Hospital burden of critical illness across global settings: a point prevalence and cohort study in Malawi, Sri Lanka and Sweden by Abi Beane, Rashan Haniffa, Martin Gerdin Wärnberg, Lisa Kurland, Tim Baker, Kwazizira Samson Mndolo, Cecilia Stalsby Lundborg, Miklos Lipcsey, Carl Otto Schell, Andreas Wellhagen, Anna Hvarfner, Markus Castegren, Petronella Bjurling-Sjöberg, Raphael Kazidule Kayambankadzanja, Chamira Kodippily, Grace Banda, Nalayini Jegathesan, Christoffer Hintze, Wageesha Wijesiriwardana, Jayasingha Arachchilage Sujeewa, Mtisunge Kachingwe, Isaac Mbingwani, Annie Kalibwe Mkandawire, Hampus Sjöstedt, Wezzie Kumwenda-Mwafulirwa, Surenthirakumaran Rajendra, Odala Kamandani Dzinjalamala

“…One in eight hospital in-patients was critically ill, 19% of the critically ill died in hospital, and 96% of the critically ill patients were cared for outside of ICUs. Implementing the most feasible and low-cost critical care in general wards throughout hospitals would impact a large number of high-risk patients and has the potential to improve outcomes across all acute care specialties.…”
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Traditional Chinese medicine for COVID-19 pandemic and emerging challenges: An online cross-sectional survey in China by Chun-Li Lu, Ruo-Xiang Zheng, Xue Xue, Xiao-Wen Zhang, Xue-Han Liu, Xin-Yan Jin, Feng-Lan Pu, Hui-Di Lan, Min Fang, Ling-Yao Kong, Merlin Willcox, Bertrand Graz, Joelle Houriet, Xiao-Yang Hu, Jian-Ping Liu

“…Results: The survey was accessed 503 times with 341 (67.8%) completions covering 23 provinces and four municipalities in China. Most (282/341, 82.7%) respondents reported no symptoms during the pandemic and the majority (290/341, 85.0%) reported having a SARS-CoV-2 PCR test at some point. …”
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Clonal overlap and resistance profiles of multidrug-resistant Klebsiella pneumoniae in humans and domestic animals in Brazil: A One Health molecular epidemiology study by Alessandra Tammy Hayakawa Ito de Sousa, Herica Makino, Marco Túlio dos Santos Costa, Stefano Luis Cândido, Kaio Lierlyson Teles Gomes, Cristiane Silva Chitarra, Marco Andrey Pepato, Francisco Kennedy Scofoni Faleiros de Azevedo, Francisco Jose Dutra Souto, Arleana Bom Parto Ferreira de Almeida, Valeria Régia Franco Sousa, Luciano Nakazato, Valéria Dutra

“…Virulence genes were present in 77.08% of isolates; entB was the most prevalent (60.61%). The blakpc-2 gene was found in three human isolates, and blaNDM was found in one human and one bovine isolate. …”
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An ecological trait matrix of Neotropical freshwater fishes by James S. Albert, Vitor Abrahão, Daniel R. Akin, Jonathan G. Allen, Marcelo Ândrade, Mariangeles Arce, Jonathan W. Armbruster, Ricardo Benine, Maxwell J. Bernt, Maria E. Bichuette, José Birindelli, Pedro Bragança, Marcelo R. Britto, Paulo A. Buckup, Michael D. Burns, Barbara B. Calegari, Fernando G. Carvalho, Tiago P. Carvalho, Lilian Casatti, Wilson Costa, William G. R. Crampton, Robson da Costa Ramos, Ronielson G. da Silva, Fernando Dagosta, Joshua Egan, Luis Fernández, Jessé M. Figueiredo-Filho, Daniel Fitzgerald, João Pedro Fontenelle, Eric B. Haddad, Matthew Kolmann, Tomas Hrbek, Francisco Langeani, Pablo Lehmann, Rafael P. Leitão, Flávio C. T. Lima, Marina V. Loeb, Carlos A. S. Lucena, Paulo H. F. Lucinda, Nathan K. Lujan, Luiz R. Malabarba, Wilfredo A. Matamoros, Bruno F. Melo, Andre Netto-Ferreira, Carla S. Pavanelli, Fernando M. Pelicice, Edson H. L. Pereira, Xavier Plasencia III, Marcelo Rocha, Fábio Roxo, Vivianne Sant’ Anna, Oscar Shibatta, Veronica Slobodian, Madlen Stange, Victor A. Tagliacollo, Milton Tan, Kevin T. Torgersen, Kirk O. Winemiller, Roberto E. Reis

“…Abstract The Neotropical freshwater fish (NFF) fauna constitutes the most diverse continental vertebrate assemblage on Earth, with more than 6,345 species distributed across South America, Central America, and the Greater Antilles. …”
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MicroRNA-371–373 cluster extracellular vesicle-based communication in testicular germ cell tumors by Nuno Tiago Tavares, Catarina Lourenço, Vera Constâncio, Fernanda Fernandes-Pontes, Diana Fonseca, Rui Silva-Santos, Isaac Braga, Joaquina Maurício, Rui Henrique, Michelle Liu, Robert S. Weiss, Aditya Bagrodia, Carmen Jerónimo, João Lobo

