Is axillary surgery still justified in DCIS diagnosed via vacuum-assisted biopsy? by Marcellus do Nascimento Moreira Ramos, André Mattar, Marcelo Antonini, Felipe Zerwes, Felipe Cavagna, Francisco Pimentel Cavalcante, Eduardo Camargo Millen, Fabricio Palermo Brenelli, Antonio Luiz Frasson, Marcelo Madeira, Andressa Gonçalves Amorim, Marina Diógenes Teixeira, Marina Fleury de Figueiredo, Larissa Chrispim de Oliveira, Leonardo Ribeiro Sorares, Gil Facina, Rogerio Fenile, Ruffo de Freitas Júnior, Renata Arakelian, Marcela Bonalumi dos Santos, Henrique Lima Couto, Renata Montarroyos Leite, Pedro Paulo de Andrade Gomes, Gabriela de Oliveira Gomes, Luiz Henrique Gebrim, Reginaldo Guedes Coelho Lopes, Juliana Monte Real

“…Multivariate logistic regression identified predictors of axillary surgery and upstaging to invasive carcinoma. Results Most patients underwent BCS (72.7%), with axillary evaluation performed in 35.1% of BCS cases versus 91.9% of mastectomies (p < 0.001). …”
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Unveiling the crucial role of CD8+ T cell and endothelial cell interaction in rheumatoid arthritis through the integrated analysis of spatial transcriptomics and bulk/single-cell R... by Yu Lai, Zishao Zhong, Runze Li, Tuliang Liang, Xizi He, Yuan Liu, Hao Yu, Chuanhai Zhang, Yao Xiao, Liang Liu, Hudan Pan

“…By integrating thirteen single-cell RNA sequencing datasets, we documented a notable elevation in the proportion of most lymphocyte types within RA synovium. The chemokine signaling pathway emerged as one of the primary pathways enriched in genes differentially expressed between RA and osteoarthritis in lymphocytes and CD8+ T cells. …”
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Intelligence quotient discrepancy indicates levels of motor competence in preschool children at risk for developmental delays by Yu T, Chen K, Chou W, Yang S, Kung S, Lee Y, Tung L

“…Significant negative correlations between IQD and most of the motor subtests (r=0.31&amp;ndash;0.46, P&amp;lt;0.01) were found only in the VIQ&amp;gt;PIQ group.Conclusion: This study demonstrates that 1) IQD indicates the level of motor competence in preschoolers at risk for developmental delays and 2) IQD is negatively associated with motor competence in preschoolers with significant VIQ&amp;gt;PIQ discrepancy. …”
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Modeling wheat growth to determine economic feasibility under deficit irrigation and nitrogen management strategies by Junaid Nawaz Chauhdary, Hong Li, Ragab Ragab, Zawar Hussain, Shakeel Ahmad Anjum, Mustafoyev Komil llxomovich

“…Economic analysis of all scenarios revealed FI.LNF150 (full irrigation with 150 % nitrogen dose) as the most profitable strategy, generating the highest net margin (826 US$ha−1) and BCR (1.44), while DI80LNF175 maximized water economic productivity (0.69 US$m⁻³). …”
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Combination of p-coumaric acid and lactoferrin ameliorates cognitive deficits through suppressing C/EBPβ/AEP pathway and modulating intestinal flora in APP/PS1 mice by Yan Zhou, Yitian Sun, Hui Guo, Yanzi Liang, Siyuan Zhu, Yu Sha, Zhongxiao Wan, Jiaying Xu, Jianrong Jiang, Liqiang Qin, Yunhong Li

“…Specifically, combined treatment was most effective in improving nesting ability and reducing amyloid β1-42 (Aβ1-42) deposition in mice. …”
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Comparative peculiarities of genomic diversity in <i>Gallus gallus domesticus</i> chickens with decorative plumage: the muffs and beard phenotype by N. V. Dementieva, Y. S. Shcherbakov, A. E. Ryabova, A. B. Vakhrameev, A. V. Makarova, O. A. Nikolaeva, A. P. Dysin, A. I. Azovtseva, N. R. Reinbah, O. V. Mitrofanova

“…Based on cluster analysis, with the cross­validation error and the most probable number of clusters K = 4 taken into account, the Orloff was singled out as a separate group. …”
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Development of the Intersectoral Care Reported by Patients Survey for Primary and Oral Healthcare by Kirsten P. J. Smits, Marieke M. van der Zande, Reanne Hek, Pim W. J. J. Assendelft, Fred R. Rozema, Kenneth R. Wright, Maria C. Dolce, Christine A. Riedy, Jane R. Barrow, Fabian Hüttig, Stefan Listl

“…Introduction: Oral and general health are closely related, and many oral and chronic-systemic diseases have the same risk factors. However, in most countries dental and general health care systems are separated. …”
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Avaliação dos principais padrões de perfil facial quanto a estética e atratividade Evaluation of the main criteria of facial profile aesthetics and attractiveness by Diego Moura Soares, Pettely Thaise de Souza Santos Palmeira, Vinícius de Farias Pereira, Marconi Eduardo Sousa Maciel Santos, Rafael Miranda Tassitano, José Rodrigues Laureano Filho

