Development of a blocking ELISA employing a VP1-specific monoclonal antibody for the detection of DHAV3 antibodies by Cuiping Song, Tianyuan Li, Jing Wang, Peidong Guo, Wenjing Yang, Ning Tang, Yang Qu, Siyu Li, Xusheng Qiu, Lei Tan, Yingjie Sun, Ying Liao, Chan Ding

“…Among the three structural proteins of DHAV, the VP1 protein is the most critical as it induces neutralizing antibody production, serves as the binding protein for viral adsorption to cell-specific receptors, and determines viral antigenicity. …”
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Exploring the mutational spectrum of key kinase genes PIK3CA, BRAF, EGFR, ALK and ROS1 in oral squamous cell carcinoma by Fouzia Nawab, Wafa Naeem, Sadia Fatima, Asif Ali, Ali Talha Khalil, Aamir Mehmood, Muhammad Fazeel, Hilal Ahmad, Mohammed Alorini, Muslim Khan, Ishtiaq Ahmad Khan, Muhammad Irfan, Syed Ali Khurram

“…Abstract Oral Squamous Cell Carcinoma (OSCC) is the sixth most aggressive type of oral cancer. Mutations in cancer-driving genes such as protein kinase are well known in cancer progression. …”
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Characteristics of polyclonal anti-interferon-gamma autoantibodies and novel diagnostic strategies: A prospective cohort study of new biomarkers by Xidong Wang, Feng Ye, Hongling Liu, Shaoqiang Li, Jinglu Yang, Xue Yu, Yilei Hui, Yongming Li, Yangqing Zhan, Yan Wang, Jing Liu, Zhengtu Li

“…Immune repertoire sequencing revealed that 74 % of the AIGA(+) patients had IgG clone types, with the somatic hypermutation (SHM) analysis being the most informative. We isolated AIGAs from the blood and interpreted their affinity and major components completely. …”
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miR-23b is a negative regulator of tumor suppressing PTPRG in colorectal cancer by Hong Duan, Jianhu Jia, Tingting Wang, Ghulam Jilany Khan, Li Wang, Sirong Zhang, Jianhua Yang, Chenghui He, Fei Li, Henggui Hu, Kefeng Zhai

“…Colorectal cancer (CRC) is among top most common cancers with high mortality rate and major health issue yet to resolve across the globe. miR-23b is an oncogene in many cancers including CRC. …”
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Features of structural and geometric remodeling of the heart and changes in the diastolic filling of the heart in patients with chronic heart failure of ischemic genesis with prese... by V. A. Lysenko, M. S. Potapenko, V. V. Syvolap

“…Chronic heart failure (CHF) is the most common cardiovascular disease worldwide, estimated at 23 million. …”
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Translating community-wide spectral library into actionable chemical knowledge: a proof of concept with monoterpene indole alkaloids by Sarah Szwarc, Adriano Rutz, Kyungha Lee, Yassine Mejri, Olivier Bonnet, Hazrina Hazni, Adrien Jagora, Rany B. Mbeng Obame, Jin Kyoung Noh, Elvis Otogo N’Nang, Stephenie C. Alaribe, Khalijah Awang, Guillaume Bernadat, Young Hae Choi, Vincent Courdavault, Michel Frederich, Thomas Gaslonde, Florian Huber, Toh-Seok Kam, Yun Yee Low, Erwan Poupon, Justin J. J. van der Hooft, Kyo Bin Kang, Pierre Le Pogam, Mehdi A. Beniddir

“…Abstract With over 3000 representatives, the monoterpene indole alkaloids (MIAs) class is among the most diverse families of plant natural products. …”
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DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus by Xiaoli Ji, Mengfan Zhi, Xiufeng Gu, Ying Han, Xiang Lan, Lixiang Song, Peipei Sun, Jingyuan Li, Xiangmin Qi, Qiang Feng

“…Abstract Background Oral lichen planus (OLP) is one of the most frequent oral mucosal diseases associated with chronic inflammation, despite a profoundly limited understanding of its underlying pathogenic mechanisms. …”
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Anti-Tyrosinase and Radical Scavenging Activities of Selected Cassipourea Plants and Isolated 7-Methoxygeranin A: Traditional Use as Skin Lighteners by Mpofana N, Paulse M, Yalo M, Dlova NC, Hussein A, Lanrewaju AA, Lukman HY, Aribisala JO, Rautenbach F, Marnewick JL, Sabiu S

