Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium by Priya Kumar, Monika L. Metzger, John K. Choi, Godwin Job, Teresa C. Santiago, Armando Peña, Miguela A. Caniza, Asya Agulnik, Pascale Y. Gassant, Wendy C. Gómez García, Patricia J. Calderón, Claudia Garrido, Roy Rosado, Soad Fuentes Alabí, Valentino Conter, Meenakshi Devidas, Angela K. Carrillo, Yichen Chen, Paola Friedrich, Carlos Rodriguez Galindo, Guillermo L. Chantada, Victor M. Santana

“…For nine (13%) patients, diagnoses changes with therapy implications were made upon central review, while in six patients, there was a minor disagreement with no therapy implications. Most (87%) patients presented with advanced disease. …”
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A global review of acupuncture and moxibustion recommendations in guidelines/expert consensus for chemotherapy- and/or radiotherapy-induced nausea and/or vomiting by Tian-yu MING, Wei-juan GANG, Lan-jun SHI, Zhen LUO, Zi-yu TIAN, Xiao-yi HU, Huan CHEN, Rui-min JIAO, Wen-cui XIU, Xiang-yu HU, Xiang-hong JING

“…Although there were many recommendations of acupuncture and moxibustion in the existing guidelines/expert consensus, there was great heterogeneity among the acupuncture and moxibustion treatment regimens. Moreover, most of the guidelines/expert consensus did not describe the details of acupuncture and moxibustion treatment regimens, such as acupuncture and moxibustion manipulation, acupoint selection, course and timing of treatment, which is difficult to guide the clinical practice of acupuncture and moxibustion. …”
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A Brilliant Career: Life as a Law Teacher by Neil Gold

“…The study of law was made up mostly of empty pursuit of rules characterised by order, clarity, continuity but not by worth, utility or aspiration. …”
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Práticas de gestão no desenvolvimento de produtos em empresas de autopeças Management practices in product development in autoparts industry by José Carlos de Toledo, Sérgio Luis da Silva, Dário Henrique Alliprandini, Manoel Fernando Martins, Fernanda Menezes Ferrari

“…Some of the main findings on the practices are: widespread dissemination and use of reference models for PDP partially implemented; methods and techniques for PDP Management are applied with weak inter functional integration; development team carries out the PDP activities; functional structure is still widely used; the follow-source projects are the most common type, while platform projects were also identified (average of 25% of carry out projects); and the first tier suppliers are the ones that more use practices of international pattern of PDP management. …”
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Integrated transcriptomic and metabolomic analyses provide new insights into alkaline stress tolerance in Gossypium hirsutum by Shiwei Geng, Wenju Gao, Fenglei Sun, Ni Yang, Teng Ma, Tingwei Wang, Bingyue Wang, Junhao Wang, Shuaishuai Qian, Shengmei Li, Jieyin Zhao

“…IntroductionCotton, one of the most important economic crops worldwide, has long been bred mainly for improvements in yield and quality, with relatively little focus on salt–alkali resistance.MethodsIn this study, transcriptomic and metabolomic sequencing were performed on Gossypium hirsutum exposed to alkaline stress for different durations.ResultsThe results of sample clustering, principal component analysis (PCA), and the number of differentially expressed genes (DEGs) revealed that 12 hours and 24 hours were the periods during which upland cotton presented the strongest response to salt stress, with flavonoid biosynthesis and alpha-linolenic acid metabolism playing significant roles during this time. …”
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Effect of Photothermal Therapy Using Gold Nanoparticles Conjugated with Hyaluronic Acid in an Intracranial Murine Glioblastoma Model by Domingo-Diez J, Foti A, Casanova-Carvajal Ó, Marrodán L, Granado N, Satriano C, Martínez-Murillo R, Serrano-Olmedo JJ, Ramos-Gómez M

“…Javier Domingo-Diez,1 Alice Foti,2 Óscar Casanova-Carvajal,1,3 Lorena Marrodán,1 Noelia Granado,4 Cristina Satriano,2 Ricardo Martínez-Murillo,4 José-Javier Serrano-Olmedo,1,5,6 Milagros Ramos-Gómez1,5,6 1Center for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Madrid, 28223, Spain; 2Nano Hybrid Biointerfaces Laboratory (NHBIL), Department of Chemical Sciences, University of Catania, Catania, 95125, Italy; 3Departamento de Ingeniería Eléctrica, Electrónica, Automática y Física Aplicada, Escuela Técnica Superior de Ingeniería y Diseño Industrial ETSIDI, Universidad Politécnica de Madrid, Madrid, 28040, Spain; 4Neurovascular Research Group, Department of Translational Neuroscience, Instituto Cajal, CSIC, Madrid, 28002, Spain; 5Centro de Investigación Biomédica en Red para Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Madrid, 28029, Spain; 6Departamento de Tecnología Fotónica y Bioingeniería, ETSI Telecomunicaciones, Universidad Politécnica de Madrid, Madrid, 28040, SpainCorrespondence: Milagros Ramos-Gómez, Universidad Politécnica de Madrid (UPM), Madrid, 28223, Spain, Email milagros.ramos@ctb.upm.esPurpose: Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor. …”
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Long-term outcomes of graves disease in children treated with anti-thyroid drugs by Ya-Ting Chiang, Wei-Hsin Ting, Chi-Yu Huang, Shih-Kang Huang, Chon-In Chan, Bi-Wen Cheng, Chao-Hsu Lin, Yi-Lei Wu, Chen-Mei Hung, Hsin-Jung Li, Chia-Jung Chan, Yann-Jinn Lee

