Gender differences in clinical and prescribing characteristics of biologic and targeted synthetic drugs in naïve patients with rheumatoid arthritis: Data from BIOBADASER III regist... by Paloma Vela-Casasempere, Lucía Otero-Varela, Silvia Gómez Sabater, Rocío Caño Alameda, Cristina Campos Fernández, Jerusalén Calvo-Gutiérrez, Yanira Pérez-Vera, Sara Manrique Arija, Sagrario Bustabad, Javier Manero Ruiz, María Dolores Ruiz Montesino, Lucía Ruíz Gutiérrez, Antonio Mera Varela, Manuel José Moreno Ramos, Fernando Sánchez-Alonso, Isabel Castrejón

“…Disease duration differed between sexes only in the most recent cohort (≥ 2017, HR 0.9 (95% CI 0.81; 0.99), p = 0.026): female sex, age, and treatment with csDMARDs (other than methotrexate) were associated with later prescribing, whereas tobacco, obesity and treatment with methotrexate or glucocorticoids with earlier. …”
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Individual stress reactivity predicts alcohol craving and alcohol consumption in alcohol use disorder in experimental and real-life settings by Judith Zaiser, Sabine Hoffmann, Sina Zimmermann, Tatjana Gessner, Milena Deck, Nina Kim Bekier, Martin Abel, Philipp Radler, Jens Langejürgen, Bernd Lenz, Sabine Vollstädt-Klein, Jan Stallkamp, Clemens Kirschbaum, Falk Kiefer, Patrick Bach

“…Subjective stress reactivity was the most influential predictor of craving during the experiment (F(1,92) = 9.43, p = 0.003) and during the ambulatory phase (β = 0.16, p = 0.039) while cortisol levels predicted alcohol consumption in real-life settings (β = 9.76, p = 0.043). …”
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Clinical significance of the phenotype of immune cells of the tumor stroma of prostate cancer by P. A. Podlesnaya, O. V. Kovaleva, M. A. Rashidova, D. V. Samoilova, A. A. Petrenko, V. V. Mochalnikova, A. N. Gratchev

“…Prostate cancer is by far the most frequently diagnosed cancer among the male population and ranks fifth in the world in terms of mortality rates among malignant neoplasms. …”
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Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome by Fang Yu, Yan Meng, Xiaoyue Wang, Jia Chen, Junling He, Xiangling Yi, Yani He, Kehong Chen

“…Notably, the rate-limiting enzyme citrate synthase (CS) exhibits significantly elevated lactylation levels post-AKI induction, and K370 was the most significant lysine residue. In vitro, the modified/lactylated K370T group significantly decreases CS activity and mitochondrial function and activates the NLRP3 inflammasomes. …”
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Prevalence and risk factors of high-risk HPV and cervical abnormalities in HIV-positive women in Bali, Indonesia by I Ketut Agus Somia, Made Lady Adelaida Purwanta, Ni Wayan Winarti, Ida Bagus Nyoman Putra Dwija, Desak Made Putri Pidari, Anak Agung Sagung Sawitri, Anak Agung Ayu Yuli Gayatri, I Nyoman Gede Budiana, Komang Januartha Putra Pinatih, Ketut Tuti Parwati Merati

“…Furthermore, 58 participants (24%) were tested positive for HPV DNA, with HPV type 18 being the most prevalent (28% in all HPV-positive samples). …”
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Ants from the tropical dry forest in the Cauca River geographic valley, Colombia: new records and expansion of distributions by Maria Alejandra Bautista-Giraldo, Emira I. García, Inge Armbrecht, Roberto Guerrero

“…Tropical dry forests (TDF) are amongst the most important tropical biomes globally, recognised for their remarkable biodiversity. …”
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Assessing Long-Term Pain Reduction with Secukinumab in Moderate to Severe Hidradenitis Suppurativa: A Post Hoc Analysis of the SUNSHINE and SUNRISE Phase 3 Trials by John R. Ingram, Jacek C. Szepietowski, Lukasz Matusiak, Georgios Kokolakis, Magdalena B. Wozniak, Christine-Elke Ortmann, Angela Llobet Martinez, Shoba Ravichandran, Nicolas Thomas, Ivette Alarcon, Christelle C. Pieterse, Maryam Shayesteh Alam, Dimitrios Ioannides, Alexa B. Kimball

