Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis by Xiaoqi Pang, Jing Yan, Xinrui Lv, Jingjing Wang, Qi Chen, Yaxin Qi, Xin Xu, Bangmao Wang, Hailong Cao

“…This study focuses on 7-ketositosterol (KS), the most abundant phytosterol oxide found in UPFs, and its role in UC. …”
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GM-CSF potentiates macrophages to retain an inflammatory feature from their circulating monocyte precursors in rheumatoid arthritis by Jianing Chen, Minghua Zhan, Yanling Zhao, Honglin Xu, Futai Feng, Zhou Bai, Ke Zhang, Lufan Fu, Fang Wang, Yongjing Cheng, Xuan Zhang, Yudong Liu

“…Strikingly, CCL22 was identified as the most upregulated chemokine in RA GM-DMs. Elevated synovial CCL22 expression strongly correlated with M1 macrophage infiltration and disease activity. …”
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Correlation between Neutrophil-to-Lymphocyte Ratio and Diabetic Neuropathy in Chinese Adults with Type 2 Diabetes Mellitus Using Machine Learning Methods by Lijie Zhu, Yang Liu, Bingyan Zheng, Danmeng Dong, Xiaoyun Xie, Liumei Hu

“…Objective. One of the most frequent consequences of diabetes mellitus has been identified as diabetic peripheral neuropathy (DPN), and numerous inflammatory disorders, including diabetes, have been documented to be reflected by the neutrophil-to-lymphocyte ratio (NLR). …”
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An assessment of facility readiness for comprehensive abortion care in 12 districts of Pakistan using the WHO Service Availability and Readiness Assessment tool by Palitha Gunarathna Mahipala, Sabeen Afzal, Qudsia Uzma, Atiya Aabroo, Nilmini Hemachandra, Katy Footman, Heidi Bart Johnston, Bela Ganatra, Tahira Ezra Reza, Ahsan Maqbool Ahmad, Hasan Bin Hamza, Maida Umar, Kauser Hanif, Sayema Awais, Mariyam Sarfraz, Ellen Thom

“…Misoprostol (75.2%) was the most common method provided by facilities that offer therapeutic abortion, followed by vacuum aspiration (60.7%) and dilatation and curettage (D&C) (59%). …”
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Economic burden of breast cancer in Chinese women: analysis o from 2016 to 2018 using national health insurance data by Yu Qi, Yaqun Fu, Yumeng Lv, Ye Zhang, Xia Wei, Li Sun, Bin Cui, Ranjit Manchanda, Rosa Legood, Li Yang

“…Background: In 2022, there were approximately 19.96 million new cancer cases globally according to GLOBOCAN, with breast cancer emerging as the most commonly diagnosed female cancer. In China, there were 0.36 million new cases and 75,000 deaths due to breast cancer of women in 2022. …”
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Analysing the psychological capital influence on academic performance in an e-learning environment by Lama Sameer Khoshaim

“…The study began with demographic data collection and an assessment of PsyCap dimensions. Most measurements were self-reported, except for GPA, retrieved from the institute directly. …”
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Chinese herbal injections in combination with radiotherapy for advanced pancreatic cancer: A systematic review and network meta-analysis by Yun-Ru Chen, Ruo-Tong Zhao, Yi-Fang Xu, Yin-Jie Ma, Shao-Bo Hu, Xue-Hui Wang, Bing-Bing Fan, Yan-Ji Zhou, Yu-Bei Huang, Nicola Robinson, Jian-Ping Liu, Zhao-Lan Liu

“…Regarding AEs, CKI plus RT was the most favorable in reducing the incidence of leukopenia (SUCRA 90.37 %) and nausea/vomiting (SUCRA 85.79 %). …”
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Irreversible organ damages in a cohort of patients with systemic lupus erythematosus (RENAISSANCE) by E. A. Aseeva, S. K. Solovyev, N. G. Klyukvina, T. V. Popkova, G. M. Koilubaeva, T. M. Reshetnyak, N. M. Kosheleva, T. A. Lisitsyna, T. A. Panafidina, E. V. Gerasimova, N. V. Seredavkina, L. V. Kondratyeva, E. S. Solovyeva, M. E. Tsanyan, E. V. Matyanova, M. V. Letunovich, N. E. Lopatina, N. Yu. Nikishina, T. P. Fedina, E. G. Sazhina, S. I. Glukhova

