Pooled prevalence of modern contraceptive utilization and its associated factors among reproductive age women in East Africa: derived from demographic and health surveys by Gosa Mankelkl, Beletu Kinfe

“…Abstract One of the most significant global public health concerns for women of reproductive age is the unmet need for modern contraceptives. …”
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Crise hipertensiva entre usuários de um serviço de pronto atendimento: estudo retrospectivo [Hypertensive crisis in patients at an acute care service: a retrospective study] [Crisi... by Tamires Alessandra Mineli, Adrielle Naiara Toneti, Daniel Martinez Lana, Victor Costa Nogueira, Leila Maria Marchi-Alves

“…Conclusion: HPCs were the most frequent situation in the study population, but a large number of records with no BP measurement indicated the need for health professionals to be aware of morbid event prevention, identification and control of HCs, and the corresponding record keeping. …”
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Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and... by Henrike Barbara Zech, Philippe Schafhausen, Leonie Ramke, Janna-Lisa Velthaus, Simon Kreutzfeldt, Daniel Hübschmann, Kai Rothkamm, Carsten Bokemeyer, Anna Sophie Hoffmann, Stefan Fröhling, Hanno Glimm, Christian Stephan Betz, Malte Kriegs, Maximilian Christopeit

“…Kinome profiling identified upregulated Src-family kinases (SFK), and SFK inhibition reduced kinase activity in vitro. Most notably, mRNA analysis demonstrated high Trop-2 overexpression, confirmed by immunohistochemistry (3+ in 100% of tumor cells). …”
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Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Türkiye by İlker Turan, Ulus Salih Akarca, Murat Aladağ, Murat Harputluoğlu, Sezai Yılmaz, Genco Gençdal, Çiğdem Arıkan, Kamil Yalçın Polat, Figen Özçay, Mesut Akarsu, Tarkan Ünek, Zeki Karasu, Murat Zeytunlu, Hale Gökcan, Meral Akdoğan Kayhan, Erdal Birol Bostancı, Aysun Çalışkan Kartal, Deniz Balcı, Murat Dayangaç, Haydar Adanır, Dinç Dinçer, Hakan Dursun, Murat Taner Gülşen, Feyza Dilber, Ender Dulundu, Yasemin Balaban, Ahmet Bülent Doğrul, Gökhan Kabaçam, Murat Akyıldız, Fulya Günşar, Ahmet Gürakar, Ramazan İdilman

“…Median MELD and PELD scores were 31 and 30, respectively. The most common ALF etiologies were viral, indeterminate, and drug-induced causes. …”
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Phenotypic characterization of wild Myrciaria dubia (Kunth) McVaugh ex situ germplasm bank for breeding, conservation, and sustainable development in the Peruvian Amazon by Sixto A. Imán, Sixto A. Imán, Angelo F. Samanamud, Angelo F. Samanamud, José F. Ramirez, Marianela Cobos, Marianela Cobos, Juan C. Castro, Juan C. Castro

“…This study aimed to characterize the phenotypic diversity of wild accessions maintained in a 36-year-old ex situ germplasm bank, one of the most comprehensive M. dubia collections globally, to provide baseline data for genetic improvement and conservation.MethodsWe evaluated 43 wild accessions systematically collected from eight major hydrographic basins in the Loreto region using a stratified sampling approach to capture maximum ecological diversity and maintained in an ex situ germplasm bank established in 1988 at the National Institute of Agrarian Innovation in Loreto, Peru. …”
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In vitro and in vivo activity of sodium houttuyfonate and sodium new houttuyfonate against Candida auris infection by affecting adhesion, aggregation, and biofilm formation abiliti... by Guangyuan Yang, Ruotong Yang, Xiaoxiao Zhu, Qianwen Xu, Xiaojia Niu, Chengui Miao, Wenfan Wei, Changzhong Wang, Tianming Wang, Daqiang Wu

“…Therefore, our presented results suggest that SH and SNH can effectively inhibit the growth, adhesion, aggregation, and biofilm formation to treat its colonization and pathological damage to the host of C. auris.IMPORTANCERecently, the annual proportion of non-C. albicans infections has been rising. The most notable characteristic of C. auris is its resistance to drugs, including multidrug resistance, which results in treatment failures and poses significant challenges in controlling its spread. …”
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Updated Mass, Eccentricity, and Tidal Heating Constraints for the Earth-sized Planet LP 791-18 d by Michael Greklek-McKeon, Heather A. Knutson, W. Garrett Levine, Renyu Hu, Morgan Saidel, Jonathan Gomez Barrientos, Konstantin Batygin, Björn Benneke