“…Disease-related pain is frequently reported as the most troublesome symptom of HS. The SUNSHINE and SUNRISE phase 3 trials previously reported that secukinumab improved control of pain in patients with moderate to severe HS. …”
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Estimating CO2 emissions from international medical electives: a literature review and quantitative analysis by Luke Coakham, Nihal Sogandji, Amy Stuart, Magnus Macleod, Faris Khan, Amina Ali, Christine Agbenu, Yuhui Zhou, Martin Tam, Edward Lau, Arthur Hibble, James N Smith, Anmol Arora, Charlotte Tulinius

“…Our estimates of the CO2 emissions from round-trip flights from Heathrow Airport, London, UK to the 10 most popular elective destinations were: Australia: 2,995 kg/person, USA: 1,039 kg/person, New Zealand: 3,316 kg/person, Canada: 941 kg/person, India: 1,185 kg/person, South Africa: 1,705 kg/person, Malaysia: 1,867 kg/person, Tanzania: 1,322 kg/person, Ireland: 79 kg/person. …”
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Safety and Tolerability of Implanted Subcutaneous Cardioverter-Defibrillator Systems by A. V. Vereshchagina, T. M. Uskach, O. V. Sapelnikov, V. A. Amanatova, I. R. Grishin, A. A. Kulikov, V. S. Kostin, R. S. Akchurin

“…According to the of 24-hour Holter ECG monitoring, episodes of unstable VT were recorded in 42.4% of patients. The most common indications for S-ICD implantation were dilated (33%) and ischemic cardiomyopathy (42%). …”
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Defect‐Rich High‐Entropy Spinel Oxide as an Efficient and Robust Oxygen Evolution Catalyst for Seawater Electrolysis by Jiayao Fan, Xing Xiang, Ying Liu, Xu Yang, Naien Shi, Dongdong Xu, Chongyang Zhou, Min Han, Jianchun Bao, Wei Huang

“…Due to the presence of abundant defects, unique “cocktail” effect, and efficient electronic structure regulation, such (NiCoMnCrFe)3O4 can deliver 500 mA cm−2 current density at the overpotentials of 268/384 mV in alkaline freshwater/seawater, outperforming its counterparts, commercial IrO2, and most reported OER catalysts. Moreover, it manifests exceptional OER durability and anticorrosion capability. …”
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A cell-free SHED lysate-hydrogel system for oral ulcer healing with anti-inflammatory and pro-angiogenic effects by Na Dong, Chen Zhang, Qiao Zhang, Sa Bao, Yunfan Hu, Haichao Xu, Peng Dai, Caiyan Li, Shengcun Li, Ping Wu, Junpeng Xu, Xiaojun Cai, Zhouguang Wang, Lihua Luo

“…Abstract Oral ulcer (OU) is one of the most common mucosal diseases, yet current drug treatments yield unsatisfactory outcomes. …”
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Multiomics Assessment of the Gut Microbiome in Rare Hyperoxaluric Conditions by Nadim Zaidan, Chan Wang, Ze Chen, John C. Lieske, Dawn Milliner, Barbara Seide, Melody Ho, Huilin Li, Kelly V. Ruggles, Frank Modersitzki, David S. Goldfarb, Martin Blaser, Lama Nazzal

“…MTT-based network analysis identified the most interactive bacterial network in patients with PH. …”
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Artesunate induces ferroptosis in diffuse large B-cell lymphoma cells by targeting PRDX1 and PRDX2 by Xiaohui Liu, Liyi Zeng, Jing Liu, Yulun Huang, Hua Yao, Jinman Zhong, Jiewen Tan, Xuenjuan Gao, Dan Xiong, Langxia Liu

“…Abstract Diffuse large B-cell lymphoma (DLBCL), the most prevalent non-Hodgkin lymphoma (NHL), is characterized by rapid growth and an unfavorable prognosis. …”
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Project HERO: a randomized trial of Tai Chi qigong versus intensity-matched exercise and usual care for fatigue in older male cancer survivors by Anita Y. Kinney, Jinghua An, Yong Lin, Samuel Tundealao, Biren Saraiya, Shou-En Lu, Dolores D. Guest, Elizabeth M. Harding, Fabiano Amorim, Emily Heidt, Evelyn Arana-Chicas, Chunxia Chen, Tawny Boyce, Isaac Y. Kim, Wadih Arap, Cindy K. Blair, Michael R. Irwin