“…Abstract Testicular germ cell tumors (TGCTs) represent the most common type of cancer in young adults. The cluster of microRNAs 371–373 is highly upregulated in TGCTs, and detection of miR-371a-3p specifically is currently being developed for clinical implementation as a sensitive and specific biomarker for TGCT, except for teratoma. …”
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International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB) by John A. Rathmacher, Lisa M. Pitchford, Jeffrey R. Stout, Jeremy R. Townsend, Ralf Jäger, Richard B. Kreider, Bill I. Campbell, Chad M. Kerksick, Patrick S. Harty, Darren G. Candow, Brandon M. Roberts, Shawn M. Arent, Douglas S. Kalman, Jose Antonio

“…Daily HMB supplementation (38 mg/kg body weight) in combination with exercise training may improve body composition through increasing lean mass and/or decreasing fat mass with benefits in participants across age, sex, and training status. The most pronounced of these improvements in body composition with HMB have been observed in studies with robust resistance training programs and dietary control. 8. …”
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Innovating through tradition: kava-talanoa as a culturally aligned medico-behavioral therapeutic approach to amelioration of PTSD symptoms by S. Apo Aporosa, Dennis Itoga, Julia Ioane, Jan Prosser, Sione Vaka, Emily Grout, Martin J. Atkins, Mitchell A. Head, Jonathan D. Baker, Tanecia Blue, David H. Sanday, Mahonri W. Owen, Chris Murray, Karthik Sivanathan, Tua’ipulotu W. Cuthers, Anau Mesui-Henry, Mary-Jane McCarthy, James Bunn, Ifereimi Waqainabete, Helen Turner, Helen Turner, Helen Turner

“…Talanoa is a dialog practice common to most Pacific cultures. Our core hypothesis is that, combined, kava-talanoa will outperform current standards of care in PTSD symptom management as a culturally augmented cognitive-behavioral group therapy intervention. …”
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Integrative multi-omics and bioinformatics analysis of the effects of BaiRui YuPingFeng Powder on intestinal health in broilers by Haonan Xu, Fang Zhang, Yan Che, Yu Cui, Qisheng Yao, Yueqin Guan, Hao Chen, Hao Chen, Hao Chen, Yuying Huang

“…IntroductionIn recent years, global poultry consumption has increased rapidly, making chicken the most widely consumed meat worldwide by 2019. To increase livestock development, antibiotics are often added to animal feed as growth promoters. …”
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Functional Outcome of Percutaneous K-wiring vs Closed Reduction and Plaster Casting in Treatment of Unstable Distal Radius Fractures: A Comparative Study by R Sahaya Jose, M Syed Moosa, N Kattu Bava

“…Introduction: Fractures in the distal end of the radius are one of the most common fractures treated by orthopedic surgeons, constituting nearly 18% of all fractures. …”
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Prophetie und Bekenntnis Eine Untersuchung aus sozialethischer Sicht by Sándor FAZAKAS

“…A hitvallási dimenzió komolyan vétele pedig a kijelentés mérlegére teszi az egyház bizonyságtételét, s beállítja azt Isten népének konszenzust kereső, Isten akaratát itt- és most megtudakolni igyekvő tanulási folyamatába. …”
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Effectiveness of Pharmacist-Led Training Regarding Medication for Type 2 Diabetes, Based on Patient and Physician Medication-Related Issues Identified in China by Yang ZH, Cheng CJ, Chen GM, Huang J, Zhou H, Jiang J, Ye Z, Weng YF, Tan HH

“…Both groups were principally composed of general practitioners with primary titles, but most had 0– 5 years of experience, followed by > 20 years. …”
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SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism by Pengxiang Yu, Jiarong Li, Wei Feng, Tao Lei, Wen Jia, Yun He, Yang Bi

“…Abstract Purpose Hepatoblastoma (HB) is the most common and lethal malignant solid tumor of liver in children. …”
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Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers by Ruo-yu Li, Jun Wu, Wan Xiao, Yang Zhou, Ke Liang, Jia-ying Bao, Zhi-yuan Yao, Chao Zhang, Yu-hui Wan

“…BPAP and PFHxS were the chemicals with the most significant weights. BKMR results also found that the mixture of BPs and PFAS had a partially significant positive association with preschoolers’ behavioral problems. …”
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Single-Cell Profiling of Tubular Epithelial Cells in Adaptive State in the Urine Sediment of Patients With Early and Advanced Diabetic Kidney Disease by Dongzhao Ma, Dan Wang, Jianwen Yu, Naya Huang, Ning Luo, Yue Yang, Minghui Xu, Jianbo Li, Yagui Qiu, Jinjin Fan, Zhijian Li, Wei Chen, Qin Zhou