“…Background: Graves disease (GD) is the most common cause of thyrotoxicosis in children and adolescents, accounting for 15% of all thyroid diseases during childhood. …”
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Bridging the Gap in Carbohydrate Counting With a Mobile App: Needs Assessment Survey by Asmaa Housni, Alexandra Katz, Lucien Junior Bergeron, Alain Simard, Ashley Finkel, Amélie Roy-Fleming, Meranda Nakhla, Anne-Sophie Brazeau

“…Among the 16 apps used by participants, most (12/16, 75%) supported nutrient analysis but only one offered bolus calculations or health care professional support, and none offered personalization. …”
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Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats by Jin-Shuo Liu, Nai-Qin Yan, Ying-Yan Mao, Chen Xin, Da-Peng Mou, Xin-Xiao Gao, Jia Guo, Ning-Li Wang, Si-Quan Zhu

“…RESULTS: Under prolonged simulated microgravity, rats exhibited a progressive increase in both IOP and ICP, with the most pronounced rise observed at 8wk. Concurrently, the TLCPD shifted from a negative value in controls to a positive value. …”
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Synthesis, Characterization, and Biological Evaluation of Some 3<i>d</i> Metal Complexes with 2-Benzoylpyridine 4-Allylthiosemicarbazone by Vasilii Graur, Ianina Graur, Pavlina Bourosh, Victor Kravtsov, Carolina Lozan-Tirsu, Greta Balan, Olga Garbuz, Victor Tsapkov, Aurelian Gulea

“…Complex <b>1</b> is the most active one towards Gram-positive bacteria and <i>C. albicans</i>, while the introduction of 1,10-phenanthroline into the inner sphere enhances the activity towards Gram-negative bacteria. …”
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Restoring Control: Real-World Success with Imipenem–Relebactam in Critical MDR Infections—A Multicenter Observational Study by Andrea Marino, Giuseppe Pipitone, Emmanuele Venanzi Rullo, Federica Cosentino, Rita Ippolito, Roberta Costa, Sara Bagarello, Ylenia Russotto, Chiara Iaria, Bruno Cacopardo, Giuseppe Nunnari

“…Clinical success was achieved in 22/29 patients (75.9%), while 30-day mortality was 24.1% (7/29). The most common pathogen was <i>Klebsiella pneumoniae</i> (62.1%), with 41.4% of infections being polymicrobial. …”
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Strength and microstructural evaluation of sustainable geopolymer mortars using calcium carbonate sludge and fly ash as precursors by Menglim Hoy, Soe Thandar, Suksun Horpibulsuk, Avirut Chinkulkijniwat, Apichat Suddeepong, Apinun Buritatum, Teerasak Yaowarat, Teerat Tesanasin, Jitwadee Horpibulsuk, Mantana Julvorawong

“…Furthermore, this study uniquely integrates machine learning (XGBoost and SHAP analysis) to predict compressive strength and revealed that the sodium silicate-to-sodium hydroxide ratio was the most influential parameter, followed by NaOH molarity. …”
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Citrate regional anticoagulation of 500 ml/min of extracorporeal blood flow: an experimental study by Sebastiano Maria Colombo, Luigi Vivona, Michele Battistin, Vittorio Scaravilli, Alessandro Galli, Chiara Anzanello, Elisa Cipriani, Francesca Gori, Serena Todaro, Carlo Valsecchi, Daniele Dondossola, Anna Paola Marcello, Andrea Carlin, Antonio Pesenti, Giacomo Grasselli, Alberto Zanella

“…Abstract Background Regional citrate anticoagulation (RCA) is the most widespread technique which allows to perform extracorporeal treatments, avoiding the complications of systemic anticoagulation. …”
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Intermediate Results of Prospective Observational Study: The 2-year Experience of Ibrutinib Therapy in Relapsed/Refractory Mantle Cell Lymphoma in Clinical Practice by VI Vorob’ev, VA Zherebtsova, EI Dubrovin, LA Bychenkova, YuB Kochkareva, LA Mukha, VL Ivanova, NK Khuazheva, VV Ptushkin

