIZATION WORKS TO IMPROVE THE CLINICAL AND ECONOMIC OUTCOMES OF CARE FOR PROSTATE CANCER by O. I. Apolikhin, A. V. Sivkov, I. V. Chernishov, M. I. Katibov, O. V. Zolotukhin, I. A. Shaderkin, S. A. Leonov, D. A. Vojtko, M. Y. Prosyannikov

“…During the realisation of the Programme on the territory of theVoronezh region they deployed 7 Interdistrict (ITC) and 1 regional centre. The most difficult clinical cases were sent to the Federal urology center - research Institute of urology. …”
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Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administe... by Nicolò Peccatori, Marta Coppola, Antonella Colombini, Daniela Silvestri, Nicoletta Bertorello, Valentina Kiren, Fraia Melchionda, Rosamaria Mura, Daniela Onofrillo, Simona Gobbi, Raffaele Mattera, Luciana Vinti, Tommaso Casini, Nicola Santoro, Domenico Sperlì, Carmelita D’Ippolito, Valentino Conter, Andrea Biondi, Carmelo Rizzari

“…Median time to glucarpidase infusion was 53 hours (range 32–72). Most patients required glucarpidase during the first cycle of HDMTX. …”
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Optimizing Haploidentical Hematopoietic Stem Cell Transplantation: Enhancing Outcomes in Hematologic Malignancies in Resource-Limited Settings by Owattanapanich W, Karoopongse E, Kittivorapart J, Meeudompong U, Sathapanapitagkit N, Kungwankiattichai S, Vittayawacharin P, Jianthanakanon J, Donsakul N, Bundhit R, Kongsomchit C, Poonmee N, Luangtrakool P, Warindpong T, Chamsai S, Bintaprasit W, Atakulreka S, Kunacheewa C

“…All patients developed CRS, presenting symptoms like fever and diarrhea within one day after the transplant. Most cases were mild to moderate and resolved after routine treatments, including post-transplant cyclophosphamide (PTCy). …”
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Modeling patient-specific adenocarcinoma as spheroids enhances the authenticity of cancer hallmarks and therapeutic susceptibility by Andres S. Espinoza, Rachael N. McVicar, Darren Finlay, Rabi Murad, Kristiina Vuori, Bethany A. Grimmig, Anne Bush, Emily Smith, Thomas Mandel-Clausen, Heather M. McGee, Evan Y. Snyder, Sandra L. Leibel

“…Therefore, we submit that patient-specific 3D spheroids are the best way to study cellular mechanisms driving disease and perhaps better plan a therapeutic regimen to which the patient is most likely to respond.…”
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CD200-based cell sorting results in homogeneous transplantable striatal neuroblasts for human cell therapy for Huntington's disease by Francisco J. Molina-Ruiz, Phil Sanders, Cinta Gomis, Jordi Abante, Francisco Londoño, Georgina Bombau, Mireia Galofré, Gal la Vinyes-Bassols, Veronica Monforte, Josep M. Canals

“…Cell replacement therapies are the most promising therapeutic strategies to restore the neuronal functions lost during these neurodegenerative processes. …”
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Deep learning based detection of enlarged perivascular spaces on brain MRI by Tanweer Rashid, Hangfan Liu, Jeffrey B. Ware, Karl Li, Jose Rafael Romero, Elyas Fadaee, Ilya M. Nasrallah, Saima Hilal, R. Nick Bryan, Timothy M. Hughes, Christos Davatzikos, Lenore Launer, Sudha Seshadri, Susan R. Heckbert, Mohamad Habes

“…The experimental results showed that T2w MRI is the most important for accurate ePVS detection, and the incorporation of SWI, FLAIR and T1w MRI in the deep neural network had minor improvements in accuracy and resulted in the highest sensitivity and precision (sensitivity = 0.82, precision = 0.83). …”
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A preliminary study of the mechanism of compound hearing loss caused by ototoxic drugs combined with impulse noise by Xin Qiu, Qing‐qing Jiang, Wei‐wei Guo, Ning Yu, Shi‐ming Yang

“…The drug group had the least severe HL, the noise group had serious HL (p < 0.05), and the compound group had the most severe HL (p < 0.01). The compound group's damage was greater than the linear sum of the single‐factor group in many ways, such as the loss and damage of hair cells and cilia, disturbed morphology and arrangement of hair cells, protein metabolism, cell function, and structural defects on the epidermal plate (p < 0.01). …”
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Effects of Haematococcus pluvialis on growth performance, hepatopancreatic transcriptome and resistance to ammonia-nitrogen stress of pacific white shrimp (Litopenaeus vannamei) by Baoyang Chen, Anqi Chen, Haiqi Pu, Wei Zhao, Yongkang Chen, Yanmei Li, Peinan Zhang, Xingyan Hou, Liuya Feng, Beiping Tan, Jin Niu

