Maintenance treatment with trofosfamide in patients with advanced soft tissue sarcoma – a retrospective single-centre analysis by Anton Burkhard-Meier, Vera Valerie Rechenauer, Luc M. Berclaz, Vindi Jurinovic, Markus Albertsmeier, Hans Roland Dürr, Sinan E. Güler, Michael Hoberger, Alexander Klein, Thomas Knösel, Wolfgang G. Kunz, Nina-Sophie Schmidt-Hegemann, Michael von Bergwelt-Baildon, Lars H. Lindner, Dorit Di Gioia

“…Results: The median age was 48 years; the most common histological subtype was synovial sarcoma (n = 22, 37%), and 71% of patients (n = 42) presented with metastatic disease. …”
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Water Stress Promotes Secondary Sexual Dimorphism in Ecophysiological Traits of Papaya Seedlings by Ingrid Trancoso, Guilherme A. R. de Souza, João Vitor Paravidini de Souza, Rosana Maria dos Santos Nani de Miranda, Diesily de Andrade Neves, Miroslava Rakocevic, Eliemar Campostrini

“…The early gender identification in papaya may help to reduce orchard costs because the most desirable fruit shape is formed by hermaphrodite plants. …”
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Orthopaedic surgeons' perspectives on peripheral nerve blocks for surgical fixation of hip fractures in older adults by Arissa M. Torrie, MD, MHS, Nathan N. O'Hara, PhD, MHA, Sheila Sprague, PhD, Flavia K. Borges, MD, PhD, Ron E. Samet, MD, Mark D. Neuman, MD, MSc, Robert V. O'Toole, MD, Gerard P. Slobogean, MD, MPH, The Survey Respondents, Héctor J. Aguado, MD, PhD, Jamal Alasiri, MBBS, FRCSC, FACS, Daniel Axelrod, MD, MSC, FRCSC, Mariano Balaguer-Castro, MD, MSc, PhD, Brent Bauer, MD, Michael J. Beltran, MD, Patrick F. Bergin, MD, Marissa Bonyun, MD, Christina Boulton, MD, Henry Broekhuyse, MD, Juan Ramón Cano, PhD, Anna Carreras-Castaner, PhD, Gerard Chang, MD, Natalie R. Danna, MD, Malcolm R. DeBaun, MD, Niloofar Dehghan, MD, Graham DeKeyser, MD, Gregory J. Della Rocca, MD, PhD, MBA, FACS, Hannah Elsevier, MD, Mark J. Gage, MD, Virginia García-Virto, MD, Joshua L. Gary, MD, Greg Gaski, MD, John Gentile, DO, Ida Leah Gitajn, MD, J.C. Goslings, MD, PhD, Enrique Guerado, BSc, MD, PhD, MS, Ernesto Guerra-Farfan, MD, Pierre Guy, MD, MBA, FRCSC, Justin T. Fowler, MD, Darin Friess, MD, Frede Frihagen, MD, PhD, Marilyn Heng, MD, MPH, Thomas F. Higgins, MD, Wayne Hoskins, PhD, FRACS, MBBS (Hons), Robert A. Hymes, MD, Izuchukwu Ibe, MD, Ruurd L. Jaarsma, MD, PhD, FRACS, Kyle Jeray, MD, Aaron J. Johnson, MD, Pierce Johnson, MD, Clifford B. Jones, MD, FACS, Patrick J. Kellam, MD, D.H.R. Kempen, MD, PhD, Conor Kleweno, MD, William Lack, MD, Kelly A. Lefaivre, MD, MSc, FRCSC, Ashley E. Levack, MD, MAS, Carol A. Lin, MD, MA, Francesc Marcano-Fernández, MD, PhD, Geoffrey S. Marecek, MD, Meir T. Marmor, MD, Amir Matityahu, MD, Todd O. McKinley, MD, Samir Mehta, MD, Sean J. Meredith, MD, Peter Mittwede, MD, PhD, Gudrun Mirick Mueller, MD, Sumon Nandi, MD, MBA, Jason Nascone, MD, Roman M. Natoli, MD, PhD, William M. Naylor, DO, William Obremskey, MD, MPH, Steve Papp, MD, Sarah N. Pierrie, MD, Andrew N. Pollak, MD, Rudolf W. Poolman, MD, PhD, JM De María Prieto, MD, Rachel M. Reilly, MD, Christopher Renninger, MD, Matthew D. Riedel, MD, Edward K. Rodriguez, MD, PhD, Nicholas M. Romeo, DO, Augustine Mark Saiz, MD, Emil H. Schemitsch, MD, Jeff E. Schulman, MD, John A. Scolaro, MD, Alesha N. Scott, DO, FAAOS, Aresh Sepehri, MD, Steven F. Shannon, MD, Anthony Sorkin, MD, David J. Stockton, MD, MASc, FRCSC, Eric Swart, MD, Guillermo Triana, MD, Aswinkumar Vasireddy, FRCS, Darius Viskontas, MD, FRCSC, Richard Vlasak, MD, Arvind von Keudell, MD, MPH, Emily A. Wagstrom, MD, Zachary M. Working, MD, Taylor M. Yong, MD, MS, Robert D. Zura, MD

