Prognostic models for cardiovascular and kidney outcomes in people with type 2 diabetes: living systematic review and meta-analysis of observational studies by Veena Manja, Arnav Agarwal, Thomas Agoritsas, Farid Foroutan, Reem A Mustafa, Per Olav Vandvik, Daniel G Rayner, Darsh Shah, Si-Cheng Dai, David Gou, Jason Z X Chen

“…Of all the appraised prognostic models, RECODe had acceptable discrimination and calibration in validation studies for most outcomes; although, additional studies directly comparing models are needed.Study registration number PROSPERO, CRD42023423075.Readers’ note This article is a living systematic review that will be updated to reflect emerging evidence. …”
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SAFETY-MODE RESPIRATORY SUPPORT IN NOSOCOMIAL PNEUMONIA by V. V. Moroz, A. N. Kuzovlev, A. M. Golubev, V. V. Stets, S. G. Polovnikov

“…Safety-mode mechanical ventilation (MV) (protective MV) is the most probable way of preventing ARDS in NP. Objective: to evaluate the efficiency of MV with safety parameters in preventing ARDS in NP in patients with surgical abdominal infection. …”
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A cell wall-targeting urease-derived peptide as a potential antifungal agent against Candida species by Ana Paula A. Perin, Julia C.V. Reuwsaat, Heryk Motta, Fernanda Cortez Lopes, Matheus V.C. Grahl, Andrea G. Tavanti, Marilene H. Vainstein, Charley C. Staats, Célia R. Carlini, Rodrigo Ligabue-Braun, Lívia Kmetzsch

“…Candida species are the most common opportunistic fungi that cause cutaneous and systemic infections, mainly in immunocompromised patients. …”
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A Model for Predicting the Risk of Developing Drug-Induced Liver Injury During Therapy with Favipiravir by Yu. V. Shevchuk, I. V. Sychev, A. V. Kryukov, I. I. Temirbulatov, K. B. Mirzaev, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, V. I. Vechorko, O. V. Averkov, D. A. Sychev

“…According to a number of studies, the incidence of adverse reactions during favipiravir therapy reaches 93%, and the most common adverse reaction is an increase in the level of liver enzymes in the blood. …”
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Experience from Turkish centers participating in the Early Access Program (EAP): Preliminary real-world safety data of nivolumab (nivo) combined with ipilimumab (ipi) in pre-treate... by Nuri Karadurmus, Mehmet Ali Nahit Sendur, Burcak Karaca, Omer Fatih Olmez, Ilhan Hacibekiroglu, Hasan Senol Coskun, Serkan Degirmencioglu, Yasemin Kemal, Saadettin Kilickap, Ahmet Taner Sumbul, Burc Aydin, Hande Turna, Muhammet Ali Kaplan, Nalan Babacan, Umut Demirci, Alper Ata, Dilek Erdem, Ahmet Ozet, Huseyin Abali

“…TRAEs of any grade led to discontinuation in 5 patients (13%). Most of the TRAEs were reversible when managed with available guidelines. …”
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Functional Independence of Taiwanese Children with Silver–Russell Syndrome by Hung-Hsiang Fang, Chung-Lin Lee, Chih-Kuang Chuang, Huei-Ching Chiu, Ya-Hui Chang, Yuan-Rong Tu, Yun-Ting Lo, Jun-Yi Wu, Yen-Yin Chou, Chung-Hsing Wang, Shio-Jean Lin, Shao-Yin Chu, Chen Yang, Tsung-Ying Ou, Hsiang-Yu Lin, Shuan-Pei Lin

“…Of the 24 children, 46% required assistance with bathing, which was strongly correlated with self-care ability and body height. In contrast, most of the children had independence in mobility tasks such as walking and stair climbing. …”
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Development and Systematic Evaluation of a Progressive Web Application for Women With Cardiac Pain: Usability Study by Monica Parry, Tony Huang, Hance Clarke, Ann Kristin Bjørnnes, Paula Harvey, Laura Parente, Colleen Norris, Louise Pilote, Jennifer Price, Jennifer N Stinson, Arland O’Hara, Madusha Fernando, Judy Watt-Watson, Nicole Nickerson, Vincenza Spiteri DeBonis, Donna Hart, Christine Faubert

“…Women across usability testing cycles had a mean age of 55.6 (SD 7.3) years, and most (9/10, 90%) were well educated. In total, 50% (5/10) were employed full or part time, and 60% (6/10) earned >CAD $70,000 (US $48,881.80) annually. …”
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Socio-demographic factors associated with early antenatal care visits among pregnant women in Malawi: 2004-2016. by Wingston Felix Ng'ambi, Joseph H Collins, Tim Colbourn, Tara Mangal, Andrew Phillips, Fannie Kachale, Joseph Mfutso-Bengo, Paul Revill, Timothy B Hallett