“…Haematococcus pluvialis is one of the most important sources of natural astaxanthin. In this 8-week feeding experiment, the impacts of gradient additions of H. pluvialis on the growth and physiological performance of Litopenaeus vannamei before and after acute ammonia nitrogen stress were investigated. …”
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An unsupervised map of excitatory neuron dendritic morphology in the mouse visual cortex by Marissa A. Weis, Stelios Papadopoulos, Laura Hansel, Timo Lüddecke, Brendan Celii, Paul G. Fahey, Eric Y. Wang, J. Alexander Bae, Agnes L. Bodor, Derrick Brittain, JoAnn Buchanan, Daniel J. Bumbarger, Manuel A. Castro, Forrest Collman, Nuno Maçarico da Costa, Sven Dorkenwald, Leila Elabbady, Akhilesh Halageri, Zhen Jia, Chris Jordan, Dan Kapner, Nico Kemnitz, Sam Kinn, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina, Gayathri Mahalingam, Eric Mitchell, Shanka Subhra Mondal, Shang Mu, Barak Nehoran, Sergiy Popovych, R. Clay Reid, Casey M. Schneider-Mizell, H. Sebastian Seung, William Silversmith, Marc Takeno, Russel Torres, Nicholas L. Turner, William Wong, Jingpeng Wu, Wenjing Yin, Szi-chieh Yu, Jacob Reimer, Philipp Berens, Andreas S. Tolias, Alexander S. Ecker

“…Inter-area differences were most evident in layer 4, where V1 contained more atufted neurons than higher visual areas. …”
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Trastuzumab deruxtecan in patients with active brain metastases from HER2-positive/low metastatic breast cancer: a retrospective multicenter real-world study by Fangfang Duan, Xin Hua, Wei Lu, Xingxing Gui, Jingdun Xie, Xudong Wang, Yuyu Ma, Wenyu Zhai, Wen Xia

“…For HER2-low cohort, the median PFS and 12-month OS rate were 6.33 months (95% CI: 3.93-not reached) and 85.7% (95% CI: 63.3–100.0%), respectively. Most common adverse events were moderate and no new safety signals were observed. …”
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Investigating the Efficiency of Different Cover Crops on Weed Populations and Yield and Yield Components of Soybean (Glycine max L.) by Ali Jafari, Behnam Kamkar, Asieh Siahmarguee, Javid Gherekhloo, Ebrahim Zeinali, Parisa Alizadeh Dehkordi

“…Perco and field oats were the most effective in achieving a high leaf area index, whereas triticale had the shortest time to reach the maximum leaf area index. …”
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Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day by A. A. Vilnits, Yu. V. Lobzin, N. V. Skripchenko, L. N. Mazankova, O. I. Klimova, A. Yu. Rtishchev, I. M. Osmanov, K. V. Markova, N. H. Tkhakushinova, G. P. Martinova, A. U. Sabitov, R. K. Babik, I. Ya. Izvekova, V. V. Krasnov, E. V. Sidorenkova, O. V. Borisova, N. M. Bochkareva, O. V. Samodova, V. V. Sokolovskaya, A. A. Girina, A. Yu. Kurganskaya, E. M. Simovanyan, M. A. Kim, O. A. Rychkova, L. V. Khanipova, S. G. Grigorev

“…Considering the epidemiological features of meningococcal infection – the risk of a sharp increase in morbidity in short periods of time, the life-threatening nature of the disease itself, it is necessary to remain alert to these risks and take all possible measures to prevent the disease using all available means, the most effective of which is vaccine prevention.…”
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Research on the pharmacological potential of 1-alkyl derivatives of 3,5-dimethyl-4-((4-nitrobenzylidene)amino)-1,2,4-triazolium bromide by O. I. Panasenko, T. S. Brytanova, A. S. Hotsulia

“…The determination of the most favorable spatial configuration of the ligand relative to the active site of the protein and the assessment of the strength of their interaction have been realized using the computational method of molecular docking. …”
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A novel post-mortem pathogen discovery program detects an outbreak of Echovirus E7: Uganda, 2022–2023 by Sonja L. Weiss, Sonja L. Weiss, Nicholas Bbosa, Nicholas Bbosa, Nicholas Bbosa, Gregory S. Orf, Gregory S. Orf, Michael G. Berg, Michael G. Berg, Deogratius Ssemwanga, Deogratius Ssemwanga, Sam Kalungi, Sam Kalungi, Stephen Balinandi, Maximillian Mata, Maximillian Mata, Henry Kyobe Bosa, Henry Kyobe Bosa, Henry Kyobe Bosa, Stella E. Nabirye, Joshua Buule, Tom Lutalo, Angela Havron, Angela Havron, Robert Downing, Mary A. Rodgers, Mary A. Rodgers, Francisco Averhoff, Francisco Averhoff, Gavin A. Cloherty, Gavin A. Cloherty, Pontiano Kaleebu, Pontiano Kaleebu

