Variants in CFAP410 cause a range of retinal and skeletal phenotypes by Ryan E. Schmidt, Amy E. Pohodich, David Birch, Kaylie Jones, Byron L. Lam, Emily H. Jung, Nieraj Jain, Michalis Georgiou, Omar A. Mahroo, Andrew R. Webster, Michel Michaelides, Benjamin Bakall, Alessandro Iannaccone, Ajoy Vincent, Deepika C. Parameswarappa, Elise Heon, Hendrik P. N. Scholl, Lucas Janeschitz-Kriegl, Elias I. Traboulsi, Wadih Zein, Brian P. Brooks, Catherine Cukras, Robert Hufnagel, Tomas S. Aleman, Mohamed M. Sylla, Stephen H. Tsang, Michelle Alabek, Jose Sahel, Michael B. Gorin, Maria M. van Genderen, Katarina Stingl, Milda Reith, Susanne Kohl, Rebeca Azevedo Souza Amaral, Juliana Maria Ferraz Sallum, Andrea L. Vincent, Sarah Hull, Jacque L. Duncan, James V. M. Hanson, Matthias Tedeus, Jordi Maggi, Urs Graf, Samuel Koller, Wolfgang Berger, Christina Gerth-Kahlert, Molly Marra, Lesley A. Everett, Paul Yang, Mark E. Pennesi

“…A minority of patients (22.4%) presented with skeletal abnormalities consistent with axial spondylometaphyseal dysplasia (SMDAX). Patients with the most severe ophthalmic and skeletal phenotypes had disease-associated variants within conserved leucine-rich regions of CFAP410, and the structural effects of these variants were modelled using ChimeraX. …”
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Mutation T9I in Envelope confers autophagy resistance to SARS-CoV-2 Omicron by Susanne Klute, Rayhane Nchioua, Arne Cordsmeier, Jyoti Vishwakarma, Lennart Koepke, Hala Alshammary, Christoph Jung, Maximilian Hirschenberger, Helene Hoenigsperger, Jana-Romana Fischer, Rinu Sivarajan, Fabian Zech, Steffen Stenger, Ruth Serra-Moreno, Ana Silvia Gonzalez-Reiche, Emilia Mia Sordillo, Harm van Bakel, Viviana Simon, Frank Kirchhoff, Timo Jacob, Dorota Kmiec, Andreas Pichlmair, Armin Ensser, Konstantin Maria Johannes Sparrer

“…Summary: Omicron has emerged as the most successful variant of SARS-CoV-2. In addition to mutations in Spike that mediate humoral immune escape, the Omicron-specific Envelope (E) T9I mutation has been associated with increased transmission fitness. …”
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Prevalence and outcomes of a pilot definition of severe refractory systemic lupus erythematosus: observations from a multinational Asia-Pacific cohort by Rangi Kandane-Rathnayake, Worawit Louthrenoo, CS Lau, Laniyati Hamijoyo, Jiacai Cho, Aisha Lateef, Shue Fen Luo, Yeong-Jian Wu, Sandra Navarra, Leonid Zamora, Zhanguo Li, Yi-Hsing Chen, Shereen Oon, Madelynn Chan, Sargunan Sockalingam, Yanjie Hao, Zhuoli Zhang, Sang-Cheol Bae, Jun Kikuchi, Tsutomu Takeuchi, Yasuhiro Katsumata, BMDB Basnayake, Fiona Goldblatt, Sean O’Neill, Kristine Pek Ling Ng, Nicola Tugnet, Mark Sapsford, Yih Jia Poh, Cherica Tee, Michael Tee, Naoaki Ohkubo, Adrienne O’Donnell Lefeber, Tamas Shisha, Yoshiya Tanaka, Vera Golder, Mandana Nikpour, Alberta Hoi, Peter Gergely, Eric Morand

