Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations by Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang

“…ABSTRACT Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the most lethal infectious diseases both historically and in the post-coronavirus disease 2019 era. …”
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Evaluación del efecto de modificadores y refinadores en el comportamiento mecánico y magnitud del rechupe de aleaciones Al-Si-Mg. // Modifier and refiners effect evaluation in the... by V. Lavaert, M. Moors, E. Wettinck, R. Castañeda, L. Goyos

“…<br />Although all these elements and combinations tend to counteract substantially the shrinkage formation, Sr appeared to be<br />the most effective to decrease top macro shrinkage whereas the combination Na-Ti led to the least formation of lateral<br />macro shrinkage. …”
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Unraveling gut microbiome alterations and metabolic signatures in hereditary transthyretin amyloidosis by Hanyu Li, Zeyuan Wang, Shan He, Xinyue Zhao, Qingyang Wu, Yueshen Sun, Yue Fan, Xiaomin Hu, Zhuang Tian, Shuyang Zhang

“…Notably, the serum levels of gamma-aminobutyric acid (GABA) and taurine were markedly decreased in the hATTR group, with the most pronounced reduction in those exhibiting hATTR-related cardiac amyloidosis. …”
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miR-10b promotes porcine immature Sertoli cell proliferation by targeting the DAZAP1 gene by Bo WENG, Mao-liang RAN, Rong CAO, Fu-zhi PENG, Hui LUO, Hu GAO, Xiang-wei TANG, Anqi YANG, Bin CHEN

“…However, the function roles of most of the miRNAs that have been identified in Sertoli cells are poorly understood. …”
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USP7 promotes temozolomide resistance by stabilizing MGMT in glioblastoma by Jiabing Li, Xiaorong Feng, Zhaohui Liu, Yunfang Deng, Zhiming Sun, Bei Chen, Lihui Wu, Xiaolong Wang, Lin Miao, Liyuan Zeng, Lei Hu, Yuming He, Ying Sheng, Yue Liu, Yu Zhao

“…Abstract Glioblastoma (GBM), a World Health Organization (WHO) grade IV glioma, is one of the most lethal brain tumors, with a poor prognosis and limited treatment options. …”
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Contralateral knee osteoarthritis severity relates to magnetic resonance imaging findings in knees with and without osteoarthritis: Data from the osteoarthritis initiative by Jeffrey B. Driban, Jonggyu Baek, Julieann C. Patarini, Emily Kirillov, Nhung Vo, Michael J. Richard, Ming Zhang, Matthew S. Harkey, Grace H. Lo, Shao-Hsien Liu, Charles B. Eaton, Jamie MacKay, Mary F. Barbe, Timothy E. McAlindon

“…Results: We included 1386 knees from participants with an average age of 62 (standard deviation ​= ​9) years. Most participants were overweight and had mild-to-moderate radiographic osteoarthritis. …”
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Several groups of LysM-RLKs are involved in symbiotic signal perception and arbuscular mycorrhiza establishment by Yi Ding, Zélie Lesterps, Virginie Gasciolli, Anne-Laure Fuchs, Mégane Gaston, Lauréna Medioni, Annélie de-Regibus, Céline Remblière, Céline Vicédo, Sandra Bensmihen, Jean Jacques Bono, Julie Cullimore, Guilhem Reyt, Marion Dalmais, Christine Saffray, Solène Mazeau, Abdelhafid Bendahmane, Richard Sibout, Michiel Vandenbussche, Jacques Rouster, Tongming Wang, Guanghua He, Arnaud Masselin, Sylvain Cottaz, Sébastien Fort, Benoit Lefebvre

“…LYR-IB function is conserved in all tested angiosperms, but in most japonica rice a deletion creates a frameshift in the gene, explaining differences in AM phenotypes between rice and other monocot single LYR-IA mutants. …”
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Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK bio... by Zhenyu Tian, Lu Yang, Yifei Li, Yueqing Huang, Jianmin Yang, Fei Xue

