Expressed mutated genes in Sezary syndrome and their potential prognostic value in patients treated with extracorporeal photopheresis by Cristina Cristofoletti, Giulia Salvatore, Cristian Bassi, Massimo Negrini, Giovanni Luca Scaglione, Luca Mazzarella, Gianmaria Frigè, Ylenia Aura Minafò, Martina Fioretti, Alessandro Monopoli, Maria Pina Accetturi, Maria Antonietta Pilla, Cosimo Di Raimondo, Alessandra Frezzolini, Enrico Scala, Stefania D’Atri, Giandomenico Russo, Maria Grazia Narducci

“…Integration of RNA-seq with WES data revealed that about half of these genes contained somatic mutations. Among them, the most frequently transcribed mutated genes were TET2, JAK3, NCOR1, PDCD11, RHOA, and TP53. …”
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Cateterização gástrica em recém-nascidos prematuros: análise de prevalência das técnicas de mensuração [Gastric tube insertion in preterm infants: prevalence analysis of measuremen... by Luane Santana Lopes, Gustavo Dias da Silva, Angelina Maria Aparecida Alves, Adriana Teixeira Reis, Glória Regina Gomes da Silva, Zenith Rosa Silvino

“…Half of these have not been described in the literature. Conclusion: the most prevalent techniques were CEX (labial commissure-earlobe-xiphoid), NEX (nose-earlobe-xiphoid) and ENX (earlobe-nose-xiphoid). …”
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Early diagnosis of mineral and bone disorders in patients with diabetic kidney disease on the background of type 2 diabetes by V.M. Yerokhovych, O.V. Karpenko, I.A. Paliienko, N.M. Kobyliak, M.I. Bobryk, L.V. Shuliarenko, O.A. Rudenko, D.V. Kyriienko, M. Bolanowski, Y.I. Komisarenko

“…Diabetic nephropathy is among the most common microvascular lesions. Patients may have clinical manifestations of diabetic kidney disease that go beyond the classic symptoms and have extrarenal consequences in the form of bone mineral disorders. …”
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Effectiveness of socioecological model-guided, smart device-based, and self-management-oriented lifestyle (3SLIFE) intervention on healthy lifestyles and metabolic syndrome risk in... by Bin Yu, Yuchen Li, Chunlan Ma, Jan D. Reinhardt, Qingyu Dou, Haojiang Zuo, Xue Yang, Ming Li, Changwei Cai, Yunzhe Fan, Zixing Huang, Tong Pang, Qi Tang, Fen Yang, Tingting Ye, Peng Jia, Shujuan Yang

“…Abstract Background Mobile health (mHealth) lifestyle interventions have showed promise in improving healthy lifestyles and reducing metabolic syndrome (MetS) risk, yet most studies adopt isolated frameworks. The 3SLIFE model—integrating the socioecological model, smart devices, and self-management strategies—provides a holistic approach to sustained behavioral change. …”
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Reexamination of Gain Theory for Intrinsic Photoconductive Devices by Nenad Vrucinic, Yong Zhang

“…The quantum efficiency <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo stretchy="false">(</mo><mi>Q</mi><mi>E</mi><mo stretchy="false">)</mo></mrow></semantics></math></inline-formula> or gain <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo stretchy="false">(</mo><mi>G</mi><mo stretchy="false">)</mo></mrow></semantics></math></inline-formula> of a photoconductive device is most commonly given in the literature as a ratio of carrier lifetime to transit time, allowing for a value much greater than unity. …”
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Functional divergence and characterization of the HOTHEAD gene family in rice by Jialin Liu, Qing Ye, Yaqi Shen, Zheng Wu, Wenxiang Jiang, Dandan Guo, Xiafei Hu, Xiaoqing Wang, Zelin Zhang, Lifang Hu

“…RT-PCR analysis showed that most HTH genes were highly expressed in anthers, with OsHTH1, OsHTH3, and OsHTH7 exhibiting an anther-preferential expression pattern. …”
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Advances in stem cell-based therapeutics for acute high-altitude illness: research progress and prospects by Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Meng-Jiao Li, Meng-Jiao Li, Meng-Jiao Li, Meng-Jiao Li, Yan-Ling Li, Yan-Ling Li, Yan-Ling Li, Yan-Ling Li, Dan Chen, Dan Chen, Dan Chen, Cheng-Wei Yang, Fang-Yi Fan, Fang-Yi Fan, Fang-Yi Fan, Fang-Yi Fan, Hao Yao, Hao Yao, Hao Yao, Hao Yao, Hao Yao