“…There were low (1), mean (2–4), and high (>4) SLICC DI values in 64 (28%), 62 (27%), and 11 (5%) patients, respectively. Ocular lesions were most common (35%); a significant proportion of patients were found to have damages to the cardiovascular (22%), musculoskeletal (19%), and nervous (10%) systems. …”
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Long-term alterations in gut microbiota following mild COVID-19 recovery: bacterial and fungal community shifts by Da Li, Da-Ya Zhang, Shi-Ju Chen, Yan-Ting Lv, Shi-Mei Huang, Chen Chen, Fan Zeng, Run-Xiang Chen, Xiao-Dong Zhang, Jian-Xin Xiong, Fa-Di Chen, Yue-Hong Jiang, Zhai Chen, Cui-Yi Mo, Jia-Jia Chen, Xu-Li Zhu, Li-Jun Zhang, Fei-Hu Bai, Fei-Hu Bai

“…ObjectiveCOVID-19 has had a profound impact on public health globally. However, most studies have focused on patients with long COVID or those in the acute phase of infection, with limited research on the health of individuals who have recovered from mild COVID-19. …”
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Novel Mutations Associated with N-Gene Target Failure in SARS-COV-2 Genome in Iran, Case Series by Ali Maleki1, 2, Zahra Fereydouni1, Mahsa Tavakoli1, Akram Ezani3, Mirshamsedin Hosseini3, Amir Hesam Nemati1, Parastoo Yektay Sanati1, Tahmineh Jalali1, 4, 5, Mohammad Hassan Pouriayevali1, 4, 5, Mostafa Salehi-Vaziri1, 4, 5

“…Following sequencing, changes were discovered in the annealing region of the forward and reverse primers and probes used in the SARS-CoV-2 detection kit. Among the most significant mutations is a large deletion of 15 nucleotides in the N gene, which has never been seen in prior variants. …”
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Cultural and behavioral drivers of zoonotic disease transmission and persistence among diverse pastoralist communities in East Africa by Dismas C.O. Oketch, Ruth Njoroge, Tonny O. Ngage, Asha Abdikadir Omar, Abdulai Magarre, Raphael Pasha, John Gachohi, Samuel Waiguru Muriuki, Samoel Ashimosi Khamadi, Ali Duba Boru, Boku Bodha, Lydia Kilowua, Nazaria Wanja Nyaga, Humphrey Kariuki Njaanake, Eunice Kamaara, Walter Jaoko, M. Kariuki Njenga, Eric Osoro, Dalmas Omia

“…Women and children handled and milked small ruminants while adult men and morans (young warriors) were mostly involved with cattle, camels and slaughtering; hence exposing them to zoonotic pathogens disproportionately. …”
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Cost-effectiveness of follow-up algorithms for chronic thromboembolic pulmonary hypertension in pulmonary embolism survivors by Dieuwke Luijten, Wilbert B. van den Hout, Gudula J.A.M. Boon, Stefano Barco, Harm Jan Bogaard, Marion Delcroix, Karl-Friedrich Kreitner, Matthias Held, Menno V. Huisman, Luis Jara-Palomares, Stavros V. Konstantinides, Lucia J.M. Kroft, Albert T.A. Mairuhu, Lilian J. Meijboom, Thijs E. van Mens, Maarten K. Ninaber, Esther J. Nossent, Piotr Pruszczyk, Luca Valerio, Anton Vonk Noordegraaf, Frederikus A. Klok

“…When comparing different algorithms with each other, the maximum differences were 0.27 QALYs and EUR 27 600. The most cost-effective algorithm was the InShape IV algorithm, with an ICER of EUR 26 700 per QALY compared to the next best algorithm. …”
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Neuroprotective Activity of 5-ethoxy-2-ethylthiobenzimidazole (Etomerzol) and 2-ethylthiobenzimidazole (Bemitil) in a Model of Middle Cerebral Artery Occlusion by E. Yu. Zavarina, E. K. Krasova, I. A. Titovich, A. N. Kimaev