“…We present three new transit observations of LP 791-18 c with Palomar/WIRC, including the most precise TTV measurements (<6 s uncertainty) of this planet to date. …”
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Study of bases influence on the biopharmaceutical characteristics of the pastes for onychomycosis therapy by V. V. Luc, V. V. Gladyshev, A.P. Lisyanskaya, A.D. Diudiun

“…Topical treatment of onychomycosis in most cases is the only acceptable method of therapy mainly due to high safety. …”
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Capability Analysis of Earth Observation Data for Integrated Emergency Management by Kristina Wolf, Jon P. Mills, Luis Cormier, Ruth Dunn, Olivia Fairless, Adewale Falaye, Stuart Gordon, Oshadee Jayamanne, Carrow Morris-Wiltshire, Eleanor Myall, Francisco Salgado-Castillo, Yashvini Shukla, Luke Taylor, Ellen Robson, Daniel Donoghue, Richard J. Dawson, Elizabeth Lewis, Sim M. Reaney, Elaine Scott, Joel Freedman, Stuart Marshall, Patrick Walker, Helen Hinds

“…Recognising this, in 2021 the UK Government’s first National Space Strategy established a new vision to make the nation one of the most innovative and attractive worldwide space economies. …”
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Structure-activity study of oncocins modified with cationic polar moieties at the termini by Johan Storm Jørgensen, Anita Wester, Carina Sofia Silva Matias, Lina Maria Cavaco, Carina Vingsbo Lundberg, Camilla Brolin, Elnaz Harifi Mood, Dorota Żabicka, Magdalena Tomczak, Malgorzata Urbas, Fredrik Björkling, Peter E. Nielsen, Henrik Franzyk

“…The highest degree of enhancement was seen for K. pneumoniae, in which the most active analogs had minimal inhibitory concentrations of 0.25 μg/mL (∼0.05 μM).Notably, antibacterial activity proved considerably less dependent on the inner-membrane peptide transporter SbmA, being the main transporter involved in internalization of PrAMPs. …”
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Outcome of Bloodstream Infections Caused by Antibiotic-Resistant Bacteria: A 7-Year Retrospective Study at the University Hospital of Palermo, Italy by Luca Pipitò, Eleonora Bono, Chiara Vincenza Mazzola, Raffaella Rubino, Antonio Anastasia, Salvatore Antonino Distefano, Alberto Firenze, Giovanni M. Giammanco, Celestino Bonura, Antonio Cascio

“…Bacteremia-related mortality per 1000 patients rose from 5.1% in 2018 to 10.5% in 2024. The most isolated pathogens were non-<i>aureus</i> staphylococci (39.7%), followed by <i>Klebsiella pneumoniae</i> (12.1%) and <i>Staphylococcus aureus</i> (7.47%). …”
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A Multi-Algorithm Machine Learning Model for Predicting the Risk of Preterm Birth in Patients with Early-Onset Preeclampsia by Xu Y, Zu Y, Zhang Y, Liang Z, Xu X, Yan J

“…SHAP analysis revealed GBDT as the top contributor to Stacking predictions, with microalbunminuria (GBDT, XGBoost) and age (SVM) being the most influential features.Conclusion: Machine learning models can serve as reliable assessment tools for predicting the risk of preterm birth in patients with EOPE. …”
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National antibiotic consumption for human use in Chad (2017–2021): a descriptive cross-sectional study by Zongo R. Frank Edgard, Kadidjia Bakari Traoré, Colette Ngabéré, Martine Yoyammel, Abatcha Oumar Kadai, John Eyong Efobi, Mathieu Hota, Didi Lamireou, Badawi Haroun Mahamat, Hamit Mahamat Alio, Jacques L. Tamuzi, Jacques L. Tamuzi, Patrick D. M. C. Katoto, Patrick D. M. C. Katoto, Patrick D. M. C. Katoto, Charles S. Wiysonge, Charles S. Wiysonge, Blanche-Philomene Melanga Anya

