A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry ey... by Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang, Kai Hu

“…Results Significant clinical improvements were observed in most symptoms and signs following MSC eye drops treatment in both NSDE and SSDE patients, particularly in tear production as measured by SIT and TMH, and the alleviation of meibomian gland blockage. …”
Get full text

Cost-Utility Analysis of Metabolic Bariatric Surgery for Individuals with Obesity in Saudi Arabia by Nagi MA, Turongkaravee S, Almalki ZS, Thavorncharoensap M, Sangroongruangsri S, Chaikledkaew U, Alqahtani AM, AlSharif LS, Alsubaihi IA, Alzarea AI, Alsultan MM

“…One-way and probabilistic sensitivity analyses were performed to assess parameter uncertainty.Results: Over a lifetime horizon, MBS yielded 0.38 incremental QALY and US$ 11,975 (Saudi Riyal [SAR] 44,905; purchasing power parity [PPP] 23,911) incremental costs, leading to an incremental cost-effectiveness ratio (ICER) of US$ 31,909 (SAR 119,660; PPP 63,717) per QALY gained from a societal perspective and US$ 36,353 (SAR 136,324); PPP 72,590) from a healthcare system perspective. The model was most sensitive to the discount rates of costs and outcomes and the direct medical costs associated with MBS. …”
Get full text

Contribution of flood early warning response measures in reducing flood effects in Kilosa District, Tanzania by Japhet Ringo, Shadrack Sabai, Anesi Mahenge

“…These actions highlight the importance of timely decision-making and coordinated family preparedness in minimising the effects of floods. ● Most respondents emphasized that the greatest contribution of early warning measures is in reducing human deaths and injuries, followed by reducing effects on livestock and easily movable household assets. …”
Get full text

Co-detection of respiratory pathogens in children with Mycoplasma pneumoniae pneumonia: a multicenter study by Xiaoyan Dong, Rui Li, Yingxue Zou, Lina Chen, Hailin Zhang, Fangfang Lyu, Wenhao Yang, Yanhua Niu, Haojie Wang, Run Guo, Xu Wang, Li Li, Zihao Lin, Li Luo, Danli Lu, Quan Lu, Hanmin Liu

“…Multi-pathogen co-detection was found in 49.62% of MPP patients, and was more frequent in severe cases than in mild cases (54.05% vs. 39.51%, P < 0.05). The most common co-detected pathogens were rhinovirus, adenovirus, influenza A virus, Haemophilus influenzae, and Streptococcus pneumoniae. …”
Get full text

Genome‐Wide Association Study for Resting Electrocardiogram in the Qatari Population Identifies 6 Novel Genes and Validates Novel Polygenic Risk Scores by Nahin Khan, Abdullah Shaar, Khalid Kunji, Atlas Khan, Mohamed Elshrif, Mohammed Bashir, Mohammed Thamer Ali, Ayman Al Haj Zen, Krzysztof Kiryluk, Georges Nemer, Akl C. Fahed, Mohamad Saad

“…Background Electrocardiography is one of the most valuable noninvasive diagnostic tools in determining the presence of many cardiovascular diseases. …”
Get full text

Current status and challenges of multi-omics research using animal models of atherosclerosis by Tijana Mitić, Adriana Georgescu, Nicoleta Alexandru-Moise, Michael J. Davies, Cecile Vindis, Susana Novella, Eva Gerdts, Georgios Kararigas, Stephanie Bezzina Wettinger, Melissa M. Formosa, Brenda R. Kwak, Filippo Molica, Nuria Amigo, Andrea Caporali, Fernando de la Cuesta, Ignacio Fernando Hall, Angeliki Chroni, Fabio Martelli, Johannes A. Schmid, Paolo Magni, Dimitris Kardassis

“…Atherosclerosis is an underlying cause of cardiovascular diseases (CVD) which account for most deaths worldwide. Use of diverse preclinical models of atherosclerosis has been implemental in understanding the underlying mechanisms, the implicated cell types, the genes and the molecules at play in the onset and progression of atherosclerotic plaques. …”
Get full text

Risk assessment based on Cr, Mn, Co, Ni, Cu, Zn, Ba, Pb, and Sc contents in soils and blood Pb levels in children: Seasonable variations and Monte Carlo simulations by He Shen, Xiaoping Li, Jie Dong, Xueming Zheng, Yueheng Jiang, Pengyuan Jin, Xuelian Kui, Huimin Liu, Xu Zhang, Xiangyang Yan

“…The Zn, Cu, and Pb from automobile emissions were identified as the most significant source and priority contaminants in Xi'an, with blood Pb levels being slightly higher in winter at 3.39 μg/dL. …”
Get full text

