SLOWING THE GROWTH OF AN AGGRESSIVE GLIOBLASTOMA CELL LINE BY ENHANCER RNA SILENCING DEPENDS ON THE KNOCKDOWN METHOD by Ekaterina Statsevich, Anastasiia Simonova, Anastasiya Poteryakhina, Uliana Beri, Elvina Bogomolova, Aksinya Uvarova, Matvey Murashko, Elina Zheremyan, Kirill Korneev, Dmitry Kuprash, Denis Demin

“…AbstractGlioblastoma is the most frequent and aggressive brain tumor, with a low survival rate. …”
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Disagreement Persists on Optimal Rehabilitation Goals and Timelines for Weight-Bearing Restriction, Knee Brace Use, and Return to Sports After Posterolateral Corner Reconstruction by Ilan Y. Mitchnik, M.D., Tomer Mimouni, M.Sc., Loren S. Haichin, M.Sc., Suzana Bayyouk, B.P.T., Gilbert Moatshe, M.D., Dror Lindner, M.D., Jorge Chahla, M.D., Ph.D., Yiftah Beer, M.D., Ron Gilat, M.D.

“…However, there was no significant change in overall agreement rates (P = . 735). Most disagreements involved postoperative weight-bearing restrictions, with one half of protocols recommending non−weight-bearing and one half partial-weight-bearing; the period of time a knee brace is required after 6 weeks; and return to sports timing, which differed with concomitant ACL (later return) and PCL (earlier return) reconstructions. …”
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Techno-economic study and optimization of the performance of nanofiltration and reverse osmosis membranes in reducing the salinity of M′rirt water city (Morocco) by Noureddine Zouhri, Fatima Zahra Addar, Mustapha Tahaikt, Mahacine Elamrani, Azzedine ELmidaoui, Mohamed Taky

“…Notably, the NF90 membrane emerged as the most efficient in terms of flow rates, exhibiting a physicochemical quality to that achieved by the two RO membranes. …”
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Estresse em graduandos de enfermagem [Stress in undergraduate nursing students] [El estrés presente en medio a los estudiantes de enfermería] by Celia Caldeira Fonseca Kestenberg, Barbara Marins Santos Rosa, Alexandre Vicente da Silva, Janaina Mengal Gomes Fabri, Izabel Cristina Ribeiro Regazzi

“…Results: 79.5% of the students showed stress. The most evident physical symptoms were constant tiredness (77.3%) and feeling constant physically drained (76.8%); psychological symptoms were excessive fatigue (70.5%) and excessive irritability (58.4%). …”
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Clinical information prompt-driven retinal fundus image for brain health evaluation by Nuo Tong, Ying Hui, Shui-Ping Gou, Ling-Xi Chen, Xiang-Hong Wang, Shuo-Hua Chen, Jing Li, Xiao-Shuai Li, Yun-Tao Wu, Shou-Ling Wu, Zhen-Chang Wang, Jing Sun, Han Lv

“…The two- (2D) and three-dimensional (3D) visualization results showed that the shape and texture of the synthetic brain images generated by the proposed method most closely resembled those of actual brain images. …”
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Quality differences and profiling of volatile components between fermented and unfermented cocoa seeds (Theobroma cacao L.) of Criollo, Forastero and Trinitario in China by Dewei Yang, Baoduo Wu, Xiaowei Qin, Xiu Zhao, Zihui Zhu, Lin Yan, Fenju Zhang, Guoxing Wu, Fupeng Li

“…Trinitario contained the most volatile compounds with the highest levels of alcohol, while Criollo contained the highest ester content in unfermented beans. …”
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Long-term application of cattle manure alters functional N cycling genes and improves maize yield and nitrogen use efficiency by Yansheng Li, Muqing Liu, Zhenhua Yu, Changkai Liu, Xiaojing Hu, Junjie Liu, Jian Jin, Yuan Chen, Xingyi Zhang, Guanghua Wang, Xiaobing Liu

“…The insignificant differences between FM1 and FM2 in the relative abundance of most N genes in 2021 and 2023 helped to explain the similar crop outcomes between these two treatments. …”
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Predicting PD-L1 status in NSCLC patients using deep learning radiomics based on CT images by Jiameng Lu, Xinyi Liu, Xiaoqing Ji, Yunxiu Jiang, Anli Zuo, Zihan Guo, Shuran Yang, Haiying Peng, Fei Sun, Degan Lu

“…Seven algorithms were used to build models, and the most optimal ones were identified. A combined model integrating DLR with clinical data was also developed. …”
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Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19 by Ji-Soo Kwon, Euijin Chang, Hyeon Mu Jang, Ji Yeun Kim, Woori Kim, Ju Yeon Son, Junho Cha, Choi Young Jang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim

“…Results In total, 156 pairs of blood samples and symptom reports from 79 participants were eligible for analysis. The most frequent symptom was fatigue, followed by post exertional malaise, chronic cough, thirst, and brain fog. …”
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Global, regional, and national burdens of non-alcoholic fatty liver disease attributable to smoking from 1990 to 2021 by Pengyue Zhang, Jie Zhu, Xinlei Chen, Chunhui Tao, Jianmei Zhou, Zhenhua Zhang, Xiaodan Hong

