Multifunctional Indomethacin Conjugates for the Development of Nanosystems Targeting Cancer Treatment by Thiruchenthooran V, Świtalska M, Maciejewska G, Palko-Łabuz A, Bonilla-Vidal L, Wietrzyk J, Souto EB, Sánchez-López E, Gliszczyńska A

“…Based on biological studies and molecular calculations, heterosubstituted phosphatidylcholine containing IND and oleic acid (IND-OA-PC) in the sn-1 and sn-2 positions, respectively, was identified as the most potent molecule. Subsequently, IND-OA-PC was encapsulated in nanostructured lipid carriers (IND-OA-PC-NLC). …”
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miR-27a-5p, miR-21-5p, miR-1246 and miR-4508: a candidate microRNA signature in the protection and regulation of viral infection in mild COVID-19 by Malena Gajate-Arenas, Candela Sirvent-Blanco, Omar García-Pérez, Angélica Domínguez-de-Barros, José E. Piñero, Jacob Lorenzo-Morales, Elizabeth Córdoba-Lanús

“…The KEGG pathways and GO analysis revealed that the differentially expressed miRNAs were related to viral processes or immunological pathways: miR-27a-5p acts on the TGF-beta pathway; miR-21-5p targets SMAD7, which is associated with the inflammatory response in the lung; miR-1246 acts on p53 pathway; and miR-4508 acts on ICAM2. In conclusion, the most relevant miRNAs, miR-27a-5p and miR-21-5p, were differently expressed in mild forms of COVID-19. …”
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Feasibility and acceptability of community-based psychosocial interventions delivered by nonspecialists for perinatal common mental disorders: A systematic review using an implemen... by Prasansa Subba, Pragya Shrestha, Atif Rahman, Nagendra Luitel, Ahmed Waqas, Siham Sikander

“…Out of the eight constructs of Proctor’s framework, “feasibility,” “acceptability,” “appropriateness” and “fidelity” were the most evaluated outcomes. None of the studies reported “penetration” and very few reported “sustainability,” “adoption” or “cost.” …”
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Characterizing antimicrobial activity of environmental Streptomyces spp. and oral bacterial and fungal isolates from Canis familiaris and Felis catus by Audrey Cowen, Bonnie Yiu, Sara Fallah, Kirsten J. Meyer, Emily Puumala, Yunjin Lee, Haley L. Zubyk, Nicole Robbins, Justin R. Nodwell, Jessie MacAlpine, Leah E. Cowen

“…Three supernatants from bacterial isolates exhibited antifungal activity against the human fungal pathogen Candida albicans in the presence of subinhibitory concentrations of fluconazole, the most widely deployed antifungal. Additionally, two bacterial isolates displayed antibacterial activity against Escherichia coli alone and in combination with the antibacterial ampicillin. …”
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Sequence analysis of rDNA intergenic spacer region (IGS) as a tool for phylogenetic studies in Trichoderma spp. by Mercatelli Elisabetta, Pecchia Susanna, Ciliegi Sandro, Vannacci Giovanni

“…Different from ribosomal genes, which contain highly conserved sequences that are detected in all^- organisms, the intergenic spacer of rDNA (IGS) appears to be the most rapidly-evolving spacer region. For this reason we tested this region for phylogenetic studies.This report focuses on the study of IGS sequences of isolates belonging to Trichoderma section (T. viride, T. koningii, T. hamatum, T. erinaceus, T. asperellum) and Pachybasium section (T. harzianum, T. crassum, T. fasciculatum, T. oblongisporum, T. virens). …”
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Los camarones (Crustácea: Decapoda: Nanantia) asociados a praderas de Thalassia Testudinum Banks ex koning, en la región de Santa Marta, caribe colombiano Los camarones (Crustácea:... by Puentes G. Libia Georgina, Campos C. Néstor Hernando

“…Although the number of species collected is high, only 9 were considered permanent, 17 occasional and 9 sporadic. The most abundant species were Periclimenes americanus, Alpheus normanni, Latreutes fucorum, Sicyonia laevigata, Hippolyte curacaoensis, A viridari, L. parvulus, Metapenaeopsis goodei, Thor manningi and Processa fimbriata. …”
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Evaluating lung cancer screening disparities in an integrated healthcare system: barriers and opportunities by Carmen Javier, Sheng-Fang Jiang, Jenna Philippe, Isabel Arana, Jeffrey B. Velotta, Jeffrey B. Velotta

