The role of doctors in provision of support for primary health care clinics in KwaZulu-Natal, South Africa by Phumla H. Nkosi, Christiane M. Horwood, Kerry Vermaak, Catherine Cosser, J.L. Haskins

“…Background: Most primary health care (PHC) services in South Africa are provided by registered nurses working in clinics. …”
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Comparative study on fire flooding development characteristics of heterogeneous heavy oil reservoirs by TAO Lei, DING Yuchen, ZHANG Xia, XU Zhengxiao, HU Ziwei, SHI Wenyang, BAI Jiajia, ZHANG Na, ZHU Qingjie, JIANG Longyu, BAN Xiaochun

“…The oil saturation in the lower part of the two reservoirs is the lowest because of the most intense combustion.…”
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Direct-fed microbials optimize ruminal fermentation, microbial ecosystem and milk quality to enhance the lactation performance of Sanhe dairy cows by Aoyu Jiang, Zixin Liu, Ziyan Yang, Shizhe Zhang, Jian Wu, Chuanshe Zhou, Zhiliang Tan

“…Abstract The growing global population and rising living standards require a higher supply of dairy products. Dairy cows are the most important source of milk production, with billions of microorganisms present in the rumen. …”
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Synthesizing field plot and airborne remote sensing data to enhance national forest inventory mapping in the boreal forest of Interior Alaska by Pratima Khatri-Chhetri, Hans-Erik Andersen, Bruce Cook, Sean M. Hendryx, Liz van Wagtendonk, Van R. Kane

“…Among the various topographic factors, we found that elevation was the most important factor for discriminating all forest types. …”
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Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma by Lise Finotto, Basiel Cole, Wolfgang Giese, Elisabeth Baumann, Annelies Claeys, Maxime Vanmechelen, Brecht Decraene, Marleen Derweduwe, Nikolina Dubroja Lakic, Gautam Shankar, Madhu Nagathihalli Kantharaju, Jan Philipp Albrecht, Ilse Geudens, Fabio Stanchi, Keith L Ligon, Bram Boeckx, Diether Lambrechts, Kyle Harrington, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet, Holger Gerhardt

“…Abstract Glioblastoma (GBM) remains the most malignant primary brain tumor, with a median survival rarely exceeding 2 years. …”
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Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check by Mengyao Gong, Mengyao Gong, Junqi Luo, Junqi Luo, Qiankun Liang, Qiankun Liang, Yi Liu, Yi Liu, Yuejuan Zheng, Yuejuan Zheng, Xiao-Dong Yang, Xiao-Dong Yang

“…This termination can be facilitated through the ubiquitination and subsequent proteasomal degradation of chromatin-bound RelA, the most active subunit of NF-κB. Several multi-subunit cullin-RING E3 ubiquitin ligases, composed of elongin B/C, cullin2/5, and SOCS-box proteins, have been identified to target RelA for degradation. …”
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Implementation of a digital health tool for seizure video transfer in a pediatric epilepsy center: A prospective pilot study by Rahel M. Burger, Gadi Miron, Pascal Fenske, Cornelia Potratz, Angela M. Kaindl, Christian Meisel

“…Expert review classified 48.1 % of videos as likely epileptic events, with generalized tonic-clonic seizures being most common (24.7 %). Concordance between submitted videos and final clinical diagnosis was demonstrated in 68.8 % of cases, with higher concordance significantly related to the number of videos submitted (mean 6.4 vs. 2.2 videos per patient, p = 0.04). …”
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Phase IB study of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors by Howard Streicher, Elad Sharon, Mariano Severgnini, Michael Manos, Anita Giobbie-Hurder, F Stephen Hodi, Andrew S Brohl, Philippe L Bedard, Kevin Tyan, Scott Rodig, Osama E Rahma, Daniel J Renouf, Emma Hathaway, Rachel Cunningham

“…Grade ≥3 adverse events occurred in 19/33 patients (58%), the most common being hypertension (36%) and proteinuria (18%). …”
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Feeding behavior of Holstein and Jersey cows fed diets based on either alfalfa silage or corn silage at 2 forage fiber levels by O.I. Santana, M.E. Uddin, M.A. Wattiaux

“…In brief, we found interactions between source and level of FNDF in the diet, most notably a reduction in DMI and cow performance when the FNDF level was increased with AS, but not with CS. …”
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Analysing the role of ultraviolet A1 phototherapy in the treatment of primary cutaneous lichen amyloidosis in a patient with skin phototype 1 by Sam Hughes, Rossel Ahmad, Maryam Kakar, Novakovic Ljubomir, John Ferguson

“…A retrospective study by Guillet et al. analysing 37 White patients with cutaneous amyloidosis identified UVA1 phototherapy with topical corticosteroids as the most effective therapy.5 However, the study included no skin phototype 1 patients, and only one received UVA1 as monotherapy.This case also demonstrated three unique features. …”
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Analysis of ICU resistome dynamics in patients, staff and environment for the identification of predictive biomarkers of sepsis and early mortality by Maja Mikolas, Peter Fauszt, Annamaria Petrilla, Peter Nemeth, Peter David, Emese Szilagyi-Tolnai, Anna Szilagyi-Racz, Aniko Stagel, Ferenc Gal, Kristof Gal, Reka Sohajda, Zsombor Szoke, Syed Akib Hossain, Laszlo Stundl, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…Tetracycline resistance was the most prevalent, with common resistances comprising 36.1% of all detected AMR markers. …”
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Real-world progression-free survival of first line afatinib patients with EGFR-mutant advanced lung adenocarcinoma: A multicentre study in Indonesia by Noni Novisari Soeroso, Elisna Syahruddin, Chaliza Soliha, Laksmi Wulandari, Ana Rima Setijadi, Sabrina Ermayanti, Suryanti Dwi Pratiwi, Andreas Infianto, Novita Andayani, Sri Melati Munir, Avissena Dutha Pratama, Ida Ayu Jasminarti Dwi Kusumawardani, Haryati Haryati, Natalie Duyan, Muhammad Alfin Hanif, Darren Wan-Teck Lim