“…Abstract Background Despite established associations between insulin resistance (IR)-related indices and cardiometabolic diseases (CMDs), most studies are limited to single CMD outcomes. …”
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Tidal Debris Candidates from the ω Centauri Accretion Event and Its Role Building Up the Milky Way Halo by Borja Anguiano, Arik W. Mitschang, Takanobu Kirihara, Yutaka Hirai, Danny Horta, Sten Hasselquist, Ricardo P. Schiavon, Steven R. Majewski, Andrew C. Mason, Adrian M. Price-Whelan, Carlos Allende Prieto, Verne V. Smith, Katia Cunha, David L. Nidever

“…Some debris candidates show prograde or retrograde disk-like kinematics, but most show kinematics consistent with the accreted halo, showing high radial actions, J _R , values. …”
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Association of β1- and β2-adrenergic receptor gene polymorphisms with the risk of heart failure in patients with type 2 diabetes mellitus by N.M. Kulaiets

“…Heart failure (HF) is the most common cause of hospitalization and mortality in patients with cardiovascular diseases. …”
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Design, Synthesis, and Evaluation of Antinociceptive Properties of Novel CBD-Based Terpene-Cinnamoyl-Acyl-Hydrazone Analogues by Mikaela Lucinda de Souza, João Pedro Barros de Paiva, Graziella dos Reis Rosa Franco, Vanessa Silva Gontijo, Marina Amaral Alves, Hygor Marcos Ribeiro de Souza, Anna Carolina Pereira Lontra, Eduardo Araújo de Oliveira, Thaís Biondino Sardella Giorno, Isabella Alvim Guedes, Laurent Emmanuel Dardenne, Patrícia Dias Fernandes, Claudio Viegas Jr.

“…In silico results indicated that the most active compounds should act through different mechanisms, probably involving interactions with TRPA1. …”
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Registry-based surveillance of paediatric home respiratory support in Switzerland: methodology and initial findings by Sophie Guerin, Christian Bieli, Regula Corbelli, Thomas Ferry, Miriam Giaranna, Matthias Horn, Silvia Miano, Nicolas Regamey, Daniel Trachsel, Sylvain Blanchon

“…RESULTS: The registry included 146 patients, and the prevalence of children with home respiratory support in Switzerland was estimated at 11.9/100,000 children (59% boys, 41% girls). The most common underlying medical conditions were related to neuro-muscular (38%) and central nervous system (25%) diseases. …”
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A novel MRI-based deep learning–radiomics framework for evaluating cerebrospinal fluid signal in central nervous system infection by Ferhat Cüce, Gökalp Tulum, Muhammed Ikbal Isik, Marziye Jalili, Güven Girgin, Ömer Karadaş, Niray Baş, Berza Özcan, Ümit Savaşci, Sena Şakir, Akçay Övünç Karadaş, Eda Teomete, Onur Osman, Jawad Rasheed, Jawad Rasheed, Jawad Rasheed, Jawad Rasheed

“…A strict, clinically motivated patient-wise classification strategy confirmed the sub-lentiform nucleus region as the most reliable anatomical target for distinguishing infected from non-infected CSF.DiscussionThis study introduces a robust and interpretable MRI-based deep learning–radiomics pipeline for CNSI classification, with promising diagnostic potential. …”
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Circulating innate lymphoid cells are dysregulated in patients with prostate cancer by Daniela Claudia Maresca, Evelina La Civita, Benedetta Romano, Maria Rosaria Ambrosio, Fabio Somma, Tania Wyss, Bernardo Rocco, Valentina Rubino, Luigi Cari, Philippe Krebs, Antonio Rodriguez-Calero, Matteo Ferro, Sara Trabanelli, Camilla Jandus, Felice Crocetto, Angela Ianaro, Daniela Terracciano, Giuseppe Ercolano

