Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties by Ennian Li, Kai Wang, Bei Zhang, Siqi Guo, Senhao Xiao, Qi Pan, Xiaowan Wang, Weiying Chen, Yunshan Wu, Hesong Xu, Xiangqian Kong, Cheng Luo, Shijie Chen, Bo Liu

“…SAR studies were conducted based on enzymatic assays. And most of the compounds showed strong inhibitory activity on human DNMT1, especially WK-23 displayed a good inhibitory effect on human DNMT1 with an IC50 value of 5.0 µM. …”
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Prevalence and genetic diversity of porcine rotavirus A from diarrheic piglets in Northern Thailand by Nutthawadee Jampanil, Pattara Khamrin, Kattareeya Kumthip, Thitapa Longum, Zhenfeng Xie, Arpaporn Yodmeeklin, Panuwat Yamsakul, Aphisek Kongkaew, Yuki Akari, Satoshi Komoto, Shoko Okitsu, Hiroshi Ushijima, Niwat Maneekarn

“…Of these, G5P[23] and G4P[23] emerged as the most predominant genotypes, which were substantially different from previous reports in the same geographical area. …”
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Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

“…Abstract Background Breast cancer is the most diagnosed cancer in women worldwide and carries a considerable psychosocial burden. …”
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Study of a giant large Magellanic Cloud Supernova Remnant, Veliki (J0450.4-7050) by Smeaton Z.J., Filipović M.D., Alsaberi R.Z.E., Arbutina B., Cotton W.D., Crawford E.J., Hopkins A.M., Kothes R., Leahy D., Payne J.L., Rajabpour N., Sano H., Sasaki M., Urošević D., van Loon J.Th.

“…We investigate several theoretical scenarios to explain the emission and radio evolution of J0450.4-7050 in the context of the LMC environment, and determine that this is most likely an older, predominantly radiative, SNR with a higher shock compression ratio, which gives a flatter non-thermal spectrum in combination with thermal (bremsstrahlung) emission contribution.…”
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Analytical Modeling of a Heat Source under Welding of a Steel Sleeve by the Centrifugal Method Using an Axisymmetric Electric Arc by S. P. Glushko

“…Therefore, in order to exclude most of the experimental components when modeling the heat source and heat flow distribution of the facing process (bimetallization) of the inner surface of steel sleeves under heating by an independent axisymmetric electric arc, the author in this paper proposes an analytical solution for calculating the effective heat flow density in the form of an exponential function. …”
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Malaria risk factors in northern Namibia: The importance of occupation, age and mobility in characterizing high-risk populations. by Jennifer L Smith, Davis Mumbengegwi, Erastus Haindongo, Carmen Cueto, Kathryn W Roberts, Roly Gosling, Petrina Uusiku, Immo Kleinschmidt, Adam Bennett, Hugh J Sturrock

“…After adjustment, cases were more likely to be cattle herders (Adjusted Odds Ratio (aOR): 4.46 95%CI 1.05-18.96), members of the police or other security personnel (aOR: 4.60 95%CI: 1.16-18.16), and pensioners/unemployed persons (aOR: 2.25 95%CI 1.24-4.08), compared to agricultural workers (most common category). Children (aOR 2.28 95%CI 1.13-4.59) and self-identified students were at higher risk of malaria (aOR: 4.32 95%CI 2.31-8.10). …”
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Acupuncture for preventing chemotherapy-induced peripheral neuropathy: study protocol for a randomised controlled trial by Jun Wang, Cun-Zhi Liu, Jing-Wen Yang, Jian-Feng Tu, Hang Zhou, Guangxia Shi, Xiao-Yan Guo, Li-Qiong Wang, Wei Liang, Na-Na Yang, Bin-Yan Li, Xiao-Ya Wei, Jin-Ying Jia

“…Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent non-haematological, dose-limiting adverse event associated with platinum derivatives and taxanes. …”
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The impact of deprivation and neighbourhood food environments on home food environments, parental feeding practices, child eating behaviours, food preferences and BMI: The Family F... by Andrea D Smith, Alice Kininmonth, Kristiane Tommerup, David Boniface, Chiara Gericke, Tiffany Denning, Carolyn Summerbell, Christina Vogel, Clare Llewellyn

“…Policies focusing on improving neighbourhood food environments will likely be most effective if combined with those addressing systemic issues related to deprivation such as welfare policies (e.g. reforms to benefit caps) or targeted subsidies for healthy food. …”
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The health burden of disease attributable to low calcium intake: a comprehensive analysis of trends and socioeconomic impacts from 1990 to 2021 by Yanping Wang, Meihui Tao, Li Wang, Siyu Zhou, Weifeng Yang, Xi Zhao, Qinyu Feng, Mengfan Tang, Wei Yan, Yu Fu

“…This research delved into the most recent datasets acquired via the 2021 Global Burden of Disease (GBD) report to uncover the worldwide impact of DLC.MethodsUtilizing the GBD 2021 database, this research examined the association of DLC with disease burden, covering colorectal and prostate cancers. …”
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RT-QuIC optimization for prion detection in soils by Madeline K. Grunklee, Stuart S. Lichtenberg, Gage Rowden, Diana L. Karwan, E. Anu Li, Marc D. Schwabenlander, Tiffany M. Wolf

“…. • We performed multiple statistical evaluations and assessments of these control experiments to enhance assay specificity and sensitivity.From these experiments, we identified maxpoint ratio (MPR) as the most effective metric to evaluate true PrPSc detections from background noise in Minnesota native soils. …”
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An enigma of hypocalcaemia: unveiling the interaction between denosumab and intravenous iron when co-administered by Sabyasachi Roy, Anand Velusamy, Muhammed Russal Latheef