“…Cerebrovascular diseases (CVD) are one of the most pressing medical and social problems due to the high rate of mortality and disability. …”
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Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model by Ádám István Horváth, Ádám István Horváth, Kata Bölcskei, Nikolett Szentes, Nikolett Szentes, Nikolett Szentes, Éva Borbély, Éva Borbély, Valéria Tékus, Valéria Tékus, Valéria Tékus, Bálint Botz, Kitti Rusznák, Kitti Rusznák, Anett Futácsi, Anett Futácsi, Boldizsár Czéh, Boldizsár Czéh, Péter Mátyus, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes

“…IntroductionMonoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. …”
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Machine Learning for Monoclonal Gammopathies of Renal Significance Risk Stratification Using Clinical and Pathology Data by Giorgio Cazzaniga, Giulia Capitoli, Raffaella Barretta, Andrew Smith, Gisella Vischini, Giuliana Papalia, Federico Alberici, Federica Mescia, Albino Eccher, Jan Ulrich Becker, Maarten Naesens, Lucrezia Furian, Bernd Schröppel, Stefania Galimberti, Fabio Pagni, Vincenzo L'Imperio

“…Results: Patients with MGRS were more frequently female (48.2% vs. 28.9%, P = 0.004) and had more frequent Bence Jones proteinuria (73.2% vs. 41.1%, P < 0.001) than non-MGRS cases, with amyloidosis being the most common diagnosis (62%). The ML model achieved an accuracy of 0.79 (95% confidence interval [CI]: 0.67–0.88) and an area under the receiver operating characteristic curve of 0.80 (95% CI: 0.65–0.93) in the validation set. …”
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Modern principles of the radiation protection from sources of ionizing radiation in medicine. Part 2: radiation risks and development of the system of radiation protection by G. G. Onischenko, A. Yu. Popova, I. K. Romanovich, A. V. Vodovatov, N. S. Bashketova, O. A. Istorik, L. A. Chipiga, I. G. Shatsky, S. S. Sarycheva, A. M. Biblin, L. V. Repin

“…That required to analyze the existing national and international approaches to the assessment of the radiation risks from medical exposure and the results of the existing epidemiological studies, as well as to assess the risks from the most common and/or high dose X-ray examination (computed tomography, interventional examinations, nuclear medicine) for pediatric and adult patients. …”
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The Assessment of Participatory Scenario Planning in Future-Study of the Environment in District 1, Tehran City by Aiub Maroofi, Jila Sajadi, Mohammadtaghi Razavian

“…The transition from traditional planning to new planning approach has been one of the most important changes in urban planning over the past several decades (Rahnema and Maroofi, 2015: 45). …”
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Features of Changes of Main Indices in Acne Patients Systemic Immunity and Their Dependence on Clinical Forms of Dermatosis Course by Syzon O., Dashko M.

“…Consequently, in the majority of examined acne patients different degree of change in certain indicators of systemic immunity has been established, i.e. a probable decrease in the relative and absolute number of general lymphocytes, T-lymphocytes and their sub-populations with the simultaneous increase in the number of B-lymphocytes and the content of IgM and IgG, which in general testifies to the formation of a secondary immunodeficiency state per the T-segment with the activation of immune humoral segment in response to the onset of skin inflammation. The most significant changes in the studied indicators of systemic immunity, associated with the depletion of T-cellular immunity segment, have been established in patients with papular-pustular and pustular acne forms, and, especially, in those with conglobate acne, which substantiates the differentiated administration of immunocorrective medications for such patients as a part of the integrated treatment. …”
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Examining Canadian Hospitals&amp;rsquo; Support for Planetary Health Through the Implementation of Green Teams and Sustainability Offices by Kalogirou MR, Baumbusch J

“…Teams that integrated both approaches were the most effective in promoting planetary health.Plain Language Summary: The health sector is harming the planet’s natural systems, and now there is a need for it to start promoting planetary health. …”
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Management of Chlamydia Cases in Australia (MoCCA): protocol for a non-randomised implementation and feasibility trial by Rebecca Guy, Marcus Y Chen, Basil Donovan, Jane S Hocking, Natalie Carvalho, Christopher Fairley, Claudia Estcourt, Meredith Temple-Smith, Jane Tomnay, Julie Simpson, David Regan, David Hawkes, Lena Sanci, Jane L Goller, Jacqueline Coombe, Helen Bittleston, Marion Saville, Lara Roeske

“…In Australia, mainstream primary care (general practice) is where most chlamydia infections are diagnosed, making it a key setting for optimising chlamydia management. …”
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