“…In terms of DDD, the ten most commonly consumed antibiotics during the time, in descending order, were amoxicillin, ampicillin, sulfamethoxazole/trimethoprim, doxycycline, ciprofloxacin, phenoxymethyl-penicillin, erythromycin, ceftriaxone, azithromycin, and gentamicin. …”
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Combined multi-omics and physiological approaches to elucidate drought-response mechanisms of durum wheat by Osvin Arriagada, Claudio Meneses, Romina Pedreschi, Romina Pedreschi, Gerardo Núñez-Lillo, Carlos Maureira, Samantha Reveco, Valentina Villarroel, Úrsula Steinfort, Francisco Albornoz, Patricia Cabas-Lühmann, Manuela Silva, Iván Matus, Andrés R. Schwember

“…IntroductionDurum wheat is the most important cereal in the Mediterranean regions, where drought negatively affects grain yield. …”
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Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation by Bastien Guillot, Bastien Guillot, Arthur Boileve, Arthur Boileve, Richard Walton, Richard Walton, Alexandre Harfoush, Alexandre Harfoush, Caroline Conte, Caroline Conte, Yannis Sainte-Marie, Yannis Sainte-Marie, Sabine Charron, Sabine Charron, Olivier Bernus, Olivier Bernus, Alice Recalde, Alice Recalde, Laurent Sallé, Laurent Sallé, Fabien Brette, Fabien Brette, Fabien Brette, Frank Lezoualc’h, Frank Lezoualc’h

“…IntroductionAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. …”
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DIDACTIC POTENTIAL OF YOUTUBE CHANNELS FOR ENHANCED ENGLISH LANGUAGE LEARNING IN NON-LINGUISTIC PROGRAMS by Blynova Neliia, Medynska Svitlana, Voloboieva Anna

“…Visual content ranks among the most effective pedagogical tools. Strategically chosen YouTube vlogs can significantly enhance students’ vocabulary development, facilitate the acquisition of idioms and colloquial speech patterns, improve pronunciation, strengthen linguistic competencies, and refine listening and speaking skills. …”
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Penerapan Covid Shooter Berbasis Android sebagai Game Edukasi Pencegahan Covid-19 pada Anak Usia Dini by Rocky Ardiansyah Yudistira Putra, Unzilla Savika Putri, Ginanjar Setyo Permadi, Dodik Arwin Dermawan

“…This is due to the much of deaths caused by the spread of Covid-19 so it is necessary to pay attention to providing education to the public, especially in early childhood about the potential danger of death due to covid-19 because at an early age children are the most vulnerable to become victims. However, children who are still at an early age certainly have not paid too much attention to the potential of the Covid-19 outbreak because at an early age children are more likely to play. …”
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Comorbidity patterns and immune-metabolic differences in patients with acute-episode of schizophrenia spectrum disorders by Guoping Wu, Zhe Dong, Zhongcai Li, Qiongxian Zhao, Song Chen, Qing Dong, Liqiong Huang, Yaru Zhang, Xuan Wang, Sai Chen, Hongbing Liu, Zanzong Sun, Shengmei Ban, Baopeng Tian, Yunlong Tan

“…Comorbidity patterns were identified through latent class analysis (LCA) based on the 20 most common comorbid conditions among SSD patients. …”
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Health Related Quality of Life and Associated Factors of Inflammatory Bowel Disease Outpatient Unit in Dr. Cipto Mangunkusumo Hospital by Muhammad Fikri Afistianto, Marcellus Simadibrata, Marcellus Simadibrata, Rudi Putranto, Rudi Putranto, Murdani Abdullah, Murdani Abdullah, Siti Setiati, Siti Setiati, Wismandari Wisnu, Wismandari Wisnu, Dono Antono, Dono Antono, Adityo Susilo, Adityo Susilo

“…Age, disease duration, comorbidities, employment status, and sleep quality showed no significant associations. Conclusion: Most IBD patients (95%) in the RSCM outpatient unit reported a good quality of life. …”
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Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration by Qunzhou Zhang, Puhan He, Shihong Shi, Qilin Xu, Eric J. Granquist, Beth A. Winkelstein, Rabie M. Shanti, Anh D. Le

“…Abstract Background Accumulating evidence demonstrates that the therapeutic effects of stem cells are most likely attributed to their secretome, composed of a myriad of bioactive factors, including small extracellular vesicles (EVs). …”
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