Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification by Wu Q, Wang H, Wang YH, Du J, Li B, Gan XN, Liu CY, Liang J, Liu C, Cao M

“…AKT1 emerged as the target most strongly correlated with HF improvement. In vivo, ZXF significantly enhanced cardiac function and mitigated myocardial fibrosis and cardiomyocyte apoptosis. …”
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Anti-tumor effects of NK cells and anti-PD-L1 antibody with antibody-dependent cellular cytotoxicity in PD-L1-positive cancer cell lines by Bhumsuk Keam, Miso Kim, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Ha-Ram Park, Soyeon Kim, Ji-Eun Park, Seong-Eun Kim, Junsang Doh

“…Background Although programmed cell death-1/programmed death-ligand 1 (PD-L1) inhibitors show remarkable antitumor activity, a large portion of patients with cancer, even those with high PD-L1-expressing tumors, do not respond to their effects. Most PD-L1 inhibitors contain modified fragment crystallizable region (Fc) receptor binding sites to prevent antibody-dependent cellular cytotoxicity (ADCC) against PD-L1-expressing non-tumor cells. …”
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Win for your kin: Neural responses to personal and vicarious rewards when mothers win for their adolescent children. by Jochem P Spaans, Sarah M Burke, Sibel Altikulaç, Barbara R Braams, Zdeňa A Op de Macks, Eveline A Crone

“…Behaviorally, mothers indicated that they experienced most enjoyment when they gained money for their children and that their children deserved to win more, relative to friends and self. …”
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Effects of exogenous 2,4-epibrassinolide on antioxidant enzyme activities of camphor seedlings under salt stress by WANG Shutian, WANG Jinping, ZHANG Jinchi, YUE Jianmin

“…Among the three antioxidant enzymes, SOD activity changed most remarkably, and POD was second, but CAT changed least, indicating SOD has a relatively greater impact on antioxidant enzyme system.In summary, under the salt stress, a certain concentration of EBR can improve antioxidant status, scavenge reactive oxygen species and membrane stability, and enhance salt resistance of camphor seedlings. …”
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No Long-Term Superiority of Cord-Derived PRP over Autologous PRP in Knee Osteoarthritis: A Prospective Cohort Study by Michele Coviello, Antonella Abate, Giuseppe Maccagnano, Alessandro Geronimo, Elio Caiaffa, Vittorio Nappi, Vincenzo Caiaffa, Giuseppe Solarino

“…Platelet-rich plasma (PRP) has been widely studied as a biological treatment for OA, with autologous PRP (A-PRP) being the most commonly used formulation. Recently, umbilical cord-derived PRP (C-PRP) has emerged as a potential alternative due to its hypothesized higher regenerative potential. …”
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Clinicopathological evaluation of the efficacy of endoscopic treatment for sessile serrated lesions comparing endoscopic mucosal resection, cold snare polypectomy, and underwater e... by Kaizo Kagemoto, Koichi Okamoto, Yasuyuki Okada, Motoko sei, Shota Fujimoto, Mai Yagi, Takeshi Mitsuhashi, Hiroyuki Ueda, Takanori Yoshimoto, Takanori Kashihara, Tomoyuki Kawaguchi, Yoshifumi Kida, Yasuhiro Mitsui, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto, Yasushi Sato, Naoki Muguruma, Tetsuji Takayama

“…In this study, we analyzed the clinicopathological features of SSL resected by EMR, CSP, and UEMR to determine the most suitable treatment for SSL. Methods A total of 92 SSL resected via EMR (n = 11), CSP (n = 36), and UEMR (n = 45) were retrospectively enrolled between February 2021 and October 2022. …”
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Corpus Callosum Index: A practical method for long-term follow-up in multiple sclerosis Índice de corpo caloso: um instrumento prático para o seguimento a longo prazo de pacientes... by Fernando Faria Andrade Figueira, Valeria Silva dos Santos, Gustavo Medeiros Andrade Figueira, Ângela Correa Marques da Silva

“…Brain atrophy imaging has sophisticated methodological requirements, not always practical and accessible to most centers. Corpus callosum (CC) is a major inter-hemispheric white matter bundle, grossly affected by long term MS and easily assessed by MRI. …”
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The B-type response regulator ZmRR5 controls maize kernel size by regulating BETL development by Menglin Pu, Bohui Wang, Chao Zhou, Youqiang Li, Mingfei Sun, Guangming Zheng, Yuejia Zhang, Jiawen Wu, Jun Li, Xiaofei He, Zhiming Zhang, Haiping Ding, Xiansheng Zhang, Xiangyu Zhao

