Cognitive and emotional disturbances in adult patients with myotonic dystrophy type 1 by E. K. Erokhina, K. V. Shamtieva, E. A. Melnik, D. O. Kazakov, S. A. Kurbatov, E. P. Pavlikova, O. A. Tikhonova, E. A. Mershina, V. E. Sinitsyn, D. V. Vlodavets

“…The group of patients with the congenital form had the most severe cognitive deficits, especially in tests of executive functions and visuospatial perception. …”
Get full text

Integrating vosoritide therapy with limb surgery in paediatric patients with achondroplasia: real-life experiences by Anna Elsa Maria Allegri, Maria Francesca Bedeschi, Maria Beatrice Bocchi, Valentina Camurri, Michaela Veronika Gonfiantini, Chiara Leoni, Milena Mariani, Osvaldo Palmacci, Matteo Porro, Simone Riganti, Caterina Tedesco, Berardo Rinaldi, Emanuela Scarano, Concetta Schiavariello, Angelo Selicorni, Stefano Stagi, Fabio Verdoni, Giuseppe Zampino, Mohamad Maghnie, Roberta Onesimo

“…Abstract Background Achondroplasia is the most common form of disproportionate short stature and can lead to serious medical complications, including foramen magnum and spinal stenosis. …”
Get full text

An HST Transmission Spectrum of the Closest M Dwarf Transiting Rocky Planet LTT 1445Ab by Katherine A. Bennett, David K. Sing, Kevin B. Stevenson, Hannah R. Wakeford, Zafar Rustamkulov, Natalie H. Allen, Joshua D. Lothringer, Ryan J. MacDonald, Nathan J. Mayne, Guangwei Fu

“…A mere 6.9 pc from Earth, LTT 1445A is the closest transiting M dwarf system, and its largest known planet, at 1.31 R _⊕ and 424 K, is one of the most promising targets in which to search for an atmosphere. …”
Get full text

STUDY OF THE STATE OF LOCAL IMMUNITY OF THE ORAL CAVITY IN CHILDREN WITH DISABILITIES by M.A. Gavrilenko

“…The problem of generalized periodontitis, which occurs in children with disabilities are among the most pressing in modern dentistry. Itself this disease contributes to premature removal of teeth in children. …”
Get full text

VOLODYMYR VINNICHENKO’S NOVEL “THE NEW COMMANDMENT”: POETICS AND FORMS OF EXISTENTIAL SELF-REFLECTION by Galyna M. Syvachenko. Shevchenko, Antonina V. Anistratenko

“…It is proved that, having spent almost the last thirty years of his life in France, the Ukrainian writer seems to aim at identifying common thematic, aesthetic, philosophical and ideological paradigms that go beyond mononational boundaries, and demonstrates that Ukrainian emigrant artists were participants in pan-European literary modernism, although for the most part it concerns Volodymyr Vynnychenko himself, as well as Yu. …”
Get full text

Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction by Vivek P. Jani, Edwin J. Yoo, Aleksandra Binek, Alina Guo, Julie S. Kim, Jennifer Aguilan, Mohammad Keykhaei, Sydney R. Jenkin, Simone Sidoli, Kavita Sharma, Jennifer E Van Eyk, David A. Kass, Virginia S. Hahn

“…Data‐independent acquisition‐mass spectrometry proteomics also yielded 2 HFpEF subgroups; the one most different from controls had a higher proportion of patients with severe obesity and exhibited lower proteins related to fuel metabolism, oxidative phosphorylation, and protein translation. …”
Get full text

Prognostic Markers of Acute Suppurative Lung Disease by D. L. Fetlam, A. G. Chumachenko, M. D. Vyazmina, V. V. Moroz, A. N. Kuzovlev, V. M. Pisarev

“…., higher values were associated with increased risk of death, with NLR index being the most informative. Overall severity of illness above 10 scores by CIRS was associated with an unfavorable ASLD outcome, regardless of patient’s history of COVID-19.…”
Get full text

