Aspirin Resistance as a Result of Impaired Interaction of Platelets and Neutrophils in Patients with Coronary Heart Disease by M. D. Goncharov, A. A. Savchenko, Yu. I. Grinshtein, I. I. Gvozdev, A. A. Kosinova, T. S. Mongush

“…On the 8–10th day after CABG, most indicators of spontaneous and zymosan-induced CL neutrophils in rASA patients were also increased compared to control values. …”
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Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target by L. Llaó-Cid, JKL Wong, I. Fernandez Botana, Y. Paul, M. Wierz, L-M Pilger, A. Floerchinger, CL Tan, S. Gonder, G. Pagano, M. Chazotte, K. Bestak, C. Schifflers, M. Iskar, T. Roider, F. Czernilofsky, P-M Bruch, JP Mallm, A. Cosma, DE Campton, E. Gerhard-Hartmann, A. Rosenwald, D. Colomer, E. Campo, D. Schapiro, EW Green, S. Dietrich, P. Lichter, E. Moussay, J. Paggetti, M. Zapatka, M. Seiffert

“…T cells in CLL lymph nodes show the most distinct profiles, with accumulation of regulatory T cells and CD8+ T cells in various exhaustion states, including precursor (TPEX) and terminally exhausted (TEX) cells. …”
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Long-Term Outcome After Mustard Repair at Young Age by Sahra Ünlütürk, MD, Robert M. Kauling, MD, Judith A.A.E. Cuypers, MD, PhD, Annemien E. van den Bosch, MD, PhD, Alexander Hirsch, MD, PhD, Mieke M.P. Driessen, MD, PhD, Chiara Pelosi, MD, PhD, Daniel J. Bowen, PhD, Ad J.J.C. Bogers, MD, PhD, Willem A. Helbing, MD, PhD, Isabella Kardys, MD PhD, Jolien W. Roos-Hesselink, MD, PhD

“…Event-free survival was 14%, with cardiac reintervention (39%), symptomatic arrhythmia (39%), and HF (37%) being the most common events. Systemic right ventricular function (sRVF) declined over time, with 73% having an ejection fraction below 40%, and 95% having a reduced VO2max. …”
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Exploring the potential transdiagnostic treatment effects of Chinese herbal medicine and acupuncture on insomnia disorder comorbid with chronic pain: A scoping review by Yan Ling Kwok, Ran Wang, Hiu To Tang, Siyu Chen, Albert Yeung, Zhaoxiang Bian, Danny J. Yu

“…Combined CHM (Da Huoluo capsules) and acupuncture showed medium effects (d = 0.72 for insomnia; d = 0.57 for pain) versus multi-medications/traction. Most studies (83.33 %) had high risk of bias. Conclusion: CHM and acupuncture show promise for ICCP management, but high risk of bias warrants cautious interpretation and further high-quality RCTs.…”
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Analysis of homologous recombination deficiency in prostate cancer by A. G. Iyevleva, S. N. Aleksakhina, A. P. Sokolenko, E. A. Otradnova, A. S. Nikitina, K. A. Kashko, M. V. Syomina, N. S. Morozova, A. D. Shestakova, E. Sh. Kuligina, E. N. Imyanitov

“…In contrast to BRCA2-associated PCs, most tumors with mutations in the CHEK2, NBN, BLM, FANCM, BRCA1 genes are not characterized by homologous recombination deficiency. in the case of ATM gene lesions, approximately half of pcs have a high HRD score. …”
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Platelet-derived exosomal LINC00183 facilitate colorectal cancer malignant progression driven by histone lactylation through stabilizing ENO1 by Guoqing Su, Jinghang Qian, Yi Wang, Yu Zhu, Yanyan Chen, Jingru Shen, Jiayuan Jiang, Yuepeng Cao, Nannan Wang, Xing Huang, Chengshuai Si, Xu Zhang, Peng Shao, Yongxia Ye, Yang Wang, Jun Bao, Liu Yang

“…Using RNA sequencing, we identified LINC00183 as the most upregulated lncRNA in platelet-derived exosomes (PLT-Exos) from CRC patients, compared to healthy individuals. …”
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Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer by Angela Santonja, Wendy N Cooper, Matthew D Eldridge, Paul A W Edwards, James A Morris, Abigail R Edwards, Hui Zhao, Katrin Heider, Dominique‐Laurent Couturier, Aadhitthya Vijayaraghavan, Paulius Mennea, Emma‐Jane Ditter, Christopher G Smith, Chris Boursnell, Raquel Manzano García, Oscar M Rueda, Emma Beddowes, Heather Biggs, Stephen‐John Sammut, Nitzan Rosenfeld, Carlos Caldas, Jean E Abraham, Davina Gale

