Myeloid Zinc Finger 1: insights into its oncogenic potential, prognostic value, and impact on immune microenvironment across cancers by Wenze Tian, Chun Yu, Xin Xu, Jiaqi Li, Shuangfu Peng, Aijun Sun, Shasha Zhang, Chao Jiang

“…Finally, MZF1 knockdown was achieved with siRNA silencing.ResultsChanges in MZF1 expression are linked to the prognosis of most cancer patients. In the tumor microenvironment, MZF1 is mainly found in CD4 Tconv cells and monocytes/macrophages. …”
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Efficacy and safety of rituximab-based chemoimmunotherapy in adult patients with Burkitt lymphoma in Korea by Gi-June Min, Ka Young Kim, Tong Yoon Kim, Young-Woo Jeon, Byung-Su Kim, Seung-Ah Yahng, Ki-Seong Eom, Seok-Goo Cho

“…Therefore, high-intensity regimens including R-hyperCVAD/MC (Course A of rituximab, cyclophosphamide, doxorubicin, vincristine, and dexamethasone; Course B of rituximab, methotrexate, and cytarabine) have been commonly used; however, no optimal strategy has been established.MethodsThis retrospective study included 69 adult patients with BL (age >15 years) diagnosed between 2009 and 2023 using the WHO criteria. Most of the patients were administered R-hyperCVAD/MC, while rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was administered to older patients or those with poor-performance-status to mitigate toxicity.ResultsThe median age of the patients was 55 years; 39.1% of the patients had Eastern Cooperative Oncology Group Performance Status (ECOG-PS) of 2–4, 62.3% had >1 extranodal site, 71.0% had stage IV, and 13.0% had central nervous system involvement. …”
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Cirque Hors Piste à l’ère Covid-19 : une histoire de contraintes et d’opportunités by Mathilde Eva Perahia

“…In Canada, Cirque Hors Piste (CHP) is the largest and most established social circus organization. While CHP’s capacity to carry out its mission has been deeply affected by the COVID-19 pandemic, the organization has also managed to transform some aspects of this unfortunate crisis into opportunities that have opened up exciting prospects. …”
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High-value utilization of agricultural residues based on component characteristics: Potentiality and challenges by Rui Xu, Jingwen Chen, Nina Yan, Bingqian Xu, Zhichao Lou, Lei Xu

“…Pretreatment technology has become a major focus of value-added transformation due to the heterogeneity and complexity of AR. However, most studies mainly concentrated on innovations in pretreatment technology and product quality, with few systematically addressing the comprehensive framework that encompasses composition analysis, pretreatment, transformation path, and energy assessment. …”
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Structural and regulatory determinants of flagellar motility in Rhodobacterales—the archetypal flagellum of Phaeobacter inhibens DSM 17395 by Jürgen Tomasch, Pascal Bartling, John Vollmers, Lars Wöhlbrand, Michael Jarek, Manfred Rohde, Henner Brinkmann, Heike M. Freese, Ralf Rabus, Jörn Petersen

“…Our phylogenetically broad taxon sampling of more than 300 genomes revealed that the most common FGC, the fla1-type, was probably already present in the common ancestor of Rhodobacterales and was strictly vertically inherited, while the other two FGC types, fla2 and fla3, were spread via horizontal operon transfers. …”
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One Health: governance and regulatory framework for antimicrobial use in Malawi by Amos Lucky Mhone, Dishon M. Muloi, Arshnee Moodley

“…Results: The analysis identified 522 policies relevant to AMU in agriculture, with most addressing aquatic animal health (11.3 %, n = 59), food safety (10.9 %, n = 57) and animal feed (10.9 %, n = 57). …”
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An overall study on efficient Cr (VI) adsorbents for improving of the application value of Chlorella pyrenoidosa by Yi-Tong Wang, Liang-Yi Zhang, Le-Le Kang, Ya-Jun Wang, Jun-Guo Li, Hang Zhao, Kai-Li Dong, Hong-Peng Li, Xuan Guo, Ren-Long Dong, Ming-Ming Chen, Zhen Fang

“…Chromium (Cr) is one of the most common pollutants in aquatic ecosystems, posing a serious threat to environmental protection and biological survival. …”
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Machine learning-driven multi-omics analysis identifies a prognostic gene signature associated with programmed cell death and metabolism in hepatocellular carcinoma by Xiang Li, Donghao Yin, Jiahao Geng, Yanyu Xu, Zijing Xu, Xuemeng Yang, Quanwei Li, Zimeng Shang, Zhiyun Yang, Zhong Xu, Jiabo Wang, Enxiang Zhang, Xinhua Song

“…Abstract Background Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignancy, contributing significantly to global mortality due to limited therapeutic options. …”
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FimH confers mannose-targeting ability to Bacillus Calmette-Guerin for improved immunotherapy in bladder cancer by Yang Zhang, Chao Yan, Ru Jia, Qiang Lv, Fan Huo, Qiang Cao, Qiju Huang, Zhu A Wang, Dan Theodorescu, Pengchao Li

“…Background Bladder cancer is a common disease worldwide with most patients presenting with the non-muscle-invasive form (NMIBC) at initial diagnosis. …”
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The infiltrating ability of abdominal wall endometriosis is associated with ectopic endometrial glandular activity by Xiao Zhang, Ying-Ying He, Nan Jiang, Zhi-Gang Sun, Feng Yan, ? Cidanyangzong, Fang Long, Fang-Xin Shi, Xiao-Guang Xu, Zhen Xiao