Application of strut-septum complex stent in nasal tip refinement of secondary unilateral cleft rhinoplasty by DONG Zhe, LI Qiaoqiao, YANG Jiegang, FU Yuchuan, LI Jian

“…All measurements were made using preoperative photographs and the most recent follow-up photographs of the patients. …”
Get full text

Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma by Qixin Zhao, Shenglu Liu, Tao Bi, Ting Wang, Lei Chen, Juan Huang, Xuemei Yang, Xiyu Dai, Zengjin Liu, Qin Sun

“…Pancreatic malignancies rank among the most aggressive and fatal carcinomas in modern oncology, presenting significant therapeutic challenges due to their inherent chemoresistance. …”
Get full text

Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients by Fuglestad AJ, Bousquet PA, Køstner AH, Meltzer S, Kleist B, Ree AH, Rajab IM, Potempa LA, Fernandez-Botran R, Kersten C

“…., Amman, Jordan; 6College of Science, Health and Pharmacy, Roosevelt University Schaumburg, Schaumburg, IL, USA; 7Department of Pathology & Laboratory Medicine, University of Louisville, Louisville, KY, USACorrespondence: Anniken Jørlo Fuglestad, Department of Oncology, Akershus University Hospital, Sykehusveien 25, Lørenskog, 1478, Norway, Tel +47 40043360, Email annikejf@uio.noPurpose: Colorectal cancer (CRC) is the third most common type of cancer worldwide. The link between inflammation and CRC is well established. …”
Get full text

LENGTH–WEIGHT RELATIONSHIPS AND BIOLOGICAL ASPECTS FOR 34 FISH SPECIES FROM TRÊS IRMÃOS RESERVOIR, LOWER TIETÊ RIVER BASIN, SP - BRAZIL by Paula Maria Gênova de Castro CAMPANHA, Anderson Arimura MATSUMOTO, Midiã Lima BRAZÃO, Lucas Matheus BASILIO, Lidía Sumile MARUYAMA

“…A total of 7,319 individuals was identified, comprising five orders: Characiformes (7 Families), Siluriformes (5 Families), Perciformes (1 Family), Cichliformes (1 Family) and Cyprinodontiformes (1 Family). The most abundant species were Plagioscion squamosissimus (N=1,513), Geophagus sveni (N=1,160), Serrasalmus maculatus (N=1,049) and Metynnis maculatus (pacu-CD) (N=974), all of them being target species for professional artisanal fishing, with the exception of pacu-CD, which is discarded since it has no commercial interest. …”
Get full text

First Detection of the Molecular Cloud Population in the Extended Ultraviolet Disk of M83 by Jin Koda, Linda Watson, Françoise Combes, Monica Rubio, Samuel Boissier, Masafumi Yagi, David Thilker, Amanda M Lee, Yutaka Komiyama, Kana Morokuma-Matsui, Celia Verdugo

“…The cloud and clump masses, estimated from CO(3−2), range from 8.2 × 10 ^2 to 2.3 × 10 ^4 M _⊙ and from 2.7 × 10 ^2 to 7.5 × 10 ^3 M _⊙ , respectively. The most massive clouds appear similar to Orion A in star formation activity as well as in mass, as expected if the cloud mass structure is common. …”
Get full text

Women's health facility choices for antenatal, delivery, and postnatal care in Eastern Visayas, Philippines by Ahreum Choi, Heunghee Kim, Sherlyn Mae P. Provido, Hee Sun Kim, Romil Jeffrey Juson, Diana Lucas, Heyeon Ji, Jihwan Jeon, Yunhee Kang, Yunhee Kang

“…Multinomial logistic regressions were applied, adjusting for socio-economic status and Barangay location, to examine associations between socio-economic factors and ANC facility choice, as well as trends in delivery and PNC facility utilization based on ANC facility type.ResultsAmong 1,414 postpartum mothers, 35.6% received ANC at BHS, 34.1% at RHU, 32.7% at hospital/clinic, and 0.6% did not receive ANC. Most deliveries (83.3%) and PNC (61.4%) services occurred in hospital/clinic settings. …”
Get full text