“…Hybrid capture sequencing targeting between 1,347 and 7,491 tumor‐identified mutations at high depth was the most sensitive assay, detecting ctDNA down to an AF of 0.00024% (2.4 parts per million, ppm). …”
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Qualidade de vida de indivíduos portadores de dispositivo cardíaco eletrônico implantável [Quality of life of individuals with implantable electronic cardiac device] [Calidad de v... by Líscia Divana Carvalho Silva, Édipo Luan de Carvalho Caminha, Nerilce Soares Ferreira

“…SF-36 and AQUAREL were used. Results: the most frequent comorbidity was systemic arterial hypertension – 39 (78%), baseline heart disease bradycardia – 18 (36%) and complaints of palpitation and pre-syncope. …”
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State of the Journal: 2023 by Sheba Nakacubo Gitta

“…Outbreaks, epidemics and pandemics continue to occur; most important among them COVID-19 and several disease outbreaks which included Mpox (formerly Monkeypox), Ebola Virus Disease (EVD) and cholera [1]. …”
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HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1 by Zhao-Jun Pan, Wei-Lun Wei, Phuong-Anh Tran, Ru-Ying Fang, Thanh Ha Pham, John L. Bowman, Chao-Tzu Chung, Bing-Nan Shen, Ju-Ting Yang, Han-Han Chang, Wann-Neng Jane, Chiung-Hsiang Cheng, Chia-Chi Wang, Hsin-Yi Wu, Syuan-Fei Hong, Qian-Wen Shang, Sin-Fen Hu, Pin-Chun Lin, Fu-Hui Wu, Choun-Sea Lin, Yu-Ling Hung, Tang-Long Shen, Shih-Shun Lin

“…P1/HC-Pro from turnip mosaic virus (P1/HC-ProTu) exhibited the most potent inhibition of HEN1, followed by P1/HC-Pro from zucchini yellow mosaic virus (P1/HC-ProZy), while P1/HC-Pro from tobacco etch virus (P1/HC-ProTe) showed the weakest inhibitory effect. …”
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Clinical Trial to Evaluate the Effect of Grape Seed Extract-Loaded Hyalurosomes on Skin Wellness by Rita Abi Rached, Maya Habre, Yara Salem, Joe Khodeir, Mohamad Allaw, Ines Castangia, Hiba N. Rajha, Luciana Habre, Joelle Feghali, Joe A. Touma, Maria Letizia Manca, Nicolas Louka, Maria Manconi, Richard G. Maroun

“…The aim of this study was to extract phytochemicals from the Lebanese grape variety “Obeidi” and incorporate them into liposomes and hyalurosomes in order to select the most effective formulation for improving skin properties and protecting against oxidative damage. …”
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Comparative effectiveness of non-pharmacological interventions on anxiety, depression, and quality of life in patients with epilepsy: a systematic review and network meta-analysis by Haoran Luo, Xianming Ding, Junyu Zhang, Ningkun Xiao, Ningkun Xiao

“…SUCRA rankings suggested that Enhanced education therapy (EET), Psychotherapy (PT), and Enhanced care (EC) were the most effective interventions for improving anxiety, depression, and Quality of Life (QoL), respectively. …”
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“Our work is recognized and we are prepared:” A qualitative evaluation of a peer-led research best practices training for community health workers and promotoras by Alexandra E. Harper, Analay Perez, M. Miaisha Mitchell, Daphne Watkins, Gina M. Jay, Vanessa I. Trujillo, Kristen Weeks-Norton, Shannen McIntosh, Brenda Eakin, Elias Samuels, Gretchen Piatt, Catherine Striley, Linda Cottler, Sergio Aguilar-Gaxiola, Susan L. Murphy

“…The mean age was 43.7 ± 14.5 years, most were female (59%), and 47% identified as Hispanic, Latino, or Spanish. …”
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Gender peculiarities of paranoid schizophrenia in the modern context by Ya. Yu. Marunkevych