“…Primary concerns about PNB use were the negative impact on clinical care efficiency and delayed mobilization. Most surgeons (85%) agreed that higher-level evidence investigating benefits beyond acute postoperative pain control would aid decision-making. …”
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Nonpharmacologic and Nonsurgical Weight Management Interventions for Patients With Advanced CKD: A Scoping Review of the Medical Literature by Kamel Omer, Kristin K. Clemens, Yunxu Zhu, Heather LaPier, Louise Moist, Jaclyn Ernst, Sonja M. Reichert, Alla Iansavichene, Michael Chiu

“…It appeared that dietary intervention that promoted significant caloric restriction over the short term led to the most weight loss (average, 7 kg). Interventions with monitored coaching appeared helpful. …”
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Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson’s disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a... by Dongning Su, Zhijin Zhang, Zhe Zhang, Rui Yan, Wanlin Zhu, Ning Wei, Yue Suo, Xinyao Liu, Ying Jiang, Lingyan Ma, Huiqing Zhao, Zhan Wang, Xuemei Wang, Huizi Ma, Xin Liu, Chaodong Wang, Zhirong Wan, Fangfei Li, Yuan Li, Joyce S. T. Lam, Junhong Zhou, Ning Zhang, Tao Wu, Jing Jing, Tao Feng

“…Conclusion DNH may be preserved in approximately one-quarter of early-stage PD and most MSA-C cases. The 6-point visibility scale on 7T effectively distinguished PD from HC, iRBD, and MSA-C. …”
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Effect of Platelet-rich Fibrin on Soft-tissue and Hard-tissue Healing following Surgical Extraction of Mandibular Third Molar: A Prospective Interventional Study by Sudip Chakraborty, Chayan Kundu, Samiran Ghosh, Richi Burman, Avishek De Sarkar, Gourab Mandal, Somak Saha

“…Introduction: Surgical removal of mandibular third molars is one of the most frequent clinical tasks conducted by dental surgeons. …”
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Multi-omics analysis uncovers predictive biomarkers for the efficacy and outcomes of chemoimmunotherapy in advanced unresectable biliary tract cancers by Jiaojiao Ni, Chaoqun Li, Xiaoqing Xu, Qi Xu, Qian Yin, Hanlin Chen, Shurui Zhou, Jingjing Li, Qinhong Zheng, Yanru Xie, Hongjun Hua, Jianying Jin, Tieming Xie, Haiping Zhao, Feng Yan, Junjun Shen, Yihui Huang, Wangye Zheng, Junrong Yan, Xiaoying Wu, Song Wang, Qiuxiang Ou, Yang Shao, Wei Wu, Wei Zhuo, Jieer Ying

“…Using these biomarkers, patients were categorized into three molecular subtypes, with Type I patients demonstrating the most favorable outcomes under chemoIO. Subsequent RNA analysis revealed that elevated CXCL9 expression was associated with increased immune checkpoint expression within the tumor and heightened immune activity in the tumor microenvironment. …”
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Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness by Hanna Mass, Jamie E. Collins, Catherine Yang, David J. Hunter, Morgan H. Jones, Love Tsai, Stephen P. Messier, Tuhina Neogi, Jeffrey N. Katz, Elena Losina

“…ICERs for PRP were higher than currently accepted willingness to pay thresholds. PRP ICER ranges were most sensitive to discontinuation probability and cost. …”
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Reducing time for vascular access salvage: initial results from a single institution’s clinical practice improvement programme by Li Zhang, Malcolm Han Wen Mak, Ying Pan, Enhui Yong, Pua Uei, Justin Kwan, Enming Yong, Kai Siang Chan, Shufen Neo, Xueping Zhou, Joana Marie Eugenio Gray, Diomampo Katriz Abanto Elah, Ee Ling Ong, Qiantai Hong, Lester Rhan Chaen Chong, Glenn Wei Leong Tan, Sundeep Punamiya, Gavin Lim, Gabriel Chan, Krishna Gummalla, Lawrence Han Hwee Quek, Bien Peng Tan

“…Background One of the most common causes of arteriovenous fistula (AVF) and/or arteriovenous graft (AVG) failure is thrombosis. …”
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Phase I/II study of BMS-986156 with ipilimumab or nivolumab with or without stereotactic ablative radiotherapy in patients with advanced solid malignancies by Wei Li, James Welsh, Vivek Verma, David S Hong, Nathan I Comeaux, Joe Y Chang, Jordi Rodon Ahnert, Daniel D Karp, Ecaterina E Dumbrava, Xinyan Xu, Girish S Shroff, Aileen Chen