“…Abstract Background Prostate cancer (PCa) is the second most common cancer affecting men globally, especially those aged 50 years and above. …”
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Design, synthesis and in Silico evaluation of novel thiazol-4(5H)-one-appended isatin–triazole hybrids with protective effects against inflammation, oxidative stress, and lymphocyt... by Walaa I. El-Sofany, Amani Toumi, Salman Latif, Ismail Daoud, Mourad Jridi, Asmaa F. Kassem, Kaseb D. Alanazi, Munirah S.O. Alhar, Abdalla Abdelwahab, Violeta Jevtovic, Sarra Boudriga

“…Triazoles 8h and 8i showed the most potent activities. Compound 8h exhibited IC₅₀ values of 19.3, 7.9, and 18.2 µg/mL, respectively, against PLA2, MPO, and ELA, outperforming the reference drug indomethacin. …”
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Temporal and spatial characteristics and environmental health risk analysis of liver cancer in a county of Central China from perspective of precise prevention and control by Shuyao XIA, Hongyan REN, Baohua WANG, Runhe SHI

“…It is an important starting point for a comprehensive prevention and control program targeting liver cancer, which can make the prevention and control of liver cancer more accurate and efficient. At present, most of the mainstream research on liver cancer prevention and control at home and abroad is only on the provincial and municipal level, which is difficult to meet the requirements of precise prevention and control. …”
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Downsizing chronic disease management programs for type 2 diabetes patients during the COVID-19 pandemic: changes in healthcare utilization patterns by Corinne Rijpkema, Corinne Rijpkema, Lotte Ramerman, Lilian Peters, Lilian Peters, Jean Muris, Tim Olde Hartman, Maarten Homburg, Isabelle Bos, Robert Verheij, Robert Verheij, Robert Verheij

“…Regression analyses compared healthcare utilization in 2020 and 2021 (pandemic) to 2019 (non-pandemic).ResultsFor most quarters of 2020 and 2021, care through CDMP was significantly lower, down to 38% in Q2 of 2020 compared to 2019. …”
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Retrospective Review of Children Hospitalized for Epstein–Barr Virus-Related Infectious Mononucleosis by Shufeng Tian, Jinjun Zheng, Zhe Zhou, Qingluan Yang, Biao Sun, Yuxi Li, Zengrui Lin, Yuchun Long, Song Guan, Sen Wang, Jiexin Zhuang, Wenhong Zhang, Lingyun Shao, Jikui Deng

“…Complications occurred in 560 (24.46%) of the 2289 patients without co-infections, with bronchitis being the most common (42.68%). Elevated ferritin and atypical lymphocyte percentage were associated with prolonged fever (<i>p</i> < 0.001), while elevated lactate dehydrogenase (LDH) and a lower CD4% predicted abnormal liver function (<i>p</i> < 0.001). …”
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Transfer learning‑based attenuation correction in 99mTc-TRODAT-1 SPECT for Parkinson’s disease using realistic simulation and clinical data by Wenbo Huang, Han Jiang, Yu Du, Haiyan Wang, Hao Sun, Guang-Uei Hung, Greta S. P. Mok

“…Attenuation correction (AC) is the most important correction among other corrections. …”
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MDM2 amplification in a real-world cohort of patients with biliary tract cancer from the Spanish RETUD gastrointestinal registry by A.J. Muñoz Martín, F. Castet, J. Soto Alsar, J. Adeva, P. Peinado, B. Graña, I. Alés Díaz, R.M. Rodríguez-Alonso, M. Lobo de Mena, R. Vera, I. Ruiz de Mena, S. Aguilar, S. Vega, L. Ortega Morán, T. Macarulla

“…MDM2 amplification was reported in 19 patients (6.3%); two of them (10.5%) had TP53 mutations. Most patients (63.2%; 12/19) with MDM2 amplification had intrahepatic tumors. …”
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