“…Age 61–70 years old, male sex, and non-Hispanic White race/ethnicity were the strongest and most statistically significant predictors of initial LDCT completion. …”
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Correlation between QRISK3, Coronary Calcium Score and Coronary Artery Disease Reporting and Data System in Patients Undergoing Evaluation for Coronary Artery Disease by Johann Christopher, Hemina Mary Jacob, Reefa Alina Dsouza

“…Finally, the CAD-RADS category was determined based on the most severe coronary finding in each patient, with scores ranging from 0 to 5. …”
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Mobile genetic elements mediating antimicrobial resistance drive the evolutionary process of Clostridioides difficile ST37/RT017 by Tao Lv, Xiajing Bi, Lisi Zheng, Yuhong Zhao, Yizheng Zhou, Tao Wu, Ping Shen, Danhua Zhu, Shiyao Chen, Yunbo Chen

“…Abstract Background Clostridioides difficile (C. difficile) ST37/RT017 is one of the most prevalent genotypes, exhibiting resistance to multiple antimicrobial agents and widespread dissemination, particularly in East Asia. …”
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Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. by Hana Saddiki, Aurore Fayosse, Emmanuel Cognat, Séverine Sabia, Sebastiaan Engelborghs, David Wallon, Panagiotis Alexopoulos, Kaj Blennow, Henrik Zetterberg, Lucilla Parnetti, Inga Zerr, Peter Hermann, Audrey Gabelle, Mercè Boada, Adelina Orellana, Itziar de Rojas, Matthieu Lilamand, Maria Bjerke, Christine Van Broeckhoven, Lucia Farotti, Nicola Salvadori, Janine Diehl-Schmid, Timo Grimmer, Claire Hourregue, Aline Dugravot, Gaël Nicolas, Jean-Louis Laplanche, Sylvain Lehmann, Elodie Bouaziz-Amar, Alzheimer’s Disease Neuroimaging Initiative, Jacques Hugon, Christophe Tzourio, Archana Singh-Manoux, Claire Paquet, Julien Dumurgier

“…<h4>Background</h4>The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most important known risk factors for developing Alzheimer disease (AD). …”
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COVID-19 vaccines side effects among the general population during the pandemic: a cross-sectional study by Samana Zaidi, Hafsa Abdul Qayyum, Izzah Abdul Qayyum, Zakir Khan, Taskeen Islam, Naveed Ahmed, Kathryn L. Hopkins, Theresa Sommers, Samar Akhtar, Shahzad Ali Khan, Sumbal Javed, Aamer Ikram, Hashaam Akhtar, Hashaam Akhtar

“…Different types of side effects were highlighted in the current study. The most frequently reported side effects after the first dose of COVID-19 were fever (n = 997), pain at the injection site (n = 994), muscle pain (n = 620), and fatigue (n = 482). …”
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John Dewey no Manifesto dos Pioneiros da Educação Nova by Marcus Vinicius da Cunha

“…John Dewey in the Manifest of the Pioneers of New Education Abstract Recognized as one of the most important documents in the history of Brazilian education, the Manifesto of the Pioneers of New Education, elaborated by Fernando de Azevedo in 1932, does not mention nominally the American philosopher and educator John Dewey. …”
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Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats by Evan Fuini, Arnold Chang, Richard J. Ortiz, Richard J. Ortiz, Taufiq Nasseef, Josh Edwards, Marc Latta, Elias Gonzalez, Taylor J. Woodward, Bryce Axe, Ashwath Maheswari, Noah Cavallaro, Heather B. Bradshaw, Praveen P. Kulkarni, Craig F. Ferris, Craig F. Ferris

“…Treatment with psilocybin resulted in a significant dose-dependent increase in positive BOLD signal. The areas most affected by the acute presentation of psilocybin were the somatosensory cortex, basal ganglia and thalamus. …”
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ATTITUDES OF FUTURE DENTISTS TOWARDS DIFFERENT TEACHING METHODS IN PAEDIATRIC THERAPEUTIC DENTISTRY by L.F. Kaskova, N.V. Yanko, I.Yu. Vashchenko, S.Ch. Novikova, O.Yu. Andriianova