Adverse Event Management in Patients with Platinum-Resistant Ovarian Cancer Treated with Niraparib and Anlotinib: Updates from the Phase II, Multi-Center ANNIE Study by Deng T, Yan L, Li J, Liu G, Yin A, Feng Y, Zheng M, Zhang C, Huang H, Huang Q, Lin A, Jiang J, Kong B, Liu J

“…Hypertriglyceridemia was mostly managed using atorvastatin and simvastatin. …”
Get full text

Inflammation and Nutritional Status Mediated the Increased of Risk of Atrial Fibrillation Recurrence Associated with eGFRdiff Post-Ablation by Huang W, Liu H, Luo Y, Xiong S, Suo S, Zhang Z, Shang L, Sun H

“…This pattern was consistent in most groups of patients, except for women who showed a different trend. …”
Get full text

Soil reinforcement potential of multifunctional crop plants on arable and non-arable tropical soils by Michael O. Adu, Peter B. Obour, Francis Kumi, Emmanuel Arthur, Paul A. Asare, Eric Oppong Danso, Samuel A. Banafo, Kwabena A. Sanleri, Hygienus Godswill, Kofi Atiah, Kwadwo K. Amoah, Joel B.K. Asiedu, Stephen E. Moore, Donatus B. Angnuureng

“…There were significant differences in Tr among crop plants, with Napier and vetiver grasses displaying the most robust roots. Soil columns planted with crops exhibited 45-80% higher mean soil shear strength than uncultivated soils, depending on the crop species, with Napier grass showing the highest values (63.99 ± 36.86 kPa). …”
Get full text

Colistin-resistant Klebsiella pneumoniae species complex: The scenario in Mexico by Jonathan Rodríguez-Santiago, Alejandro Alvarado-Delgado, Nadia Rodríguez-Medina, Elvira Garza-González, Juan Tellez-Sosa, Luis Duarte-Zambrano, Neli Nava-Domínguez, Christian Sohlenkamp, Miguel A. Vences-Guzmán, Luis Esaú López-Jácome, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Rigoberto Hernández-Castro, Christian Mireles-Dávalos, Eduardo Becerril-Vargas, Juan Pablo Mena-Ramírez, Edgar Cruz-García, Ulises Garza-Ramos

“…Conclusions: This study provides a comprehensive snapshot of the epidemiology of ColR-KpSC in Mexico, highlighting a high prevalence of NDM-1 carbapenemase among ColR-KpSC isolates; this is in line with previous reports identifying NDM-1 as the most prevalent carbapenemase in KpSC. This problem is particularly concerning in Mexico because of the lack of therapeutic options.…”
Get full text

Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind,... by Bernardo Bollen Pinto, Benjamin Shelley, Priyanthi Dias, Salma Begum, Florence Ennahdi-Elidrissi, Tom E.F. Abbott, Russell Hewson, Akshaykumar Patel, Kamran Khan, Rupert M. Pearse, Gareth L. Ackland, Bernardo Bollen Pinto, Benjamin Shelley, Priyanthi Dias, Salma Begum, Florence Ennahdi-Elidrissi, Russell Hewson, Anna Wozniak, Shaun M. May, Mareena Joseph, Agustine Miguel Saavedra, Tim Martin, Onika Ottley, Ana Santos, Fatima Seidu, Stéphanie Mulin, Stéphane Luise, Isabelle Pichon, John Daniels, Béatrice Gil-Wey, Soraya Bicher, Gaël Rais, Christene Aitken, Elizabeth Boyd, Patricia Griffen, Charlene Hamilton, Kathryn Valdeavella, Rhiannon McAreavey, Phillip McCall, Alfie Lloyd, Jocelyn Barr, Julie Buckley, Anne Marie Tiah, Henrike Janssen, Lisa Kandala, Angela Fitzpatrick, Alexander Lysomirski, Ahmed Ahltobi, Ana Gutierrez del Arroyo, Tom E.F. Abbott, Akshaykumar Patel, Kamran Khan, Rupert M. Pearse, Gareth L. Ackland

“…We hypothesise that individuals with autonomic dysfunction may benefit most from ivabradine reducing heart rate control to minimise myocardial injury-associated morbidity. …”
Get full text

STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS‐Dependent... by Chunlin Jiang, Chong Wang, Jian Ao, Yangping Liu, Fengjie Sun, Wangpan Shi, Zeyi Guo, Yanping Wu, Luxiang Gan, Meimei Wu, Yaofeng Zhi, Zijie Meng, Wanting Wu, Juanhua Wu, Yong Ye, Xin Zhang, Dong Ren, Mingxin Pan

“…ABSTRACT Background Dysregulation of transcription factors is one of the most common factors for the pathogenesis of hepatocellular carcinoma (HCC). …”
Get full text