“…Exon 19 deletion was the most common mutation (57.1 %), followed by L858R (29.5 %). …”
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Agroecological Alternatives for Substitution of Glyphosate in Orange Plantations (<i>Citrus sinensis</i>) Using GIS and UAVs by María Guadalupe Galindo Mendoza, Abraham Cárdenas Tristán, Pedro Pérez Medina, Rita Schwentesius Rindermann, Tomás Rivas García, Carlos Contreras Servín, Oscar Reyes Cárdenas

“…Field mapping is one of the most important aspects of precision agriculture, and community drones will be able to empower young rural entrepreneurs who will be the generational replacement of a new agrosocial paradigm. …”
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Comparative analysis of the functional status of hip joints before total hip replacement in patients with ankylosing spondylitis, rheumatoid arthritis and coxarthrosis: preliminary... by A. O. Dubinin, A. E. Khramov, T. V. Dubinina, E. V. Ilinykh, E. I. Byalik

“…The mean total Harris scale score before surgical treatment in AS was significantly higher than in RA and lower than in OA: 38.0±15.4, 33.9±12.7, and 44.9±12.2, respectively. In most parameters of the Harris scale, patients with AS had similar indicators with RA patients. …”
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Streptococcal endocarditis: a meta-analysis of species dependant riskResearch in context by Gavin Deas, Todd C. Lee, Julia Colston, Mahableshwar Albur, Julia Vasant, Angela H. Nobbs, Philip Williams, Fergus Hamilton

“…Combined, these species accounted for only 8.4% of bacteraemias but 38.6% of IE. The most common IE pathogen overall was Streptococcus mitis/oralis (23.6% of IE, 8% of bacteraemias) but these infections themselves only carried an IE risk of 12% (95% CI 11–13%). …”
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Dynamic 3D-Network Coating Composite Enables Global Isolation of Phosphopeptides, Stepwise Separation of Mono- and Multi-Phosphopeptides, and Phosphoproteomics of Human Lung Cells by Linlin Liu, Zhenhua Chen, Danni Wang, Weida Liang, Binbin Wang, Chenglong Xia, Yinghua Yan, Chuanfan Ding, Xiaodan Meng, Hongze Liang

“…Protein phosphorylation is one of the most common and important post-translational modifications (PTMs) and is highly involved in various biological processes. …”
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Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients by Nga Thi Ngoc Pham, Lien Nguyen Thao Tran, Cang Huynh Trung, Hoang Minh Phan, Dung The Bui, Chau Minh Tran, Thuc Tri Nguyen, Phuong Minh Nguyen, An Viet Tran

“…Results: Among 150 patients (mean age 63.8 ± 10.3 years, 70.7 % male), genotype distribution showed TT as the most prevalent (55.3 %), TC (38.7 %), and CC (6.0 %). …”
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Key technology of pressure-relief gas extraction in low dynamic fracture zone of mining overburden in single ultra-thick coal seam by Longyong SHU, Yuanlong ZHANG, Xin SONG, Yongpeng FAN, Yang LI

“…Field engineering practice shows that, after optimizing and adjusting the directional long drilling arrangement parameters based on the scope of the low dynamic fissure zone, the average proportion of air-drained gas decreased by 4.4%, the average single-hole unloading gas extraction efficiency increased by 75.7%, and the gas concentration in the upper corner of the corner was 0.48% at the most, while the number of holes was reduced by 3, and the overall amount of drilling work was decreased by 28.7%. …”
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Antitumour activity of 1,1-bis-(pyrimidine-2,4-diono-1-il)-2-bromo-2-chloroethylenes substituted molecular complexes and bacterial lectin by E. V. Welchinska

“…The aim of research. One of the most successful directions of new antitumour preparations finding is the investigation of antimetabolites of pyrimidin’s and purin’s change which forwards as preformed compounds at the link of biosynthetic processes (DNA, RNA, specific proteins) and brakes tumour’s growth. …”
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Cardiopulmonary Complications During and After Endoscopy in Elderly Patients:a Prospective Study by Sabrina Munggarani Yusuf, Noto Dwimartutie, Noto Dwimartutie, Hasan Maulahela, Hasan Maulahela, Kuntjoro Harimurti, Kuntjoro Harimurti, Ikhwan Rinaldi, Ikhwan Rinaldi, Evy Yunihastuti, Evy Yunihastuti, Achmad Fauzy, Achmad Fauzy, Rudi Putranto, Rudi Putranto

“…Results: Among the 194 patients included, 49.52% experienced cardiopulmonary complications. The most common complications were tachycardia (23.20%), hypoxemia (15.03%), and hypotension (6.20%). …”
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