“…The median [IQR] SLEDAI-2K at the srSLE index visit was 12 [10, 14], which decreased to 6 [4, 10] at 6m and 12m. Most patients remained on combination anti-malarial, GC, and IS at all follow-up time points. …”
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Study of the Structure and Mechanical Properties of Ti-38Zr-11Nb Alloy by Konstantin V. Sergienko, Sergei V. Konushkin, Yaroslava A. Morozova, Mikhail A. Kaplan, Artem D. Gorbenko, Boris A. Rumyantsev, Mikhail E. Prutskov, Evgeny E. Baranov, Elena O. Nasakina, Tatiana M. Sevostyanova, Sofia A. Mikhlik, Andrey P. Chizhikov, Lyudmila A. Shatova, Aleksandr V. Simakin, Ilya V. Baimler, Maria A. Sudarchikova, Mikhail L. Kheifetz, Alexey G. Kolmakov, Mikhail A. Sevostyanov

“…Hip joint implants are among the most prevalent types of medical implants utilized for the replacement of damaged joints. …”
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PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer by Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang

“…Abstract Small cell lung cancer (SCLC) is the most aggressive and lethal subtype of lung cancer. …”
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Multi-laboratory comparisons of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices by Claudia Alvarez Baron, Jun Zhao, Huimei Yu, Ming Ren, Nicolas Thiebaud, Donglin Guo, Giri Vegesna, Cheng-Hui Hsiao, Ryan DePalma, Sabyasachy Mistry, Isra Tariq, Md Shadiqur Rashid Roni, Omnia A. Ismaiel, Murali K. Matta, Vikram Patel, Manni Mashaee, Jose Vicente, Lars Johannesen, Jiansong Sheng, Simon Hebeisen, James Kramer, Andrew Bruening-Wright, Koji Nakano, Hiroshi Matsukawa, Jennifer Beck Pierson, Wendy W. Wu

“…Abstract Acute block of hERG channels is the most common mechanism underlying drug-induced QTC prolongation and potentially fatal Torsade de Pointes arrhythmia. …”
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Prevalência das características definidoras da proposição diagnóstica de enfermagem de sede perioperatória [Prevalence of defining characteristics of the proposed nursing diagnosis... by Luisa Arietti Andriotti, Ligia Fahl Fonseca, Leonel Alves do Nascimento, Maria Eduarda Sodre Franco, Hosana Cristina Ferreira Ramos

“…Results: mean fasting time was 13 hours (±5:11). 69.3% of the patients presented thirst preoperatively and 81.3%, in the postoperative period; mean intensity was 4.62 (±3.6) and 5.67 (±3.53). The most frequently reported defining characteristic in both periods was dry mouth (75.3%- 86.7%), followed by dry lips (71.3%-82.7%); desire to drink water (64%-72.7%); constant swallowing of saliva (62.7%-70%); dry throat (58%-72%); thick saliva (48.7%-53.4%); thick tongue (46%-54.7%); bad taste in the mouth (41%-46%); caregiver’s report (0.7%-0%). …”
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Immunological properties of a chimeric protein containing the major capsid protein of echovirus 30 (Picornaviridae: <i>Enterovirus: Enterovirus betacoxsackie</i>) by Dmitry A. Melentev, Dmitry V. Novikov, Ekaterina V. Mokhonova, Nadezhda A. Novikova, Alexander Yu. Kashnikov, Svetlana G. Selivanova, Lyudmila N. Golitsyna, Vladislav A. Lapin, Maria I. Tsyganova, Dmitry E. Zaitsev, Viktor V. Novikov

“…Enterovirus infection, widespread in the world and in Russia, is characterized by a variety of clinical forms, one of which is serous meningitis. The most common cause of enterovirus meningitis in children is echovirus 30 (E30). …”
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Music therapy embedded in the life of dementia inpatient care to help prevent and manage distress: a feasibility study to inform a future trial by Naomi Thompson, Naomi Thompson, Helen Odell-Miller, Helen Odell-Miller, Chris Pointon, Chris Pointon, Benjamin R. Underwood, Benjamin R. Underwood, Benjamin R. Underwood, Emma Wolverson, Emma Wolverson, Emma Wolverson, Rachel Hunt, Rachel Hunt, Joanne Inglis, Joanne Inglis, Abdulwarrith Olawale, Lucy Pickering, Lucy Pickering, Alison Wilkinson, Alison Wilkinson, Christine Wise, Christine Wise, Cansu Buyukulas, Robert Dudas, Robert Dudas, Jufen Zhang, Ming-Hung Hsu, Ming-Hung Hsu