Macrophages facilitate tumor cell PD‐L1 expression via an IL‐1β‐centered loop to attenuate immune checkpoint blockade by Cheng Xu, Yu Xia, Bai‐Wei Zhang, Emmanuel Kwateng Drokow, Hua‐Yi Li, Sen Xu, Zhen Wang, Si‐Yuan Wang, Ping Jin, Tian Fang, Xiao‐Ming Xiong, Pu Huang, Ning Jin, Jia‐Hong Tan, Qing Zhong, Yu‐Xin Chen, Qi Zhang, Yong Fang, Fei Ye, Qing‐Lei Gao

“…Here, we revealed that interleukin (IL)‐1β was among the most abundant cytokines within the in vitro tumor‐macrophage coculture system, and enhanced IL‐1β expression was associated with impaired cytotoxicity of CD8+ T cells in human ovarian cancer, indicating the possibility that IL‐1β mediated immunosuppression during tumor‐TAMs crosstalk. …”
Get full text

Mechanisms of drug resistance in hepatocellular carcinoma by Yongchun Zou, Xinliang Wan, Qichun Zhou, Gangxing Zhu, Shanshan Lin, Qing Tang, Xiaobing Yang, Sumei Wang

“…Abstract Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, associated with high morbidity and mortality worldwide. …”
Get full text

Effect of Two Selected Levels of <i>Padina gymnospora</i> Biowaste and Enteric Methane Emission, Nutrient Digestibility, and Rumen Metagenome in Growing Sheep by Archit Mohapatra, Shraddha Trivedi, Chaluvanahalli S. Tejpal, Manojkumar Janardhan Aware, Shalini Vaswani, Vedant Jayeshkumar Prajapati, Atul Purshottam Kolte, Pradeep Kumar Malik, Artabandhu Sahoo, Chandragiri Nagarajarao Ravishankar, Raghavendra Bhatta

“…The methanogenic phyla Euryarchaeota was the 5th most abundant; however, it constituted only 3.14% of the metagenome. …”
Get full text

N-Acetyl-L-Cysteine modulates indium-tin oxide nanoparticles-caused interstitial lung diseases in male rats through oxidative stress-activated apoptosis and autophagy by Yanzi Zhao, Yujing Niu, Xuefei Wang, Peng Wan, Zhanfei Ma, Jian Sun, Shoufang Jiang, Ling Xue, Nan Liu

“…NAC supplementation restored most of the pathological structural features of rat lung tissue to their physiological range and effectively weakened apoptosis, as demonstrated by the notable reductions in TUNEL, Bax, and Bcl-2 protein expression levels in the lungs. …”
Get full text

Synergistic Antibacterial Interaction of Geraniol and Biogenic Silver Nanoparticles on Methicillin-Resistant <i>Staphylococcus aureus</i> by Isabela Madeira de Castro, Camila Antunes, Camila Cristina Valentim, Laís Fernanda de Almeida Spoladori, Helena Tiemi Suzukawa, Guilherme Ferreira Correia, Gislaine Silva-Rodrigues, Paulo Henrique Guilherme Borges, Guilherme Bartolomeu-Gonçalves, Mariana Luiza Silva, Marcelle de Lima Ferreira Bispo, Rayanne Regina Beltrame Machado, Celso Vataru Nakamura, Gerson Nakazato, Phileno Pinge-Filho, Eliandro Reis Tavares, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta

“…Plants offer exceptional chemical diversity with a wide range of biological activities, and have therefore been the most promising sources for the discovery and development of drugs, including antimicrobial agents. …”
Get full text

Pancreatic stump closure techniques and pancreatic fistula formation after distal pancreatectomy: Meta-analysis and single-center experience. by Elke Tieftrunk, Ihsan Ekin Demir, Stephan Schorn, Mine Sargut, Florian Scheufele, Lenika Calavrezos, Rebekka Schirren, Helmut Friess, Güralp O Ceyhan

“…<h4>Background</h4>Pancreatic fistula/PF is the most frequent and feared complication after distal pancreatectomy/DP. …”
Get full text

Targeting CDK4/6 suppresses colorectal cancer by destabilizing YAP1 by Yalei Wen, Xiao Yang, Shengrong Li, Lei Huang, Jiayi Chen, Lirong Tan, Xiuqing Ma, Yingjie Zhu, Zhengqiu Li, Changliang Shan, Chunze Zhang, Qiushi Zhang, Mingchao Liang, Haoxing Zhang, Tongzheng Liu

“…Abstract Colorectal cancer (CRC) is among the most prevalent and deadly cancers worldwide. The Yes‐associated protein 1 (YAP1) is frequently dysregulated in cancers, contributing to cancer stemness, chemoresistance, and cancer‐related death. …”
Get full text