“…Among them, Mesenchymal stem cells (MSCs), the most extensively investigated, exert therapeutic efficacy through immunomodulation, attenuation of oxidative stress, and enhancement of tissue repair mechanisms. …”
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Medium Optimization for Recombinant Human Papillomavirus Type 52 L1 Protein Production in Pichia pastoris GS115 Platform on Bioreactor Scale by Apon Zaenal Mustopa, Febriyanti Nur Amani, Herman Irawan, Ela Novianti, Sri Swasthikawati, Nurlaili Ekawati, Maritsa Nurfatwa, Daniel Joko Wahyono, Ario Betha Juanssilfero, Jendri Mamangkey, Yudi Purnomo, Ai Hertati, Hans Wijaya, Kartika Sari Dewi, Ratih Asmana Ningrum

“…Notably, HPV type 52 is one of the most prevalent genotypes found in squamous cell carcinoma cases in Indonesia. …”
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SOURCES OF FINANCING INDUSTRIAL COMPLEX ENTERPRISES by Anzhela Zakhitovna Namitulina, Mikhail Nikolaevich Prokofiev, Nikolay Viktorovich Vorovsky

“…This preserves the low investment activity in the sectors of the military-industrial complex, which is the most high-tech part of the industry. In modern conditions in the Russian Federation military-industrial complex includes industrial companies and research organizations involved in defense research and creation of weapons and military equipment, governments and federal bodies of executive power. …”
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Association of Accelerometer‐Derived Physical Activity Pattern With the Risks of All‐Cause, Cardiovascular Disease, and Cancer Death by Dan‐Qing Liao, Hong‐Min Li, Hao‐Jie Chen, Shu‐Min Lai, Xu‐Lian Tang, Cheng‐Shen Qiu, Li‐Ying Du, Hong‐Xuan Huang, Zhi‐Yuan Xiong, Ling Kuang, Bing‐Yun Zhang, Pei‐Dong Zhang, Jian Gao, Wen‐Fang Zhong, Pei‐Liang Chen, Dan Liu, Jin Yang, Qing‐Mei Huang, Chen Mao, Zhi‐Hao Li

“…This study aims to investigate the associations of “weekend warrior” pattern, where most MVPA is completed in 1 to 2 days, and a more evenly spread MVPA pattern with mortality risk. …”
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Transcriptomic analysis of transformed small-cell lung cancer from EGFR-mutated lung adenocarcinoma reveals distinct subgroups and precision therapy opportunities by Hao Sun, Chan-Yuan Zhang, Xiu-Hao Zhang, Zai-Xian Tai, Jun-Wei Su, Xiao-Cheng Lin, Shi-Ling Zhang, Yu-Fa Li, Chao Zhang, Miao Cai, Xu-Chao Zhang, Hua-Jun Chen, Qing Zhou, Yi-Long Wu, Wei-Neng Feng, Jin-Ji Yang

“…Customizing therapeutic protocols to align with these specific subtypes have the potential to identify the most appropriate treatment for T-SCLC. Graphical Abstract…”
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[Translated article] Efficacy of new active viscosupplements on the behaviour of an experimental model of osteoarthritis by R.E. Pérez Expósito, M.A. Ortega Núñez, M.J. Buján Varela, R.M. Vega Rodríguez, A.I. Ortíz Chércoles, B.J. De La Torre Escuredo

“…Conclusions: The use of active viscosupplements could have an additional effect to conventional hyaluronic acid treatment due to its antioxidant and anti-inflammatory effect. The most promising group was hyaluronic acid with nanoparticles that encapsulate curcumin and the second group was the one that encapsulates dexamethasone. …”
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Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis by Manpreet Singh Atwal, Jerneja Nimac, Jerneja Nimac, Urša Čerček, Urša Čerček, Sarah Ricarda Goesch, Hannah Rebecca Goesch, Paraskevi Tziortzouda, Tiziana Ercolani, Anna Zatorska, Terouz Pasha, Ivo Carre, Jacqueline Mitchell, Claire Troakes, Bart Tummers, Vera Župunski, Boris Rogelj, Boris Rogelj, Tibor Hortobágyi, Tibor Hortobágyi, Frank Hirth

“…Cytoplasmic mislocalisation and nuclear depletion of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis (ALS), including mutations in the C9ORF72 gene that characterise the most common genetic form of ALS (C9ALS). Studies in human cells and animal models have associated cytoplasmic mislocalisation of TDP-43 with abnormalities in nuclear transport receptors, referred to as karyopherins, that mediate the nucleocytoplasmic shuttling of TDP-43. …”
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The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control... by Celine Vanhee, Eric Deconinck, Mark George, Andrew Hansen, Andreas Hackl, Uwe Wollein, Oliver El-Atma, Nico Beerbaum, Federica Aureli, Anna Borioni, Magdalena Poplawska, Agata Blazewicz, Karin Roschel, Claude Marson, Magnolia Mendoza Barrios, Birgit Hakkarainen, Andreas Blomgren, Ingrid Bakker-‘t Hart, Marta Miquel

