Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination by Cancan Qi, Zhaoli Liu, Gizem Kilic, Andrei S. Sarlea, Priya A. Debisarun, Xuan Liu, Yonatan Ayalew Mekonnen, Wenchao Li, Martin Grasshoff, Ahmed Alaswad, Apostolos Petkoglou, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Leo A. B. Joosten, Yang Li, Mihai G. Netea, Cheng-Jian Xu

“…Interestingly, by integrating with genetic, epigenetic, and cytokine response data from the same individuals, mediation analysis demonstrated that most of the identified DNA methylation changes played a mediating role between genetic variants and cytokine responses; for example, the changes of cg21375332 near SLC12 A3 gene mediated the regulation of genetic variants on IFN-γ changes after BCG vaccination. …”
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Pharmacological treatment and psychiatric polypharmacy in forensic psychiatric care in Sweden by Taalke Maria Sitter, Suvi Virtanen, Hanna Edberg, Peter Andiné, Anja Fernqvist, Ebba Noland, Tatja Hirvikoski, Thomas Nilsson, Zheng Chang

“…Antipsychotics were the most used psychotropic medication class, with 86.2% (95%CI: 84.5–87.8) of patients receiving at least one typical or atypical antipsychotic at admission. …”
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Evaluation of Deviations Produced by Soft Tissue Fitting in Virtually Planned Orthognathic Surgery by Álvaro Pérez-Sala, Pablo Montes Fernández-Micheltorena, Miriam Bobadilla, Ricardo Fernández-Valadés Gámez, Javier Martínez Goñi, Ángela Villanueva, Iñigo Calvo Archanco, José Luis Del Castillo Pardo de Vera, José Luis Cebrián Carretero, Carlos Navarro Cuéllar, Ignacio Navarro Cuellar, Gema Arenas, Ana López López, Ignacio M. Larrayoz, Rafael Peláez

“…A total of 63% of patients required VSP modifications due to poor soft tissue fitting, with 72% of these being Class II DFDs. Most deviations involved less maxillary advancement than planned, while maintaining optimal occlusion. …”
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Sarcoma treatment in the era of molecular medicine by Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz, Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela, Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann

“…Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. …”
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The effect of topography on the choice of optimal step intermediate supports along the line of the cable metro by Lagerev A.V., Lagerev I.A.

“…The position of the minimum is quite stable and only slightly changes when enough significant change in the cost of intermediate supports and installed on them technological equipment. The most effective conditions for the construction of the cable metro is the terrain with considerable differences in altitude along the length of the route of transport: only if the surface inclination of more than 50...60 degrees cost of 1 km line starts to exceed the cost of 1 km line laid along a strictly horizontal surface. …”
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Plankton and benthos in Lake Blagodatnoye (Iturup Island) in summer by V. S. Labay, I. V. Motylkova, D. S. Zavarzin, A. V. Litvinenko, I. A. Atamanova, E. V. Abramova, O. N. Berezova, T. S. Shpilko, A. I. Vodop’janova, O. B. Sharlay

“…Number of species and total distribution density and biomass of macrozoobenthos mostly declined with the depth: there were 18 species, 370 ± 50 ind.…”
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Clinical and hematological factors predicting the effectiveness of ruxolitinib in primary and secondary myelofibrosis. Results of a prospective single-center study by O. Yu. Vinogradova, M. M. Pankraskina, A. L. Neverova, D. I. Shikhbabaeva, M. A. Murzabekova, M. V. Chernikov, A. V. Popova, V. P. Kosenkova, L. B. Egoryan, V. V. Ptushkin

“…Currently, targeted therapy is the most promising for the treatment of myelofibrosis (MF). …”
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Metabolomic profiling of plasma reveals differential disease severity markers in avian influenza A(H7N9) infection patients by Yuefeng Wang, Jili Ni, Mingzhu Huang, Wenxin Qu, Chang Liu, Zheying Mao, Jiaqi Bao, Weizhen Chen, Dongsheng Han, Fei Yu, Yifei Shen, Zhenzhen Deng, Shufa Zheng

“…The enrichment analysis of tryptophan metabolism, porphyrin metabolism, and riboflavin metabolism were significantly up-regulated in the death group. We found that most lipids and lipid–like molecules were down-regulated in the death group, and organoheterocyclic compounds were significantly up-regulated in the death group. …”
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Comparative Metabolomics Analysis of Four Pineapple (<i>Ananas comosus</i> L. Merr) Varieties with Different Fruit Quality by Ping Zheng, Jiahao Wu, Denglin Li, Shiyu Xie, Xinkai Cai, Qiang Xiao, Jing Wang, Qinglong Yao, Shengzhen Chen, Ruoyu Liu, Yuqin Liang, Yangmei Zhang, Biao Deng, Yuan Qin, Xiaomei Wang