“…Kidney single nucleus RNA-seq, spatial scRNA-seq, and bulk RNA-seq datasets were employed to reconstruct their local environment and to delineate differences between shed cells and local residence. Results: Most urinary TEC in patients with DKD are under adaptive states. …”
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Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis by Gabriel C. Barsotti, Randy Luciano, Ashwani Kumar, Kristin Meliambro, Vijayakumar Kakade, Joji Tokita, Abhijit Naik, Jia Fu, Elizabeth Peck, John Pell, Anand Reghuvaran, E.M. Tanvir, Prashant Patel, Weijia Zhang, Fan Li, Gilbert Moeckel, Sudhir Perincheri, Lloyd Cantley, Dennis G. Moledina, F. Perry Wilson, John C. He, Madhav C. Menon

“…Introduction: Focal segmental glomerulosclerosis (FSGS), the most common primary glomerular disease leading to end-stage kidney disease (ESKD), is characterized by podocyte injury and depletion, whereas minimal change disease (MCD) has better outcomes despite podocyte injury. …”
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Mechanistic insights into the influences of photovoltaic panel construction on algal crust microbial communities in alpine desert grasslands by Desheng Qi, Desheng Qi, Desheng Qi, Desheng Qi, Xin Zhao, Ni Zhang, Ni Zhang, Ni Zhang, Ni Zhang, Ziwei Yang, Ziwei Yang, Ziwei Yang, Ziwei Yang, Yarong Chen, Yarong Chen, Yarong Chen, Yarong Chen, Kelong Chen, Kelong Chen, Kelong Chen, Kelong Chen

“…In addition, temperature and carbon content were the most important factors influencing the structure and diversity of algal BSC bacterial communities in alpine desert grasslands. …”
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Dose escalation phase 1 study of radiotherapy in combination with anti-cytotoxic-T-lymphocyte-associated antigen 4 monoclonal antibody ipilimumab in patients with metastatic melano... by Caroline Robert, Christine Mateus, Christophe Massard, Roger Sun, Eric Deutsch, Lydie Cassard, Rastilav Bahleda, Severine Roy, Emilie Routier, Nathalie Chaput-Gras, Caroline Caramella, Emilie Lanoy, Alicia Larive, Yun Gan Tao, Dominique Schwob, Nathalie Ibrahim, Rita Maria Khoury Abboud, J -C Soria

“…Grade 3 adverse events occurred in nine patients, the most common being colitis and hepatitis. No drug-related death occurred. …”
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Characterization of key aroma in Huangjincha black tea processed from four different cultivars by Ronggang Jiang, Jian Ouyang, Hongyu Chen, Xinyi Zhang, Hao Xu, Kuofei Wang, Yun Peng, Jinhua Chen, Zhonghua Liu, Jianan Huang

“…The OAV and GC-O results indicated that geraniol and benzeneacetaldehyde (HJC1), 3-methylbutanal and 1-penten-3-ol (HJC2), (E, E)-2,4-hexadienal and damascenone (HJC18), as well as methyl salicylate and citral (HJC168) were the most significant aroma compounds. Furthermore, PLS analysis revealed four odorants contributed to floral characteristic, three were related to fruity attribute, four were associated with green attribute, three were connected to fresh attribute, three were linked to nutty profile, and three were tied to the sweet profile.…”
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Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respirator... by Mike Clarke, Marc Chikhani, Cliona McDowell, Ranjit Lall, Michael McKelvey, Margaret McFarland, Brenda O'Neill, Cecilia O'Kane, Murali Shyamsundar, Gavin Perkins, Clifford C Taggart, Gordon Sturmey, Barry Williams, John Warburton, Paul Dark, Bronwen Connolly, Ashley Agus, Naomi Dickson, Mark Borthwick, Bronagh Blackwood, Daniel F McAuley, Christina Campbell, Judy Bradley

“…Carbocisteine and hypertonic saline are the most used agents, but evidence for their effectiveness is absent or minimal. …”
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Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability by Jiaao Su, Abdullah Hashsham, Nandan Kodur, Carla Burton, Amanda Mancuso, Anjan Singer, Jennifer Wloszek, Abigail J. Tomlinson, Warren T. Yacawych, Jonathan N. Flak, Kenneth T. Lewis, Lily R. Oles, Hiroyuki Mori, Nadejda Bozadjieva-Kramer, Adina F. Turcu, Ormond A. MacDougald, Martin G. Myers, Alison H. Affinati

“…Objectives: The brain mobilizes glucose in emergency situations such as hypoglycemia as well as during day-to-day physiology such as fasting. While most hypothalamic neuronal populations that contribute to glucose mobilization also contribute to other aspects of metabolism, neurons in the ventromedial nucleus of the hypothalamus that express the cholecystokinin b receptor (VMHCckbr neurons) support glucose production during hypoglycemia without controlling energy homeostasis. …”
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