“…Abstract Background Fatigue is often one of the most commonly reported symptoms in older male cancer survivors, but it is also one of the least understood cancer-related symptoms. …”
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Efficacy of meglumine antimoniate treatment on boxer Leishmania infantum skin lesions: case report by Cristina Carresi, Clara Francesca Ferrucci, Cyndi Mangano, Anna Rita Coppoletta, Antonio Cardamone, Vincenzo Musolino, Micaela Gliozzi, Vincenzo Mollace, Domenico Britti

“…In southern Europe, the main etiological agent is Leishmania infantum, transmitted by sandflies of the subfamily Phlebotominae, which is the most common cause of cutaneous leishmaniasis (CL) in these regions, where dogs are considered the primary domestic reservoir of the parasite. …”
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Virtual Reality as a Pedagogical Tool: Motivation and Perception in Teacher Training for Social Sciences and History in Primary Education by Rafael Villena-Taranilla, Pascual D. Diago, Juan Carlos Colomer Rubio

“…On a Likert scale (1–5), the results showed a high overall motivation level (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>M</mi><mo>=</mo><mn>4.56</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><mi>D</mi><mo>=</mo><mn>0.26</mn></mrow></semantics></math></inline-formula>), with satisfaction (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>M</mi><mo>=</mo><mn>4.92</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><mi>D</mi><mo>=</mo><mn>0.20</mn></mrow></semantics></math></inline-formula>) being the most prominent factor. Relevance, however, received a lower score (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>M</mi><mo>=</mo><mn>4.36</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><mi>D</mi><mo>=</mo><mn>0.44</mn></mrow></semantics></math></inline-formula>), suggesting difficulty connecting immersive content with prior knowledge. …”
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Evidence for Whom? A Systematic Review of Eligibility Criteria in RCTs of Anti-VEGF for Neovascular Age-Related Macular Degeneration by Andreas Arnold-Vangsted, Emil Alexander Rosenørn, Emilie Theresa Sørrig Butler, Rodrigo Anguita, Rita Serrano Anjos, Lasse Jørgensen Cehofski, Vibeke Christensen, Lorenzo Ferro Desideri, Jakob Grauslund, Javad Nouri Hajari, Musa Yasin Kaya, Oliver Niels Klefter, Celine Lee, Line Petersen, Miklos Schneider, Yousif Subhi

“…We identified a range of eligibility criteria on areas of visual function (minimum 18–50 ETDRS letters; maximum 69–78 ETDRS letters), disease definition and stage (FA only vs. multimodal approach), ocular and systemic comorbidities (most frequent exclusion criteria across studies were any history of the following: intraocular surgery, diabetic retinopathy, panretinal photocoagulation, glaucoma, and myopia), demographics, as well as a miscellaneous category with other topics. …”
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Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study. by Alyaa M Ajabnoor, Salwa S Zghebi, Rosa Parisi, Darren M Ashcroft, Martin K Rutter, Tim Doran, Matthew J Carr, Mamas A Mamas, Evangelos Kontopantelis

“…Patients living in the most deprived areas were less likely to receive OAC 0.85 (0.79; 0.91) than patients living in the least deprived areas. …”
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Micronodular thymoma with lymphoid stroma: a clinicopathologic analysis of five cases and literature review by CHE Guanhua, ZENG Chang, CHEN Xiaoyan

“…No significant gender preference was observed. Most cases were incidentally detected during physical examinations. …”
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Knowledge, attitude and practices regarding Hepatitis B vaccination among students of a government medical college in Mumbai by Subhana Siyad, Kamran Qureshi, Deepika Bishnoi, Smita Chavhan, Akanksha Singh

“…Conclusion The study assessed Knowledge, Attitude and Practices regarding Hepatitis B among medical and nursing students in a government medical college in Mumbai, revealing that most were unaware of their vaccination status or had not been vaccinated, mainly due to a lack of programs offered. …”
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