“…In the majority of cases ibrutinib was well tolerated by patients. The most common complications were myalgia and muscle cramps (57 % cases), diarrhea (46 %, and grade 3 in 5 % cases), hemorrhagic complications (63 %, all of them of grade 1–2), and arrhythmia (7 %). …”
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Risk factors for different cement distribution indexes for refracture of operated vertebrae and adjacent vertebrae after percutaneous vertebroplasty in patients with thoracolumbar... by Sulaiman Reheman, Wuluhan Mahan, Aerpati Maimaiti, Liu Yuntao, Aiben Kayierhan, Ma Liang, Alimujinag Aximu, Tuerhongjiang Abudurexiti, Meng Xiangyu

“…Abstract Background Although most studies suggest that unilateral percutaneous vertebroplasty (PVP) increases the probability of secondary adjacent vertebral compression fractures, controversy remains the associated risk factors. …”
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Efficacy and safety of netakimab, anti-IL-17A monoclonal antibody, in patients with ankylosing spondylitis. Results of phase III international, multicenter, randomized double-blind... by V. I. Mazurov, I. Z. Gaydukova, Sh. Erdes, T. V. Dubinina, A. M. Pristrom, E. V. Kunder, N. F. Soroka, A. A. Kastanayan, T. V. Povarova, E. S. Zhugrova, T. V. Plaksina, P. A. Shesternya, T. V. Kropotina, O. V. Antipova, E. A. Smolyarchuk, O. A. Tciupa, D. I. Abdulganieva, S. A. Lapshina, D. G. Krechikova, I. G. Gordeev, O. B. Nesmeyanova, V. V. Tyrenko, E. P. Ilivanova, A. V. Strelkova, A. V. Eremeeva

“…NTK safety profile was comparable to that of placebo. The most common for NTK adverse events were neutropenia (7,0%) and ALT increase (6,1%).Conclusion. …”
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Diagnostic potential of miRNA-135A1 in human papillomavirus associated cervical lesions by D. S. Elkin, M. I. Taubinskaya, N. V. Elkina, R. S. Faskhutdinov, M. D. Fedorova, A. N. Katargin, K. I. Zhordania, E. A. Mustafina, E. A. Grivachev, L. S. Pavlova, S. V. Vinokurova

“…Human papillomavirus (HPV) infection with high-risk HPVs is an etiological factor in the development of cervical cancer, with HPV type 16 (HPV16) being the most common. The mechanisms leading to disruption of viral oncogene expression and initiation of epithelial cell transformation are poorly understood. …”
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Artificial nano-sized ZnAgO/ZnO/ZnAlO composite material for photocatalytic applications by Trinh Duc Thien, Hoang Van Thanh, Le T.M. Cham, Pham Duc Thang, Nguyen Van Thang, Duong Van Pham, Minh Hong Pham, Hoang Nam Nhat, Vuong Van Hiep, Nguyen Dinh Lam

“…SCAPS-1D shows that the most optimal material parameters are ZnAlO layer donor density and thickness of 5 × 1017 cm−3 and 60 nm, respectively, and ZnAgO layer of 1 × 1016 cm−3 and 150 nm.…”
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Decision-Making Process of Home and Social Care Professionals Using Telemonitoring of Activities of Daily Living for Risk Assessment: Embedded Mixed Methods Multiple-Case Study by Renée-Pier Filiou, Mélanie Couture, Maxime Lussier, Aline Aboujaoudé, Guy Paré, Sylvain Giroux, Hubert Kenfack Ngankam, Patricia Belchior, Carolina Bottari, Kevin Bouchard, Sébastien Gaboury, Charles Gouin-Vallerand, Faustin Armel Etindele Sosso, Nathalie Bier

“…This is consistent with qualitative data indicating that, in light of the telemonitoring data, most clinicians decided to maintain the current intervention plan rather than increase or reduce services. …”
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PhotoD with LSST: Stellar Photometric Distances Out to the Edge of the Galaxy by Lovro Palaversa, Željko Ivezić, Neven Caplar, Karlo Mrakovčić, Bob Abel, Oleksandra Razim, Filip Matković, Connor Yablonski, Toni Šarić, Tomislav Jurkić, Sandro Campos, Melissa DeLucchi, Derek Jones, Konstantin Malanchev, Alex I. Malz, Sean McGuire, Mario Jurić

“…As demonstrated with the Sloan Digital Sky Survey (SDSS), Pan-STARRS, and most recently with Gaia data, broadband near-UV to near-IR stellar photometry can be used to estimate distance, metallicity, and interstellar dust extinction along the line of sight for stars in the Galaxy. …”
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