“…Obtained results were processed with Excel. 75,7% males chose сase study method, 73,78% selected work in small groups, and 71,2% preferred PBL that was higher compared to females, but the difference was statistically significant only for сase study (р<0,01). 70,65% females prefer PP, 68,48% conventional lecture, 70,65% questioning, 55,43 % work at whole group and 51,09% role playing, but the difference was statistically significant only for PP (р<0,01). The most effective teaching methods were lecture (69,82%), case study (69,08%), usual questioning (70,07%), videomaterials (76,05%) and PBL (71,07%), however, the lowest estimation had role playing, on our opinion, due no familiarization with this method. …”
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Arrhythmia burden, symptoms and quality of life in female and male endurance athletes with paroxysmal atrial fibrillation: a multicentre cohort study in Norway, Australia and Belgi... by Adrian Elliott, Andre La Gerche, Bente Morseth, Maja-Lisa Løchen, Arnljot Tveit, Marius Myrstad, Jon Magne Letnes, Guido Claessen, Rik Willems, Bjarne Martens Nes, Turid Apelland, Amy Mitchell, Kristel Janssens, Hielko Miljoen, Kristoffer Robin Johansen, Eivind Sørensen, Jan Pål Loennechen, Kristine Folkenborg, Kristin Espolin Johnson, Vegard Malmo, Andreas Berg Sellevold, Rune Byrkjeland, Steve Enger, Sophia Onarheim, Ingrid Haagenrud Langmo, Fedelix Pethogo Brown, Lena Marie Kristiansen, Sevda Ece Kizilkilic, Vigdis Bache Semb

“…There were large individual variations between the athletes concerning AF burden, symptoms and QoL.Conclusions Although most athletes were still competing, more than half had troublesome symptoms. …”
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Abstract 009: 1‐Year Outcomes of Resolute Onyx Zotarolimus‐Eluting Stent for Intracranial Atherosclerotic Disease: Multicenter Comparison with SAMMPRIS by Saisree, Farhan, Ravi S, Syed Khalid, Inamullah Khan, Wondwossen G Tekle, Omar Tanweer, Jan‐Karl Burkhardt, Pascal M Jabbour, Stavropoula Tjoumakaris, Nabeel A Herial, Adnan H Siddiqui, Ramesh Grandhi, Adnan I Qureshi, Ameer E Hassan

“…Introduction Intracranial atherosclerotic disease (ICAD) is one of the most prevalent causes of stroke across the world, with a high morbidity and mortality rate. …”
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Late Quaternary fluvial terrace formation in the Luan River drainage basin, north China and its possible linkages with climate change and tectonic activation by Yu-chen Tian, Xu-jiao Zhang, Zhi-qiang Yin, Hai Shao, Ming-xu Gu, Yingying -Ding, Chao Peng, Xiang-ge Zhang

“…ABSTRACT: The Luan River is the most important water system in north-eastern Hebei Province, China and is located in the transitional zone of the Eastern Yan Mountains, North China Plain and Songliao Plain. …”
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POSITION OF THE THIRD MOLARS AND THEIR GERMS FOR DATA ORTOPANTOMOGRAM IN PATIENTS WITH DISTAL OCCLUSION by V. D. Kuroedova, Y. Y. Vyzhenko

“…That is, the average amount of Moesia-distal lower third molars 13.4 mm, pear-shaped average distance equal to 9.85 mm. Conclusions. Thus, most patients with distal occlusion in a period of permanent teeth available third molars (or germs) on both jaws - at 81.08%. …”
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The magnitude of second-trimester induced abortion and associated factors in Ethiopia: a systematic review and meta-analysis by Maru Mekie, Setegn Muche Fenta, Wassie Yazie Ferede, Enyew Dagnew Yehuala, Eyaya Habtie Dagnaw, Alemu Degu Ayele, Temesgen Dessie Mengistu, Belaynew Alemye Mengistie, Selamawit Girma Tadesse, Dagne Addisu

“…BackgroundEven though Ethiopia has a non-restrictive abortion law, abortion complications are one of the top five maternal morbidity and mortality causes in the country. Most women visit health facilities for pregnancy termination at second-trimester which leads to higher abortion-related complications than first-trimester abortion. …”
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Study of the General Toxic Properties of the Vaccine CoviVac in Immature Rats by A. A. Siniugina, A. A. Saprykina, N. A. Lycheva, K. L. Kryshen, A. S. Lunin, V. D. Apolohov, A. D Chernavtseva, A. A. Kovpak, Y. Y. Ivin, A. N. Piniaeva, M. N. Makarova, V. G. Makаrov, A. A. AA Ishmukhametov

“…At the same time, vaccination remains the most effective way to protect against infection. …”
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