The TNFα-binding domain of the therapeutic antibody adalimumab elicits CD4 T-cell responses in rheumatoid arthritis patients by Mateusz Makuch, Josine van Beek, Josine van Beek, Carla A. Wijbrandts, Marja Aalbers, Philippe Stas, Alexander B. Meijer, Anja ten Brinke, Theo Rispens, Paul Peter Tak, Paul Peter Tak, Gertjan Wolbink, Gertjan Wolbink, Janine Schuurman, Paul W. H. I. Parren, Paul W. H. I. Parren, S. Marieke van Ham, S. Marieke van Ham

“…These are observed in most adalimumab-treated rheumatoid arthritis patients, despite the adjuvant-free and human sequence-derived nature of the antibody. …”
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Risk factors of bone metastasis in lung adenocarcinoma by Zhongnian Cao, Rong Zheng, Jing Li, Xuejuan Wang, Chao Ding, Fan Zhang, Jianhua Geng, Zhengmao Wei, Rong Fan

“…A receiver operating characteristic curve was used to verify the predictive value of the regression model, and the area under the curve was 0.912 (P < 0.001). Conclusion The most common sites of bone metastases in newly diagnosed lung adenocarcinoma are the spine and ribs. …”
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Estrogen/androgen balance in men with hyperestrogenism normalized by using letrozole of the aromatase inhibitor drug class by Z. Sh. Pavlova, A. S. Ametov, I. I. Golodnikov, A. A. Kamalov

“…At the same time, patients with androgen deficiency and hyperestrogenism, in most cases, have excess body weight due to adipose tissue, metabolic syndrome in a combination of its various components, which underlie a need to use standard methods of therapy primarily modified lifestyle and metformin, which provide the maximum positive effect in the treatment of such patients.…”
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Pericarpium Trichosanthis Injection Protects Isoproterenol-Induced Acute Myocardial Ischemia via Suppressing Inflammatory Damage and Apoptosis Pathways by Zizheng Wu, Xing Chen, Jiahao Ye, Xiaoyi Wang, Zhixi Hu

“…Topological analysis of the protein interactome highlighted AKT1, EGFR, MMP9, SRC, PTGS2, STAT3, BCL2, CASP3, and MAPK3 as the most interconnected nodes with the highest betweenness centrality. …”
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Effects of exposure to phthalates and a phthalate substitute on food sensitization in children in China: evidence from a population study by Yiyun Zhang, Lei Zhang, Yan Chen, Hua Feng, Wei Zhou, Lianglu Wang, Di Wu, Jingguang Li, Yongning Wu

“…Background: Phthalates are among the most ubiquitous environmental pollutants and endocrine disruptors. …”
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Comprehensive Genomic Profiling of Indian Patients With Lung Cancer by Shivani Sharma, Vanita Noronha, Arti Yadav, Madhvi Mandhania, Sambit K. Mohanty, Rahul Katara, Aditi Aggarwal, Sagar Samrat Mohanty, Akash Kumar, Sanjeev Kumar, Vipin Kumar, Kanika Jaggi, Deepak Kumar Sharma, Sanjay Kumar, Vaishalee Apoorva, Akash Pawar, Nandini Menon, Minit Shah, Kumar Prabhash

“…Sex and age influenced mutation prevalence, with EGFR mutations more common in females and KRAS in males, while ALK, ROS1, and RET fusions were prevalent in younger adults. Most genomic alterations were mutually exclusive, although 25% patients had co-occurring mutations. …”
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Academic stress and irregular menstruation influence the dysmenorrhea, school absenteeism and healthcare seeking among adolescent girls in junior high school in Shanghai: a cross-s... by Tiantian Liu, Deyun Qi, Li Zhang, Jun Hou, Jing Zhao, Yuan Zhou, Bingbing Sun, Fei Wang, Hui Tan, Ruiping Wang

“…More attention and intervention measures focusing on menstrual health problems should be implemented directly among adolescent girls in junior high school, especially among those with low body weight, irregular menstruation, and academic stress. Most importantly, this study provides scientific evidence on adolescent dysmenorrhea issues, offering targeted recommendations for policymakers to advance the refinement and implementation of public health policies.…”
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Epidemiological profiles and outcomes of healthcare workers hospitalized for COVID-19 in five Sub-Saharan African countries: a cohort study [version 1; peer review: 1 approved, 2 a... by Tamba Mina Millimouno, Laura Merson, Alexandre Delamou, Shermarke Hassan, Timire Collins, Jerry-Jonas Mbasha, Ibrahima Kaba, Karifa Kourouma, Fassou Mathias Grovogui, Ibrahim Franklyn Kamara

“…In three of the five countries, however, the majority of the HCWs were <39 years old and were males. Antibiotics were the most commonly used medical treatments across three countries (Ghana, 67.8%; Guinea, 97.3%; Malawi, 80%), while antimalarials were commonly used in Guinea (87.8%) and Ghana (30.4%). …”
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Variation in Leaf C, N, and P Stoichiometric Characteristics of <i>Populus euphratica</i> Communities in a Desert Riparian Ecosystem of Northwest China by Xiaolong Zhang, Xianmeng Liu, Lijiang Shi, Yinbo Zhang, Jingwei Wang, Feng Gao, Hao Qin, Min Shi, Yongji Wang, Yuanrun Zheng