“…Specifically, branched-chain amino acids (L-leucine, L-isoleucine, and L-valine) and many DAMs in the flavonoid, phenolic acid, lignan, and coumarin categories were most abundant in MG, which might contribute to its distinct and enriched flavor and nutritional value. …”
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Preclinical validation of electrospun fibers to achieve vaginal colonization by Lactobacillus crispatus by Christy N. Armstrong, Christy N. Armstrong, Sudeshna Saha, Sudeshna Saha, Marnie A. Aagard, Marnie A. Aagard, Mohamed Y. Mahmoud, Mohamed Y. Mahmoud, Nissi M. Varki, Nissi M. Varki, Nissi M. Varki, Nicole M. Gilbert, Nicole M. Gilbert, Hermann B. Frieboes, Hermann B. Frieboes, Hermann B. Frieboes, Hermann B. Frieboes, Warren G. Lewis, Warren G. Lewis, Amanda L. Lewis, Amanda L. Lewis

“…L. crispatus-loaded fibers enabled L. crispatus colonization in most animals for more than one week. Mice receiving L. crispatus-loaded fibers had significantly higher measured concentrations of lactate in vaginal washes at 48 hrs compared to pre-colonization washes.DiscussionThese data provide pre-clinical proof of concept that vaginal administration of electrospun fibers can achieve viable delivery and vaginal colonization by metabolically active L. crispatus, without eliciting inflammation or injury.…”
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Antibody Kinetics of Immunological Memory in SARS-CoV-2-Vaccinated Healthcare Workers—The ORCHESTRA Project by Seyedalireza Seyedi, Sara Sottile, Mahsa Abedini, Paolo Boffetta, Francesco Saverio Violante, Vittorio Lodi, Giuseppe De Palma, Emma Sala, Marcella Mauro, Francesca Rui, Stefano Porru, Gianluca Spiteri, Luigi Vimercati, Luigi De Maria, Pere Toran-Monserrat, Concepción Violán, Eleonóra Fabiánová, Jana Oravec Bérešová, Violeta Calota, Andra Neamtu

“…A significant decline in anti-S levels was observed 3–5 months post-vaccination, with adaptive immunity—characterized by the dominance of internal factors effects relative to external ones—achieved in most groups after the fourth dose. However, adaptive immunity post second dose was limited to specific demographics. …”
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Dynamics of Somatic and Comorbid Mental Disorders (Distress, Anxiety, Somatisation and Depression) in Patients with Irritable Bowel Syndrome during Therapy with Alimemazine: Result... by V. T. Ivashkin, O. Z. Okhlobystina, M. V. Mayevskaya, O. S. Shifrin, Z. A. Mamieva, Yu. E. Azimova

“…The level of somatisation decreased from 13.5 ± 7.3 to 8.7 ± 5.6 (14th day) and to 5.1 ± 4.4 scores (28th day), and the proportion of patients without somatisation increased by 52.9 % and comprised 92.9 % (n = 52) (28th day) (according to the 4DSQ). Most of the patients tolerated alimemazine at a dose of 15 mg/day. …”
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Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X... by Amani Alsharidah, Zeyad Alehaideb, Sahar S. Alghamdi, Rasha S. Suliman, Saleh Althenayyan, Feras Almourfi, Bader Hazazi, Aljawharah Almogren, Abeer Al Tuwaijri, Mohamed Boudjelal, Afrah Alkhuriji, Sabine Matou-Nasri

“…Abstract Background The use of natural health products (NHP) is constantly increasing worldwide. Among the most NHP consumed in the Arabian Peninsula are the resins of Commiphora myrrha (C. myrrha) tree. …”
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Magnolia officinalis enhanced immune responses and the resistance to Vibrio harveyi infection in pearl gentian groupers by Yilin Zhang, Yilin Zhang, Yuhao Li, Yuhao Li, Xinlan Xu, Xinlan Xu, Luxi Xu, Luxi Xu, Weifu Li, Weifu Li, Zhen Gan, Zhen Gan, Yishan Lu, Yishan Lu

