Whole-genome sequencing and biofilm gene characterization in multidrug-Resistant Staphylococcus aureus clinical strains by Emira Noumi, Tarek Zmantar, Nouha Bouali, Abdulrahman S. Bazaid, Khulood Fahad Alabbosh, Kamel Chaieb, Hisham N. Altayb, Vincenzo De Feo, Mejdi Snoussi

“…These results were correlated with those obtained from genome annotation highlighting that all multidrug resistant and biofilm-producing S. aureus strains harbored four ica genes (icaA, icaB, icaC, icaD) and their regulator icaR), clumping factor A and B (clfA and clfB genes), fibronectin binding proteins (fnbA in all strains and fnbB in 87.5 % of tested strains), elastin binding protein (ebps gene), extracellular adherence protein (Eap), staphylococcal protein A (spa gene), and Ser-Asp rich fibrinogen-binding proteins (sdrC). Most of the studied strains contained six to ten genomic islands associated with virulence factors, phage proteins, transcriptional regulators, insertion sequences and antimicrobial resistance genes. …”
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Educational mediamorphosis and constructivist paradigm by Arūnas Vyšniauskas

“…Having identified active correlation and relationship between education and wider - social aspects of the individual, namely, his societal status, affirms that the theme of educational and novel informational technologies becomes one of the most important in the internal politics of Great nations. …”
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Palynology of Carica and Vasconcellea (Caricaceae) Palinología de Carica y Vasconcellea (Caricaceae) by Lagos Túlio César, Chávez-Servia José Luis, Caetano Creucí María, Sandoval Sierra Claudia Lorena

“…The pollen grains were characterized using descriptors, which include the characters of taxonomic value for pollen identiï¬cation, genetically determined. The most important are the number, position and character of the aperture (NPC) and exine ornamentation and stratiï¬cation. …”
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Genome‐wide association study and BSR‐seq identify nitrate reductase–related genes in rice landraces (Oryza sativa L.) by Shuangshuang Luo, Zuyu Liao, Shilv Huang, Xiuzhong Xia, Zongqiong Zhang, Baoxuan Nong, Tongping Luo, Chenli Zhu, Can Chen, Hui Guo, Rui Feng, Yinghua Pan, Shuhui Liang, Yongcheng Li, Jianhui Liu, Yongfu Qiu, Danting Li, Xinghai Yang

“…Through integrated analysis, we identified a most likely candidate genomic region 15,627,420–16,084,761 bp on chromosome 1. …”
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Timing of Surgery and Preoperative Predictors of Surgical Site Infections for Patients with Depressed Skull Fractures in a Sub-Saharan Tertiary Hospital: A Prospective Cohort Study by Hervé Monka Lekuya, Jelle Vandersteene, Larrey Kasereka Kamabu, Rose Nantambi, Ronald Mbiine, Anthony Kirabira, Fredrick Makumbi, Stephen Cose, David Patrick Kateete, Mark Kaddumukasa, Edward Baert, Moses Galukande, Jean-Pierre Okito Kalala

“…The incidence of SSI was 18.9%, mainly superficial incisional infection; Gram-negative microorganisms were the most common isolates (64.7%). The group of surgical intervention >48 h had an increased incidence of SSI (57.3% vs. 42.7%, p = 0.006), a longer median of postoperative hospital stay (8[IQR = 6–12] days versus 5 [IQR = 4–9], [p < 0.001]), and a higher rate of reoperation (71.4% vs. 28.6%, p = 0.05) in comparison with the group of ≤48 h. …”
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Hybrid-J shape needle in ultrasound-guided looped thread carpal tunnel release: a cadaveric study on safety and efficacy by Lin Jiasen, Li Yuxiang, Jiang Liang, Long Yi, Li Honglve, Wang Yongbo, Geng Weikuan, Deng Xinghao, Zhang Congda, Yang Rui, Hou Jingyi

“…Abstract Background Carpal tunnel syndrome (CTS) is the most prevalent peripheral nerve entrapment disorder, often requiring surgical intervention. …”
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Fracture Patterns in Craniofacial Gunshot Wounds: A Seven-Year Experience by Gabriela G. Cruz, Sameer H. Siddiqui, David Z. Allen, Kunal R. Shetty, Sean P. McKee, Brady J. Anderson, Mark Knackstedt, W. Katherine Kao, Tang Ho

