Improving the capture and reporting of adverse events in clinical trials of non-pharmacological interventions: learnings from the PaCCSC/CST membership by Rayan Saleh Moussa, Jack Power, Vanessa Yenson, Belinda Fazekas, Celia Marston, Annmarie Hosie, Layla Edwards, Domenica Disalvo, Linda Brown, Imelda Gilmore, John Stubbs, Andrea Cross, Sally Fielding, Meera R. Agar

“…We recommend future trials of non-pharmacological interventions adopt a four-step framework that incorporates: (1) enhanced trial protocol development to define the participant, environmental context in which the intervention is taking place and identify other personnel involved; (2) pre-specify anticipated AEs in trial protocol; (3) selection of the most appropriate measurement system to define, report and grade AEs; and (4) develop corrective and preventative action plans. …”
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Multilevel analysis of late antenatal care booking and its predictors among pregnant women in extremely high and very high maternal mortality sub-Saharan African countries: evidenc... by Tesfahun Zemene Tafere, Kaleb Assegid Demissie, Getachew Teshale, Misganaw Guadie Tiruneh, Endalkachew Dellie, Demiss Mulatu Geberu, Asebe Hagos, Nigusu Worku, Melak Jejaw

“…Methods Our analysis utilized secondary data from the most recent Demographic and Health Surveys conducted between 2014 and 2022. …”
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Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids by David Chafi Zeitune, Marcelo Folhadella Martins Faria Azevedo, Mariane Senna Rangel, Robert de Sousa Bastos, José de Brito Vieira Neto, Claudia do Ó Pessoa, Camilla Djenne Buarque

“…However, structural rigidity did not consistently predict activity, as 1-(2,5-dibromophenyl)-4-(9H-fluoren-9-yl)-1H-1,2,3-triazole (LSO275), a rigid fluorene-triazole, was inactive. MOLM-13 was the most sensitive cell line, with compounds such as 4-(9H-fluoren-9-yl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazole (LSO259) and (1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)(4’-fluoro-[1,1’-biphenyl]-2-yl)methanol (LSO280), achieving maximum growth inhibition (MGI > 55%) despite not reaching IC50 values. …”
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Real-world data on clinical outcomes and validation of prognostic models for angioimmunoblastic T-cell lymphoma: a multicentric retrospective study in Southern China by Qiu-Yuan Xiang, Jing-Song Wu, Ling Huang, Zong-Kai Zou, Ting-Bo Liu, Zhi-Gang Peng, Li-E. Lin, Xiao-Lei Wei, Hong-Yu Zhang, Yun Lin, Guo-Wei Li, Yi-Rong Jiang, Hua Wang, Ke-Qian Shi, Rui-Ji Zheng, Zhi-Jun Han, Xiao Qiu, Wen-Yu Li, Ji-Hao Zhou

“…The AITL scores, PIAI scores, and Chinese AITL scores demonstrated superior C-index values, with the Chinese AITL score providing the most distinct risk stratification. Advanced age (over 70 years), bone marrow involvement, and CD7 negativity were identified as significant prognostic factors associated with poorer PFS in both univariate and multivariate analyses. …”
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Impacto de la actividad física en el estrés escolar en niños y adolescentes antes del COVID-19: una revisión sistemática (Impact of physical activity on school-related stress in ch... by Josivaldo De Souza-Lima, Rodrigo Alejandro Yañez Sepulveda, Gerson Ferrari, Frano Giakoni-Ramírez, Jorge Olivares-Arancibia, Pedro Valdivia-Moral

“…However, more high-quality experimental research is needed to clarify the specific characteristics (intensity, type, and duration) of PA that provide the most benefits for stress reduction in adolescents. …”
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Comparison of the effect of role-playing and team-based learning on interpersonal communication skills of emergency medical personnels by Mohsen Sayahi, Reza Nabi Amjad, Mahmoud Kohan

“…Role-playing and team-based learning are key methods to improve these skills, but determining the most effective approach is challenging. This study aimed to compare the impact of these 2 methods on the interpersonal communication skills of medical emergency staff at Abadan University of Medical Sciences in 2024. …”
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PREDICTORS OF THE DEVELOPMENT OF HYPOXIC-ISHEMIC ENCEPHALOPATHY IN FULL-TERM AND PREMATURE INFANTS BORNFROM MOTHERS WITH METABOLIC SYNDROME IN THE EARLY NEONATAL PERIOD by А. Давиденко, В. Похилько, О. Ковальова, Ю. Чернявська, С. Цвіренко, Г. Соловйова

“…Among term infants, the most frequently diagnosed conditions included neonatal depression syndrome, respiratory distress syndrome, heart failure, seizures, and muscular dystonia. …”
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The Clinical and Economic Burden of Idiopathic Hypersomnia and Narcolepsy: A United States Claims-Based Analysis by Saad R, Markt SC, Lillaney P, Profant DA, Fuller DS, Poole EM, Alvord T, Prince P, Desai S, Whalen M, Ni W, Black J