“…Maize (Zea mays L.) is one of the world’s most important staple crops, and is used for manufacturing food, feed, and industrial products. …”
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Machine learning-based integration identifies plasma cells-related gene signature ST6GAL1 in idiopathic pulmonary fibrosis by Fanjie Lin, Ken Lin, Donglei Li, Weiguo Kong, Jiayu Zhuang, Wei He, Xinguang Wei, Tianchi Xiao, Hao Zu, Zili Zhang, Wenju Lu

“…Methods The marker genes for plasma cells were extracted via single-cell RNA sequencing (scRNA-seq) analysis. Hub genes most relevant to the IPF state and plasma cells infiltration level were screened by weighted gene co-expression network analysis (WGCNA). …”
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Real-world prescribing in accordance to ACC/AHA guidelines for lipid-lowering therapy in high-risk primary and secondary prevention of ASCVD by Jonathan Arnold, Deeksha Acharya, Hetal Boricha, Himal Chapagain, Aleesha Kainat, Allison Bradley, Jong-Hyeon Jeong, Kevin A. Townsend, Mohammad B. Ateya, David A. DeMicco, YousefAlish, Michael J. Becich, Cynthia H. Chuang, Soledad A. Fernandez, Daniel E. Ford, Wenke Hwang, H. Lester Kirchner, Richard Morgan, Anuradha Paranjape, Neena A. Thomas, David A. Williams, RozelleHegeman-Dingle, Euan McLeod, Phillip A. Saccone, Kathleen M. McTigue

“…Conclusions: In this real-world descriptive study across multiple health systems for patients meeting criteria for secondary or high-risk primary ASCVD prevention, most patients had no documented high-intensity statin prescriptions and did not meet LDL-C targets. …”
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Metagenomic next-generation sequencing-based diagnosis of Pneumocystis jirovecii pneumonia in patients without human immunodeficiency virus infection: A dual-center retrospective p... by Jin-zhu Wang, Jiang-bo Wang, Ding Yuan, Chang-hua Sun, Lin-lin Hou, Yan Zhang, Xiang-hong Yang, Hong-xiang Xie, Yan-xia Gao

“…The sensitivity and specificity of mNGS in diagnosing PJP were higher than those of serum BDG testing (sensitivity: 100 % vs. 63.0 %; specificity: 96.4 % vs. 90.4 %; both P< 0.05). The most common coinfection was viral (30.9 %), followed by bacterial–viral coinfections (13.0 %). …”
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Evaluation of echocardiography monitoring in myotonic dystrophy type 1 patients by D. S. H. Bovenkerk, D. S. H. Bovenkerk, C. E. W. Janssen, F. M. A. Van den Heuvel, I. B. T. Joosten, D. Den Uijl, B. G. M. Van Engelen, S. M. J. Van Kuijk, R. Nijveldt, R. Evertz, C. G. Faber, K. Vernooy, G. P. Bijvoet

“…IntroductionMyotonic Dystrophy type 1 (DM1) is the most prevalent genetic neuromuscular disorder. The potential cardiac involvement, including arrhythmia and left ventricular dysfunction, demands routine follow-up with ECG and echocardiography, however recommendations on the interval of echocardiographic follow-up varies substantially. …”
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Improving the shelf-life and functionality of an orange juice by the addition of polyphenol-enriched extracts obtained using natural deep eutectic solvents by Clara Gomez-Urios, Lorenzo Siroli, Davide Gottardi, Simona Benedetti, Rosalba Lanciotti, Ana Frigola, Susanna Buratti, Jesus Blesa, Mattia Di Nunzio, Francesca Patrignani, Maria J Esteve

“…The innovative juices showed a varying phenolic content depending on the extract used, ranging from 70 to 132 µg/mL, with hesperidin being the most abundant compound. Yeasts were the predominant microflora during storage, with control samples exceeding 5.0 log CFU/mL after just 9 days, regardless of storage temperature. …”
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Incidence of underlying CAD in chest pain patients with intermediate risk for ACS: a retrospective analysis by Abigail Coutinho, Faith Oluwaseun Williams, Ibukunoluwa Ogunbowale, Mohamed Azmi Kasmi Elmetwali, Abdul Basit Malik, Ramabala Vuyyuru, Sayak Roy, Taiwo Ikuesan, Pradeep Singh, Francis Castaneda, Marifel Rojo