“…The maxilla (<i>n</i> = 127, 62%), orbit (<i>n</i> = 114, 55%), and mandible (<i>n</i> = 104, 51%) were the most fractured. Operative rates differed by location (<i>p</i> < 0.001) with highest rates for fractures involving the mandible (76%). …”
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Multi-omics profiling of metastatic colorectal cancer reveals the transcriptional network of focal adhesion and immune suppression and the role of p-RPS6 by Yimei Jiang, Zhe Li, Fang Zheng, Wenqing Jia, Zichao Guo, Zhuoqing Xu, Chenhao Huang, Zhiliang Li, Changgang Wang, Kun Liu, Haoran Feng, Ren Zhao, Xi Cheng

“…Phosphorylated RPS6 (p-RPS6) was the most differentially expressed protein between mCRC and nmCRC tumor tissues, which was found to be positively correlated with EMT proteins and poor prognosis in CRC. …”
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Propolis as a Treatment Option for Hand, Foot, and Mouth Disease (HFMD) in Children: A Prospective Randomized Clinical Study by Manolya Kara, Murat Sütçü, Ömer Kılıç, Doruk Gül, Tugçe Tural Kara, Gulşen Akkoç, Ayşe Baktır, Şefika Elmas Bozdemir, Özlem Özgür Gündeşlioğlu, Funda Yıldız, Ciğdem Yanar Ayanoğlu, Meltem Bozacı Kılıçoğlu, Raif Yıldız, Ateş Kara

“…<b>Results</b>: The median age of the patients was 28 months (range: 12–112), and the male-to-female ratio was 1:1. Most patients (62.8%) had no history of a household contact with HFMD. …”
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Impact of Iron Deficiency on the Growth and Bioelectrical Profile of Different Gut Bacteria by Elisa Quarta, Marwane Bourqqia‐Ramzi, David Muñoz‐Rodriguez, María Teresa García‐Esteban, Antonio Murciano‐Cespedosa, Álvaro Mateos González, Francisco José Conejero‐Meca, Juan Lombardo‐Hernandez, Jesús Mansilla‐Guardiola, Simona Baroni, Simonetta Geninatti Crich, Stefano Geuna, Luca Munaron, Deborah Chiabrando, Celia Herrera‐Rincon

“…ABSTRACT Scope: Iron deficiency (ID) is the most common nutritional deficiency worldwide, impacting gut bacteria's metabolism and cellular biochemistry, but its effects on the microbiota‐gut‐brain axis (MGB) are poorly understood. …”
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Bioassay-Guided Isolation of <i>cis</i>-Clerodane Diterpenoids and Monoglycerides from the Leaves of <i>Solidago gigantea</i> and Their Antimicrobial Activities by Márton Baglyas, Péter G. Ott, Zoltán Bozsó, Ildikó Schwarczinger, József Bakonyi, Dénes Dlauchy, András Darcsi, Szilárd Varga, Ágnes M. Móricz

“…All compounds exhibited weak to moderate antibacterial activity against the Gram-positive plant pathogen <i>Clavibacter michiganensis</i>, with MIC values ranging from 17 to 133 µg/mL, with compound <b>5</b> being the most potent. Only compound <b>1</b> was active against <i>Curtobacterium flaccumfaciens</i> pv. …”
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Microglial Transient Receptor Potential Melastatin 2 Deficiency Accelerates Seizure Development via Increasing AMPAR‐Mediated Neuronal Excitability by Yingwei Xu, Luyu Ye, Zhisheng Li, Yi Zhang, Ning Hua, Xiaojun Wang, Wangjialu Lu, Jing Xi, Liying Chen, Cenglin Xu, Jiajia Fang, Jianhong Luo, Linhua Jiang, Feng Han, Zhong Chen, Yi Wang, Wei Yang

“…ABSTRACT Epilepsy is one of the most common neurological disorders, characterized by the enhancement of neural excitability from a neurocentric perspective. …”
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Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved] by Haruna Luz Barazorda-Ccahuana, Mayron Antonio Candia-Puma, Miguel Angel Chavez-Fumagalli, Luis Daniel Goyzueta-Mamani, Rodolfo Cordeiro Cordeiro Giunchetti, Ricardo Andrez Machado-de-Ávila, Alexsandro Sobreira Galdino, Brychs Milagros Roque-Pumahuanca, Eduardo Antonio Ferraz Coelho, Laura Yesenia Machaca-Luque

“…However, of these emerging therapies, only posaconazole and fexinidazole have progressed to clinical trials, yielding unsatisfactory outcomes as CD monotherapies Conclusions This meta-analysis highlights the existence of promising new drug candidates for CD treatment, but most remain in the preclinical stages. Those that reached clinical trials did not demonstrate optimal results, underscoring the ongoing challenges in CD therapy. …”
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Transcriptome sequencing reveals novel Citrus bark cracking viroid (CBCVd) variants from citrus and their molecular characterization. by Yafei Wang, Sagheer Atta, Xuefeng Wang, Fangyun Yang, Changyong Zhou, Mengji Cao