Burden of chronic spontaneous urticaria in Italy through healthcare resource utilization and direct costs: a retrospective analysis of real-world using administrative healthcare da... by Giulia Ronconi, Letizia Dondi, Silvia Calabria, Leonardo Dondi, Irene Dell’Anno, Lucia Casoli, Diletta Valsecchi, Ornella Bonavita, Eustachio Nettis, Nello Martini, Carlo Piccinni

“…Cardiometabolic diseases were the most common comorbidities. Throughout the first follow-up year: 72.9% patients were treated with second-generation H1-antihistamines (mainly cetirizine), 19.5% with omalizumab; concomitantly, 55.5% received oral corticosteroids (OCS), and 25.0% non-steroidal antiinflammatory drugs. …”
Get full text

Nephroprotective and anticoagulant therapy in patients with atrial fibrillation and chronic kidney disease: real-world data by A. I. Listratov, I. I. Ivanov, N. K. Ziskina, V. V. Efimenko, A. V. Zhavoronkova, E. S. Milyakova, A. A. Kudrjavtseva, D. A. Napalkov, A. A. Sokolova

“…In 196 patients with AF, DOACs were prescribed, in 10 cases — warfarin.Conclusion. Most patients with CKD receive nephroprotective therapy with RASi and statins according to current KDIGO guidelines. …”
Get full text

The response time to emotional stimuli (including facial expressions photos) during the fMRI scanning in affective disorders: mild and moderate depression and dysthymic disorder by M. Ye. Mel’nikov, D. D. Bezmaternykh, E. D. Petrovskiy, L. I. Kozlova, M. B. Shtark, A. A. Savelov, O. S. Shubina, K. A. Natarova

“…The response time and accuracy were the subjects of analysis.Results. On the most of the computed parameters patients with depressive disorder did not differ from controls. …”
Get full text

Paralisia facial: análise epidemiológica em hospital de reabilitação Facial paralysis: epidemiological analysis in a rehabilitation hospital by Kátia Torres Batista

“…Among these patients, paralysis had different causes, and these patients were admitted with lower House-Brackmann grades. Most cases were associated with neurological deficits leading to facial paralysis of central or congenital origin.…”
Get full text

Case Report: Clinical management of a severe DBA patient with a novel RPS19 mutation by Junfen Zhou, Jiayi Zhong, Yisha Zhao, Miaojun Mo, Xianbo Chen, Huangjia Zhou, Luya Zhang, Li Lin, Yichi Zhang, Xiaohong Tao, Xianhua Mao, Haiting Li, Enfu Tao

“…Diamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure disorder characterized by defective erythropoiesis, typically caused by mutations in ribosomal protein (RP) genes, most commonly RPS19. It usually presents in early infancy with severe anemia, growth retardation, and an increased risk of congenital malformations and malignancies. …”
Get full text

Metabolomic integration with machine learning identifies potential biomarkers for type 2 diabetes mellitus and diabetic retinopathy progression by PANG Yuhui, LUO Chaokun, ZHANG Qingruo, ZHANG Xiongze, LIAO Nanying, JI Yuying, MI Lan, GAN Yuhong, SU Yongyue, WEN Feng, CHEN Hui

“…Metabolic pathway analysis revealed that "valine, leucine and isoleucine biosynthesis", "arginine biosynthesis," and "cysteine and methionine metabolism" were the most enriched pathways for T2DM. Predictive models achieved R2 values of 81.3%, and 74% for T2DM and DR progression, respectively. …”
Get full text

Interpretable machine learning for predicting isolated basal septal hypertrophy. by Lei Gao, Boyan Tian, Qiqi Jia, Xingyu He, Guannan Zhao, Yueheng Wang

“…The SHAP method identified eight predictor variables for BSH based on importance rankings, with the top four being IVS-AO Angle, LVMI, LVIDdI, and SBP, with IVS-AO Angle emerging as the most important predictor. The external validation of the RF model yielded an AUC of 0.86.…”
Get full text