“…Interventionist diaries and qualitative data supported intervention refinement.ConclusionIn a highly complex setting caring for some of the most vulnerable patients in the NHS it was possible to co-design and deliver a novel music therapy intervention. …”
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Different responses involving Tfh cells delay parasite-specific antibody production in Trypanosoma cruzi acute experimental models by Ana Carolina Leão, Ana Carolina Leão, Maria Jose Villar, Maria Jose Villar, Rakesh Adhikari, Rakesh Adhikari, Cristina Poveda, Cristina Poveda, Cristina Poveda, Leroy Versteeg, Leroy Versteeg, Leroy Versteeg, Gregório Almeida, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, Maria Elena Bottazzi, Maria Elena Bottazzi, Maria Elena Bottazzi, Maria Elena Bottazzi, Kathryn M. Jones, Kathryn M. Jones, Kathryn M. Jones

“…Despite treatment options in the acute phase, most infections progress to a chronic indeterminate form or develop severe cardiac/gastrointestinal complications. …”
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Seismic Response Analysis Method of Damping Structures Based on the Inter-history Iteration and Secondary Development of ABAQUS by JIA Chuanguo, QUAN Ziyu, CHEN Xi, LI Yutao

“…Although direct integration methods provide precise results, their extensive computational cost and susceptibility to numerical instability stemming from the integration step hinder their practical use in most engineering applications. The equivalent linearization method provides a more tractable alternative by linearizing the system and incorporating stiffness and damping proportional to the response level. …”
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China Protocol for early screening, precise diagnosis, and individualized treatment of lung cancer by Chengdi Wang, Bojiang Chen, Shufan Liang, Jun Shao, Jingwei Li, Liuqing Yang, Pengwei Ren, Zhoufeng Wang, Wenxin Luo, Li Zhang, Dan Liu, Weimin Li

“…Abstract Early screening, diagnosis, and treatment of lung cancer are pivotal in clinical practice since the tumor stage remains the most dominant factor that affects patient survival. …”
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Diagnostic Value of the Laboratory Markers of Acute Cytomegalovirus Infection in Patients With Systemic Lupus Erythematosus by Abrahamovych U., Abrahamovych O., Guta S., Thyhanyk L., Romaniuk O.

“…Systemic lupus erythematosus (SLE) is one of the major medical and social problems, as it is most commonly seen in young people, accompanied by a variety of multiple organ lesions and clinical manifestations that often lead to disability and threaten life. …”
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Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response by Xuefeng Niu, Qihong Yan, Zhipeng Yao, Fan Zhang, Linbing Qu, Chunlin Wang, Chengrui Wang, Hui Lei, Chaoming Chen, Renshan Liang, Jia Luo, Qian Wang, Lingzhai Zhao, Yudi Zhang, Kun Luo, Longyu Wang, Hongkai Wu, Tingting Liu, Pingchao Li, Zhiqiang Zheng, Yee Joo Tan, Liqiang Feng, Zhenhai Zhang, Jian Han, Fuchun Zhang, Ling Chen

“…Certain VH genes such as VH5-10-1 and VH4-39 appeared to be preferentially enlisted for a rapid antibody response to ZIKV infection. Most of these antibodies require relatively few somatic hypermutations to acquire the ability to bind to the E protein, pointing to a possible mechanism for rapid defence against ZIKV infection. …”
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Impacts of reproductive systems on grapevine genome and breeding by Hua Xiao, Yue Wang, Wenwen Liu, Xiaoya Shi, Siyang Huang, Shuo Cao, Qiming Long, Xu Wang, Zhongjie Liu, Xiaodong Xu, Yanling Peng, Pengfei Wang, Zhonghao Jiang, Summaira Riaz, Andrew M. Walker, Brandon S. Gaut, Sanwen Huang, Yongfeng Zhou