“…Introduction: The infiltration pattern of endometriosis is one of the most important pathophysiological features of this lesion. …”
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Aloe vera-derived extracellular vesicle-like particles suppress pancreatic carcinoma progression through triggering pyroptosis via ROS-GSDMD/E signaling pathway by Jieyu Shen, Tianfu Wei, Mingchen Li, Yuankuan Jiang, Jiahui Zhang, Yueyi Qi, Cai Chen, Xiaojie Li, Peng Huang, Jialin Qu

“…Abstract Background Pancreatic carcinoma (PC) remains one of the most aggressive malignancies that is often referred to as the “king of cancers” in clinic. …”
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How forest types shape soil quality: The evidence from eastern China’s north sub-tropical ecosystems by Yanhong Chen, Zhifei Chen, Wenqi Zhang, Zhiying Tang, Yinghu Zhang

“…RL with the 3- to 4-mm diameter class and SBD were the indicators with the highest relative importance in the pine forest, while the most primary indicators contributing to the changes in SQI were RAD and TK in the oak forest. …”
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Efficacy of psychosocial interventions on social functioning in individuals with childhood maltreatment experiences: a protocol for a systematic review and network meta-analysis by Natalia E. Fares-Otero, Silvia Amoretti, Brisa Solé, Sarah L. Halligan, Eduard Vieta, Stefan Leucht, Soraya Seedat, Mathias Harrer

“…Our results may provide practical guidance concerning the most effective psychosocial interventions to reduce the societal burden associated with CM.Protocol registration: PROSPERO CRD42022347034.…”
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Self-Perceived Barriers to Pediatric Cancer Care in Sub-Saharan Africa: A Cross-Sectional Multinational Study by Ole Stoeter, Nikolaus C.S. Mezger, Tamara Koenig, Eric Chokunonga, Girum Tessema, Adugna Fekadu Damise, Alda Stevy Makouanzi, Esther Majaliwa, Mahine Ivanga, Bakarou Kamate, Franck Gnahatin, Sarah Nambooze, Ima-Obong A. Ekanem, Toralf Bernig, Biying Liu, Sumit Gupta, Eva Johanna Kantelhardt

“…The fear of treatment effects and the perceived (poor) health of the child were named most frequently as barriers for all treatment modalities (78.9% and 75.5%, respectively). …”
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Consumption of folic acid fortified foods among Hispanic women of reproductive age in the US: a systematic review by Nicole Villalba, Kayla Byrne, Sunny Abdelmageed, Megan Votoupal, Sandi K. Lam, Roxanna M. Garcia

“…Hispanic women consumed grains, cereals, bread, flour, pasta, and corn masa flour. Most Hispanic women obtained folic acid from ECGP only. …”
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Coaching: An Effective Approach to Facilitate Performance, Learning and Advancement of Medical Students by Fariba Asgari, Hojjat Houshyari khah, Marzieh Shayestehfard

“…While various models exist for implementing this approach, the GROW model is regarded as the most suitable for training students. Participation in this model typically begins before the introductory session, where the coach explains the concept of coaching, outlines expected outcomes and establishes clear, measurable goals. …”
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Preferences for HIV pre‐exposure prophylaxis among men who have sex with men and trans women in 15 countries and territories in Asia and Australia: a discrete choice experiment by Warittha Tieosapjaroen, Benjamin R. Bavinton, Heather‐Marie A. Schmidt, Curtis Chan, Kim E. Green, Nittaya Phanuphak, Midnight Poonkasetwattana, Nicky S. Suwandi, Doug Fraser, Hua Boonyapisomparn, Michael Cassell, Lei Zhang, Weiming Tang, Jason J. Ong

“…Novel innovations, such as STI and HIV self‐testing, should be explored as alternatives to conventional testing, given that most MSM and TGW prefer less frequent clinic visits and long‐acting PrEP options.…”
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Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19. by David M Lowe, Li-An K Brown, Kashfia Chowdhury, Stephanie Davey, Philip Yee, Felicia Ikeji, Amalia Ndoutoumou, Divya Shah, Alexander Lennon, Abhulya Rai, Akosua A Agyeman, Anna Checkley, Nicola Longley, Hakim-Moulay Dehbi, Nick Freemantle, Judith Breuer, Judith Breuer, Joseph F Standing, FLARE Investigators

“…The major limitation was that the study population was relatively young and healthy compared to those most affected by the COVID-19 pandemic.<h4>Conclusions</h4>At the current doses, no treatment significantly reduced viral load in the primary analysis. …”
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OncoE25: an AI model for predicting postoperative prognosis in early-onset stage I-III colon and rectal cancer—a population-based study using SEER with dual-center cohort validatio... by Luyun Yuan, Liyu Wang, Jiamin Gao, Xin Chen, Haoyue Wang, Wei Shan Tan, Kexiang Sun, Yabin Gong, Wanli Deng

“…Based on comprehensive evaluation across multiple datasets and metrics, the RSF model demonstrated the best and most stable performance, outperforming not only other machine learning models but also the traditional TNM staging system. …”
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Endoscopic management of large laterally spreading colorectal tumors (LSTs): a comparative study of techniques and outcomes by V. S. Tkachov, O. M. Kiosov, A. V. Klymenko

“…Endoscopic resection is the standard of care for non-invasive LSTs, with the choice of technique guided by lesion size, morphology, and recurrence risk. The most commonly employed methods include endoscopic mucosal resection (EMR), piecemeal EMR (pEMR), endoscopic submucosal dissection (ESD), and hybrid ESD. …”
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