“…However, we found that most women did not access the recommended number of ANC visits in Malawi, prior to the 2016 WHO policy change which may mean that women are less likely to undertake the 2016 WHO recommendation of 8 contacts per pregnancy. …”
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International Ski and Snowboard Federation consensus statement on warm-up and cool-down in competitive alpine and freestyle skiers and snowboarders by Vincent Gouttebarge, Evert Verhagen, Roald Bahr, Jörg Spörri, Sheree Bekker, Caroline Bolling, Wolfgang Schobersberger, Lars Engebretsen, Maarit Valtonen, Johannes Scherr, Marine Alhammoud, Hubert Hörterer, Dave Collins, Gerald Mitterbauer, Oriol Bonell Monsonís, Julie Harvey, Lisa Beck, Jan Seiler, Karlheinz Waibel, Tina Weirather

“…However, there was a gender imbalance in the composition of the panel (7 women and 13 men) and certain freestyle disciplines (eg, aerials and moguls) were under-represented. Most importantly, there was a strong over-representation of European members (85%) on the consensus panel. …”
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CORRELATION INTERRELATION OF PSYCHOEMOTIONAL STATE OF CHILDRENWITH SOCIO-HYGIENIC FACTORS OF CARIES OCCURRENCE by L.F. Kaskova, K.M. Popyk, L.P. Ulasevych, L.D. Korovina

“…Children with a fear of knowledge testing are the most likely to complain about the presence of carious cavities. …”
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Nestin in multiple myeloma: emerging insights into a potential therapeutic target by Yingmiao Wu, Yingmiao Wu, Ji Luo, Ji Luo, Yue Zhou, Yue Zhou, Jiaoya Lin, Yajie Wu, Yajie Wu, Shuai Zheng, Shuai Zheng, Jiao Chen, Feifei Che, Qiang Wang, Ling Zhong

“…Multiple myeloma (MM) is the second most common hematological malignancy and remains incurable, with high rates of relapses and refractory. …”
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Identification of essential topics and procedural skills for inclusion in a contextualised undergraduate anaesthesia and critical care clerkship in Rwanda: results of a modified De... by Callum Forbes, Bruce Mutembe Nzobele, Barnabas T. Alayande, Françoise Nizeyimana, Jean Paul Mvukiyehe, Jocelyn M. Booth, Selam Degu Woldegiorgis, Benoucheca Pierre, James Littlejohn, Sheida Tabaie, Abebe Bekele, Craig D. McClain, Gaston Nyirigira, The African Anaesthesia Education Delphi Group

“…The clerkship outcome ranked as most important and achievable was to ‘inspire students to undertake anaesthesia specialty training’ (n = 25, 49.0% and n = 26, 51.0% respectively). …”
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Effect of Compost Addition on Carbon Mineralization and Kinetic Characteristics in Three Typical Agricultural Soils by Shanglong Zhang, Xianni Chen, Aoxue Shi, Minggang Xu, Fenggang Zhang, Lu Zhang, Jiaojiao Zang, Xiaofeng Xu, Jiakai Gao

“…At the end of the incubation, the SOC contents were higher in the R2M treatment than in the Control for all three soils (<i>p</i> < 0.05), with the most notable increase in the cinnamon soil (60.93%). …”
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Experimental study of settlement and migration patterns of proppant in long narrow fractures in deep shale by LIU Haoqi, CHEN Fuhong, YU Zhili, GONG Wei, LUO Xi, LIN Hun

“…Additionally, proppant type, density, and concentration further affect proppant distribution. However, most existing studies are based on the fracture geometries of medium and shallow shale reservoirs, which differ from those of deep shale formations in both fracture width and suitable proppant size. …”
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Ethnic disparities in COVID-19 mortality and cardiovascular disease in England and Wales between 2020-2022 by Marta Pineda-Moncusí, Freya Allery, Hoda Abbasizanjani, David Powell, Albert Prats-Uribe, Johan H. Thygesen, Angela Wood, Christopher Tomlinson, Amitava Banerjee, Ashley Akbari, Antonella Delmestri, Laura C. Coates, Spiros Denaxas, Kamlesh Khunti, Gary Collins, Daniel Prieto-Alhambra, Sara Khalid, On behalf of the CVD-COVID-UK/COVID-IMPACT Consortium