“…Investigating the cause of hypocalcaemia in records found a history of denosumab (60 mg s/c) 3.5 months previously and previous use of multiple bisphosphonates for osteoporosis.4 The patient was also under haematology for iron deficiency anaemia, receiving IV iron therapy at least twice a year, with the most recent one administered around the time of denosumab administration.5The patient was managed with IV calcium initially, followed by oral calcium supplementation, phosphate replacement and magnesium monitoring. …”
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Clinical Outcomes of Non Vitamin K Antagonist Oral Anticoagulants versus Vitamin K Antagonist Oral Anticoagulants in Non Valvular Atrial Fibrillation Patients: A Cohort Study in a... by Sohilkhan Riyazkhan Pathan, Bharat M Gajjar, Sunilkumar Karna, Kushal Pujara

“…Introduction: Atrial Fibrillation (AF) is the most common arrhythmia, with an increased risk of ischaemic stroke and subsequent morbidity and mortality. …”
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Neural models in diagnostics of the financial result of housing and utility enterprises by I. P. Kurochkina, I. I. Kalinin, L. A. Mamatova, E. B. Shuvalova

“…The  neural network  modeling methodology allows you to create models that have  several advantages:  learning ability  (they  adapt  to various  changes);  universality  (able  to solve a wide  range of data analysis and processing tasks);  speed (process various  data  in  parallel  mode);  ease  of use (easy  to operate  after training);  fault  tolerance  (resistant  to local  damage  to the  neural network  structure and external  noise).One of the main  tasks that neural networks  successfully solve is the problem of classification  – the assignment  of the sample  to one or several predefined classes. Most often, the input sample is determined by  the  input  data  vector.  …”
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Evaluation of common respiratory viruses other than SARS-CoV-2 in hospitalized children during the COVID-19 pandemic by Reihaneh Hosseinpour Sadeghi, Babak Pourakbari, Shima Mahmoudi, Reza Ahmadi, Erfaneh Jafari, Sadaf Sajedi Moghaddam, Maryam Sotoudeh Anvari, Mahmoud Khodabandeh, Setareh Mamishi

“…Results Among the 92 patients, 67.3% (n = 62) tested positive for at least one of the targeted respiratory viruses. FluB was the most prevalent, detected in 60.9% (n = 56) of cases, followed by CMV in 12% (n = 11), and HCOV-OC43 in 5.4% (n = 5). …”
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QUALITY OF LIFE ASSESSMENT IN PATIENTS AFTER PROSTHETIC TREATMENT USING THE DENTAL PROFILE QUESTIONNAIRE by A. Y. Kordiyak, R. R. Bratus-Hrynkiv

“…During the study of oral health related quality of life (OHRQoL, 1996), most authors take the OHIP (Oral Health Impact Profile, G.D. …”
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Risk Factors, Clinical Features of the Course of Myocardial Infarction and Treatment of Young Patients Based on Two Hospital Registries by O. L. Barbarash, D. Yu. Sedykh, I. S. Bykova, V. V. Kashtalap, A. D. Erlich

“…Young patients with MI from Kemerovo were also mostly male smokers (p=0.001), who more often had a history of chronic kidney disease, chronic heart failure, and lipid metabolism disorders (p=0.001), who admitted to the hospital with uncomplicated STEMI, actively undergoing thrombolytic therapy and endovascular diagnosis and treatment (p=0.001). …”
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Awareness, attendance, and attitudes toward cervical cancer screening among HIV-positive Chinese women in Yunnan province: a cross-sectional study by Jiawei Hu, Rufei Duan, Hongyun Zhang, Xuelian Zhao, Aihui Wu, Le Li, Fanghui Zhao, Yong Zhang

“…The main facilitators to attending cervical cancer screening were health promotion activity and well-organized programs, while the main barriers were high costs of the service and inadequate awareness. Conclusions Although most HIV-positive women attending a large ART clinic in Yunnan were aware of cervical cancer screening, the up-to-date attendance was low. …”
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Energy-efficient W-doped VO2-based smart glasses by glancing angle co-deposition and subsequent rapid thermal annealing by A.J. Santos, A. Casas-Acuña, N. Martin, J.J. Jiménez, A. Krystianiak, O. Heintz, R. García, F.M. Morales

“…In general, a gradual lowering of the critical temperature to 37 °C during heating was achieved for a maximum intended doping of x = 0.95, albeit at the expense of some detriments in optical performances. The best and most balanced results were accomplished in a 50 nm nominal thickness layer deposited with overall x = 0.97 (i.e. ∼1 at% W) subjected to flash annealing at 550 °C, presenting a remarkable balance of light transmittance (52.0 %), solar modulation capability (5.2 %) and critical temperature drop (44 °C), which leads to a temperature drop rate of about 20 °C per at% W attempted, taking as reference its undoped counterpart fabricated under the same conditions. …”
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Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway by Yan Luo, Feng Zhou, Xiaojing Wang, Runwei Yang, Yi Li, Xiaochun Wu, Bin Ye

“…Chondrocyte apoptosis is the most common pathological feature of OA. Interleukin-1β (IL-1β), a major inflammatory cytokine that promotes cartilage degradation in OA, often stimulates primary human chondrocytes in vitro to establish an in vitro OA model. …”
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Mitral valve leaflet clipping in patients with previously implanted heart failure devices by Ya. Sh. Karamova, T. M. Uskach, T. E. Imaev, S. N. Tereshchenko

“…Absence of significant dynamics of heart chamber sizes and volumes according to EchoCG data in patients with implanted devices is most likely due to small sample size.…”
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