“…These newly discovered Pakistani CBCVd variants were provisionally called "CBCVd-LSS" for their low sequence similarity (80.9%-88.9%) with the CBCVd RefSeq sequence (NC_003539). The two most predominant CBCVd sequences from Pakistan had the closest identity, 90.6% and 87.9%, with two CBCVd sequences isolated from hops. …”
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Neoadjuvant ARX788 plus pyrotinib versus trastuzumab, pertuzumab, docetaxel and carboplatin for HER2-positive breast cancer: a randomised phase 2b trial by Nan Niu, Jinqi Xue, Guanglei Chen, Fang Qiu, Qianshi Xu, Xinyu Zheng, Chao Liu, Yafei Zhao, Xi Gu, Yi Zhao, Hong Xu, Hao Zhang, Guijin He, Ke Li, Pengfei Li, Xiaoying Chen, Yong Li, Shuo Wang, Demiao Zhu, Tong Liu, Fei Xing, Yongqing Xu, Ye Han, Meiyue Tang, Mingxin Liu, Gege Jiao, Xiaofan Jiang, Tony Yuen, Zheng Pang, Caigang Liu

“…No treatment-related deaths occurred. The most common grade 3–4 adverse events were diarrhea and hepatic dysfunction in the ARX788 plus pyrotinib group, and fatigue, nausea and anorexia in the TCbHP group. …”
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Impact of foliar application using amino acids, yeast extract, and algae extract in different concentrations on growth parameters, yield traits, grain quality, and nitrogen-related... by Mohamed Ebaid, Mohamed E. El-Temsah, Mohamed A. Abd El-Hady, Amirah S. Alahmari, Ahmed S. M. El-Kholy, Diaa Abd El-Moneim, Ahmed M. Saad

“…Principal component analysis and heatmap analyses confirmed that higher concentrations of amino acids, algae extract, and yeast extract had the most positive effects on wheat growth and nitrogen-related parameters, while the untreated control and lower concentrations showed weaker results. …”
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Exploring the potential associations between single and mixed volatile compounds and preserved ratio impaired spirometry using five different approaches by Chenyuan Deng, Yu Jiang, Yuechun Lin, Hengrui Liang, Wei Wang, Ying Huang, Jianxing He

“…SHAP analysis identified race, body mass index (BMI), and 1,4-dichlorobenzene as the three most important factors. Conclusion: Our findings demonstrate the correlations between VOCs and PRISm, with inflammation potentially mediating the relationship. …”
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Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, co... by Liem Thanh Nguyen, Phuong Mai Nguyen, Hoang-Phuong Nguyen, Hau Thi Bui, Lan Thi Mai Dao, Minh Van Pham, Chi Khanh Hoang, Phuong Thi Nguyen, Thao Thi Phuong Nguyen, Anh Thi Phuong Nguyen, Van Thi Hoang, Hoa Thi Phuong Bui, Ngan Kim Vuong, Doan Van Ngo

“…Results At 12 months, the CT group presented a 48.0% reduction in individuals classified at the most severe DSM-5 level compared with 8.0% in the control group (p = 0.004). …”
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Feeding broccoli and cauliflower to dairy sheep: influence on feed intake, metabolic health status and milk production and composition by A. Martín, F.J. Giráldez, I. Mateos, C. Saro, J. Mateo, S. Andrés, I. Caro, M.J. Ranilla

“…Regarding milk composition, the most relevant differences were observed in protein content, being higher in the BRO group (P = 0.006) than in the CON and CAU groups, and in the fatty acids profile, which showed an increase in the saturated fatty acid content (P = 0.012) and a decrease in the monounsaturated fatty acid content (P = 0.005) in the groups supplemented with broccoli and cauliflower. …”
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Abstract 044: Single‐Step Intracranial Angioplasty followed by Atlas Stent Deployment Through Mini Trek Rx Balloon by Mohamed F. Doheim, Raul G. Nogueira, Mahmoud C. Mohammaden, Bishow C. Mahat, Priya N. Nidamanuri, Bharat Pillai, Diogo C. Haussen, Alhamza R. Al‐Bayati

“…Results Among 9 patients who met our criteria, the median age was 63 (51‐69.5) years and 55.6% were females. Most patients had left middle cerebral artery‐ M1 occlusion (66.7%) and one third received thrombolytics (33.3%). …”
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