“…Ill-defined conditions (95.6%, 94.4%), nervous system diseases (83.8%, 100.0%), and respiratory system diseases (83.6%, 79.1%) were most common broad clinical classification categories. …”
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Correlation between follicle diameter and pre-ovulatory metabolic profile in Bos grunniens by Jiuru Yan, Jiuru Yan, Jiuru Yan, Yuxin Fu, Yuxin Fu, Yuxin Fu, Lan Lan, Huizhu Zhang, Huizhu Zhang, Huizhu Zhang, Ling Huang, Ling Huang, Yaying Wang, Yaying Wang, Xianrong Xiong, Xianrong Xiong, Xianrong Xiong, Shi Yin, Shi Yin, Shi Yin, Jian Li, Jian Li, Jian Li, Honghong He, Honghong He, Honghong He

“…Differential metabolites enriched KEGG pathways to screen the pathways that might be related to follicle development.ResultsWe found that most of the metabolites were mainly enriched in amino acid metabolism pathways, energy metabolism pathways and other pathways of cofactor synthesis, and that during the development of the small follicle to the large follicle, 2-Lysophosphatidylcholine, PC (17:0/0:0), PC (16:0/0:0), and LysoPC (18:0/0:0) were down-regulated; Dioctyl succinate, P-Coumaraldehyde, ISOPRENE, L-Isoleucine, Dioctyl succinate up-regulated.ConclusionThese results suggest that amino acid metabolism, the production of steroid hormones and their metabolites, and the metabolic activity of granulosa cells play important roles in follicle development. …”
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Dextran sulfate sodium-induced colitis exacerbates periodontitis via the NADPH oxidase 2/reactive oxygen species axis in M1-like macrophages by Tiansong Xu, Liqi Zhang, Murong Li, He Zhu, Ying Ni, Cancan Huang, Peihui Zou, Jie Zhang, Qian Zhang, Zhong Zheng, Chenggang Duan, Feng Chen

“…Periodontitis is associated with various systemic diseases, among the most important of which is inflammatory bowel disease (IBD). …”
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Associations of serum fatty acids, serum urea nitrogen, and ruminal ammonia nitrogen with residual feed intake in lactating dairy cows by W.M. Coelho, Jr., H.F. Monteiro, C.C. Figueiredo, B. Mion, J.E.P. Santos, R.S. Bisinotto, F. Peñagaricano, P. Vahmani, E.S. Ribeiro, F.S. Lima

“…This subset was strategically selected to represent extremes of least feed-efficient (LFE; n = 12, RFI = 2.44) and most feed-efficient (MFE; n = 12, RFI = −2.69) cows with no difference in the 3 energy sinks, namely BW change, metabolic BW, and energy secreted in milk. …”
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Efficacy and safety of Chinese botanical drug Si Shen Wan in irritable bowel syndrome: a meta-analysis and trial sequential analysis of randomized controlled trials by Qian Liu, Zongming Shi, Yang Jiang, Tao Zhang, SiJing Du, Yemei Gao

“…Background and ObjectivesIrritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders (FGIDs), characterized by complex pathogenesis, prolonged disease duration, frequent recurrence, and a significant impact on patients’ quality of life. …”
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Impact of coronary revascularization on clinical outcomes of postacute myocardial infarction patients with left ventricular thrombus by Andre Wen–Jie Seah, Aloysius Sheng–Ting Leow, Fang–Qin Goh, Benjamin Yong–Qiang Tan, Leonard Leong–Litt Yeo, William K.F. Kong, Kian–Keong Poh, James W.L. Yip, Raymond Ching–Chiew Wong, Ping Chai, Tiong–Cheng Yeo, Mark Yan–Yee Chan, Xin Zhou, Gregory Y.H. Lip, Ching–Hui Sia

“…Results: Mean (SD) follow-up duration was 2.1 ± 2.1 years. Most post-AMI LVT patients underwent revascularization via percutaneous coronary intervention (71.5%; n = 188). …”
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Multiparameter Constraints on Empirical Infrasound Period-Yield Relations for Bolides and Implications for Planetary Defense by Elizabeth A. Silber, Josep M. Trigo-Rodríguez, Iyare Oseghae, Eloy Peña-Asensio, Mark Boslough, Rodney Whitaker, Christoph Pilger, Philip Lubin, Vedant Sawal, Claus Hetzer, Randy Longenbaugh, Peter Jenniskens, Brin Bailey, Esther Mas Sanz, Patrick Hupe, Alexander N. Cohen, Thom R. Edwards, Sasha Egan, Reynold E. Silber, Summer C. Czarnowski, Miro Ronac Giannone

“…Through a bootstrap approach, we show that various event subsets can deviate from widely cited period–energy models and we identify which specific conditions most strongly reshape the period–energy scaling. …”
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APPLICATION OF COMPLEX BIOREGULATORY DRUGS IN MODERN DENTAL PRACTICE (REVIEW OF LITERATURE) by S.P. Yarova, E.O. Yurina, Y.Y. Yarov, S.E. Yurin

