Clinical remission of mild-to-moderate asthma: Rates, contributing factors, and stability by Mana Ishizuka, MD, Naoya Sugimoto, MD, PhD, Konomi Kobayashi, MD, Yuri Takeshita, MD, PhD, Sahoko Imoto, MD, PhD, Yuta Koizumi, MD, PhD, Yusuke Togashi, MD, Yutaro Tanaka, MD, Maki Nagata, MD, Saya Hattori, MD, Yuki Uehara, MD, Yuki Suzuki, MD, PhD, Hikaru Toyota, MD, PhD, Satoru Ishii, MD, PhD, Hiroyuki Nagase, MD, PhD

“…Conclusion: CR, including normalized forced expiratory volume, is obtainable and sustainable in most Japanese patients with mild-to-moderate asthma. …”
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EMS Potentials in MENA region by Haytham Qosa, Mohamed Rashad Abdelaziz

“…Quality assurance and regular monitoring are areas that need to be standardized and systematized in most cases. EMS Disaster Preparedness Specialized training program for Mass Causality Incidences (MCI) is conducted in LRC, PRCS and SRCA. …”
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Holocene vegetation dynamics on the Bolshoi Ainov Island (Barents Sea, Russia) as a reflection of land uplift and the seabird influence by Ludmila V. Filimonova, Stanislav A. Kutenkov

“…An abundant and diverse vegetation, presence of extensive cover peatlands and the habitat of a large number of seabirds distinguish the Ainov Islands (Kandalaksha State Nature Reserve, Russia) from most other Arctic islands and nearby mainland areas of the Kola Peninsula, considering them an attractive object for paleoecological reconstructions. …”
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Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression by Cuilin Zhu, Cuilin Zhu, Qing Liu, Yale Su, Yale Su, Yixin Zhang, Yixin Zhang, Aanal Patel, Adam Greasley, Jifu Jiang, Douglas Quan, Douglas Quan, Douglas Quan, Weiping Min, Weiping Min, Weiping Min, Weiping Min, Weiping Min, Kexiang Liu, Xiufen Zheng, Xiufen Zheng, Xiufen Zheng, Xiufen Zheng, Xiufen Zheng, Xiufen Zheng

“…BackgroundRenal failure and dysfunction remain one of the most significant morbidities impacting patient’s life. …”
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Population risk predictors of major adverse kidney events attributed to focal segmental glomerulosclerosis from the CURE-CKD registry by Susanne B. Nicholas, Lindsey M. Kornowske, Cami R. Jones, Kenn B. Daratha, Radica Z. Alicic, Christina L. Reynolds, Joshua J. Neumiller, Mark E. Bensink, Wu Gong, Keith C. Norris, Katherine R. Tuttle

“…MAKE were predicted by unique population level factors, such as healthcare utilization and insurance type, which may help to identify patients with FSGS, who could most benefit from diagnostic testing and interventions to improve clinical outcomes. …”
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Peroral endoscopic myotomy as a new approach in the treatment of patients with achalasia cardia by O.M. Kiosov, M.B. Danyliuk, M.A. Kubrak

“…So, for stage II, the beginning of the endoscopic tunnel formation and myotomy was determined from the first persistent esophageal spasm, which most often corresponded to a distance of 25.0 ± 2.0 cm from the incisors and, accordingly, myotomy of the esophagus, lower esophageal sphincter, and gastric myotomy averaged 15.0 ± 3.0 cm. …”
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Genomic characterization of plasmids harboring blaNDM-1, blaNDM-5, and blaNDM-7 carbapenemase alleles in clinical Klebsiella pneumoniae in Pakistan by Muhammad Usman Qamar, Roberto Sierra, Kokab Jabeen, Muhammad Rizwan, Ayesha Rashid, Yumna Fatima Dar, Diego O. Andrey