“…COVID-19 28-day mortality and 30-day CVD risk was increased in most non-White ethnic groups in England, and Asian population in Wales, between 23rd January 2020 and 1st April 2022. …”
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A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers by Alberto D. Guerra, Smita Matkar, Christina Acholla, Colleen Casey, Grant Li, Martina Mazzeschi, Khushbu Patel, Kateryna Krytska, Chuan Chen, Skye Balyasny, Joshua Kalna, Paul Kamitsuka, Mark Gerelus, Grace Polkosnik, David Groff, Apratim Mukherje, Cynthia Adams, Gabriela Witek, Amber K. Hamilton, Daniel Martinez, Jennifer Pogoriler, Timothy T. Spear, Yimei Li, Piotr Jung, Diego Alvarado, Mattia Lauriola, John M. Maris, Adam J. Wolpaw, Kristopher R. Bosse, Dimiter Dimitrov, Mustafa Mir, Dontcho V. Jelev, Yael P. Mossé

“…Abstract The Anaplastic Lymphoma Kinase (ALK) gene is a receptor tyrosine kinase (RTK) with expression restricted to the developing nervous system. Most neuroblastomas express native ALK protein on the cell surface and ALK is uniformly overexpressed in fusion-positive rhabdomyosarcoma and in subsets of metastatic colorectal carcinoma, melanoma, ovarian carcinoma, and breast carcinoma. …”
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Dexamethasone in brain tumor patients: a real-world pharmacovigilance audit by Vindhya Prasad, Ali Elhag, Louis Onyiriuka, Engelbert Mthunzi, Sarah Hatch, Awais Naeem, Fatmahelzahraa Noureldin, Francesco Marchi, Francesco Marchi, Ahmed Raslan, Yasir A. Chowdhury, Jonathan Shapey, Jonathan Shapey, Richard Gullan, Ranjeev Bhangoo, Francesco Vergani, Keyoumars Ashkan, Jose Pedro Lavrador, Jose Pedro Lavrador

“…Steroid-related complications occurred in 11.4% (24/210) of patients, most commonly wound infections. Prolonged steroid use (&gt;2 weeks) (OR = 3.5, [95% CI: 1.1–11.0], p = 0.04), and absence of an MDT steroid plan (OR = 4.2, [95% CI: 1.2–15.0], p = 0.03) were significant predictors of complications, particularly of Common Terminology Criteria for Adverse Events (CTCAE) Grade 2–3 severity. …”
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Circulating genomic landscape following cyclin-dependent kinase 4/6 inhibitors exposure in HR + /HER2− metastatic breast cancer: a retrospective multi-institutional Consortium anal... by Letizia Pontolillo, Andrew A. Davis, Lorenzo Gerratana, Arielle J. Medford, Judy Wang, Eleonora Nicolo’, Katherine Clifton, Marko Velimirovic, Surbhi Warrior, Emily Podany, Eleni Andreopoulou, Mara Serena Serafini, Laura Munoz-Arcos, Elisabetta Molteni, Marla Lipsyc-Sharf, Caterina Gianni, Nadia Bayou, Charles S. Dai, Diana Giannarelli, Emilio Bria, Cynthia X. Ma, Aditya Bardia, Carolina Reduzzi, Massimo Cristofanilli

“…Among 93 patients previously treated with CDK4/6i, PIK3CA (37.6%), ESR1 (46.2%) and TP53 (31.2%) were the most altered genes. Comparing with a CDK4/6i plus ET naïve control cohort, ESR1 (p < 0.001) was significantly associated with first-line exposure. …”
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Reactive oxygen species-responsive hydrogel loaded with melatonin as a minimally invasive treatment for myocardial I/R injury by Hechen Shen, Xu Bao, Bingcai Qi, Xiaoyu Liang, Yun Chang, Xiaomin Hu, Wenqing Gao, Di Sun

“…Summary: Myocardial infarction (MI) poses a severe threat to human life, and timely reperfusion of ischemic myocardium stands as the most effective treatment approach. However, myocardial ischemia-reperfusion (I/R) could lead to the excessive generation of reactive oxygen species (ROS), worsening myocardial injury. …”
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Passive Sensing for Mental Health Monitoring Using Machine Learning With Wearables and Smartphones: Scoping Review by ShiYing Shen, Wenhao Qi, Jianwen Zeng, Sixie Li, Xin Liu, Xiaohong Zhu, Chaoqun Dong, Bin Wang, Yankai Shi, Jiani Yao, Bingsheng Wang, Xiajing Lou, Simin Gu, Pan Li, Jinghua Wang, Guowei Jiang, Shihua Cao

“…ResultsThe 42 included studies were predominantly cohort designs (23/42, 55%), with a median sample size of 60.5 (IQR 54-99). Most studies focused on depression (23/42, 55%) and anxiety (9/42, 21%) using primarily wrist-worn devices (32/42, 76%) collecting heart rate (28/42, 67%), movement index (25/42, 60%), and step count (17/42, 40%) as key biomarkers. …”
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