“…Statistical analyses, including ANOVA and post-hoc tests, compared extract activities.Results: C. flanaganii exhibited the most potent anti-tyrosinase activity (IC50: 37.10 μg/mL), though statistical differences among species were non-significant. …”
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Psychometric findings for LIMB-Q kids based on an international study of 800 children and adolescents with lower limb differences by Harpreet Chhina, Charlene Rae, David Podeszwa, James A. Fernandes, Louise Johnson, Bjoern Vogt, Jan Duedal Rolfing, Alicia Kerrigan, Ashish Ranade, Juergen Messner, Mohan Belthur, Melissa Esparza, Jonathan Wright, David Bade, Sarah McMahon, Christopher Iobst, Sanjeev Sabharwal, Marcel Abouassaly, Anthony Cooper, Anne F. Klassen

“…By measuring outcomes that matter most to children and adolescents with LLDs, LIMB-Q Kids can provide information to support evidence-based decisions. …”
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Effect of the Composition of Lytic Bacteriophages of P. aeruginosa Formation and Destruction of Bacterial Biofilms by O. A. Polygach, A. N. Dabizheva, N. N. Voroshilova

“…Bacteria P. aeruginosa have a high, as well as rapidly acquired resistance to most antibiotics, as well as the ability to form biofilms in the foci of inflammation.Goal of the study are a comparative study of the antibacterial activity of antibiotics and the bacteriophage composition of lytic groups of KMV-likevirus, PB-1 likevirus, N4-likevirus and phiKZ-likevirus against plankton cultures of clinical and hospital strains of P. aeruginosa, detection and study of the frequency of biofilm formation by bacteria P. aeruginosa and the preventive action of lytic bacteriophage compositions on them, as well as its ability to destroy bacterial biofilms.Materials and methods. …”
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Reference-guided detection of the transcriptome reveals circular RNA-related competing endogenous RNA networks in response to three respiration pathogens in pig lungs by Qian Wu, Kun Du, Mao-qing Gu, Yu Xia, Miao Yin, Xian Li, Shu-ting Zhang, Hong Zhao, Zhang-lin Li, Xi-wen Chen

“…Our results identified 72,203 known and 14,344 novel circRNAs and showed that 66, 67, and 197 circRNAs were differentially expressed when lungs were infected by PRRSV, ASFV, and Mhp, respectively. Most differentially expressed circRNAs were up- and down-regulated in response to specific pathogens among PRRSV, ASFV, and Mhp. …”
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Development of Optimal Technology for Drying Herbal Medicinal Raw Materials from Autumn Wormwood (<i>Artemisia serotina</i> Bunge) Based on Comparative Analysis by A. Kadyrbay, Z. B. Sakipova, N. A. Krishtanova, L. N. Ibragimova, M. B. Ibrayeva, A. E. Sakipov, E. N. Bekbolatova, Ch. Ridvanov, O. V. Sermukhamedova, Y. Adilbek, T. Y. Seiduali, A. K. Anartayeva, A. U. Kazim

“…The results of studies of various drying methods have shown that the most optimal is drying with IR radiation, which allows to maintain the content of essential oils (the main group of biologically active substances) at the optimal level – about 1,7 % with a raw material moisture content of no more than 13 %. …”
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Variations in the quality of tuberculosis care in urban India: A cross-sectional, standardized patient study in two cities. by Ada Kwan, Benjamin Daniels, Vaibhav Saria, Srinath Satyanarayana, Ramnath Subbaraman, Andrew McDowell, Sofi Bergkvist, Ranendra K Das, Veena Das, Jishnu Das, Madhukar Pai

“…<h4>Background</h4>India has the highest burden of tuberculosis (TB). Although most patients with TB in India seek care from the private sector, there is limited evidence on quality of TB care or its correlates. …”
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Exploring the Chemical Composition and Antimicrobial Activity of Extracts from the Roots and Aboveground Parts of <i>Limonium gmelini</i> by Dariya Kassymova, Francesco Cairone, Donatella Ambroselli, Rosa Lanzetta, Bruno Casciaro, Aizhan Zhussupova, Deborah Quaglio, Angela Casillo, Galiya E. Zhusupova, Maria Michela Corsaro, Bruno Botta, Silvia Cammarone, Maria Luisa Mangoni, Cinzia Ingallina, Francesca Ghirga