“…The results revealed that the expression levels of immune-related genes (IL-12, TLR2, TLR5S, CD4, MHC-Iα, and IFN-γ) in spleen, head kidney, liver and thymus, and the enzyme activities of CAT, SOD, LZM, and total serum protein in serum were significantly up-regulated at most of time points in MO -treated groupers. After being challenged with V. harveyi ZJ0603 at 28 days post-injection, the survival rate (SR) of groupers were 50.0, 60.0, 73.3, and 66.7% in MO groups at different concentrations, respectively, indicating that MO administration could improve the resistance to V. harveyi infection in groupers. …”
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Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis by Adam N. Trautwig, Edward J. Fox, Eric B. Dammer, Anantharaman Shantaraman, Lingyan Ping, Duc M. Duong, Caroline M. Watson, Fang Wu, Seneshaw Asress, Qi Guo, Allan I. Levey, James J. Lah, Federico Verde, Alberto Doretti, Antonia Ratti, Nicola Ticozzi, Cindy V. Ly, Timothy M. Miller, Mark A. Garret, James D. Berry, Eleanor V. Thomas, Christina N. Fournier, Zachary T. McEachin, Nicholas T. Seyfried, Jonathan D. Glass

“…., C9orf72 hexanucleotide repeat expansion or SOD1 mutation), the cause(s) of most cases are unknown. Consequently, there is a critical need for biomarkers that reflect disease onset and progression across ALS subgroups. …”
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Green manure incorporation with nitrogen reduction improves water productivity of spring wheat in arid areas by Bo Yin, Aizhong Yu, Pengfei Wang, Yulong Wang, Yongpan Shang, Dongling Zhang, Yalong Liu, Xiaoneng Pang, Keqiang Jiang, Jianzhe Huo, Feng Wang, Yue Li

“…The results showed that compared with N100, GM incorporation with N reduction had the advantages of increasing soil organic matter (SOM) and total nitrogen (STN) at 0 −120 cm and canopy coverage (CC), root biomass (RB), and dry matter accumulation (DMA) from the anthesis to maturity stage, among which M3N85 had the most significant effect. Meanwhile, this treatment effectively increased soil water storage (SWS) at 0 −120 cm in the three main growth stages (vegetative, concurrent, and reproductive growth stages), reduced soil evaporation (SE) in the three main growth stages, and increased transpiration (T) in the concurrent and reproductive growth stages, finally increasing wheat grain yield (GY) and water productivity (WP) by 28.1 % and 22.7 %, respectively. …”
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Health risk assessment of heavy metals in soils and crops in a mining area (Au-Ag-Cu-trona-oil et al.) of the Nanyang Basin, Henan Province, China by Qiu-yao Dong, Hao-tian Wen, Pan Wang, Chao Song, Shu-ya Lai, Zhen-jing Yang, Yuan-yi Zhao, Ming-jiang Yan

“…The degree of heavy metal pollution in maize fields is higher than that in wheat fields, and both types of fields suffer the most severe Cd pollution. Moreover, the root soils of different crops suffer compound pollution. …”
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Co-infections during SARS-CoV-2 infection in hematologic patients and cell therapy recipients in the omicron era: a Spanish hematopoietic stem cell transplantation and cell therapy... by Pedro Chorão, Alex Avendaño, Inmaculada Heras, Francesco Aiello, Mireia Micó-Cerdá, Ana Arrufat Bel, Valentín Garcia-Gutierrez, María T. Olave, Marina Acera Gómez, Ildefonso Espigado, María Ángeles Cuesta-Casas, Clara González-Santillana, José Ángel Hernández-Rivas, Alicia Roldán-Pérez, Jorge Labrador, Marta Villalba, Lourdes Vázquez, Carolina Garcia Vidal, Rodrigo Martino, Javier López-Jiménez, Ángel Cedillo, Carlos Solano, Irene García-Cadenas, José Luís Piñana, on behalf of the Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation Cell Therapy Group (GETH-TC)

“…Among the microbiologically confirmed agents (n = 82), the most common sites of identification were lower respiratory tract (33%), urinary tract (27%) and bloodstream (17%). …”
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Aplicación del rayo láser de CO2 para soldar laminas de acero bajo carbono // Application of the ray laser of CO2 to weld sheets of steel low carbon by Enrique J. Martínez D, Miguel A. Cisneros G

“…The obtained results show that it can be carried out the<br />process easily, by means of the control of the most important variables, in such a way that once established, the operator doesn't need<br />a great experience in the handling of this technique to carry out the process with high quality. …”
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Comparative effectiveness of various immunosuppressive therapy regimens for uveitis in patients with Behçet’s disease by T. A. Lisitsyna, G. A. Davydova, Z. S. Alekberova, R. G. Goloeva, L. A. Katargina, E. L. Nasonov

“…According to the dynamics of BOS24, the most effective for relieving symptoms of intraocular inflammation were CS (ΔBOS24=–7.0 (–12.0; –3.0)), AZA (ΔBOS24=–7.0 (–15.0; –2.0)), a combination of CS+AZA (ΔBOS24=–5.0 (–8.0; –2.0)) and CPh (ΔBOS24=–4.0 (–14.0; –2.0). …”
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