“…Hence, we stressed the urgent need for enhanced surveillance, not least in low-middle income countries, infection control measures, and adherence to the “Access,” “Watch,” and “Reserve” guidelines in antibiotics use.IMPORTANCEInfections caused by NDM-producing Klebsiella pneumoniae are a significant challenge to treat and represent a crucial health burden in low- and middle-income countries (LMICs). Most of the blaNDM are located on plasmids that promote horizontal gene transfer. …”
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Clinical characteristics of bronchopulmonary dysplasia and the risk of sepsis onset prediction via machine learning models by Yanhua Wang, Yanhua Wang, Yanhua Wang, Yanhua Wang, Yi Wang, Yi Wang, Yi Wang, Linhong Song, Jun Li, Jun Li, Jun Li, Yuanyuan Xie, Yuanyuan Xie, Yuanyuan Xie, Lei Yan, Lei Yan, Lei Yan, Siqi Hu, Siqi Hu, Siqi Hu, Zhichun Feng, Zhichun Feng, Zhichun Feng, Zhichun Feng

“…Bronchopulmonary dysplasia (BPD), also known as chronic lung disease, is the most common cause of respiratory morbidity in preterm infants. …”
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Role of lifestyle factors on the development and long-term prognosis of pneumonia and cardiovascular disease in the Chinese population by Yizhen Hu, Qiufen Sun, Yuting Han, Canqing Yu, Yu Guo, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Mengwei Wang, Rebecca Stevens, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv, On behalf of the China Kadoorie Biobank Collaborative Group, Jing Ni, Xuehong Zhang

“…Using data from the China Kadoorie Biobank study, we used the multistate models to investigate the role of five high-risk LFs, including smoking, excessive alcohol drinking, unhealthy dietary habits, physical inactivity, and unhealthy body shape, alone or in combination in the transitions from a generally healthy state at baseline to pneumonia hospitalization or cardiovascular disease (CVD, regarded as a reference outcome), and subsequently to mortality. Results:. Most of the five high-risk LFs were associated with increased risks of transitions from baseline to pneumonia and from pneumonia to death, but with different risk estimates. …”
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Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin by Cheryll M Sia, Rebecca L Ambrose, Mary Valcanis, Patiyan Andersson, Susan A Ballard, Benjamin P Howden, Deborah A Williamson, Jaclyn S Pearson, Danielle J Ingle

“…Collectively, this study represents the most comprehensive investigation of S. Dublin to date and, importantly, has revealed distinct adaptations of two genotypes within the same serovar, leading to different epidemiological success. …”
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Contemporary techniques and outcomes of surgery for locally advanced renal cell carcinoma with focus on inferior vena cava thrombectomy: The value of a multidisciplinary team by Riccardo Campi, Paolo Barzaghi, Alessio Pecoraro, Maria Lucia Gallo, Damiano Stracci, Alberto Mariotti, Saverio Giancane, Simone Agostini, Vincenzo Li Marzi, Arcangelo Sebastianelli, Pietro Spatafora, Mauro Gacci, Graziano Vignolini, Francesco Sessa, Paolo Muiesan, Sergio Serni

“…At histopathological analysis, 2 (6.2%) patients who underwent partial nephrectomy harboured oncocytoma, while the most common malignant histotype was clear cell RCC (62.5%), with a median Leibovich score of 6 (interquartile range 5–7). …”
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Integrating CT radiomics and clinical features using machine learning to predict post-COVID pulmonary fibrosis by Qianqian Zhao, Yijie Li, Chunliu Zhao, Ran Dong, Jiaxin Tian, Ze Zhang, Lin Huang, Jingwen Huang, Junhai Yan, Zhitao Yang, Jiangnan Ruan, Ping Wang, Li Yu, Jieming Qu, Min Zhou

“…Least absolute shrinkage and selection operator (LASSO) regression with 5-fold cross-validation was used to select the most predictive features. Twelve machine learning algorithms were independently trained. …”
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Selective BCL-2 inhibitor triggers STING-dependent antitumor immunity via inducing mtDNA release by Xi Chen, Bo Yang, Wen Li, Mingming Zheng, Wenxin Zhang, Ling Ding, Longsheng Wang, Xiaohui Pan, Xiaoyang Dai, Hongjie Guo, Yanjun Xu, Honghai Wu, Qiaojun He

“…Interest in STING agonist development has increased, and the candidates hold significant promise; however, most are still in the early stages of human clinical trials. …”
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Uncovering the Burden of Influenza-Associated Illness across Levels of Severity in the Kingdom of Saudi Arabia Across Three Seasons by Amal M. Alshahrani, Ezzualdeen Okmi, Sheena G. Sullivan, Stefano Tempia, Amal Barakat, Hala Abou El Naja, Amir Aman, Osman Hamedelneil, Mutaz Mohamed, Seham F. Basheer, Ghaliah Albugami, Randah Alalweet, Norah Alhazir, Lama Alwalan, Najim Z. Alshahrani, Haleema Alsreehi, Abdullah M. Asiri