“…Further investigation is needed to isolate and validate the most active constituents for potential therapeutic applications.…”
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Safety of pericardiocentesis in pulmonary arterial hypertension: a systematic review by Maria Jose Cabada-Garcia, Maria Jose Cabada-Garcia, Jahir Rodriguez-Rivera, Carlos Jerjes-Sanchez, Carlos Jerjes-Sanchez, Mauricio Castillo-Perez, Paola Gutierrez-Gallegos, Ana Lucia Martinez-Rodriguez, Enrique Paredes-Gutierrez, Renata Claudia Quevedo-Salazar, Humberto De Leon-Gutierrez, Oscar David Lopez-Cortes, Jathniel Panneflek, Jathniel Panneflek, Raul Monjaras-Alvarado, Jesus Antonio Moron-Mosso, Jaime Guillermo Gonzalez-Medina

“…Connective tissue disease was the most common etiology of PAH. Drainage strategies during PC differed across studies. …”
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A 15-year study of neuraminidase mutations and the increasing of S247N mutation in Spain by Iván Sanz-Muñoz, Alejandro Martín-Toribio, Adrián García-Concejo, Irene Arroyo-Hernantes, Marina Toquero-Asensio, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Silvia Rojo-Rello, Marta Domínguez-Gil, Eduardo Tamayo-Gómez, Marta Hernández-Pérez, José M Eiros

“…Our results showed that the occurrence of NA resistance mutations remained constant in the four viruses during the 15 seasons evaluated, being around 0.5–5 %. Most of the resistance was found in the A(H1N1)pdm09 subtype (around 70 %), especially from the 2023–2024 season onwards, when a significant increase in the occurrence of S247N mutation was observed. …”
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UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice by Dalei Sun, Shu Ouyang, Xiaoxuan Xu, Jingjing Yan, Heqian Wang, Chenkai Lan, Wubin Ouyang, Liangjun Zhong, Jun Lin

“…Local high-dose UMI-77 (Group Ba) demonstrated the most potent efficacy, reducing BOP by 76 % (0.67 ± 0.5 vs. …”
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Worldwide hotspots and trends in stem cell therapy for kidney disease in the last decade: a bibliometric and visualization analysis from 2015 to 2024 by Shengchun Liao, Shengchun Liao, Shengchun Liao, Xinyue Zhang, Yiting Zhou, Yiting Zhou, Yiting Zhou, Lingchen Wang, Lingchen Wang, Chi Chen, Chi Chen, Chaoyang Ye, Chaoyang Ye, Yuan Zhou, Yuan Zhou, Yuan Zhou, Chen Wang, Chen Wang, Chen Wang

“…Additionally, Lerman LO was the most prolific author in this field. Currently, there is a growing focus on mesenchymal stem cells and acute kidney injury models in this field. …”
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Effect of bagging on nutritional quality and mineral element content of peach fruit in different varieties by CHEN Meng, ZHANG Xue, LI Yue, LI Yong, CHEN Xiaolong, CHEN Jian, YU Xiangyang

“…[Conclusion] The bagging did not affect fruit mass or firmness but significantly reduced the contents of soluble solids, vitamin C, amino acids, total phenols, and most mineral elements, leading to reduce the nutritional quality of the peach fruits. …”
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Repellent Activity of DEET Combined with Botanical Compounds Against <i>Amblyomma sculptum</i> Nymphs: Laboratory and Field Evaluations by Mayara Macêdo Barrozo, Haile Dean Figueiredo Chagas, Gabrielly Bernardes Rodrigues Damaceno, Emilly Faria Santos, Rafael Assunção Carvalho, Isabela Santos Silva, Francisca Letícia Vale, Lainny Jordana Martins Pereira e Sousa, Hermes Ribeiro Luz, Lorena Lopes Ferreira, Caio Monteiro

“…Eugenol and methyl eugenol exhibited the highest average repellent percentages (60 to 90%), with significant effects (<i>p</i> < 0.05) across most evaluation periods, in contrast to 1,8-cineole. …”
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