“…It was established that the most common symptoms of paranoid schizophrenia were expressed and significant changes in the general behavioral quality (100.0 %), negative symptoms (96.1%) and persistent delusional symptomatology (93.1 %), while chronic paranoid symptoms (66.7 %) and delusion of mastery, influence or inactivity, and delusional perception (61.8 %), as well as verbal hallucinations (58.8 %) were less common. …”
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Mapping QTLs for Pyricularia leaf spot, nematode resistance, and yield related traits in pearl millet [Cenchrus americanus (L.) Morrone] by Sairam Vutla, Joseph E. Knoll, Anvesh Sankuratri, Risha G. Nayak, Limei Liu, Limei Liu, Peng W. Chee, Raghupathy Karthikeyan, Bashasab Fakrudin, Mahendar Thudi, Patricia Timper, Karen Harris-Shultz, Jason G. Wallace, Jason G. Wallace, Hari Singh, Bharat Singh, Somashekhar M. Punnuri

“…Morrone, formerly Pennisetum glaucum (L.) R. Br.] is the sixth most important cereal globally and is used for forage and feed in the U.S. …”
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Biomolecular Predictors of Recurrence Patterns and Survival in IDH-Wild-Type Glioblastoma: A Retrospective Analysis of Patients Treated with Radiotherapy and Temozolomide by Paolo Tini, Flavio Donnini, Francesco Marampon, Marta Vannini, Tommaso Carfagno, Pierpaolo Pastina, Giovanni Rubino, Salvatore Chibbaro, Alfonso Cerase, Giulio Bagnacci, Armando Perrella, Maria Antonietta Mazzei, Alessandra Pascucci, Vincenzo D’Alonzo, Anna Maria Di Giacomo, Giuseppe Minniti

“…Background and Aim: Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with poor prognosis despite maximal surgical resection, radiotherapy (RT), and temozolomide (TMZ) per the Stupp protocol. …”
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Pemilihan Strategi Implementasi Kesehatan Digital Pada Kelompok Pengambil Keputusan Menggunakan Metode Vikor by Sri Kusumadewi, Rahadian Kurniawan

“…The VIšekriterijumsko KOmpromisno Rangiranje (VIKOR) method is then used to determine the most effective strategy. The selected strategy is determined by a threshold (q), which selects alternative strategies with a Vikor index of ≥ q. …”
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Better models, better treatment? a systematic review of current three dimensional (3D) in vitro models for implant-associated infections by Neele Brümmer, Neele Brümmer, Katharina Doll-Nikutta, Katharina Doll-Nikutta, Patrik Schadzek, Patrik Schadzek, Carina Mikolai, Carina Mikolai, Andreas Kampmann, Andreas Kampmann, Dagmar Wirth, Dagmar Wirth, Andrea Hoffmann, Andrea Hoffmann, Philipp-Cornelius Pott, Philipp-Cornelius Pott, Oliver Karras, Sören Auer, Meike Stiesch, Meike Stiesch

“…For bacterial challenge, most authors used Gram positive bacteria, but three studies employed Gram negative bacterial species. …”
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Survey on the perceptions of Asian endoscopists to artificial intelligence by Sabrina Xin Zi Quek, Chieh Sian Koo, Lin Liu, Wai Keung Leung, Raymond Shing Yan Tang, Hyunsoo Chung, Xuesong Zhang, Katsuro Ichimasa, Denis Ngo, Ruter Maralit, Viet Hang Dao, Vu Van Khien, Ajay Duseja, Nitesh Pratap, Yeong Yeh Lee, Kaka Renaldi, Shi Min Sim, Clement Chun Ho Wu, James Weiquan Li, Jarrod Kah Hwee Tan, Calvin Jianyi Koh, Jimmy Bok Yan So, Jonathan Wei Jie Lee

“…Notably, those without prior AI exposure express high concern regarding accountability for the wrong diagnoses (73.2% vs. 60.6%, p = 0.03) and lack of clinical trials (76.4% vs. 57.1%, p = 0.001). Most respondents prioritise developing a reference paper guide for clinicians interested in AI (81.2%) and supporting funding applications for AI research (81.5%) as key areas that an Asia AI Endoscopy task force should address. …”
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THE INFLUENCE OF THE AGE ON THE PREVALENCE OF GINGIVAL RECESSION IN PATIENTS WITH PERIODONTITIS by P. Mazur, I. M. Suprunovych

“…Incisors and first molars were the most affected teeth by the gingival recession. In patients with periodontitis, the gingival recession of mild degree (up to 3 mm) was determined around 44.01 (40.8-47.2) % of teeth, the gingival recession of moderate degree (from 3 to 4 mm) – around 17.41 (14.3-20.5) % of teeth, the gingival recession of severe degree (5 mm or more) – around 4.42 (2.7-6.2)% of teeth. …”
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