“…Six (12%) had Grade 3 TRAEs (2, 2, 1, 1 for G1/L1, G1/L2, G2, G3), with elevated alanine aminotransferase (n=3, in G1/L2, G2 and G3) and aspartate aminotransferase (n=2, in G2 and G3) being the most common. There was no Grade 4–5 TRAEs. Overall, 19/39 (48.7%) patients eligible for efficacy analysis had stable disease and 3 (7.7%) achieved a partial response. …”
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High spatial resolution crop type and land use land cover classification without labels: A framework using multi-temporal PlanetScope images and variational Bayesian Gaussian mixtu... by Minh Tri Le, Khuong H. Tran, Phuong D. Dao, Hesham El-Askary, Tuyen V. Ha, Taejin Park

“…The VBGMM, unlike the traditional unsupervised classification methods, (1) first estimated optimal parameters that are most suitable based on the input features and then (2) assigned pixels to the cluster with maximum posteriori probability of a mixture of several Gaussian distributions. …”
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Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats by Hancheng Li, Hancheng Li, Hancheng Li, Yongen Peng, Yangkai Wu, Yangkai Wu, Yiling Chen, Yiling Chen, Jieyu Li, Jieyu Li, Yunbing He, Yunbing He, Hongwu Wang, Hongwu Wang, Chaohua Luo, Zhixian Mo

“…BackgroundMethamphetamine (MA) is one of the most harmful synthetic drugs, yet the mechanisms underlying its addiction and relapse remain incompletely understood. …”
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Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma by Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili

“…The functional profiles of the most interesting derivatives were assessed at D4R Go and Gi protein and β-arrestin by BRET assay and their potential anticancer activity was determined in GBM cell lines. …”
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Crystal structures of trans-dibromidobis(3,5-lutidine)gold(III) tribromide and three 3,5-lutidinium salts containing tetrabromidoaurate(III) anions (including three cases of polymo... by Cindy Döring, Peter G. Jones

“…Polymorph 1b shows similar Au...Branion and Hortho...Branion contacts, resulting in a chain of residues parallel to the c axis. The most striking feature of the previous polymorph of compound 2 was a topologically square, but distorted, network of tetrabromidoaurate ions. …”
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Facteurs associés aux avortements provoqués à l’hôpital de référence du district sanitaire de Sotouboua, Togo, 2020 à 2023 by Lawouratou Okotan, Péléké Mawaba Hilim, Rebecca Kinde, Ablaga Amenyido, Malilioubè Tchandana

“…The 18 to 35 age group was the most represented, with 73.2%. Rural women accounted for 58.3% of cases. …”
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Hepatic immune environment differences among common mouse strains in models of MASH and liver cancer by Patrick Huang, Francisco J. Rodriguez-Matos, Jonathan Qi, Rajiv Trehan, Yuta Myojin, Xiao Bin Zhu, Tim F. Greten, Chi Ma

“…Results: In healthy mice, liver CD4+ T (24% vs. 14% vs. 34%, p <0.05) and B cells (36.5% vs. 35% vs.18%, p <0.05) varied the most among three strains. C57BL/6 mice showed TH1 dominance, whereas BALB/c and FVB/N mice had TH2 dominance (log[TH1:TH2] = 0.17, -0.31, -0.17). …”
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Analisis statistik kinerja dan koreksi kesalahan data curah hujan berbasis satelit di Provinsi Bali by Putu Aryastana, Cokorda Agung Yujana, Kadek Windy Candrayana, Krisna Himawan Subiyanto

“…The probability distribution function value correction demonstrated the most significant performance improvement compared to the other correction methods. …”
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Fasting, ketogenic, and anti-inflammatory diets in multiple sclerosis: a randomized controlled trial with 18-month follow-up by Lina S. Bahr, Judith Bellmann-Strobl, Daniela A. Koppold, Rebekka Rust, Tanja Schmitz-Hübsch, Maja Olszewska, Jean Stadlbauer, Markus Bock, Michael Scheel, Claudia Chien, Jan Multmeier, Alexander Krannich, Andreas Michalsen, Friedemann Paul, Anja Mähler

“…Abstract Background Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system in young adulthood leading to disability and early retirement. …”
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Isolation, Characterization, and Comparative Analysis of Two Subtypes of Goose Astrovirus in Guangdong Province, China by Chenggang Liu, Linlin Li, Jiawen Dong, Jin Jin, Yong Xiang, Junqin Zhang, Qi Zhai, Yunzhen Huang, Binyi Sun, Ming Liao, Minhua Sun

“…Since 2017, an infectious disease characterized by gosling gout and caused by goose astrovirus (GAstV) has affected geese in most major goose-producing regions of China. In this study, a total of 385 geese displaying gout symptoms were sampled from 12 cities in Guangdong Province, China, between 2019 and 2021. …”
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Which Radiographic Measurements Best Predict Contralateral Slip in Patients Who Undergo Pinning for Unilateral Slipped Capital Femoral Epiphysis? by Eduardo N. Novais, MD, Timothy Borden, MD, Thierry Pauyo, MD, Mariana G. Ferrer, Patricia Miller, MS, Maranho Daniel, MD

“…The Billings angle was the most sensitive (83%; 95% CI = 72–92%). All methods displayed good negative predictive values (NPV) between 80 and 90% and excellent interrater (ICC = 0.92–0.99) and intrarater (ICC = 0.84–0.98) reliability. …”
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