“…Within this dataset, 34 distinct molecules were identified. Most samples were sold or presented as dietary supplements (49%) or medicines (32%). …”
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Gender differences in neurocognitive impairment among first-episode, drug-naïve schizophrenia patients: a cross-sectional study by Qing Zhang, AiMin Sui, Min Su, MingLiang Ju, YanYan Wei, XiaoChen Tang, LiHua Xu, HuiRu Cui, YingYing Tang, ZhengHui Yi, HaiChun Liu, Jin Gao, JiJun Wang, JiJun Wang, TianHong Zhang

“…When stratified by gender, FES patients exhibited similar patterns of impairment severity relative to their gender-matched HCs: both male and female FES patients showed the most pronounced deficits in processing speed (BACS) and sustained attention (CPT), with effect sizes of 1.64 and 1.52 for males, and 1.36 and 1.48 for females, respectively. …”
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Spatially Resolved Galactic H ii Regions Observed by the LAMOST Medium-resolution Spectroscopic Survey of Nebulae (LAMOST MRS-N) by Wei Zhang, Yunning Zhao, Lin Ma, Shiming Wen, Chaojian Wu, Juanjuan Ren, Jianjun Chen, Yuzhong Wu, Zhongrui Bai, Yonghui Hou, Yongheng Zhao, Hong Wu

“…The matter-bounded H II regions exhibit shallower slopes in their radial flux profiles compared to the ionization-bounded ones. In most cases, the [N II ]/H α and [S II ]/H α ratios increase with distance from the center of the H II regions, consistent with model predictions that low-ionization emissions dominate the outer zones of these regions. …”
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Frequency and Prognostic Value of Acute Periprocedural Myocardial Injury in Elective Percutaneous Coronary Interventions by E. O. Nalesnik, A. N. Repin

“…An association of late thrombotic events, such as stent thrombosis (index and re-interventions), stent occlusion (index and non-index) as a reason for re-intervention within 5 years after index PCI, was found with most PMI subgroups. Kaplan-Meier analysis of the dependence of clinically significant bleeding within 5 years after index PCI on the development of “moderate” PMI (p=0.003), as well as the association of non-cardiovascular death within 5 years after index PCI with “minor” PMI (p= 0.007). …”
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Transdiagnostic clustering of self-schema from self-referential judgements identifies subtypes of healthy personality and depression by Geoffrey Chern-Yee Tan, Ziying Wang, Ethel Siew Ee Tan, Rachel Jing Min Ong, Pei En Ooi, Danan Lee, Nikita Rane, Sheryl Yu Xuan Tey, Si Ying Chua, Nicole Goh, Glynis Weibin Lam, Atlanta Chakraborty, Anthony Khye Loong Yew, Sin Kee Ong, Jin Lin Kee, Xin Ying Lim, Nawal Hashim, Sharon Huixian Lu, Michael Meany, Serenella Tolomeo, Christopher Lee Asplund, Hong Ming Tan, Jussi Keppo

“…The generated clusters were examined in terms of most endorsed words, cross-sample correspondence, association with depressive symptoms and the Depressive Experiences Questionnaire and diagnostic category.ResultsWe identify a 5-cluster solution in each sample and a 7-cluster solution in the combined sample. …”
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Optimal early endpoint for second-line or subsequent immune checkpoint inhibitors in previously treated advanced solid cancers: a systematic review by Jingqiu Li, Xiaoding Zhou, Lei Wu, Jiabao Ma, Yan Tan, Songke Wu, Jie Zhu, Qifeng Wang, Qiuling Shi

“…This systematic review aimed to explore the most optimal early efficacy endpoint for such trials. …”
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High-risk HPV distribution and importance of continuing cervical cancer screening of women aged 65 years and older: a study based on 2 152 766 women in China by Bo Wu, Yu Jiang, Jiahui Wang, Xiaotian Li, He Wang, Fanghui Zhao, Zichen Ye, Yingyu Zhong, Shuyan Jin, Xuelian Zhao, Yueyun Wang

“…Single, double and triple hr-HPV infections were found in 10.56% (n=1839), 2.32% (n=404) and 0.57% (n=99) of cases in women aged≥65, with CIN2+ detection rates of 2.01%, 2.73% and 4.04%, respectively, all exceeding those aged&lt;65 (all p&lt;0.001). The most common genotypes in older women were HPV52, HPV16, HPV58, HPV56 and HPV68, with HPV18, HPV16 and HPV33 being major causes of CIN2+, along with frequent double infections such as HPV52/58, HPV16/52 and HPV52/56, while CIN2+ was predominantly associated with HPV33/39, HPV35/31 and HPV18/39, which differ from those in younger women. …”
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