“…An epidemiologic assessment indicated that most identified pathogens were acquired via direct and/or indirect contact (e.g., fecal-oral, fomites) and that other modes of transmission (e.g., food-borne, insect-vectored) played a less significant role.ConclusionIntegration of mortuary surveillance, coupled with mNGS, into public health systems represents a powerful strategy for identifying unrecognized outbreaks and monitoring the (re-) emergence of infectious diseases.…”
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Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations by Yiyue Jiang, Zheng Zhang, Kangkang Ren, Shujuan Zhou, Yang Qiao, Weilu Huang, Nanyang Zhang, Hanyan Xu, Xinping Xu, Bing Wen, Wei Zhang, Lu Yin

“…Therefore, identifying and selecting the most potent subpopulation of DPMSCs following expansion is key to improving therapeutic efficacy and consistency. …”
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Mandibular reconstruction outcomes for in-house patient-specific solutions by Matthew D. Marquardt, Erin Cowen, Rachel Fenberg, Natalia von Windheim, Margaret Lashutka, Abigail E. Reid, Amit Agarwal, Enver K. Ozer, Ricardo L. Carrau, James W. Rocco, Catherine T. Haring, Stephen Y. Kang, Nolan B. Seim, Matthew O. Old, Kyle K. VanKoevering

“…Squamous cell carcinoma (n = 19) was the most common pathology, and males (n = 18) were represented more than females (n = 7). 96% (24/25) of patients had good plate adaptation and 96% (24/25) had good osteotomy adaptation. …”
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PERINATAL ASPECTS OF DELIVERY OF WOMEN WITH OBESITY AND GESTATIONAL DIABETES by О. Железняков, В. Лазуренко, І. Васильєва, Т. Фролова, Р. Сафонов, О. Лященко, О. Овчаренко

“… Obesity increases the likelihood of hypertension and pre-eclampsia and increases the risk of thrombosis in pregnant women, which can lead to thromboembolism and maternal and fetal death. Obesity most commonly increases the incidence of gestational diabetes mellitus (GDM) in pregnant women. …”
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Open-label pilot study using hydroxytyrosol as dietary supplements in patients with mitochondrial diseases by Tsz Sum Wong, Emily Man, Ian Chi Kei Wong, Shirley Xue Li, Hui Zhi, Ka Man Carmen Yeung, Ka Yee Yip, Anna Ka Yee Kwong, Kiran Moti Belaramani, Suet Na Wong, Anne Mei Kwun Kwok, Miu Mak, Toby Chun Hei Chan, Pui Yee Lau, Yee Ling Elaine Kan, Kwok Chun Wong, Freddie Poon, Vansie Kwok, Chun Yin Dick Li, Paul Lau, Sze Man Lam, Vanessa Chu, Chi Fung Godfrey Chan, Cheuk Wing Fung

“…Results Among the outcome measures assessed, HT supplementation demonstrated the most considerable impact on improving the health-related quality of life according to the PedsQL scoring system and potential effects on a subgroup of MD patients with Mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS). …”
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Protective effect of purple sweet potatoes (Ipomoea batatas L.) against rat breast cancer by Carmen R. Silva-Correa, Julio Hilario‑Vargas, Abhel A. Calderón-Peña, Víctor E. Villarreal-La Torre, Cinthya L. Aspajo-Villalaz, Natalia Bailon-Moscoso, Juan Carlos Romero-Benavides, Oscar Herrera-Calderon, William A. Sagástegui-Guarniz, Julio A. Castañeda-Carranza, Walter E. Janampa-Castillo, José L. Cruzado-Razco

“…Background and Aim: Breast cancer is one of the most prevalent and lethal malignancies affecting women worldwide. …”
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Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor by Rebecca Slutsky, Roberto Romero, Yi Xu, Jose Galaz, Derek Miller, Bogdan Done, Adi L. Tarca, Sabrina Gregor, Sonia S. Hassan, Yaozhu Leng, Nardhy Gomez-Lopez

“…., the decidual tissues), which plays a central role in the inflammatory process of labor. Most of the innate immune cells in this compartment have been well characterized; however, adaptive immune cells are still under investigation. …”
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