“…The use of CBDs in the treatment of periodontal diseases was the most researched. In the treatment of chronic generalized periodontitis of mild and moderate severity, along with the conventional methods (removal of dental deposits, curettage of periodontal pockets with subsequent polishing of the root’s surface), the Traumeel S ointment was applied to the vestibular and oral surfaces of the marginal gums of patients with mild degree of disease. …”
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Efficacy and safety of TQB2450 combined with anlotinib as maintenance therapy for LS-SCLC after definitive concurrent or sequential chemoradiotherapy: a prospective phase Ib study by Xiaoli Liu, Xiaoyan Yin, Lulu Zhuang, Junxu Wen, Zhonghui Wei, Wenxing Cui, Minghao Yu, Kaikai Zhao, Lanping Liu, Lingling Kong, Liyang Jiang, Xuquan Jing, Hui Zhu, Xunqiang Wang, Xinjun Dong, Jinming Yu, Xiangjiao Meng

“…AEs were reported in 13 patients (86.67%), with fatigue being the most common treatment related AE (40.00%). And two SAEs were observed (elevation in cardiac troponin T and cerebral infarction), which were determined to be unlikely unrelated to the trial drugs. …”
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Impact of SARS-CoV-2 P.1 Variant Infection on the Nasopharyngeal Commensal Bacterial Microbiome of Individuals from the Brazilian Amazon by Amanda Mendes Silva Cruz, Jedson Ferreira Cardoso, Kenny Costa Pinheiro, Jessylene Almeida Ferreira, Luana Soares Barbagelata, Sandro Patroca Silva, Wanderley Dias Chagas Junior, Patrícia Santos Lobo, Dielle Monteiro Teixeira, Walter André Junior, Inaiah Ordenes Silva, Mirleide Cordeiro Santos, Luana Silva Soares Farias, Maisa Silva Sousa, Fernando Neto Tavares

“…It is important to understand which bacterial taxa are most abundant during SARS-CoV-2 infection and to promote mitigation strategies for conditions subsequent to infection. …”
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hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation by Ian Weidling, Christina N. Preiss, Sarah E. Chancellor, Gyan Srivastava, Lauren Gibilisco, Gen Lin, Melanie Shackett Brennan, Janice Lee, Lindsay M. Roth, Olga Morozova, Kyong Nyon Nam, Nehal R. Patel, Qing Liu, J. K. Thomas, Peter Reinhardt, Ruven Wilkens, Dagmar E. Ehrnhoefer, Andreas Striebinger, Stefan Barghorn, Christina Xanthopoulos, Marie-Theres Weil, Sandra Biesinger, Miroslav Cik, Nandini Romanul, Kiran Yanamandra, Alessandra M. Welker, Jessica Wu, Laura Gasparini, Jan Stöhr, Xavier Langlois, Justine D. Manos

“…Abstract Alzheimer’s disease (AD) is characterized by the accumulation and spread of Tau intraneuronal inclusions throughout most of the telencephalon, leaving hindbrain regions like the cerebellum and spinal cord largely spared. …”
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Rationale and protocol for a longitudinal cohort study of children with cerebral palsy in China assessing functional developmental trends, genetic aetiology and imaging by Jing Zhang, Jinhua Lu, Wenhao Zhou, Yuan Zhang, Hongyu Zhou, Fan Wu, Ting Gao, Jie Luo, Jinling Li, Jingbo Zhang, Lu He, Tingting Peng, Zhaoyao He, Qingfen Hou, Danxia Fan, Mengru Zhong, Yage Zhang, Rongji Liao, Liru Liu, Yun Zheng, Hongmei Tang, Lei Pi, Hongsheng Liu, Kaishou Xu

“…Introduction Cerebral palsy (CP), the most common physical disability in children, imposes substantial economic and psychological burdens on families and society. …”
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Characteristics and outcomes of patients with double refractory and double exposed chronic lymphocytic leukemia by James T. Yoon, Yinglu Zhou, Mariia Mikhaleva, Daniel S. Choi, Stacey M. Fernandes, Philippe Armand, Amy C. Bessnow, Jennifer L. Crombie, David C. Fisher, Eric D. Jacobsen, Caron A. Jacobson, Austin I. Kim, Ann S. LaCasce, Reid W. Merryman, Oreofe O. Odejide, Erin M. Parry, David A. Qualls, Christine E. Ryan, Aswin Sekar, Jacob D. Soumerai, Jon Arnason, Svitlana Tyekucheva, Matthew S. Davids, Jennifer R. Brown, Inhye E. Ahn

“…Nearly all DR patients (97%) required subsequent therapy after developing DR CLL. The most commonly used treatment was noncovalent BTKis (34%), followed by concurrent covalent BTKi and BCL2i (28%) and CD19 chimeric antigen receptor-modified T cells (24%). …”
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