“…Crossing and cloning conceal while selfing purges most deleterious and structural burdens. Moreover, the close leakage of large-effect deleterious and structural variations in repulsion phases maintains heterozygous genomic regions in 4.3% of the grapevine genome after successive selfing for nine generations. …”
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Russian Cross-disciplinary Consensus on the diagnosis and treatment of spondyloarthritis associated with inflammatory bowel diseases by Galina V. Lukina, Oleg V. Knyazev, Elena A. Belousova, Diana I. Abdulganieva, Elena N. Aleksandrova, Igor G. Bakulin, Olga I. Barysheva, Maria А. Borisova, Bella А. Vykova, Alla А. Godzenko, Irina V. Gubonina, Tatiana V. Dubinina, Tatiana N. Zhigalova, Evgeny V. Zhilyaev, Anna V. Kagramanova, Tatiana V. Korotaeva, Alexander V. Kuzin, Maria A. Livzan, Aleksander M. Lila, Vadim I. Mazurov, Evgeny L. Nasonov, Alexander A. Novikov, Marina F. Osipenko, Asfold I. Parfenov, Larisa V. Tarasova, Olga V. Khlynova, Marina V. Shapina, Oksana B. Shchukina, Shandor F. Erdes, Aleksei A. Iakovlev

“…Its purpose was to consolidate the opinions of experts on the most actual issues of diagnosis and treatment of concomitant immuno-inflammatory diseases (SpA and IBD). …”
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China's annual forest age dataset at a 30&thinsp;m spatial resolution from 1986 to 2022 by R. Shang, R. Shang, X. Lin, J. M. Chen, J. M. Chen, Y. Liang, K. Fang, M. Xu, Y. Yan, W. Ju, G. Yu, N. He, L. Xu, L. Liu, J. Li, W. Li, J. Zhai, Z. Hu

“…Remote sensing provides crucial data for large-scale forest age mapping, but existing products often suffer from a low spatial resolution (typically 1000 m), making them unsuitable for most forest stands in China, which are generally smaller than this threshold. …”
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Species Composition, Phenotypic and Genotypic Resistance Levels in Major Malaria Vectors in Teso North and Teso South Subcounties in Busia County, Western Kenya by Edward K. Githinji, Lucy W. Irungu, Paul N. Ndegwa, Maxwell G. Machani, Richard O. Amito, Brigid J. Kemei, Paul N. Murima, Geoffrey M. Ombui, Antony K. Wanjoya, Charles M. Mbogo, Evan M. Mathenge

“…Mosquito samples collected in 2013 had the highest S allelic frequency of 0.87. Discussion. Most likely, the higher the selection pressure exerted indoors by insecticidal nets, the higher were the resistance alleles. …”
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Prevalence, Awareness, Treatment, Control, and Related Factors of Hypertension among Tajik Nomads Living in Pamirs at High Altitude by Lin Wang, Nanfang Li, Mulalibieke Heizhati, Suofeiya Abulikemu, Delian Zhang, Qin Luo, Ling Zhou, Jing Hong, Junli Hu, Li Cai, Xin Zhao, Le Sun, Liang Shao

“…Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers were the most commonly used antihypertensive medication (45.4%) as monotherapy, and 13.6% of treated hypertensive patients used two drugs. …”
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Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future by Johan Noble, Johan Noble, Juliette Leon, Arnaud Del Bello, Dany Anglicheau, Gilles Blancho, Gilles Blancho, Simon Ville, Simon Ville, Lionel Couzi, Lionel Couzi, Philippe Grimbert, Philippe Grimbert, Yannick Le Meur, Bruno Moulin, Nassim Kamar, Lionel Rostaing, Florence Herr, Antoine Durrbach, Dominique Bertrand

“…However, their use is associated with adverse effects, most notably chronic nephrotoxicity, which remains a leading cause of long-term allograft dysfunction. …”
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