“…Among these factors, soil water content had the most pronounced effect, surpassing soil available phosphorus, bulk density, and electrical conductivity in shaping leaf stoichiometric characteristics. …”
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Perceived effectiveness and recommendations from a childbirth quality assurance and improvement programme in India’s private sector: a qualitative evaluation using the RE-AIM frame... by Katherine Semrau, Meghna Desai, Lauren Spigel, Somesh Kumar, Megan Marx Delaney, Lauren Bobanski, Suranjeen Pallipamula, Natalie Henrich, Tapas Sadasivan Nair, Hema Divakar, Rajat Chabba, Shweta Jindal, Gulnoza Usmanova, Sukanya Dutta, Aarushi Gupta, Sucheta Kinjawadekar, Priti Kumar, Priyanka Kumari, Prerna Mukharya, Hrishikesh Pai, Ameya Purandare, Pompy Sridhar

“…Barriers to joining included cost, unclear value and little motivation to improve practice. Participants most valued Manyata for improving staff competency, quality of care, standardised care processes and staff satisfaction. …”
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加薪是萬靈丹？ 桃園市國民小學教師兼任行政職務意願影響因素建構之研究 Is Increasing Salary a Panacea? A Study on the Factors Influencing Taoyuan City Elementary School Teachers’ Willingness to Assume Administrative... by 黃鈺容 Yu-Jung Huang, 陳建志 Chien-Chih Chen

“…The study found that among the four dimensions influencing teachers’ willingness to take on administrative roles, “family factors” are the most significant, followed by “personal factors” ; 2. …”
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Register of adult patients with noncompact left ventricular myocardium: classification of clinical forms and a prospective assessment of progression by E. V. Pavlenko, O. V. Blagova, N. V. Varionchik, A. V. Nedostup, V. P. Sedov, M. E. Polyak, E. V. Zaklyazminskaya

“…A significant improvement in dynamics of EF and LV end-diastolic diameter was noted only in the group of patients with acute/subacute, most of which received basic myocarditis therapy. …”
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Therapeutic efficacy of Centratherum anthelminticum in subclinical mastitis: A biochemical and hematological assessment in lactating cattle by Muhammad Adil, Farrah Deeba, Muhammad Tariq, Muhammad Usman, Saba Saeed, Eliana Ibáñez-Arancibia, Patricio De los Ríos-Escalante, Muhammad Safdar

“…Group C exhibited the most pronounced improvements in lactose, fat, and SNF, with no change in protein. …”
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Complement C3a promotes the formation of osteoclasts by inhibiting Sirt1 to activate the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma by Fengjuan Jiang, Yunhe Zhang, Fengping Peng, Hui Liu, Kai Ding, Panpan Cao, Xiaohan Liu, Lijuan Li, Zhaoyun Liu, Rong Fu

“…Abstract Background Myeloma bone disease (MBD) is the most common complication of multiple myeloma (MM). …”
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Human‐wildlife conflict at high altitude: A case from Gaurishankar conservation area, Nepal by Abhinaya Pathak, Saneer Lamichhane, Maheshwar Dhakal, Ajay Karki, Bed Kumar Dhakal, Madhu Chetri, Jeffrey Mintz, Prakash Pun, Pramila Neupane, Tulasi Prasad Dahal, Trishna Rayamajhi, Prashamsa Paudel, Ashim Thapa, Pramod Raj Regmi, Shankar Thami, Ganesh Thapa, Suraj Khanal, Supriya Lama, Jenisha Karki, Sujan Khanal, Arockia E J Ferdin

“…The study analyzes a decade of HWC reports and identifies goats as the livestock most targeted by leopards. The Dolakha district of GCA received the highest number of reports, highlighting the need for mitigation measures in the area. …”
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Molecular heterogeneity and analysis of the long-term survival of patients with gastrointestinal stromal tumors by N. N. Mazurenko, V. V. Yugay, I. V. Tsyganova, M. P. Nikulin, P. P. Arkhiri, O. A. Anurova, N. A. Kozlov, I. S. Stilidi

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract the character diagnostic feature of which is CD117 (KIT) expression. …”
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Reflecting on the Implementation of United Kingdom (UK) General Practitioner Training Models in China: Highlights From a Train-the-Trainer Pilot Program by Luo F, Chen M, Chen Y, Huang H, Zhan W, Chen L, Xu D, Lv B

“…To achieve the internationally recognized training standard, this project is collaborating with the most advanced general practitioner training system in UK, which has excellent track record of innovative research for co-designing train-the-trainer program. …”
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Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients by Koji Imoto, Motoyuki Kohjima, Tomonobu Hioki, Tomoyuki Kurashige, Miho Kurokawa, Shigeki Tashiro, Hideo Suzuki, Akifumi Kuwano, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa

“…Thirty-four patients (60.7%) developed cholestatic or mixed-type liver injury, although only one patient showed abnormal image findings in the bile duct. Most patients with grade ≤2 liver injury improved spontaneously, while two patients with biliary dysfunction required ursodeoxycholic acid or prednisolone. …”
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Recombinant expression of receptor binding domains of all eight subtypes of botulinum neurotoxin type A for generation of antitoxins with broad reactivity [version 1; peer review:... by Anh Thi Phuong Tran, Chien Trong Nguyen, Quynh Mai Vu, Ly Huong Tran, Tran Bao Anh Dang, Tam Trang Mai, Nga Quynh Pham, Hoa Quang Le, Van Khanh Tran, Thinh Huy Tran, Van Anh Tran, Tran Nhat Minh Dang

“…Background Botulinum neurotoxin type A (BoNT/A) represents a major threat to global public health because of its most potent toxicity with the longest persistence. …”
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Integrative radiomics of intra- and peri-tumoral features for enhanced risk prediction in thymic tumors: a multimodal analysis of tumor microenvironment contributions by Liang zhu, Jiamin Li, Xuefeng Wang, Yan He, Siyuan Li, Shuyan He, Biao Deng

“…Subsequently, hierarchical clustering and the LASSO algorithm were applied to identify the most predictive features. These selected features were then used to train machine learning models, which were optimized on the training dataset and assessed for predictive performance. …”
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