“…The grey zone is the one that comes with the most intermediate-risk factors.1 As per data, it is noted that ∼2% of patients presenting to the ED with acute coronary syndrome (ACS) are mistakenly discharged, leading to a significant increase in risk.2 This can cause a twofold rise in 30-day morbidity and mortality, underscoring the critical importance of our diagnostic approach. …”
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Endovascular Treatment in Patients with Large Vessel Occlusion Stroke of Different Mechanisms by Zhiyuan Feng, Ming Yang, Aoming Jin, Ning Ma, Feng Gao, Dapeng Mo, Xiaojuan Liu, Fangyuan Zhang, Xinchen Li, Yimeng Li, Qi Chu, Jing Xue, Aichun Cheng, Jinxi Lin, Hao Li, Xia Meng, Zhongrong Miao, Yongjun Wang, Jie Xu

“…Results Among 162 patients included, IST (n = 81) was the most common mechanism, followed by CE (n = 41) and AAE (n = 40). …”
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Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review by Mohamed T. El-Saadony, Ahmed M. Saad, Dina Mostafa Mohammed, Sameh A. Korma, Mohammad Y. Alshahrani, Ahmed Ezzat Ahmed, Essam H. Ibrahim, Essam H. Ibrahim, Heba M. Salem, Heba M. Salem, Samar Sami Alkafaas, Abdullah M. Saif, Sara Samy Elkafas, Sara Samy Elkafas, Mohamed A. Fahmy, Taia A. Abd El-Mageed, Mariam M. Abady, Mariam M. Abady, Hanya Y. Assal, Marawan K. El-Tarabily, Betty T. Mathew, Synan F. AbuQamar, Khaled A. El-Tarabily, Salam A. Ibrahim

“…This current review aims to identify the most common pathogens threatening human health, analyze the factors contributing to the rise of drug-resistant microorganisms, and evaluate the widespread use of medicinal plants across various countries as alternative antibiotics, highlighting their unique mechanisms of antimicrobial resistance.…”
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Immunopathological features of highly pathogenic Korean Lineage B PRRSV-2: insights into virulence indicators and host immune responses by Gyeong-Seo Park, Gyeong-Seo Park, Seung-Chai Kim, Hwan-Ju Kim, Chang-Gi Jeong, Chang-Gi Jeong, Sang-Chul Kang, Go-Eun Shin, Seoung-Hee Kim, Hye-Young Jeong, Kyoung-Ki Lee, Sang-Myeong Lee, Won-Il Kim

“…IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most economically devastating pathogens in swine, primarily due to its extensive genetic diversity and lineage-dependent pathogenicity. …”
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Machine learning-based identification of key biotic and abiotic drivers of mineral weathering rate in a complex enhanced weathering experiment [version 2; peer review: 1 approved,... by Thomas Corbett, Harun Niron, Lukas Rieder, Reinaldy P. Poetra, Abhijeet Singh, Michiel Van Tendeloo, Siegfried E. Vlaminck, Steven Latré, Jan Willem van Groenigen, Jens Hartmann, Alix Vidal, Anna Neubeck, Mathilde Hagens, Ivan A. Janssens, Tim Verdonck, Sara Vicca, Thomas Servotte, Iris Janssens, Steven Mortier, Tullia Calogiuri

“…However, key drivers were consistently abiotic, though biota also made a significant contribution to the predictions. The most representative CDR indicator, ∆TIC, was predominantly driven by steel slag addition and mixed rock grain sizes but was also substantially impacted by earthworms and microbes. …”
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Sensitivity analysis of process parameters on the properties of carbon fiber reinforced polyether-ether-ketone composites in screw extrusion 3D printing by Siwei Lu, Beining Zhang, Yunze Wang, Jincang Bai, Chuncheng Yang, Changning Sun, Dichen Li

“…Regarding part strength, the most influential parameters were printing temperature and annealing temperature, followed by filling angle, nozzle diameter, printing layer height, and printing line width, while printing speed and annealing time had relatively minor effects on strength. …”
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Machine learning applications in forecasting patient satisfaction and clinical outcomes after carpal tunnel release: a retrospective study by Zohreh Manoochehri, Sara Manoochehri, Seyed Reza Bagheri, Alireza Abdi, Ehsan Alimohammadi

“…Background Carpal tunnel syndrome (CTS) is the most common neuropathy affecting the upper limbs. …”
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