“…Results: Globally, the ASMR of NAFLD attributable to smoking demonstrated a upward trend (AAPCASMR=0.27[95 % CI, 0.17–0.37], P < 0.001). The most substantial increases from 1990 to 2021 were observed in Australasia and Southern Latin America. …”
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Possibilities of non-operative and minimally invasive organ-preserving spleen injuries management in blunt abdominal injuries in adults by Y. V. Gavrishuk, V. A. Manukovskiy, A. N. Tulupov, A. E. Demko, E. A. Kolchanov, V. E. Savello, D. V. Kandyba, I. V. Kazhanov, S. A. Platonov, A. S. Kazankin

“…In the absence of CT signs of ongoing bleeding, non-operative management was performed, if ongoing bleeding signs were detected, angiography with selective angioembolization was performed.Results. In both groups, most of the victims with blunt spleen injury were admitted to the trauma center after traffic accidents and catatraumas. …”
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TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT by Alexandre de Nonneville, Sébastien Salas, François Bertucci, Alexander P Sobinoff, José Adélaïde, Arnaud Guille, Pascal Finetti, Jane R Noble, Dimitri Churikov, Max Chaffanet, Elise Lavit, Hilda A Pickett, Corinne Bouvier, Daniel Birnbaum, Roger R Reddel, Vincent Géli

“…In many ALT cancers, the α‐thalassemia/mental retardation syndrome X‐linked (ATRX) gene is mutated leading to the conclusion that the ATRX complex represses ALT. Here, we report that most high‐grade pediatric osteosarcomas maintain their telomeres by ALT, and that the majority of these ALT tumors are ATRX wild‐type (wt) and instead carry an amplified 17p11.2 chromosomal region containing TOP3A. …”
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Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…We suggest starting by developing understanding of the most important research questions by working with stakeholders, then working back to how we would achieve desirable project outcomes and who else is needed for this.…”
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Bibliometric analysis of liposarcomas treatment from 2004 to 2023 by Xiaopeng Wang, Jingjing Ye, Daoning Liu, Liang Yan, Shuquan Li, Ang Lv, Chengpeng Li, Jianhui Wu, Hui Qiu, Chunyi Hao

“…Results The number of publications on liposarcomas treatment has increased over the past two decades, from 39 in 2004 to 232 in 2023, with the United States of America contributing the most publications. Among the institutions, the Memorial Sloan Kettering Cancer Center had the highest volume of 87 publications. …”
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Spatial-temporal baseline study of nutrients and trace elements characterization of a large tropical transition system in West Africa by Celso Paulo, João A. Carreiras, Susanne Tanner, Carmen Van-Dúnem dos Santos, Vanessa F. Fonseca, Bernardo Duarte

“…The pressure gradient revealed PLO as the most polluted area and BO as a potential reference site for future impact assessment studies. …”
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Unlocking the Potential of <i>Gracilaria chilensis</i> Against Prostate Cancer by Verónica Torres-Estay, Lorena Azocar, Camila Schmidt, Macarena Aguilera-Olguín, Catalina Ramírez-Santelices, Emilia Flores-Faúndez, Paula Sotomayor, Nancy Solis, Daniel Cabrera, Loretto Contreras-Porcia, Francisca C. Bronfman, Alejandro S. Godoy

“…Prostate cancer (PCa) is the second leading cause of cancer-related death among men in most Western countries. Current therapies for PCa are limited, often ineffective, and associated with significant side effects. …”
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MC4R Single Nucleotide Polymorphisms Were Associated with Metabolically Healthy and Unhealthy Obesity in Chinese Northern Han Populations by Luying Gao, Linjie Wang, Hongbo Yang, Hui Pan, Fengying Gong, Huijuan Zhu

“…Among the six SNPs of the MC4R gene, rs2331841 (A/G) was the most significant and could account for 0.9% of obesity etiology. …”
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Impact of Tetrahydropyrido[2,1-b][1,3,5]thiadiazines on L-DOPA Effects in the Tail Suspension Test by E. Yu. Bibik, I. A. Nekrasa, A. V. Demenko, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko, A. S. Startseva

“…We selected compounds that demonstrated the most potent antidepressant effect in the Porsolt’s forced swim test. …”
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Root Transcriptome Analysis Identifies Salt-Tolerance Genes in Sweet Corn Chromosome Segment Substitution Lines (CSSLs) by Zili Zhang, Xuxuan Duan, Pengfei Liu, Qingchun Chen, Wei Sun, Xiaorong Wan, Yixiong Zheng, Jianting Lin, Feng Jiang, Faqiang Feng

“…Salt stress severely constrains global crop productivity. However, most sweet corn cultivars exhibit weak tolerance to salt stress. …”
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Enhancing skull base tumor management: the combination of 3D printing technology and endoscopic surgical techniques by Xiao Li, Peng Gao, Angsi Liu, Fuxing Zuo, Ke Hu, Yang Wang, Haiyan Li, Jianxin Kong, Xueji Li

“…These models served a critical role in preoperatively determining the most effective surgical approaches. Additionally, they were instrumental in facilitating endoscopic surgery simulations and enhancing anatomical education. …”
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