“…CONCLUSIONS: The facial criteria of both Caucasian class I and African class I were the most attractive, whereas to the facial criteria of class III were less attractive. …”
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Age-related features of calcium pyrophosphate deposition disease by M. S. Eliseev, O. V. Zhelyabina, M. N. Chikina

“…Thirty-eight (33.6%) of the 113 examined patients with CPPD were aged less than 55 years. The most common clinical form of CPPD was chronic arthritis (n=54; 47.8%), the less common forms were osteoarthritis (OA) with calcium pyrophosphate (CPP) crystals (n=35; 31%) and acute arthritis (n=24; 21.2 %); their rates did not differ in the formed groups.In patients older than 55 years, the pain intensity according to VAS was higher than that at a younger age (50 [40; 70] mm and 40 [25; 54] mm, respectively; p&lt;0.001); they had more frequently to take nonsteroidal anti-inflammatory drugs (NSAIDs) and/or colchicine (94.7 and 76.3%, respectively; p=0.0039) and had a higher serum CRP level (4.1 [1.9; 10.3] and 2.1 [1.9; 10.3] mg/L, respectively; p=0.0034); however, the number of patients with a CRP concentration of &gt;5 mg/dL was comparable for both groups. …”
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The diet of bats in forest ecosystems and their potential as natural enemies of forest pests: A case study in the Khingan Mountains, Northeast China by Lixin Gong, Zhiqiang Wang, Can Ke, Maojun Zhong, Wenhao Zhang, Yaping Lu, Kangkang Zhang, Jiang Feng, Tinglei Jiang

“…Bats, as natural predators of pests in agroforestry ecosystems, provide pest control services. However, most studies have focused on agroecosystems, but studies on forest ecosystems are scarce. …”
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Characteristics of stem sings of EpCAM-negative and EpCAM-positive tumor cells in primary tumor and 2D and 3D cultures in breast cancer by V. V. Alifanov, M. S. Tretyakova, E. S. Grigoryeva, M. A. Buldakov, L. A. Tashireva, E. S. Kolegova, E. S. Andryuhova, M. V. Zavyalova, E. V. Denisov, N. V. Cherdyntseva, V. M. Perelmuter

“…The results indicate that EpCAM-negative and EpCAM-positive tumor cells of luminal molecular subtype of breast cancer are capable of exhibiting various phenotypic variants of stemness and EMT in the primary tumor and 2D and 3D cultures. In most cases, individual tumor cells show co-expression of several stemness markers. …”
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Characteristics and Outcome of Partial Liver Transplant among Pediatrics in a Referral Transplant Center in Iran from 2010 to 2020 by Pooya Vatankhah, Mohammad Bagher Khosravi, Mohammad Hossein Eghbal, Naeimehossadat Asmarian, Mohammad Ali Sahmeddini, Fatemeh Khalili, Samaneh Ghazanfar Tehran, Hamed Nikoupour, Alireza Shamsaeefar, Kourosh Kazemi, Sahar Sohrabi Nazari, Saman Nikeghbalian, Seyed Ali Malekhosseini

“…This study aimed to assess the impact of perioperative factors on LT outcomes in pediatric patients.Methods: This retrospective cohort study, conducted from 2010-2020, included 563 pediatric patients who underwent LT in Shiraz, Iran. Most patients received liver grafts from living donors due to cholestatic and metabolic diseases, and all had complete medical and laboratory records. …”
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Objective and Subjective Assessment of the Sound Attenuation Efficiency Obtained by Custom Moulded Earplugs with Various Acoustic Filters – a Preliminary Study by Roman Gołębiewski, Andrzej Wicher, Artur Duraj, Milena Kaczmarek-Klinowska, Karina Mrugalska-Handke

“…Background: Hearing loss caused by excessive exposure to noise is one of the most common health risks for employees. One solution for noise reduction is the use of hearing protectors, which is a very effective method for protecting hearing from the workplace noise. …”
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Indigenous herbal medicine use and its associated factors among pregnant women attending antenatal care at public health facilities in Dire Dawa, Ethiopia: a cross-sectional study by Addisu Sertsu, Aminu Mohammed, Bezabih Amsalu, Mickiale Hailu, Yitagesu Sintayehu, Tadesse Weldeamanuel, Yalelet Belay, Tesema Dinkesa, Natnael Dechasa, Betelhem Mengist, Teshale Mengesha, Aliya Nuri, Tewodros Getnet, Yibekal Manaye, Ahmedin Aliyi Usso, Henok Legesse, Zeyniya Hussen