“…The flutool analysis estimated annual influenza-associated deaths ranging from 30 to 4,441 and mild/moderate cases reaching up to 6.3 million in the most severe season. Conclusions This study demonstrates a significant burden of influenza-associated SARI hospitalizations in Saudi Arabia, with the highest rates observed in the elderly and young children. …”
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A conceptual framework to develop a patient-reported experience measure of the quality of mental health care: a qualitative study of the PREMIUM project in France by S Fernandes, G Fond, X Zendjidjian, P Michel, C Lançon, F Berna, F Schurhoff, B Aouizerate, C Henry, B Etain, L Samalin, M Leboyer, D Misdrahi, PM Llorca, M Coldefy, P Auquier, K Baumstarck, L Boyer

“…Results: Our analysis generated a conceptual model composed of 7 main themes, ranked from most important to least important as follows: interpersonal relationships, care environment, drug therapy, access and care coordination, respect and dignity, information and psychological care. …”
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Variation pattern of crustacean zooplankton in a bigheaded carps-dominated reservoir by Jinyi Zhang, Jiaoyang Duan, Ji'ao Zhang, Jianguo An, Hongyan Zhang, Zhongjun Hu, Zhongbing Chen, Qigen Liu

“…The relationship between crustacean zooplankton and (planktivorous) fish has not been well clarified in bigheaded-carps-dominated reservoirs, for most of the past studies to explore that kind of knowledge above are often obtained from the studies in temperate lakes and/or shallow lakes. …”
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QTL analysis for plant height and fine mapping of two environmentally stable QTLs with major effects in soybean by Yu TIAN, Lei YANG, Hong-feng LU, Bo ZHANG, Yan-fei LI, Chen LIU, Tian-li GE, Yu-lin LIU, Jia-nan HAN, Ying-hui LI, Li-juan QIU

“…Of numerous QTLs for plant height reported in soybean, most are in large genomic regions, which results in a still unknown molecular mechanism for plant height. …”
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Fluid characteristics, gas accumulation controlling factors and gas enrichment modes in coal reservoirs: A case study of the Upper Paleozoic in the central-eastern Ordos Basin, NW... by Shida CHEN, Dazhen TANG, Wei HOU, Daojun HUANG, Yongzhou LI, Jianling HU, Hao XU, Shu TAO, Song LI, Shuling TANG

“…The adsorbed gas saturation exceeds 100% in most seams, and the free gas content primarily ranges from 1 m3/t to 8 m3/t (greater than 10 m3/t in some seams). …”
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Elevated Leukocyte Glucose Index (LGI) Is Associated with Diabetic Ketoacidosis (DKA) Severity and Presence of Microvascular Complications by Mircea Cătălin Coșarcă, Raluca Maria Tilinca, Nicolae Alexandru Lazăr, Suzana Vasilica Șincaru, Bogdan Corneliu Bandici, Cosmin Carașca, Ráduly Gergő, Adrian Vasile Mureșan, Mariana Cornelia Tilinca

“…<i>Background and Objectives</i>: Diabetic ketoacidosis (DKA) represents the most prevalent hyperglycemic emergency and poses a significant life-threatening metabolic risk for individuals with diabetes. …”
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The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review by Yan Chen, Yan Chen, Jiaojiao Zhao, Jiaojiao Zhao, Yifei Wang, Yifei Wang, Long Ge, Long Ge, Joey Sum-wing Kwong, Junjie Lan, Rui Zhang, Huaye Zhao, Linfang Hu, Jiaxue Wang, Shuimei Sun, Songsong Tan, Xiaoqing Lin, Rui He, Wenyi Zheng, Xiaosi Li, Jiaxing Zhang

“…ISA (SUCRA = 93.50%; mean rank, 1.20) seemed to be the most effective therapy in the above population. As to proven, probable, and possible IA patients, the triazoles were superior to D-AmB in terms of reducing all-cause mortality. …”
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