“…Lack of formal education (adjusted OR, AOR 5.47, 95% CI 2.40 to 12.46), primary level (AOR 4.74, 95% CI 2.15 to 10.44), housewives (AOR 4.15, 95% CI 1.83 to 9.37), number of ANC visits (AOR 2.58, 95% CI 1.27 to 5.25), insufficient knowledge (AOR 4.58, 95% CI 3.02 to 6.77) and favourable perception (AOR 2.54, 95% CI 1.71 to 3.77) were factors significantly associated with herbal medicine use. The most commonly used herbs were garden cress (Lepidium sativum) (32%), bitter leaf (Vernonia amygdalina) (25.2%), moringa (Moringa oleifera) (24.5%). …”
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Global Status of Adult Immunization Post COVID-19 Pandemic by Alba Vilajeliu, Victor Vega, Randie Gibson, Francisco Nogareda, Xiaojun Wang, Donald J. Brooks, Charles Shey Wiysonge, Osman Niyazi Cakmak, Osama Mere, Melanie Marti, Phillip Lambach, Stephanie Shendale, Marcela Contreras, Emmanuel Njambe, Erin Grace Sparrow, Joachim Hombach, Ann Lindstrand

“…Results: WHO policy recommendations exist for most of the licensed vaccines targeting adults; however, the inclusion in national immunization schedules is higher in high-income (HICs) and middle-income (MICs) countries. …”
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Impact of neutron radiation on the viability of tumor cells cultured in the presence of boron-10 isotope by O. Yu. Volkova, L. V. Mechetina, A. V. Taranin, A. A. Zaboronok, K. Nakai, S. I. Lezhnin, S. A. Frolov, D. A. Kasatov, A. N. Makarov, I. N. Sorokin, T. V. Sycheva, I. M. Shchudlo, S. Yu. Taskaev

“…Elevated boron levels in the culture medium resulted in a significant decrease in the proportion of survived cells. Radiation had the most pronounced impact on the proliferative capacity of the human U251 glioma cell lines.Conclusion. …”
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Analysis of clinical infection characteristics of multidrug-resistant organisms in hospitalized patients in a tertiary sentinel hospital in Shanghai from 2021 to 2023 by MAO Qi, ZHAO Tenglong, LYU Xihong, GU Zhiyuan, CHEN Bin, ZHAO Lidi, LI Xifeng, ZHANG Xing, TIAN Liang, ZHU Renyi

“…The type of specimen was mainly sputum, the hospitalized ward was mainly comprehensive ICU, the sampling time was mainly in the first quarter throughout the year, the number of underlying diseases was mainly between 1 to 2 kinds, the application of antibiotics ≥4 kinds, and those who didn’t receive any surgery recently accounted for the most. There were statistically significant differences in the distribution of strains between different specimen types, wards occupied and history of ICU stay (P<0.05), but no statistically significant difference in the distribution of strains between different sampling times, number of underlying diseases and types of antibiotics applied (P>0.05).ConclusionThe situation of prevention and control on MDROs in this hospital is still serious. …”
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Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles by Aidan Flynn, Andrew D. Pattison, Shiva Balachander, Emma Boehm, Blake Bowen, Trisha Dwight, Fernando J. Rossello, Oliver Hofmann, Luciano Martelotto, Maia Zethoven, Lawrence S. Kirschner, Tobias Else, Lauren Fishbein, Anthony J. Gill, Arthur S. Tischler, Thomas Giordano, Tamara Prodanov, Jane R. Noble, Roger R. Reddel, Alison H. Trainer, Hans Kumar Ghayee, Isabelle Bourdeau, Marianne Elston, Diana Ishak, Joanne Ngeow Yuen Yie, Rodney J. Hicks, Joakim Crona, Tobias Åkerström, Peter Stålberg, Patricia Dahia, Sean Grimmond, Roderick Clifton-Bligh, Karel Pacak, Richard W. Tothill

“…TERT and ATRX-alterations are associated with metastatic PCPG and these tumours have an increased mutation load, and distinct transcriptional and telomeric features. Most PCPG have quiet genomes with some rare co-operative driver events, including EPAS1/HIF-2α mutations. …”
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Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome by Laura M. Baas, Kioa L. Wijnsma, Fokje Zijlstra, Nicole C. A. J. van de Kar, Lieke ter Steeg, Antonia H. M. Bouts, Marloes A. H. M. Michels, Marloes A. H. M. Michels, Jeroen D. Langereis, Dirk Lefeber, Dirk Lefeber, Hans J. C. T. Wessels, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel

“…This abnormal glycosylation was most prominent during the acute phase in all patients and showed partial or complete normalization during remission. …”
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Adhesion and friction patterns of CVD-grown monolayer flakes induced by vacancy-rich defect domains by Paolo Canepa, Ermes Peci, Michele Magnozzi, Hasret Ağırcan, Domenica Convertino, Stiven Forti, Camilla Coletti, Ornella Cavalleri, Maurizio Canepa, Renato Buzio, Francesco Bisio

“…These findings help identify the type of defects and mechanisms that most significantly affect the properties of TMD monolayer flakes prepared by scalable production routes.…”
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